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DOI: 10.1016/J.MOLSTRUC.2009.09.032

Binding Of Caffeine, Theophylline, And Theobromine With Human Serum Albumin: A Spectroscopic Study

H. Zhang, T. Chen, Q. Zhou, Y. Wang
Published 2009 · Chemistry

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Abstract The interaction between three purine alkaloids (caffeine, theophylline, and theobromine) and human serum albumin (HSA) was investigated using UV/vis absorption, circular dichroism (CD), fluorescence, synchronous fluorescence, and three-dimensional fluorescence spectra techniques. The results revealed that three alkaloids caused the fluorescence quenching of HSA by the formation of alkaloid–HSA complex. The binding site number n and apparent binding constant K A , corresponding thermodynamic parameters the free energy change (Δ G ), enthalpy change (Δ H ), and entropy change (Δ S ) at different temperatures were calculated. The hydrophobic interaction plays a major role in stabilizing the complex. The distance r between donor (HSA) and acceptor (alkaloids) was obtained according to fluorescence resonance energy transfer. The effect of alkaloids on the conformation of HSA was analyzed using circular dichroism (CD), UV/vis absorption, synchronous fluorescence and three-dimensional fluorescence spectra techniques.
This paper references
10.1016/J.MOLSTRUC.2007.09.002
Study of the interaction between icariin and human serum albumin by fluorescence spectroscopy
Guowen Zhang (2008)
10.1016/S0022-2860(02)00256-9
Interaction of drugs with bovine and human serum albumin
A. Sułkowska (2002)
10.1016/j.saa.2009.04.018
Study on the interaction between antibacterial drug and bovine serum albumin: a spectroscopic approach.
P. Naik (2009)
10.1016/J.DYEPIG.2008.12.008
A fluorimetric study of the interaction of C.I. Solvent Red 24 with haemoglobin
Hong-mei Zhang (2009)
10.1016/s0026-265x(00)00048-5
Introduction to fluorescence spectroscopy
S. Schulman (1999)
10.1016/J.SAA.2006.01.024
Fluorescence study on the interaction of human serum albumin with bromsulphalein.
Fangqin Cheng (2006)
10.1016/J.PHARMTHERA.2006.02.002
Immunomodulatory effects of caffeine: friend or foe?
Louise A Horrigan (2006)
10.1016/S0065-3233(08)60640-3
Structure of serum albumin.
D. Carter (1994)
10.1016/J.JPBA.2006.01.028
Studies of the interaction between palmatine hydrochloride and human serum albumin by fluorescence quenching method.
Y. Wang (2006)
10.1016/J.SAA.2004.05.028
Molecular spectroscopic study on the interaction of tetracyclines with serum albumins.
Shuyun Bi (2005)
10.1016/J.JCIS.2007.03.006
Spectroscopic studies on the interaction between human hemoglobin and CdS quantum dots.
X. Shen (2007)
10.1038/358209A0
Atomic structure and chemistry of human serum albumin
X. M. He (1992)
10.1016/J.BBAGEN.2004.06.021
Interactions of human serum albumin with chlorogenic acid and ferulic acid.
J. Kang (2004)
10.1006/JMBI.2000.5208
Crystal structures of human serum albumin complexed with monounsaturated and polyunsaturated fatty acids.
I. Petitpas (2001)
10.1021/BI00514A017
Thermodynamics of protein association reactions: forces contributing to stability.
Philip D. Ross (1981)
10.1016/J.SAA.2006.02.004
Spectroscopic studies on the interaction between 3,4,5-trimethoxybenzoic acid and bovine serum albumin.
Y. Hu (2006)
10.1016/J.MOLSTRUC.2007.11.043
Studies of the interaction between Sudan I and bovine serum albumin by spectroscopic methods
Ye-Zhong Zhang (2008)
10.1016/J.SAA.2003.08.003
Chlorpromazine interactions to sera albumins. A study by the quenching of fluorescence.
D. Silva (2004)
10.1016/S1567-5394(01)00170-0
Fluorescence studies on PAMAM dendrimers interactions with bovine serum albumin.
B. Klajnert (2002)
10.1007/BF03259836
Theophylline Poisoning
P. Gaudreault (1986)
10.1016/J.IJBIOMAC.2006.02.015
Binding of all-trans retinoic acid to human serum albumin: fluorescence, FT-IR and circular dichroism studies.
T. K. Maiti (2006)
10.1016/J.MOLSTRUC.2009.05.036
Investigation of the interaction between pentachlorophenol and human serum albumin using spectral methods
Y. Wang (2009)
10.1002/CJOC.200590009
Study on the Interaction between Pefloxacin Mesylate and Human Serum Albumin
Fei Tan (2005)
10.1021/BM050996B
Effect of albumin conformation on the binding of ciprofloxacin to human serum albumin: a novel approach directly assigning binding site.
B. Ahmad (2006)
10.1016/j.saa.2008.12.003
Probing the binding sites and the effect of berbamine on the structure of bovine serum albumin.
