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Foreign Body Reaction To Biomaterials.

J. Anderson, A. Rodriguez, D. Chang
Published 2008 · Biology, Medicine

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The foreign body reaction composed of macrophages and foreign body giant cells is the end-stage response of the inflammatory and wound healing responses following implantation of a medical device, prosthesis, or biomaterial. A brief, focused overview of events leading to the foreign body reaction is presented. The major focus of this review is on factors that modulate the interaction of macrophages and foreign body giant cells on synthetic surfaces where the chemical, physical, and morphological characteristics of the synthetic surface are considered to play a role in modulating cellular events. These events in the foreign body reaction include protein adsorption, monocyte/macrophage adhesion, macrophage fusion to form foreign body giant cells, consequences of the foreign body response on biomaterials, and cross-talk between macrophages/foreign body giant cells and inflammatory/wound healing cells. Biomaterial surface properties play an important role in modulating the foreign body reaction in the first two to four weeks following implantation of a medical device, even though the foreign body reaction at the tissue/material interface is present for the in vivo lifetime of the medical device. An understanding of the foreign body reaction is important as the foreign body reaction may impact the biocompatibility (safety) of the medical device, prosthesis, or implanted biomaterial and may significantly impact short- and long-term tissue responses with tissue-engineered constructs containing proteins, cells, and other biological components for use in tissue engineering and regenerative medicine. Our perspective has been on the inflammatory and wound healing response to implanted materials, devices, and tissue-engineered constructs. The incorporation of biological components of allogeneic or xenogeneic origin as well as stem cells into tissue-engineered or regenerative approaches opens up a myriad of other challenges. An in depth understanding of how the immune system interacts with these cells and how biomaterials or tissue-engineered constructs influence these interactions may prove pivotal to the safety, biocompatibility, and function of the device or system under consideration.
This paper references
10.1016/0142-9612(89)90023-9
Characterization of biomedical polymer-adherent macrophages: interleukin 1 generation and scanning electron microscopy studies.
K. Miller (1989)
10.1016/J.BIOMATERIALS.2006.01.019
Surface-induced changes in protein adsorption and implications for cellular phenotypic responses to surface interaction.
L. Allen (2006)
10.1002/JBM.820270311
Human plasma alpha 2-macroglobulin promotes in vitro oxidative stress cracking of Pellethane 2363-80A: in vivo and in vitro correlations.
Q. Zhao (1993)
10.1016/S0142-9612(99)00170-2
Integrin-fibronectin interactions at the cell-material interface: initial integrin binding and signaling.
A. García (1999)
10.1097/00004669-199701000-00009
Biomaterials Science: An Introduction to Materials in Medicine
B. Ratner (1996)
10.1002/JBM.A.10425
In vivo leukocyte cytokine mRNA responses to biomaterials are dependent on surface chemistry.
W. Brodbeck (2003)
10.4049/jimmunol.164.11.5952
Th2 Cell Membrane Factors in Association with IL-4 Enhance Matrix Metalloproteinase-1 (MMP-1) While Decreasing MMP-9 Production by Granulocyte-Macrophage Colony-Stimulating Factor-Differentiated Human Monocytes1
C. Chizzolini (2000)
10.1016/S0955-0674(02)00368-X
Integrin signaling: it's where the action is.
C. Damsky (2002)
10.1016/J.BIOMATERIALS.2004.04.018
Protein array method for assessing in vitro biomaterial-induced cytokine expression.
Y. Li (2005)
10.1083/JCB.143.3.837
CD44 Occupancy Prevents Macrophage Multinucleation
H. Sterling (1998)
Effect of biomaterial surface properties on fibronectin-alpha5beta1 integrin interaction and cellular attachment.
M. Lee (2006)
10.1182/BLOOD.V98.4.1231
Molecular basis of biomaterial-mediated foreign body reactions.
W. J. Hu (2001)
10.1073/PNAS.89.18.8676
Interleukin 10 inhibits macrophage microbicidal activity by blocking the endogenous production of tumor necrosis factor alpha required as a costimulatory factor for interferon gamma-induced activation.
