Online citations, reference lists, and bibliographies.
← Back to Search

Compression Profiles Of Different Molecular Weight Chitosans

Faisal Al-Akayleh, I. Rashid, Mahmoud Al-omari, K. Al-Sou’od, B. Chowdhry, A. Badwan
Published 2016 · Materials Science

Cite This
Download PDF
Analyze on Scholarcy
Share
Abstract The compression behavior of hydrophilic chitosan has been investigated as a function of molecular weight (MW), ranging from 8 to 100 kDa. Powder packing, plasticity, elasticity, brittle-fracture nature were evaluated using force displacement curves and Heckel/Kawakita analysis upon compression of different MW chitosan powders. The compacts produced were subjected to ejection work determination and tensile strengths analysis, the later using Leuenberger equation. Molecular modeling was used to correlate the MW-binding energy dependence on the physical strength of the chitosan compacts. The high work of compression of the low MW (≤ 30 kDa) chitosans is accounted for their brittle nature upon compression. At high compression forces (> 3 kN), the low MW chitosan compacts exhibited slightly lower tensile strength due to their increasing extents of elastic recovery and ejection work. Lower particle size of chitosan enhances lower fragmentation, packing, and frictional tendency that can be related to an increase in plastic deformation and compacts tensile strength. In molecular modeling, the calculated higher binding energies of the high MW chitosan (88 kDa) than that of the low MW chitosan (8 kDa) may further explain its rigid, complex nature when compared to low MW chitosan. Upon compression, increasing MW of chitosan is manifested as higher energies for densification which in turn determines the extent of helical packing from intermingled molecular to open structure as the MW is decreased. Such changes in structural configuration are suggested to contribute to the transfer from plastic to brittle-fracture nature with high packing extent of chitosan upon compression when the MW is reduced. The foregoing may justify the slow diclofenac Na drug release upon dissolution testing when low MW chitosan is used in tablet preparation.
This paper references
10.1016/J.RADPHYSCHEM.2014.08.023
Irradiated chitosan nanoparticle as a water-based antioxidant and reducing agent for a green synthesis of gold nanoplatforms
W. Pasanphan (2015)
10.1016/S0939-6411(99)00078-8
A new theoretical approach to tablet strength of a binary mixture consisting of a well and a poorly compactable substance.
M. Kuentz (2000)
10.1007/S10953-009-9405-4
Investigation of the Interactions in Complexes of Low Molecular Weight Chitosan with Ibuprofen
A. Qandil (2009)
10.1016/J.POWTEC.2006.06.011
Investigation of particle packing in model pharmaceutical powders using X-ray microtomography and discrete element method
Xiaowei Fu (2006)
10.3109/10837451003664107
Moulded cross-linked chitosan matrix systems for controlled drug release.
Clemence Tarirai (2011)
10.1111/J.1432-1033.2003.03975.X
Non-specific depolymerization of chitosan by pronase and characterization of the resultant products.
A. B. V. Kumar (2004)
10.3109/03639048609042616
Heckel Plots as Indicators of Elastic Properties of Pharmaceuticals
P. Paronen (1986)
10.1016/j.carbpol.2013.04.073
Impact of salt form and molecular weight of chitosan on swelling and drug release from chitosan matrix tablets.
K. Huanbutta (2013)
10.1007/s11095-006-9129-8
Effect of Particle Size and Compression Force on Compaction Behavior and Derived Mathematical Parameters of Compressibility
Sarsvatkumar Patel (2006)
10.1016/S0928-0987(00)00119-6
Impact of particle density and initial volume on mathematical compression models.
J. Sonnergaard (2000)
10.1007/S10953-010-9517-X
Some Physico-Chemical Properties of Low Molecular Weight Chitosans and their Relationship to Conformation in Aqueous Solution
R. Obaidat (2010)
10.1016/J.FOODHYD.2013.03.016
Synthesis, characterization and functional properties of galactosylated derivatives of chitosan through amide formation
A. I. R. Matute (2013)
Evaluating the elastic behavior of pharmaceutical excipients and binary mixtures using the modified Fraser-Suzuki function
G. Shlieout (2002)
10.1002/APP.12016
Depolymerized chitosan nanoparticles for protein delivery: Preparation and characterization
Kevin A. Janes (2003)
10.1016/0032-5910(92)85072-4
Compaction behavior of cellulose polymers
Padmaja Shivanand (1992)
Controlling Molecular Weight and Degree of Deacetylation of Chitosan by Response Surface Methodology
Hwang Kwon-Tack (1999)
10.1016/j.ejpb.2008.06.031
Effect of chitosan structure properties and molecular weight on the intranasal absorption of tetramethylpyrazine phosphate in rats.