Xiao-xia Cheng (2009)
10.1007/S10953-008-9351-6
Spectroscopic Studies on the Interaction of Vitamin C with Bovine Serum Albumin
H. Xu (2009)
10.1016/s0021-9258(19)76406-0
Studies on the ultraviolet difference spectra of proteins and polypeptides.
A. Glazer (1961)
10.1016/j.braindev.2003.12.008
Theophylline impairs memory/learning in developing mice
M. Hirose (2004)
10.1016/J.BPC.2005.12.003
Complexation of norfloxacin with DNA in the presence of caffeine.
M. Evstigneev (2006)
10.1111/j.1749-6632.1973.tb20465.x
PHYSICOCHEMICAL ASPECTS OF DRUG‐PROTEIN INTERACTIONS: A GENERAL PERSPECTIVE
I. M. Klotz (1973)
10.1016/J.MOLSTRUC.2006.10.058
Effect of temperature on the methotrexate - BSA interaction: Spectroscopic study
A. Sułkowska (2007)
10.1016/J.JPBA.2007.08.032
Analysis of binding interaction between puerarin and bovine serum albumin by multi-spectroscopic method.
J. Xiao (2007)
10.1016/0091-6749(85)90102-2
The relationship of cerebrospinal fluid and plasma theophylline concentrations in children and adolescents taking theophylline.
W. A. Auritt (1985)
10.1016/S1386-1425(02)00362-1
Study of the interaction between daunorubicin and human serum albumin, and the determination of daunorubicin in blood serum samples.
Chong-qiu Jiang (2003)
10.1016/J.CANLET.2006.02.005
Role of environmental factors in the pathogenesis of classic and African-endemic Kaposi sarcoma.
T. Simonart (2006)
10.1016/J.JPBA.2007.01.001
Spectroscopic studies on the interaction between silicotungstic acid and bovine serum albumin.
Y. Wang (2007)
10.1016/j.colsurfb.2008.03.008
Spectroscopic investigation on the binding of bioactive pyridazinone derivative to human serum albumin and molecular modeling.
T. Wang (2008)
10.1016/J.SAA.2004.03.030
Vibrational spectral investigation on xanthine and its derivatives--theophylline, caffeine and theobromine.
S. Gunasekaran (2005)
10.1016/J.MOLSTRUC.2007.09.001
Competitive binding of phenylbutazone and colchicine to serum albumin in multidrug therapy: A spectroscopic study
A. Sułkowska (2008)
10.1007/s002490100150
Hetero-association of caffeine and aromatic drugs and their competitive binding with a DNA oligomer
D. Davies (2001)
10.1021/JP012314U
Interaction of Ochratoxin A with Human Serum Albumin. Preferential Binding of the Dianion and pH Effects
Y. V. Il'ichev (2002)
10.1016/J.MOLSTRUC.2008.12.053
Fluorescence analysis of sulfasalazine bound to defatted serum albumin in the presence of denaturating factors
J. Równicka-Zubik (2009)
10.1016/J.MOLSTRUC.2007.11.051
Molecular interaction and energy transfer between human serum albumin and bioactive component Aloe dihydrocoumarin
Xiu-feng Zhang (2008)
10.1016/J.SAA.2004.09.024
Study for luminescence performance of three methyl xanthine derivatives.
Y. Wei (2005)
10.1016/J.MOLSTRUC.2004.01.003
Spectroscopic studies on the interaction of cinnamic acid and its hydroxyl derivatives with human serum albumin
Jiang Min (2004)
10.1021/JF00124A038
Biosynthesis and biodegradation of caffeine, theobromine, and theophylline in Coffea arabica L. fruits
Takeo Suzuki (1984)



This paper is referenced by
10.1016/j.saa.2012.08.014
Spectrophotometric and thermodynamic studies of the interactions of 4-carboxyl-2,6-dinitrophenylazohydroxynaphthalenes with bovine serum albumin.
O. Adegoke (2012)
10.3892/br.2019.1270
Study of HSA interactions with arachidonic acid using spectroscopic methods revealing molecular dynamics of HSA-AA interactions
Fereshte Mahdizade Valojerdi (2020)
10.22037/JPS.V5I1.5021
Drug comparison and categorizing regarded with human serum albumin from years 2006 to 2012
Minoo Shahani (2014)
10.1080/00387010.2012.753091
Interaction Between Neuroglobin and Caffeine by Multispectroscopic Methods
L. Huang (2013)
10.1080/07391102.2011.10507382
Investigations with Spectroscopy, Zeta Potential and Molecular Modeling of the Non-Cooperative Behaviour Between Cyclophosphamide Hydrochloride and Aspirin upon Interaction with Human Serum Albumin: Binary and Ternary Systems from the View Point of Multi-Drug Therapy
Z. Omidvar (2011)
10.1016/j.saa.2015.07.051
Caffeine and sulfadiazine interact differently with human serum albumin: A combined fluorescence and molecular docking study.