I. Oswald (1992)
10.1073/PNAS.95.15.8841
Mast cells mediate acute inflammatory responses to implanted biomaterials.
L. Tang (1998)
10.1038/nrm1436
Foot and mouth: podosomes, invadopodia and circular dorsal ruffles
R. Buccione (2004)
10.1016/S0142-9612(02)00088-1
Differential response to chemically altered polyethylene by activated mature human monocyte-derived macrophages.
S. Xing (2002)
The role of adsorbed proteins in tissue response to biomaterials
T. Horbett (2004)
10.1128/MCB.18.11.6213
MFR, a Putative Receptor Mediating the Fusion of Macrophages
C. Saginario (1998)
Interleukin-13 induces human monocyte/macrophage fusion and macrophage mannose receptor expression.
K. M. Defife (1997)
10.1046/j.1365-3083.2001.00885.x
Alternatively Activated Macrophages Differentially Express Fibronectin and Its Splice Variants and the Extracellular Matrix Protein βIG‐H3
A. Gratchev (2001)
10.1016/J.BIOMATERIALS.2005.05.048
The human macrophage response during differentiation and biodegradation on polycarbonate-based polyurethanes: dependence on hard segment chemistry.
R. Labow (2005)
10.1042/BST0320443
Integrin regulation of cell signalling and motility.
R. Juliano (2004)
10.1161/01.RES.0000070112.80711.3D
Matrix Metalloproteinases and Tissue Inhibitors of Metalloproteinases: Structure, Function, and Biochemistry
R. Visse (2003)
DC-STAMP is essential for cell-cell fusion in osteoclasts and foreign body giant cells
八木 満 (2006)
Interleukin-4 induces foreign body giant cells from human monocytes/macrophages. Differential lymphokine regulation of macrophage fusion leads to morphological variants of multinucleated giant cells.
A. K. McNally (1995)
10.1016/J.BIOMATERIALS.2005.11.003
Effect of biomaterial surface properties on fibronectin–α5β1 integrin interaction and cellular attachment
M. Lee (2006)
10.1073/pnas.162124199
Biomaterial adherent macrophage apoptosis is increased by hydrophilic and anionic substrates in vivo
W. Brodbeck (2002)
Cytotoxic reaction and TNF-alpha response of macrophages to polyurethane particles.
Nan Ma (2002)
10.1002/(SICI)1097-4636(199708)36:2<246::AID-JBM14>3.0.CO;2-E
In vivo biocompatibility and biostability of modified polyurethanes.
A. Mathur (1997)
10.1023/A:1024951330265
Effects of adsorbed heat labile serum proteins and fibrinogen on adhesion and apoptosis of monocytes/macrophages on biomaterials
W. Brodbeck (2003)
10.1016/S0002-9440(10)64882-1
β1 and β2 Integrins Mediate Adhesion during Macrophage Fusion and Multinucleated Foreign Body Giant Cell Formation
A. K. McNally (2002)
10.1016/J.BIOMATERIALS.2004.01.062
Surface chemistry modulates focal adhesion composition and signaling through changes in integrin binding.
B. Keselowsky (2004)
10.1016/J.BIOMATERIALS.2004.01.023
Biomaterial-associated thrombosis: roles of coagulation factors, complement, platelets and leukocytes.
M. Gorbet (2004)
10.1006/CYTO.2002.1048
Biomaterial surface chemistry dictates adherent monocyte/macrophage cytokine expression in vitro.
W. Brodbeck (2002)
10.1002/JBM.A.30313
Lymphocytes and the foreign body response: lymphocyte enhancement of macrophage adhesion and fusion.
W. Brodbeck (2005)
10.1016/S0898-6568(99)00003-0
Integrin signalling in neutrophils and macrophages.
G. Berton (1999)
10.1084/jem.20051123
Macrophage fusion
A. Vignery (2005)
10.1097/01.prs.0000225430.42531.c2
The Basic Science of Wound Healing
G. Broughton (2006)
10.1002/JBM.A.31658
Vitronectin is a critical protein adhesion substrate for IL-4-induced foreign body giant cell formation.