Dan Mei (2008)
10.1002/DDR.10416
Preparation and characterization of drug‐loaded chitosan–tripolyphosphate microspheres by spray drying
K. G. Desai (2005)
10.1002/APP.22099
Reacetylated chitosan/cashew gum gel : Preliminary study for potential utilization as drug release matrix
Jeanny S. Maciel (2006)
10.1007/s00396-012-2669-z
Chitosan-based nanocapsules: physical characterization, stability in biological media and capsaicin encapsulation
F. Goycoolea (2012)
10.1023/A:1015864415693
Percolation Theory and Compactibility of Binary Powder Systems
Dieter Blattner (2004)
10.1002/JPS.2600590523
Determination of tablet strength by the diametral-compression test.
J. T. Fell (1970)
An analysis of powder compaction phenomena
R. W. Heckel (1961)
10.1016/J.IJPHARM.2007.06.024
Preparation of an extended-release matrix tablet using chitosan/Carbopol interpolymer complex.
Sung-hyun Park (2008)
10.1016/j.ejpb.2008.01.029
Direct compression properties of chitin and chitosan.
Viviana García Mir (2008)
10.1002/JBM.A.31133
Branched chitosans: effects of branching parameters on rheological and mechanical properties.
Dinesh Aggarwal (2007)
10.1002/jbm.b.31214
Studies on the condensation of depolymerized chitosans with DNA for preparing chitosan-DNA nanoparticles for gene delivery applications.
V. B. Morris (2009)
10.4314/JUST.V26I2.32990
Effects of ph of medium and molecular weight on polyelectrolyte complex formation between pectin and chitosan
K. Ofori-Kwakye (2007)
10.1016/J.POWTEC.2010.06.028
Characterization of the impact of magnesium stearate lubrication on the tableting properties of chitin-Mg silicate as a superdisintegrating binder when compared to Avicel® 200
I. Rashid (2010)
10.1016/S1773-2247(06)50061-9
Chitosan nanocapsules: a new carrier for nasal peptide delivery
C. Prego (2006)
10.3109/10837450.2011.620968
Formulation and In vitro assessment of sustained release terbutaline sulfate tablet made from binary hydrophilic polymer mixtures
Faisal T Al-Akayleh (2013)
10.1080/03639040701657792
A novel superdisintegrating agent made from physically modified chitosan with silicon dioxide.
M. El-Barghouthi (2008)
10.1023/B:PHAM.0000016249.52831.a5
Uptake and Cytotoxicity of Chitosan Molecules and Nanoparticles: Effects of Molecular Weight and Degree of Deacetylation
M. Huang (2004)
10.1080/03639040802149053
Spray-dried chitosan as a direct compression tableting excipient.
Dakshinamurthy Devanga Chinta (2009)
Density-Pressure Relationships in Powder Compaction
R. (2010)
10.1016/S0939-6411(03)00112-7
Comparison of the effect of chitosan and polyvinylpyrrolidone on dissolution properties and analgesic effect of naproxen.
N. Zerrouk (2004)
10.1177/088391159200700406
Applications and Properties of Chitosan
Qiangliang Li (1992)
10.4103/2230-973X.104399
Development and evaluation of chitosan based oral controlled matrix tablets of losartan potassium
T. V. Rao (2012)
10.1021/BM0496357
Physicochemical behavior of homogeneous series of acetylated chitosans in aqueous solution: role of various structural parameters.
G. Lamarque (2005)
10.1016/j.jconrel.2013.09.032
Hyaluronic acid-coated chitosan nanoparticles: molecular weight-dependent effects on morphology and hyaluronic acid presentation.
Abdulaziz Almalik (2013)
10.1016/0378-5173(94)00343-4
Compression behavior and tensile strength of heat-treated polyethylene glycols
Ching-Wei Lin (1995)
10.1201/B15636
Chitin and chitosan derivatives : advances in drug discovery and developments
Se-kwon Kim (2013)
10.1016/0378-5173(82)90112-0
An evaluation of the techniques employed to investigate powder compaction behaviour
I. Krycer (1982)
10.1002/JPS.3030440413
The physics of tablet compression. VII. Determination of energy expenditure in the tablet compression process.
E. Nelson (1955)
10.1016/0144-8617(92)90186-T
Chitosans from Euphausia superba. 2: Characterization of solid state structure
B. Focher (1992)
10.1208/pt070375
Evaluation of powder and tableting properties of chitosan
K. Picker-Freyer (2008)
10.1081/PDT-100000738
Influence of Elastic Deformation of Particles on Heckel Analysis
C. Sun (2001)
10.3390/md8051716
Bioadhesive Controlled Metronidazole Release Matrix Based on Chitosan and Xanthan Gum
A. Eftaiha (2010)
10.1021/am302246s
Novel chitosan-functionalized spherical nanosilica matrix as an oral sustained drug delivery system for poorly water-soluble drug carvedilol.