Mullah Muhaiminul Islam (2016)
AFRL-RX-TY-TP-2011-0057 BACTERIAL SUNSCREEN : LAYER-BY-LAYER DEPOSITION OF UV-ABSORBING POLYMERS ON WHOLE-CELL BIOSENSORS ( POSTPRINT )
D. Matthew Eby (2013)
10.1155/2014/734850
Investigation of the Interaction between Patulin and Human Serum Albumin by a Spectroscopic Method, Atomic Force Microscopy, and Molecular Modeling
Li Yu-qin (2014)
10.1016/J.MOLSTRUC.2014.10.032
Spectroscopic evidence of xanthine compounds fluorescence quenching effect on water-soluble porphyrins
M. Makarska-Bialokoz (2015)
10.1016/j.ijbiomac.2017.11.107
Interaction of catecholamine precursor l-Dopa with lysozyme: A biophysical insight.
S. Nusrat (2018)
10.1016/j.saa.2018.04.037
Comparative study of binding interactions between porphyrin systems and aromatic compounds of biological importance by multiple spectroscopic techniques: A review.
M. Makarska-Bialokoz (2018)
10.1371/journal.pone.0158833
A Comprehensive Spectroscopic and Computational Investigation to Probe the Interaction of Antineoplastic Drug Nordihydroguaiaretic Acid with Serum Albumins
S. Nusrat (2016)
10.1016/J.MOLLIQ.2017.07.116
Conformational and functional changes of bovine serum albumin induced by TiO2 nanoparticles binding
Y. Wu (2017)
10.1016/j.saa.2017.11.038
Non-covalent interactions between thio-caffeine derivatives and water-soluble porphyrin in ethanol-water environment.
A. Lipke (2018)
10.1016/J.JLUMIN.2012.12.056
Synchronous fluorescence spectrometry: Conformational investigation or inner filter effect?
M. Pacheco (2013)
10.1016/j.saa.2014.08.149
Spectroscopic and molecular modeling study on the separate and simultaneous bindings of alprazolam and fluoxetine hydrochloride to human serum albumin (HSA): with the aim of the drug interactions probing.
Faeze Dangkoob (2015)
10.1016/j.saa.2017.11.063
Interactions of hemin with bovine serum albumin and human hemoglobin: A fluorescence quenching study.
M. Makarska-Bialokoz (2018)
10.1007/s10895-012-1090-9
Spectroscopic Study of Porphyrin-Caffeine Interactions
M. Makarska-Bialokoz (2012)
10.1016/j.saa.2017.05.014
Investigation of the binding affinity in vitamin B12-Bovine serum albumin system using various spectroscopic methods.
M. Makarska-Bialokoz (2017)
10.1016/J.JLUMIN.2012.12.023
Magnetic field effect on the binding of HSA with amlodipine and propranolol
M. R. Housaindokht (2013)
10.1016/J.DYEPIG.2012.01.010
Binding interaction between serum albumins and perylene-3,4,9,10-tetracarboxylate – A spectroscopic investigation
S. Naveenraj (2012)
10.1016/J.MOLLIQ.2018.12.026
Study of the binding interactions between uric acid and bovine serum albumin using multiple spectroscopic techniques
M. Makarska-Bialokoz (2019)
10.1016/j.bmc.2016.02.020
Interaction of prodigiosin with HSA and β-Lg: Spectroscopic and molecular docking studies.
Banafsheh Rastegari (2016)
10.1007/S10973-010-0792-Y
Study on the binding of puerarin to bovine serum albumin by isothermal titration calorimetry and spectroscopic approaches
J. Xi (2010)
10.1016/j.saa.2011.09.019
Investigation of the behavior of HSA upon binding to amlodipine and propranolol: Spectroscopic and molecular modeling approaches.
M. R. Housaindokht (2012)
10.1002/jmr.2715
Molecular interaction of some cardiovascular drugs with human serum albumin at physiological‐like conditions: A new approach
Navid Niaei (2018)
10.1016/j.ijbiomac.2016.11.050
Studies to reveal the nature of interactions between catalase and curcumin using computational methods and optical techniques.
Fayezeh Mofidi Najjar (2017)
10.1016/j.jpba.2012.01.005
Evaluation of inhibition of cancer cell proliferation in vitro with different berries and correlation with their antioxidant levels by advanced analytical methods.
S. Flis (2012)
10.1021/jf2005194
Comparative studies on the interaction of genistein, 8-chlorogenistein, and 3',8-dichlorogenistein with bovine serum albumin.
J. Zhang (2011)
10.1016/j.ijbiomac.2017.09.080
Decrease of the affinity of theophylline bind to serum proteins induced by flavonoids and their synergies on protein conformation.
X. Wang (2018)
10.1016/j.fct.2019.110867
Exploration of the binding between ellagic acid, a potentially risky food additive, and bovine serum albumin.
F. Liu (2019)
10.1080/07391102.2016.1264887
Interaction of stattic, a STAT3 inhibitor with human serum albumin: spectroscopic and computational study
Ida Syazwani M Affandi (2017)
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