A. K. McNally (2008)
10.1016/S0169-6009(08)80211-5
The expression of osteoclast markers on foreign body giant cells.
Y. Kadoya (1994)
10.1126/SCIENCE.312.5782.1868
Podosomes and Invadopodia Help Mobile Cells Step Lively
J. Marx (2006)
10.1016/j.febslet.2007.03.033
Cell–cell fusion
E. Chen (2007)
10.1089/TEN.2005.11.1
Mediation of biomaterial-cell interactions by adsorbed proteins: a review.
C. J. Wilson (2005)
10.1089/TEN.2006.12.1955
Cellular and molecular dynamics in the foreign body reaction.
D. T. Luttikhuizen (2006)
10.1111/J.0022-202X.2005.23841.X
Chemokines: key players in innate and adaptive immunity.
Clemens Esche (2005)
10.1002/JBM.820260702
Cytokine and growth factor production by monocytes/macrophages on protein preadsorbed polymers.
T. Bonfield (1992)
10.1016/S0142-9612(00)00181-2
In vitro reaction to orthopaedic biomaterials by macrophages and lymphocytes isolated from patients undergoing revision surgery.
M. Trindade (2001)
10.1016/S0142-9612(03)00056-5
Macrophage response to cross-linked and conventional UHMWPE.
R. Sethi (2003)
10.1007/BF00315989
Extracellular matrix receptor and platelet antigens on osteoclasts and foreign body giant cells
J. Quinn (2004)
10.1002/JBM.A.31220
Matrix metalloproteinases and their inhibitors in the foreign body reaction on biomaterials.
J. A. Jones (2008)
10.1016/J.BIOMATERIALS.2005.05.079
Understanding the biodegradation of polyurethanes: from classical implants to tissue engineering materials.
J. Santerre (2005)
10.1016/J.YEXMP.2005.06.008
Multinucleated giant cell formation exhibits features of phagocytosis with participation of the endoplasmic reticulum.
A. K. McNally (2005)
10.1038/sj.onc.1203877
Focal Adhesion Kinase: a regulator of focal adhesion dynamics and cell movement
J. Parsons (2000)
10.1016/S0142-9612(03)00097-8
Adhesion, apoptosis and cytokine release of human mononuclear cells cultured on degradable poly(urethane urea), polystyrene and titanium in vitro.
C. Gretzer (2003)
10.1023/A:1018575504518
Modulation of the phenotypic and functional properties of phagocytic macrophages by wear particles from orthopaedic implants
N. Al-Saffar (1997)
The immunologic release of constituents from neutrophil leukocytes. II. Mechanisms of release during phagocytosis, and adherence to nonphagocytosable surfaces.
P. Henson (1971)
10.1359/jbmr.2001.16.11.2082
Adherent Endotoxin on Orthopedic Wear Particles Stimulates Cytokine Production and Osteoclast Differentiation
Y. Bi (2001)
10.1083/jcb.200212031
Tetraspanins CD9 and CD81 function to prevent the fusion of mononuclear phagocytes
Y. Takeda (2003)
10.1111/j.1365-2567.2004.01976.x
Signal transduction by the lipopolysaccharide receptor, Toll‐like receptor‐4
E. Pålsson-McDermott (2004)
10.1006/CIMM.2000.1687
Influence of alternatively and classically activated macrophages on fibrogenic activities of human fibroblasts.
E. Song (2000)
10.1002/jbm.a.31630
Lymphocyte/macrophage interactions: biomaterial surface-dependent cytokine, chemokine, and matrix protein production.
D. Chang (2008)
10.1177/002215549904700107
Cytoskeletal and Adhesive Structural Polarizations Accompany IL-13-induced Human Macrophage Fusion
K. M. Defife (1999)
10.1002/JBM.A.31221
Proteomic analysis and quantification of cytokines and chemokines from biomaterial surface-adherent macrophages and foreign body giant cells.
J. A. Jones (2007)
10.1002/JBM.10225
Activation of caspase 3 during shear stress-induced neutrophil apoptosis on biomaterials.
M. Shive (2002)
10.1002/JBM.820230808
In vitro stimulation of fibroblast activity by factors generated from human monocytes activated by biomedical polymers.
