Online citations, reference lists, and bibliographies.
Please confirm you are human
(Sign Up for free to never see this)
← Back to Search

Gentamicin Release From Chitosan And Collagen Composites

A. Sionkowska, B. Kaczmarek, R. Gadzała-Kopciuch
Published 2016 · Materials Science

Save to my Library
Download PDF
Analyze on Scholarcy
Share
Abstract The release of antibiotic, gentamicin sulfate, from chitosan/collagen composites was studied using high-performance liquid chromatography ( HPLC) analysis. Chitosan and collagen mixtures were prepared by mixing two solutions at different weight ratios: 75/25, 50/50, 25/75. Gentamicin sulfate was added to the mixture of two biopolymers and then films were obtained through evaporation of the solvent. Results showed that gentamicin sulfate can be incorporated in the material made of the blends of chitosan and collagen, and moreover, the antibiotic release rate can be adjusted and controlled by the alteration of the weight ratios of the components. The highest antibiotic release was observed for chitosan and collagen composite at the 75/25 ratio.
This paper references
10.2165/00137696-200402010-00003
Factors affecting mechanism and kinetics of drug release from matrix-based oral controlled drug delivery systems
M. Varma (2004)
10.1021/AR9800993
Biomaterials in drug delivery and tissue engineering: one laboratory's experience.
R. Langer (2000)
10.1302/0301-620X.74B4.1320622
Calcium hydroxyapatite ceramic used as a delivery system for antibiotics.
Y. Shinto (1992)
10.1016/S0168-3659(01)00248-6
On the importance and mechanisms of burst release in matrix-controlled drug delivery systems.
X. Huang (2001)
10.1016/0378-4347(95)00355-X
Sensitive fluorimetric determination of gentamicin sulfate in biological matrices using solid-phase extraction, pre-column derivatization with 9-fluorenylmethyl chloroformate and reversed-phase high-performance liquid chromatography.
D. Stead (1996)
10.1002/JPS.2600840816
Drug diffusion front movement is important in drug release control from swellable matrix tablets.
P. Colombo (1995)
10.1007/BF02316439
Gentamicin C: Separation of C1, C1a, C2, C2a and C2b components by HPLC using lsocratic ion-exchange chromatography and post-column derivatisation
G. Seidl (1988)
10.1016/S0142-9612(03)00374-0
Collagen/chitosan porous scaffolds with improved biostability for skin tissue engineering.
L. Ma (2003)
10.1021/BM7009015
Electrospun water-soluble carboxyethyl chitosan/poly(vinyl alcohol) nanofibrous membrane as potential wound dressing for skin regeneration.
Y. Zhou (2008)
10.1016/0378-5173(94)00324-X
Recent advances on the use of biodegradable microparticles and nanoparticles in controlled drug delivery
L. Brannon-Peppas (1995)
Generation of new bone around titanium implants using a membrane technique: an experimental study in rabbits.
C. Dahlin (1989)
10.1164/RCCM.200504-613PP
The potential advantages of nanoparticle drug delivery systems in chemotherapy of tuberculosis.
S. Gelperina (2005)
10.1126/SCIENCE.1095833
Drug Delivery Systems: Entering the Mainstream
T. Allen (2004)
10.2174/1567201811666140414120002
Antibiotic releasing biodegradable scaffolds for osteomyelitis.
M. Nair (2014)
10.1016/J.PROGPOLYMSCI.2011.05.003
Current research on the blends of natural and synthetic polymers as new biomaterials: Review
A. Sionkowska (2011)
10.1021/CR940351U
Polymeric systems for controlled drug release.
K. Uhrich (1999)
10.1038/42218
Biodegradable block copolymers as injectable drug-delivery systems
B. Jeong (1997)
10.1023/A:1016272212833
The Effect of Electrostatic Charge Interactions on Release Rates of Gentamicin from Collagen Matrices
M. Singh (2004)
10.1016/J.PROGPOLYMSCI.2007.05.017
Biodegradable polymers as biomaterials
L. Nair (2007)
10.4028/www.scientific.net/KEM.587.205
Biological Properties of Chitosan/Collagen Composites
A. Sionkowska (2013)
10.1016/j.jconrel.2005.10.028
Delivery of the antibiotic gentamicin sulphate from precipitation cast matrices of polycaprolactone.
H-I Chang (2006)
10.1016/j.ijbiomac.2012.10.002
Properties and modification of porous 3-D collagen/hydroxyapatite composites.
A. Sionkowska (2013)
10.1016/0142-9612(81)90059-4
Present and future applications of biomaterials in controlled drug delivery systems.
R. Langer (1981)
10.1080/10717540590889781
Chitosan-Based Particles as Controlled Drug Delivery Systems
M. Prabaharan (2005)
10.2174/1567201811310040010
Current trends in microsponge drug delivery system.
H. Gangadharappa (2013)
10.1016/S0142-9612(01)00094-1
In vivo biocompatibility and degradability of a novel injectable-chitosan-based implant.
F. Mi (2002)
10.4028/www.scientific.net/KEM.672.247
Properties and Characterization of Chitosan/Collagen/PMMA Composites Containing Hydroxyapatite
A. Sionkowska (2016)
10.1016/S0140-6736(81)91730-X
APPLICATION OF THE BIOLOGICAL PRINCIPLE OF INDUCED OSTEOGENESIS FOR CRANIOFACIAL DEFECTS
J. Glowacki (1981)
10.1016/J.CARBPOL.2011.03.051
Preparation, characterization and in vitro release of chitosan nanoparticles loaded with gentamicin and salicylic acid
Jingou Ji (2011)
10.1016/S0144-8617(01)00331-9
Preparation, characterization and in-vitro release of gentamicin from coralline hydroxyapatite–chitosan composite microspheres
M. Sivakumar (2002)
10.1002/JBM.10312
Calcium phosphate/chitosan composite scaffolds for controlled in vitro antibiotic drug release.
Y. Zhang (2002)
10.1016/S0378-5173(03)00087-5
Bioadhesive microspheres as a controlled drug delivery system.
Jaspreet K. Vasir (2003)
10.1016/J.MOLLIQ.2014.09.028
Modification of collagen and chitosan mixtures by the addition of tannic acid
A. Sionkowska (2014)
10.1016/S0021-9673(00)00980-8
Sample preparation for residue determination of gentamicin and neomycin by liquid chromatography.
A. Posyniak (2001)
10.1016/S1461-5347(00)00269-8
Swellable matrices for controlled drug delivery: gel-layer behaviour, mechanisms and optimal performance.
Colombo (2000)
10.1023/A:1018921830385
A Floating Controlled-Release Drug Delivery System: In Vitro-in Vivo Evaluation
Subhash Desai (2004)
10.1021/CR00046A003
Application of functionalized polymers in organic synthesis
A. Akelah (1981)
10.1016/S0142-9612(03)00595-7
Molecular interactions in collagen and chitosan blends.
A. Sionkowska (2004)



