Online citations, reference lists, and bibliographies.

Synthesis, Characterization, Cytotoxicity And DNA Binding Studies Of Fe3O4@SiO2 Nanoparticles Coated By An Antiviral Drug Lamivudine

Nahid Shahabadi, Aref Khorshidi, Hossein Zhaleh, Soheila Kashanian
Published 2018 · Chemistry
Cite This
Download PDF
Analyze on Scholarcy
Abstract Chemically, lamivudine is amino-1-[(2R,5S)-2-(hydroxymethyl)-4,1,3-oxathiolan-5-yl]-1,2-dihydropyrimidin-2-one, that commonly named 3TC, is a water soluble potent nucleoside analog reverse transcriptase inhibitor. The present protocol reports the covering of silica on the surface of Fe3O4 nanoparticles (NPs) using Stober method via sol-gel process and preparation of magnetic Fe3O4@SiO2-lamivudine NPs via chemical co-precipitation procedure. The structural features of Fe3O4@SiO2-3TC NPs were characterized by FT-IR spectroscopy, TEM, FESEM, Zetasizer and TGA analyzer, observations. The obtained results from structural analysis clearly indicate the core-shell array with average sizes of 30 nm for Fe3O4@SiO2-3TC NPs. The in vitro cytotoxic activity of Fe3O4@SiO2-3TC NPs was explored against AGS and MCF-7 cancer cell lines in comparison with lamivudine using LDH colorimetric assay and differential staining cell death assay (Hoechst/Propodium Ioide). Achieved results revealed that the influences of Fe3O4@SiO2-3TC NPs on the cell lines were nearly two orders of magnitude higher than that of lamivudine. Furthermore, the spectroscopic methods proved that DNA used groove binding mode for aggregated on Fe3O4@SiO2-3TC NPs.
This paper references
Superparamagnetic silica nanoparticles with immobilized metal affinity ligands for protein adsorption
Zhiya Ma (2006)
Lamivudine as a Nucleoside Template To Engineer DNA-Like Double-Stranded Helices in Crystals
Alline Torquato Vasconcelos (2014)
Influence of Processing Methodology on Magnetic Behavior of Multicomponent Ferrite Nanocrystals
Sanjeev Kumar (2010)
Nanoreticulations of etherified locust bean polysaccharide for controlled oral delivery of lamivudine.
Sabyasachi Maiti (2014)
Morphine Inhibits Cell Death in PC12 Cells by Activation of PI3K/Akt Signal Pathway
Hossein Zhaleh (2012)
Quantum chemical and experimental studies on polymorphism of antiviral drug Lamivudine.
G. R. Ramkumaar (2012)
Antitumour metal compounds: more than theme and variations.
Michael A. Jakupec (2008)
Pyrimidine nucleoside analogs in cancer treatment
Carlos M Galmarini (2003)
Infrared Spectroscopy - Materials Science, Engineering and Technology
Theophile Theophanides (2012)
Harrison's Principles of Internal Medicine
edotir's Eugene Braunwald... (1950)
A Novel Two-Step Silica-Coating Process for Engineering Magnetic Nanocomposites
Qingxia Liu (1998)
Textbook of Therapeutics: Drug and Disease Management
Eric T. Herfindal (2000)
WITHDRAWN: Magnetite nanoparticles coated with tannic acid as a green reductant and stabilizer sorbent for palladium ions: Synthetic application of Fe3O4@TA-Pd NPs as magnetically separable and reusable nanocatalyst for reduction of 4-nitrophenol and Suzuki reactions
Hojat Veisi (2017)
Spectroscopic studies on the interaction of sodium benzoate, a food preservative, with calf thymus DNA.
Guowen Zhang (2013)
A spectroscopic investigation on the interaction of a magnetic ferrofluid with a model plasma protein: effect on the conformation and activity of the protein.
Bijan Kumar Paul (2012)
The role of nucleoside transporters in cancer chemotherapy with nucleoside drugs
Jing Zhang (2007)
Infrared Spectroscopy of Functionalized Magnetic Nanoparticles
Perla E. García Casillas (2012)
Determination of nucleic acids based on the fluorescence quenching of Hoechst 33258 at pH 4.5
Yuan Yu Guan (2006)
Principles of fluorescence spectroscopy
Joseph R. Lakowicz (1983)
Drug-DNA interactions and their study by UV-Visible, fluorescence spectroscopies and cyclic voltametry.
Muhammad Sirajuddin (2013)
Analysis of Organosilicon Compounds
Thomas Roy Crompton (2004)
Polymer grafted recyclable magnetic nanoparticles
Lei Wang (2015)
Experience with the use of a first-line regimen of stavudine, lamivudine and nevirapine in patients in the TREAT Asia HIV Observational Database.
Jialun Zhou (2007)
Single-step nanoengineering of silica coated maghemite hollow spheres with tunable magnetic properties
Pedro Tartaj (2001)
PVP magnetic nanospheres: biocompatibility, in vitro and in vivo bleomycin release.
Ding Guo-wei (2007)
Functionalization of Fe3O4@SiO2 magnetic nanoparticles with nicotinamide and in vitro DNA interaction
Nahid Shahabadi (2016)
Thermodynamic and spectrographic studies on the interactions of ct-DNA with 5-fluorouracil and tegafur
Xiangyu Xu (2009)
An improved way to prepare superparamagnetic magnetite-silica core-shell nanoparticles for possible biological application
Yongkang Sun (2005)
Spectroscopic and Electrochemical Studies on the Interaction of Carmoisine Food Additive with Native Calf Thymus DNA
Mitra Arvin (2013)
Binding of Hoechst 33258 to the minor groove of B-DNA.
Philip Pjura (1987)
A general method to coat colloidal particles with titania.
Ahmet Faik Demirörs (2003)
Different conformations of double-stranded nucleic acid in solution as revealed by circular dichroism.
Valery Ivanov (1973)
Synthesis optimization and characterization of chitosan-coated iron oxide nanoparticles produced for biomedical applications
Gozde Unsoy (2012)
Fe3O4 inverse spinal super paramagnetic nanoparticles
Obaid ur Rahman (2012)
Study of interactions of flavonoids with DNA using acridine orange as a fluorescence probe
Shuyun Bi (2006)
Nanomagnetic sensing of blood plasma protein interactions with iron oxide nanoparticles: impact on macrophage uptake.
Lénaic Lartigue (2012)
Electrochemical and Spectral studies on the Interaction of the Antiparasitic Drug Nitazoxanide with DNA
A. Radi (2014)
Bleomycin Loaded Magnetic Chitosan Nanoparticles as Multifunctional Nanocarriers
Doga Kavaz (2010)
Drug-Loaded Nanoparticle Systems And Adult Stem Cells: A Potential Marriage For The Treatment Of Malignant Glioma?
Brenda Auffinger (2013)
Irreversible changes in protein conformation due to interaction with superparamagnetic iron oxide nanoparticles.
Morteza Mahmoudi (2011)