K. Miller (1989)
10.1146/ANNUREV.MATSCI.31.1.81
Biological Responses to Materials
J. Anderson (2001)
Interleukin-4-induced macrophage fusion is prevented by inhibitors of mannose receptor activity.
A. K. McNally (1996)
10.1002/(SICI)1097-4636(20000315)49:4<435::AID-JBM2>3.0.CO;2-Y
Adsorbed serum proteins responsible for surface dependent human macrophage behavior.
C. R. Jenney (2000)
10.1136/jcp.45.5.398
Immunophenotype of multinucleated and mononuclear cells in giant cell lesions of bone and soft tissue.
I. Doussis (1992)
10.1016/S1471-4906(02)02302-5
Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes.
A. Mantovani (2002)
10.1007/s10555-005-5134-3
Clinging to life: cell to matrix adhesion and cell survival
P. Reddig (2005)
10.1016/J.BIOMATERIALS.2004.11.028
Myoblast proliferation and differentiation on fibronectin-coated self assembled monolayers presenting different surface chemistries.
M. A. Lan (2005)
10.1002/JBM.820290217
Human monocyte/macrophage adhesion and cytokine production on surface-modified poly(tetrafluoroethylene/hexafluoropropylene) polymers with and without protein preadsorption.
J. Yun (1995)
10.1002/JBM.820280110
Theoretical analysis of in vivo macrophage adhesion and foreign body giant cell formation on polydimethylsiloxane, low density polyethylene, and polyetherurethanes.
W. J. Kao (1994)
10.1182/BLOOD-2005-05-1902
The intracellular domain of CD44 promotes the fusion of macrophages.
W. Cui (2006)
10.1016/J.BIOMATERIALS.2007.03.032
Effects of surface wettability and contact time on protein adhesion to biomaterial surfaces.
L. Xu (2007)
10.1002/JBM.A.10516
Monocyte/macrophage interactions with base and linear- and star-like PEG-modified PEG-poly(acrylic acid) co-polymers.
V. E. Wagner (2003)
10.1016/J.IT.2004.09.015
The chemokine system in diverse forms of macrophage activation and polarization.
A. Mantovani (2004)
10.1002/JBM.A.30067
Oxidative mechanisms of poly(carbonate urethane) and poly(ether urethane) biodegradation: in vivo and in vitro correlations.
E. Christenson (2004)
Generation of IL-1-like activity in response to biomedical polymer implants: a comparison of in vitro and in vivo models.
K. Miller (1989)
10.1136/jcp.43.12.997
Immunophenotypic differences between osteoclasts and macrophage polykaryons: immunohistological distinction and implications for osteoclast ontogeny and function.
N. Athanasou (1990)
10.1016/S0002-9440(10)63265-8
The CC chemokine ligand, CCL2/MCP1, participates in macrophage fusion and foreign body giant cell formation.
T. Kyriakides (2004)
10.1073/PNAS.91.21.10119
Complement C3 participation in monocyte adhesion to different surfaces.
A. K. McNally (1994)
10.1021/LA060948S
Cell adhesion on nanofibrous polytetrafluoroethylene (nPTFE).
K. Ainslie (2007)
10.1002/JBM.A.30316
Student Research Award in the Undergraduate Degree Candidate category, 30th Annual Meeting of the Society for Biomaterials, Memphis, Tennessee, April 27-30, 2005. Monocyte/lymphocyte interactions and the foreign body response: in vitro effects of biomaterial surface chemistry.
Matthew MacEwan (2005)
10.1002/JBM.A.30396
In vivo biostability of polyether polyurethanes with polyethylene oxide surface-modifying end groups; resistance to biologic oxidation and stress cracking.
Mike Ebert (2005)
10.1002/JBM.A.30075
Effect of titanium surface topography on macrophage activation and secretion of proinflammatory cytokines and chemokines.
A. K. Refai (2004)
10.1073/pnas.0407356102
Integrin binding specificity regulates biomaterial surface chemistry effects on cell differentiation
B. Keselowsky (2005)
10.1002/JBM.820290403
Adhesion and cytokine production by monocytes on poly(2-methacryloyloxyethyl phosphorylcholine-co-alkyl methacrylate)-coated polymers.
