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Pain Phenomena And Sensory Recovery Following Brachial Plexus Avulsion Injury And Surgical Repairs

M. Htut, P. Misra, P. Anand, R. Birch, T. Carlstedt
Published 2006 · Medicine

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Seventy-six patients with severe brachial plexus avulsion injuries were studied using pain questionnaires and quantitative sensory testing. There was significant correlation between pain intensity and the number of roots avulsed prior to surgery (P = 0.0004) and surgical repairs were associated with pain relief. Sensory recovery to thermal stimuli was observed, mainly in the C5 dermatome. Allodynia to mechanical and thermal stimuli was observed in the border zone of affected and unaffected dermatomes in 18% of patients assessed early (<6 months) and 37% patients at later stages. Pain and sensations referred to the original source of afferents occurred at a later stage (>6 months) in 12% of patients and were related to nerve regeneration. By contrast, “wrong-way” referred sensations (e.g. down the affected arm while shaving or drinking cold fluids) were reported by 44% of patients and often occurred early, suggesting CNS plasticity. Understanding sensory mechanisms will help develop new treatments for severe brachial plexus injuries.
This paper references
10.1016/J.LFS.2004.01.003
Dissecting out mechanisms responsible for peripheral neuropathic pain: implications for diagnosis and therapy.
C. Woolf (2004)
10.1097/00002508-200006001-00004
Peripheral Neuropathic Pain: From Mechanisms to Symptoms
R. Baron (2000)
The relationship of perceptual phenomena and cortical reorganisation in upper extremity
SM Grusser (2001)
10.1016/0006-8993(86)91153-4
Long-term cortical consequences of reinnervation errors after nerve regeneration in monkeys
J. Wall (1986)
Dorsal root entry zone lesions: a new neurosurgical therapy for deafferentation pain
BS Nashold (1983)
10.3171/JNS.2000.93.2.0237
Analysis of aqueductal cerebrospinal fluid flow after endoscopic aqueductoplasty by using cine phase-contrast magnetic resonance imaging.
H. Schroeder (2000)
10.1073/PNAS.090572597
Growth of new brainstem connections in adult monkeys with massive sensory loss.
N. Jain (2000)
: are cutaneous nociceptors and spinothalamic neurons involved in the signaling and maintenance of spontaneous and touch - evoked pain ? A case report
R Baron (1995)
10.1002/CNE.902760308
Expansion of spinal cord primary sensory afferent projection following combined sciatic nerve resection and saphenous nerve crush: A horseradish peroxidase study in the adult rat
C. Molander (1988)
10.1093/BRAIN/121.9.1603
The perception of phantom limbs. The D. O. Hebb lecture.
V. Ramachandran (1998)
10.1016/0014-4886(73)90287-2
Referred cutaneous sensation.
P. Sterling (1973)
10.1016/0304-3959(94)00188-K
Phantom limb pain: are cutaneous nociceptors and spinothalamic neurons involved in the signaling and maintenance of spontaneous and touch-evoked pain? A case report
R. Baron (1995)
Neuroscience: Exploring the Brain
M. Bear (1996)
10.1016/S0140-6736(95)92342-X
Return of function after spinal cord implantation of avulsed spinal nerve roots
T. Carlstedt (1995)
10.1054/jhsb.1999.0339
Brain Plasticity and Hand Surgery: an Overview
G. Lundborg (2000)
10.1093/BRAIN/AWF017
Restoration of sensory function and lack of long-term chronic pain syndromes after brachial plexus injury in human neonates.
P. Anand (2002)
10.1073/PNAS.90.22.10413
Behavioral and magnetoencephalographic correlates of plasticity in the adult human brain.
V. Ramachandran (1993)
10.1016/0304-3940(95)12186-2
Cortical reorganization in human amputees and mislocalization of painful stimuli to the phantom limb
S. Knecht (1995)
10.1073/PNAS.74.10.4702
Mysterious form of referred sensation in man.
C. P. Richter (1977)
10.1146/ANNUREV.NE.06.030183.001545
The reorganization of somatosensory cortex following peripheral nerve damage in adult and developing mammals.