This paper is referenced by
Magnetic adsorbent based on mesoporous silica nanoparticles for magnetic solid phase extraction of pyrethroid pesticides in water samples.
Meixing Zhang (2019)
Spectroscopic studies on the interaction of Fe
Nahid Shahabadi (2019)
Anchored Ni‐dimethylglyoxime complex on Fe 3 O 4 @SiO 2 core/shell nanoparticles for the clean catalytical synthesis of dicoumarols
Nishtman Hassanloie (2020)
Fe3O4–ZnO Core–Shell Nanoparticles Fabricated by Ultra-Thin Atomic Layer Deposition Technique as a Drug Delivery Vehicle
Sejong Seong (2019)
Reverse Transcriptase Inhibitors Nanosystems Designed for Drug Stability and Controlled Delivery
F. Grande (2019)
New materials in sample preparation: Recent advances and future trends
Edvaldo Vasconcelos Soares Maciel (2019)
Synthesis, characterization, and evaluation of a magnetic molecular imprinted polymer for 5-fluorouracil as an intelligent drug delivery system for breast cancer treatment
Mohammad Shadabfar (2020)
Spectroscopic studies on the interaction of Fe3O4@CaAl LDH@Lamivudine with the calf thymus DNA
Nahid Shahabadi (2019)
Synthesis, surface modification, and applications of magnetic iron oxide nanoparticles
Wenhui Ling (2019)
Study of phase transformations, structural, corrosion properties and cytotoxicity of magnetite-based nanoparticles
A. Kozlovskiy (2019)
Semantic Scholar Logo Some data provided by SemanticScholar