K. M. Defife (1995)
10.1084/JEM.176.1.287
Interleukin 4 potently enhances murine macrophage mannose receptor activity: a marker of alternative immunologic macrophage activation
M. Stein (1992)
10.1163/156856295X00670
Protein adsorption and macrophage activation on polydimethylsiloxane and silicone rubber.
J. Anderson (1995)
Cell-cell fusion. FEBS Lett 2007;581(11):2181–93
EH Chen (2009)
10.1074/JBC.M002334200
CD47, a Ligand for the Macrophage Fusion Receptor, Participates in Macrophage Multinucleation*
X. Han (2000)
10.1002/JBM.820230602
Plasma protein adsorbed biomedical polymers: activation of human monocytes and induction of interleukin 1.
T. Bonfield (1989)
10.1016/J.MOLIMM.2006.06.020
The role of complement in biomaterial-induced inflammation.
B. Nilsson (2007)
10.1002/1097-0169(200011)47:3<174::AID-CM2>3.0.CO;2-N
PYK2 is an adhesion kinase in macrophages, localized in podosomes and activated by beta(2)-integrin ligation.
L. Dương (2000)
10.1016/S1357-2725(99)00043-6
Bi-directional signal transduction by integrin receptors.
M. Coppolino (2000)
Differential regulation of IL-1 production in human monocytes by IFN-gamma and IL-4.
R. Donnelly (1990)
10.1016/S0142-9612(99)00115-5
In vivo cell recruitment, cytokine release and chemiluminescence response at gold, and thiol functionalized surfaces.
M. Källtorp (1999)
10.1002/JBM.A.30553
In vivo biostability of polysiloxane polyether polyurethanes: resistance to metal ion oxidation.
B. Ward (2006)
10.1016/S0002-9440(10)63474-8
Foreign body-type multinucleated giant cell formation is potently induced by alpha-tocopherol and prevented by the diacylglycerol kinase inhibitor R59022.
A. K. McNally (2003)
The immunologic release of constituents from neutrophil leukocytes. I. The role of antibody and complement on nonphagocytosable surfaces or phagocytosable particles.
P. Henson (1971)
10.1002/JBM.A.30155
Cytokine secretion from mononuclear cells cultured in vitro with starch-based polymers and poly-L-lactide.
A. Marques (2004)
10.1074/jbc.M412713200
MCP-1 Is Induced by Receptor Activator of Nuclear Factor-κB Ligand, Promotes Human Osteoclast Fusion, and Rescues Granulocyte Macrophage Colony-stimulating Factor Suppression of Osteoclast Formation*
M. S. Kim (2005)
10.1034/j.1600-065X.2003.00067.x
Chemokines in the systemic organization of immunity
D. Campbell (2003)
10.1007/s00253-006-0488-1
Biodegradability and biodegradation of poly(lactide)
Y. Tokiwa (2006)
10.2174/1566524013363645
Role of the mannose receptor in the immune response.
V. Apostolopoulos (2001)
10.1002/JBM.820291014
Role for interleukin-4 in foreign-body giant cell formation on a poly(etherurethane urea) in vivo.
W. J. Kao (1995)
10.1111/j.1600-065X.2007.00536.x
Integrin modulation and signaling in leukocyte adhesion and migration
D. M. Rose (2007)
10.1126/science.285.5430.1028
Integrin signaling.
F. Giancotti (1999)
10.1002/JBM.A.10537
Surface chemistry modulates fibronectin conformation and directs integrin binding and specificity to control cell adhesion.
B. Keselowsky (2003)
10.1016/S0142-9612(01)00049-7
Hydrolytic degradation of poly(carbonate)-urethanes by monocyte-derived macrophages.
R. Labow (2001)
10.2353/AJPATH.2007.061213
Foreign body giant cell formation is preceded by lamellipodia formation and can be attenuated by inhibition of Rac1 activation.