J. Kaas (1983)
10.1353/pbm.1981.0002
A Curious Kind of Distant Referral from a Slightly Painful Stimulus to the Skin
W. Bean (1981)
10.1111/j.1600-0404.1999.tb07386.x
Mechanisms of pain in peripheral neuropathy
N. Attal (1999)
10.1152/PHYSIOLOGYONLINE.1998.13.3.143
Reorganization of Somatosensory Cortex After Nerve and Spinal Cord Injury.
N. Jain (1998)
10.1080/07367244.1984.11800557
Absence of intraspinal sprouting in dorsal root axons caudal to a partial spinal hemisection: a horseradish peroxidase transport study.
B. Rodin (1984)
10.1111/j.1085-9489.2003.03027.x
Nerve injury and repair – a challenge to the plastic brain
G. Lundborg (2003)
10.1002/mus.1143
Nerve lesions and the generation of pain
J. Campbell (2001)
10.1097/00001756-199303000-00001
Thumb in cheek? Sensory reorganization and perceptual plasticity after limb amputation.
P. Halligan (1993)
10.1076/neur.7.5.397.16251
Referred Sensations Following Stroke
A. Turton (2001)
10.1093/BRAIN/111.5.1187
Distant referral of cutaneous sensation (Mitempfindung). Observations on its normal and pathological occurrence.
G. Schott (1988)
10.1016/S0894-1130(12)80290-0
Reorganization of cortical representations of the hand following alterations of skin inputs induced by nerve injury, skin island transfers, and experience.
M. Merzenich (1993)
10.1097/00001756-200111160-00012
Long-term trans-synaptic glial responses in the human thalamus after peripheral nerve injury
R. Banati (2001)
10.1007/BF00380970
Phantom phenomena (Phantom Arm) following cervical root avulsion
J. Malin (2004)
10.3171/FOC.2004.16.5.8
Restoration of hand function and so called "breathing arm" after intraspinal repair of C5-T1 brachial plexus avulsion injury. Case report.
T. Carlstedt (2004)
10.1007/S001010070105
[Neuropathic pain. The long path from mechanisms to mechanism-based treatment].
R. Baron (2000)
10.1136/bmj.2.6040.839
Referred itch (Mitempfindungen).
P. R. Evans (1976)
10.1002/CNE.902150206
An examination of intraspinal sprouting in dorsal root axons with the tracer horseradish peroxidase
B. Rodin (1983)
10.1212/WNL.45.12_Suppl_8.S63
Mechanical allodynia in postherpetic neuralgia
R. Baron (1995)
10.1111/j.1749-6632.2001.tb05822.x
Central Neuroplasticity and Pathological Pain
R. Melzack (2001)
10.1126/SCIENCE.1843843
Massive cortical reorganization after sensory deafferentation in adult macaques.
T. Pons (1991)
10.1093/BRAIN/121.4.717
Plasticity of plasticity? Changes in the pattern of perceptual correlates of reorganization after amputation.
S. Knecht (1998)
10.1016/S0014-2999(01)01302-4
The clinical picture of neuropathic pain.
T. Jensen (2001)
Current Problems of Lower Vertebrate Phylogeny.
G. J. Romanes (1969)
: review of clinical and experimental evidence
M Condes-Lara (2000)
PAIN PHENOMENA AND SENSORY RECOVERY 605 humans
BS Nashold
10.1159/000099953
Abnormal physiology of the dorsal horn as related to the deafferentation syndrome.