Lizhang Sun (2013)
10.1016/B978-0-12-405191-1.00012-0
Synthesis
P. Wakeley (2013)
BONDING SURFACE AREA AND BONDING UNDERSTANDING OF POWDER COMPACTABILITY MECHANISM - TWO IMPORTANT FACTORS FOR THE
C. Nystroem (1993)
10.1016/J.AJPS.2014.08.002
Evaluation of chitosan–anionic polymers based tablets for extended-release of highly water-soluble drugs
Y. Shao (2015)
10.1080/0265204031000093078
Synthesis and characterization of cross-linked chitosan microspheres for drug delivery applications.
E. Dini (2003)
10.1021/bm800298u
Highly efficient system to deliver taxanes into tumor cells: docetaxel-loaded chitosan oligomer colloidal carriers.
M. Lozano (2008)
10.1002/APP.11628
Effect of time/temperature treatment parameters on depolymerization of chitosan
H. K. No (2003)
10.1002/1520-6017(200105)90:5<569::AID-JPS1013>3.0.CO;2-4
Influence of crystal shape on the tableting performance of L-lysine monohydrochloride dihydrate.
C. Sun (2001)
10.1016/S0008-6215(99)00172-X
Chitosan processing: influence of process parameters during acidic and alkaline hydrolysis and effect of the processing sequence on the resultant chitosan’s properties
P. Rege (1999)
10.1016/0144-8617(92)90185-S
Chitosans from Euphausia superba. 1: Solution properties
M. Terbojevich (1992)
10.3390/molecules14114370
Characterization and Dissolution Study of Chitosan Freeze-Dried Systems for Drug Controlled Release
R. Ruiz‐Caro (2009)
10.1111/j.2042-7158.1989.tb06518.x
Calculation of Punch Displacement and Work of Powder Compaction on a Rotary Tablet Press
R. Oates (1989)
10.1016/S0378-5173(99)00319-1
A critical evaluation of the Heckel equation.
J. Sonnergaard (1999)
The quantitative interpretation of forcedisplacement curves
C. J. De Blaey (1970)
10.1021/BM025724C
Typical physicochemical behaviors of chitosan in aqueous solution.
C. Schatz (2003)
CHITOSAN: A NOVEL EXCIPIENT IN PHARMACEUTICAL FORMULATION: A REVIEW
M. Singh (2011)
10.1515/9783111576855-016
K
Martin P. Catherwood (1824)
10.1016/j.ijpharm.2013.04.052
Drug release characteristics from chitosan-alginate matrix tablets based on the theory of self-assembled film.
L. Li (2013)
10.1016/j.ijpharm.2010.01.020
Mechanistic investigation on pressure dependency of Heckel parameter.
Sarsvatkumar Patel (2010)
10.1016/S0168-3659(03)00327-4
N-acylated chitosan: hydrophobic matrices for controlled drug release.
C. Le Tien (2003)
10.1081/DDC-100000481
Physical Properties and Molecular Behavior of Chitosan Films
J. Nunthanid (2001)



This paper is referenced by
10.1080/1536383X.2016.1226285
Grafting of chitosan Schiff base on graphene oxide and its characterization
G. Xu (2016)
10.1007/s12247-019-09397-1
Enhancement in Dissolution Rate of Atorvastatin Trihydrate Calcium by Formulating Its Porous Tablet Using Sublimation Technique
S. Singh (2019)
10.1016/j.ijpharm.2018.10.007
Towards a better understanding of dry binder functionality
Oscar-Rupert Arndt (2018)
10.1016/j.carbpol.2018.04.091
Effect of the molecular weight of chitosan on its antifungal activity against Candida spp. in planktonic cells and biofilm.
Lana Glerieide Silva Garcia (2018)
10.1016/J.POWTEC.2017.12.021
Functionality and performance evaluation of directly compressible co-processed excipients based on dynamic compaction analysis and percolation theory
Milica Drašković (2018)
10.1016/J.POWTEC.2017.04.014
Synthesis and characterization of chitosan membranes functionalized with amino acids and copper for adsorption of endoglucanase
María Julia Boggione (2017)
10.1016/j.ijbiomac.2017.07.063
Adsorption of Pb(II) ions from aqueous environment using eco-friendly chitosan schiff's base@Fe3O4 (CSB@Fe3O4) as an adsorbent; kinetics, isotherm and thermodynamic studies.
Zhang Wei-jiang (2017)
10.3390/pharmaceutics11110603
A Direct Compression Matrix Made from Xanthan Gum and Low Molecular Weight Chitosan Designed to Improve Compressibility in Controlled Release Tablets
Deeb Abu Fara (2019)
10.1080/10837450.2019.1596131
Preparation and characterization of co-processed starch/MCC/chitin hydrophilic polymers onto magnesium silicate
S. Assaf (2019)
10.3390/md18020115
Understanding the Performance of a Novel Direct Compression Excipient Comprising Roller Compacted Chitin
Deeb Abu Fara (2020)
10.5772/INTECHOPEN.76038
An Overview of Chitosan-Xanthan Gum Matrices as Controlled Release Drug Carriers
Suha M. Dadou (2018)
Semantic Scholar Logo Some data provided by SemanticScholar