S. Jay (2007)
10.1067/MLC.2002.121260
Interleukin-4 inhibits tumor necrosis factor-alpha-induced and spontaneous apoptosis of biomaterial-adherent macrophages.
W. Brodbeck (2002)
10.1084/JEM.174.5.1209
Interleukin 10(IL-10) inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes
R. de Waal Malefyt (1991)
10.1111/j.1600-0854.2006.00531.x
The Phagosome: Compartment with a License to Kill
A. Haas (2007)
10.1002/JBM.10286
Biodegradation of polycarbonate-based polyurethanes by the human monocytes-derived macrophage and U937 cell systems.
L. Matheson (2002)
10.1002/JBM.820270910
Functional versus quantitative comparison of IL-1 beta from monocytes/macrophages on biomedical polymers.
T. Bonfield (1993)
10.1002/eji.200636788
Macrophage fusion induced by IL‐4 alternative activation is a multistage process involving multiple target molecules
Laura Helming (2007)
10.1002/JBM.A.31161
α subunit partners to β1 and β2 integrins during IL-4-induced foreign body giant cell formation
A. K. McNally (2007)
10.1016/J.CEB.2006.12.013
Integrins and the actin cytoskeleton.
I. Delon (2007)
10.1002/1097-4636(2001)58:3<302::AID-JBM1021>3.0.CO;2-Y
Biodegradation of polyether polyurethane inner insulation in bipolar pacemaker leads.
M. Wiggins (2001)
10.1002/(SICI)1097-4636(19971215)37:4<481::AID-JBM6>3.0.CO;2-H
Macrophage subpopulation differentiation by stimulation with biomaterials.
N. Rhodes (1997)
10.1002/(SICI)1097-4636(20000605)50:3<281::AID-JBM1>3.0.CO;2-5
Adsorbed IgG: a potent adhesive substrate for human macrophages.
C. R. Jenney (2000)
10.1038/ncb0402-e83
Sensing the environment: a historical perspective on integrin signal transduction
C. Miranti (2002)
10.1016/S0142-9612(02)00137-0
Human macrophage-mediated biodegradation of polyurethanes: assessment of candidate enzyme activities.
R. Labow (2002)
10.1163/156856202320269148
The effect of oxidation on the enzyme-catalyzed hydrolytic biodegradation of poly(urethane)s
R. Labow (2002)
10.1038/84209
Chemokines and disease
C. Gerard (2001)
10.1038/nm1514
v-ATPase V0 subunit d2–deficient mice exhibit impaired osteoclast fusion and increased bone formation
Seoung-Hoon Lee (2006)
10.1097/00062752-200001000-00008
Multinucleated giant cells
J. Anderson (2000)
10.1163/1568562053115480
Monocyte activation on polyelectrolyte multilayers
Jason J Hwang (2005)
10.1016/J.BBRC.2006.11.057
Osteoclast formation is strongly reduced both in vivo and in vitro in the absence of CD47/SIRPalpha-interaction.
P. Lundberg (2007)
10.1002/JBM.820200702
Adhesion behavior of rat lymphocytes to poly(ether)-poly(amino acid) block and graft copolymers.
M. Yokoyama (1986)
10.1016/J.TCB.2005.09.002
Inflammatory cells during wound repair: the good, the bad and the ugly.
P. Martin (2005)
10.1016/0142-9612(94)90220-8
Adhesion of human peripheral blood lymphocytes is dependent on surface wettability and protein preadsorption.
T. Groth (1994)
10.1163/156856206777346340
The inflammatory cell influx and cytokines changes during transition from acute inflammation to fibrous repair around implanted materials
C. Gretzer (2006)
Beta1 and beta2 integrins mediate adhesion during macrophage fusion and multinucleated foreign body giant cell formation.
A. K. McNally (2002)
10.1016/s0955-0674(00)00251-9
Anoikis mechanisms.
S. Frisch (2001)
10.1189/jlb.0602325
The many faces of macrophage activation
D. Mosser (2003)
10.1016/J.BIOMATERIALS.2007.04.035
Role of plasma fibronectin in the foreign body response to biomaterials.