J. Ovelmen-Levitt (1988)
10.1016/S0304-3959(97)00220-0
Pain following human brachial plexus injury with spinal cord root avulsion and the effect of surgery
J. Berman (1998)
Large-Scale Sprouting of Cortical Connections After Peripheral Injury in Adult Macaque Monkeys
Richard M. Napier (1998)
10.1523/JNEUROSCI.22-17-07746.2002
Degeneration of Myelinated Efferent Fibers Induces Spontaneous Activity in Uninjured C-Fiber Afferents
G. Wu (2002)
10.1016/0304-3959(93)90161-H
Contribution of central neuroplasticity to pathological pain: review of clinical and experimental evidence
T. J. Coderre (1993)
10.1038/375482A0
Phantom-limb pain as a perceptual correlate of cortical reorganization following arm amputation
H. Flor (1995)
10.1007/s00221-003-1649-4
Remote activation of referred phantom sensation and cortical reorganization in human upper extremity amputees
S. Grüsser (2003)
10.1016/0304-3959(80)90027-5
Pain in avulsion lesions of the brachial plexus
C. Parry (1980)
10.1016/S0306-4522(00)00491-7
The relationship of perceptual phenomena and cortical reorganization in upper extremity amputees
S. Grüsser (2001)
10.1302/0301-620X.78B5.0780759
Pain relief from preganglionic injury to the brachial plexus by late intercostal nerve transfer.
J. Berman (1996)
10.3171/SPI.2000.93.2.0237
Spinal nerve root repair and reimplantation of avulsed ventral roots into the spinal cord after brachial plexus injury.
T. Carlstedt (2000)
10.1097/00001756-199804200-00011
Acute plasticity in the human somatosensory cortex following amputation
D. Borsook (1998)
10.1097/00001756-200005150-00011
A neural substrate for nonpainful phantom limb phenomena
H. Flor (2000)
10.1002/CNE.903040211
Sprouting of peripherally regenerating primary sensory neurones in the adult central nervous system
S. McMahon (1991)
10.1053/eujp.2000.0176
Brain somatic representation of phantom and intact limb: a fMRI study case report
M. Condés-Lara (2000)
10.1136/jnnp.67.2.259c
Surgical Disorders of the Peripheral Nerves.
I. Whitworth (1999)
The perception of phantom limbs
V. S. Ramachandran (1998)
10.1073/PNAS.250348997
Referred phantom sensations and cortical reorganization after spinal cord injury in humans.
C. Moore (2000)
10.1016/S0006-8993(96)01230-9
Glial cell reactions in the spinal cord after sensory nerve stimulation are associated with axonal injury
C. Molander (1997)
10.1016/S0896-6273(00)81117-4
Two Directions of Plasticity in the Sensory-Deprived Adult Cortex
D. Polley (1999)
10.1016/0959-4388(92)90191-M
Dynamic features of sensory and motor maps
P. Garraghty (1992)
10.1016/S0079-6123(00)28015-1
The reorganization of somatosensory and motor cortex after peripheral nerve or spinal cord injury in primates.
J. Kaas (2000)
10.1016/S0928-4257(02)00018-9
Brain plasticity and microglia: is transsynaptic glial activation in the thalamus after limb denervation linked to cortical plasticity and central sensitisation?
R. Banati (2002)
10.1001/ARCHNEUR.1967.00470300071012
Some effects of deafferentation on neurons of the cat spinal cord.
J. Loeser (1967)
10.1016/0304-3959(75)90044-5
The McGill Pain Questionnaire: Major properties and scoring methods
R. Melzack (1975)
10.1126/SCIENCE.1439826
Perceptual correlates of massive cortical reorganization.
V. Ramachandran (1992)
10.1152/JN.1997.77.5.2753
Abnormal access of axial vibrotactile input to deafferented somatosensory cortex in human upper limb amputees.
J. Kew (1997)



This paper is referenced by
10.1038/nrneurol.2009.137
Cortical activity and hand function restoration in a patient after spinal cord surgery
T. Carlstedt (2009)
10.1097/AJP.0000000000000493
The Associated Factors and Clinical Features of Neuropathic Pain After Brachial Plexus Injuries: A Cross-sectional Study
Yingjie Zhou (2017)
10.1177/1753193414539865
Timing of surgical reconstruction for closed traumatic injury to the supraclavicular brachial plexus
R. Birch (2015)
Histological analysis of motoneuron survival and microglia inhibitionafter nerve root avulsion treated with nerve graft implantationand minocycline: an experimental study
Faizul H. Ghazali (2016)
10.1111/j.1751-0813.2008.00379.x
Clinical diagnosis and treatment of suspected neuropathic pain in three dogs.