This paper is referenced by
10.3390/ma13245641
Blended Natural Support Materials—Collagen Based Hydrogels Used in Biomedicine
Ruxandra-Elena Geanaliu-Nicolae (2020)
10.1016/J.MSEC.2019.109757
Mechanical testing of antimicrobial biocomposite coating on metallic medical implants as drug delivery system.
I. Karacan (2019)
10.1016/j.carbpol.2018.01.044
Microbicidal gentamicin-alginate hydrogels.
Stalin Kondaveeti (2018)
10.1002/ADV.21912
Chitosan/collagen blends with inorganic and organic additive—A review
B. Kaczmarek (2018)
10.1002/PEN.25122
Preparation and characterization of biomedical collagen–chitosan scaffolds with entrapped ibuprofen and silver nanoparticles
M. S. Rubina (2019)
Design of micelle embedded chitosan nanocomposites for targeted delivery of hydrophobic drugs
Esra Cihan (2016)
10.1007/S42452-018-0064-1
Development of antimicrobial composite coatings for drug release in dental, orthopaedic and neural prostheses applications
I. Macha (2018)
10.1016/j.carbpol.2017.02.066
Sustainable hydroxypropyl methylcellulose/xyloglucan/gentamicin films with antimicrobial properties.
Stalin Kondaveeti (2017)
10.1002/jbm.a.36719
Fabrication of alginate modified brushite cement impregnated with antibiotic: Mechanical, thermal, and biological characterizations.
S. M. H. Dabiri (2019)
10.3390/polym12030548
Development and Characterization of Hemicellulose-Based Films for Antibacterial Wound-Dressing Application
N. Ahmad (2020)
10.3390/polym11020283
Laser Processed Antimicrobial Nanocomposite Based on Polyaniline Grafted Lignin Loaded with Gentamicin-Functionalized Magnetite
A. Visan (2019)
10.1016/j.msec.2018.01.005
Antimicrobial activity of new materials based on the blends of collagen/chitosan/hyaluronic acid with gentamicin sulfate addition.
M. Michalska-Sionkowska (2018)
10.1016/j.colsurfb.2019.110535
Nanotubes and nano pores with chitosan construct on TiZr serving as drug reservoir.
A. B. Stoian (2019)
10.3390/ma13153433
Silk Fibroin/Collagen/Chitosan Scaffolds Cross-Linked by a Glyoxal Solution as Biomaterials toward Bone Tissue Regeneration
Sylwia Grabska-Zielińska (2020)
Preparation and characterization of polymer based composite nanospheres for bone infection prevention
Ceren Kimna (2018)
10.1039/c9cp02357g
Structure and dynamics of gold nanoparticles decorated with chitosan-gentamicin conjugates: ReaxFF molecular dynamics simulations to disclose drug delivery.
S. Monti (2019)
10.1016/J.JDDST.2017.11.017
Novel synergistic activities of tetracycline copper oxide nanoparticles integrated into chitosan micro particles for delivery against multiple drug resistant strains: Generation of reactive oxygen species (ROS) and cell death
Zahra Assadi (2018)
10.1016/j.polymertesting.2020.106698
In vitro and in vivo evaluation of silk fibroin-hardystonite-gentamicin nanofibrous scaffold for tissue engineering applications
Z. Hadisi (2020)
10.4028/www.scientific.net/KEM.782.212
Multifunctional-Dual Drug Delivery Poly-Lactic Acid Biocomposite Coating with Hydroxyapatite for Bone Implants
I. Karacan (2018)
Semantic Scholar Logo Some data provided by SemanticScholar