B. Keselowsky (2007)
10.1002/JBM.A.30002
Poly(carbonate urethane) and poly(ether urethane) biodegradation: in vivo studies.
E. Christenson (2004)
10.1002/JBM.820220805
Human monocyte/macrophage activation and interleukin 1 generation by biomedical polymers.
K. Miller (1988)
10.1002/JBM.820230904
Generation of IL1-like activity in response to biomedical polymer implants: a comparison of in vitro and in vivo models
K. Miller (1989)
10.1146/ANNUREV.CELLBIO.17.1.463
How matrix metalloproteinases regulate cell behavior.
M. Sternlicht (2001)
10.1056/NEJMRA052723
The many roles of chemokines and chemokine receptors in inflammation.
I. Charo (2006)
10.2174/1568010054022024
Macrophages in inflammation.
N. Fujiwara (2005)
10.1002/JBM.A.30506
Antioxidant inhibition of poly(carbonate urethane) in vivo biodegradation.
E. Christenson (2006)
10.1016/J.EJCB.2005.09.003
The leukocyte podosome.
Y. Calle (2006)
10.1046/j.1365-2567.2000.00025.x
Inflammatory cytokine production by immunological and foreign body multinucleated giant cells
R. Hernández-Pando (2000)
alpha subunit partners to beta1 and beta2 integrins during IL-4-induced foreign body giant cell formation.
A. K. McNally (2007)
10.1038/nri978
Alternative activation of macrophages
S. Gordon (2003)
10.1001/ARCHSURG.1990.01410210084013
Differential production of interleukin 1 on the surface of biomaterials.
Tyrone J. Krause (1990)
Regulation of macrophage chemokine expression by lipopolysaccharide in vitro and in vivo.
K. Kopydlowski (1999)
IL-4 reciprocally regulates IL-1 and IL-1 receptor antagonist expression in human monocytes.
M. Fenton (1992)
10.1002/1097-4636(20010615)55:4<661::AID-JBM1061>3.0.CO;2-F
Influence of biomaterial surface chemistry on the apoptosis of adherent cells.
W. Brodbeck (2001)
10.1083/jcb.200608010
Focal adhesion kinase modulates tension signaling to control actin and focal adhesion dynamics
M. Schober (2007)
Silicone gel-filled breast and testicular implant capsules: a histologic and immunophenotypic study.
S. Abbondanzo (1999)
10.1163/156856204323046843
Macrophage behavior on surface-modified polyurethanes
J. A. Jones (2004)
10.1186/1479-5876-5-31
Histamine release and fibrinogen adsorption mediate acute inflammatory responses to biomaterial implants in humans
J. Zdolsek (2007)
10.1016/J.BIOMATERIALS.2005.03.003
The role of osteopontin in foreign body giant cell formation.
A. Tsai (2005)
10.3109/17453679909000980
Cytokine receptor profile of arthroplasty macrophages, foreign body giant cells and mature osteoclasts.
S. Neale (1999)



This paper is referenced by
Osseo Regeneration of the Cranio-Maxillo-Facial and Oro-Dento-Alveolar Complexes Using a Novel Self-Assembling Peptide Nanofibrous Hydrogel Scaffold and Its Composites
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de Melo Pereira A soft lithography method for patterning calcium phosphate ceramics
Daniel. (2014)
10.3389/neuro.16.009.2009
Design and Adsorption of Modular Engineered Proteins to Prepare Customized, Neuron-Compatible Coatings
Karin S. Straley (2009)
Improved titanium and steel implants : Studies on bisphosphonate, strontium and surface treatments
Paula Linderbäck (2011)
ESTUDO COMPARATIVO DA RESPOSTA INFLAMATÓRIA CRÔNICA INDUZIDA EM Piaractus mesopotamicus E Oreochromis niloticus POR CORPO ESTRANHO E BACILO DE CALMETTE - GUÉRIN
Gómez Manrique (2012)
10.1201/B13757-25
Biomaterials as Platforms for Topical Administration of Therapeutic Agents in Cutaneous Wound Healing
Rhiannon Braund (2013)
10.1007/978-1-62703-505-7_1
An in vivo model system for evaluation of the host response to biomaterials.