R. G. Cashmore (2009)
10.3389/fneur.2016.00135
New Treatments for Spinal Nerve Root Avulsion Injury
T. Carlstedt (2016)
Rehabilitation of brachial plexus injuries in adults and children.
N. Smania (2012)
10.1016/j.jhsa.2008.11.017
Patient-reported outcome after peripheral nerve injury.
C. Novak (2009)
10.3344/kjp.2013.26.4.401
Percutaneous T2 and T3 Radiofrequency Sympathectomy for Complex Regional Pain Syndrome Secondary to Brachial Plexus Injury: A Case Series
Chee Kean Chen (2013)
10.1111/pme.12635
Phantom pain in a patient with brachial plexus avulsion injury.
H. Shankar (2015)
10.5772/29384
Sensory Nerve Regeneration at the CNS-PNS Interface
Xiaoqing Tang (2012)
Chapter 6 Treatment of Neuropathic Pain in Brachial Plexus Injuries
N. Sáiz-Sapena (2019)
Stem cell transplantation and regeneration after dorsal root avulsion
Carl Trolle (2016)
10.1142/S0218810415500057
Neuropathic pain in brachial plexus injury.
Direk Tantigate (2015)
10.1007/978-1-84882-108-8_5
Clinical Aspects of Nerve Injury
R. Birch (2010)
10.5772/INTECHOPEN.82431
Nerve Root Reimplantation in Brachial Plexus Injuries
V. Vanaclocha-Vanaclocha (2019)
10.3389/fneur.2010.00011
Perspectives on the Treatment of the Longitudinal Spinal Cord Injury
T. Carlstedt (2010)
10.3171/2018.1.JNS172068
Timing of surgery in traumatic brachial plexus injury: a systematic review.
E. Martin (2018)
10.1016/j.expneurol.2010.05.007
Clinical prospects for transplantation of OECs in the repair of brachial and lumbosacral plexus injuries: Opening a door
G. Raisman (2011)
10.1177/1758998318796010
The lived experience of motor recovery of elbow flexion following Oberlin nerve transfer: A qualitative analysis
H. Brown (2018)
10.1007/978-3-642-34746-7_44
Traumatic Lesions of the Brachial Plexus
Rolfe Birch (2014)
Provisional chapter Treatment of Neuropathic Pain in Brachial Plexus Injuries
N. Sáiz-Sapena (2019)
10.1016/B978-0-444-52137-8.00021-8
The longitudinal spinal cord injury: lessons from intraspinal plexus, cauda equina and medullary conus lesions.
T. Carlstedt (2012)
10.1097/ACO.0b013e32830c900c
Acute neuropathic pain: diagnosis and treatment
P. Gray (2008)
10.1016/B978-1-4160-6839-6.10130-3
Dorsal Root Entry Zone Lesions
Kevin S. Cahill (2012)
Rel * tionships Among Pain Disability , Pain fnrensnry , trllness fnffusiveness , and Upper Extremity Disability in Patients With Tr * umatic Peripiasral Nerve Injury
C. Novak (2011)
10.1007/978-1-84882-108-8_9
The Closed Supraclavicular Lesion
R. Birch (2010)
10.2340/16501977-0526
Three cases of referred sensation in traumatic nerve injury of the hand: implications for understanding central nervous system reorganization.
Salima D Pourrier (2010)
10.1016/j.avsg.2015.10.038
Axillary Artery Injury Associated with Proximal Humeral Fractures: Review of Long-Term Vascular, Orthopedic, and Neurologic Outcomes.
A. Ng (2016)
10.1097/SCS.0000000000000841
Brachial Plexus Injury: Treatment Options and Outcomes
Samantha Arzillo (2014)
10.3969/j.issn.1673-5374.2013.30.005
Human periodontal ligament stem cells repair mental nerve injury
Bohan Li (2013)
Root repair review: basic science background and clinical outcome.
T. Carlstedt (2008)
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