B. Sicari (2013)
10.1044/PERSP1.SIG3.26
Emerging Scientist: Vocal Fold Immunology
Suzanne N. King (2016)
Real-time single-molecule observations of proteins at the solid-liquid interface
Blake B Langdon (2015)
10.31274/etd-180810-4712
Altering macrophage and fibroblast responses with biomaterials for drug delivery, wound healing, and tissue engineering
Hannah C Bygd (2016)
THE SPICY, THE EVERLASTING AND THE UNEXPECTED: INVESTIGATING THREE COMPOUNDS THAT SUPPRESS MACROPHAGES AND MYOFIBROBLASTS TO REDUCE BIOMATERIAL-INDUCED FIBROSIS
Tich Thien Truong (2017)
Conception et élaboration d'échafaudages de nanofibres à dégradation contrôlée pour des applications en médecine régénératrice vasculaire
Gad Sabbatier (2015)
Alginate Microcapsules for Cell Therapy : Effect of capsule composition on complement activation, cytokine secretion, and protein adsorption in a whole blood model
Mathias Pontus Andreas Ørning (2012)
Visualizing the spatial localization of active matrix metalloproteinases (MMPs) using MALDI imaging MS
S. Muruganantham (2011)
10.1073/pnas.1105152108
Inflammasome components Asc and caspase-1 mediate biomaterial-induced inflammation and foreign body response
A. Malik (2011)
10.1111/ceo.12428
Safety and efficacy of explanting or replacing suprachoroidal electrode arrays in a feline model
Ronald T. Leung (2015)
10.1126/sciadv.aay0076
The surface stress of biomedical silicones is a stimulant of cellular response
Z. Cheng (2020)
10.1002/btpr.246
Bone tissue engineering: A review in bone biomimetics and drug delivery strategies
Joshua R Porter (2009)
10.3109/08941939.2010.548904
Influence of Mesh Materials on the Expression of Mediators Involved in Wound Healing
Jennifer R Asarias (2011)
10.1016/j.transproceed.2010.04.027
Intramedullary cavity as implantation site for bioartifical pancreas: preliminary in vivo study.
K. Yang (2010)
10.1016/j.actbio.2019.03.014
Synthesis of degradable-polar-hydrophobic-ionic co-polymeric microspheres by membrane emulsion photopolymerization: In vitro and in vivo studies.
Eric Tawagi (2019)
10.1016/j.msec.2019.01.075
Functionalized cell-free scaffolds for bone defect repair inspired by self-healing of bone fractures: A review and new perspectives.
L. Li (2019)
Clinical analysis of bronchoscopic electrocoagulation in pediatric patients.
Cai-yun Ni (2014)
Overview of the current theories on aseptic loosening and periprosthetic osteolysis
Y. Konttinen (2012)
10.1016/j.biomaterials.2015.12.026
Injectable dual-gelling cell-laden composite hydrogels for bone tissue engineering.
T. Vo (2016)
Bimodal Amphiphilic Polymer Conetworks: Structure-Property Characterization, Processing and Applications
Guzman Cardozo (2016)
Additive effect of pulp pequi oil (Caryocar brasiliense Camb.) on the biocompatibility of collagen and gelatin membranes in subcutaneous implants
S. A. (2019)
10.21427/D7X75W
Oxygen Transport in Carotid and Stented Coronary Arteries
E. Murphy (2017)
10.1007/978-3-319-10972-5
Biomaterials for Cardiac Regeneration
E. Suuronen (2015)
10.12697/POA.2017.26.2.11
Long-term complications evidenced studying the explanted Gore® HELEX® atrial septal defect occluder seven years after implantation: a case report
J. Sekretarjovs (2017)
10.3390/ijms17060908
A New Route of Fucoidan Immobilization on Low Density Polyethylene and Its Blood Compatibility and Anticoagulation Activity
Kadir Ozaltin (2016)
10.1016/j.actbio.2016.10.016
Model polymer system for investigating the generation of hydrogen peroxide and its biological responses during the crosslinking of mussel adhesive moiety.
Hao Meng (2017)
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