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Total Synthesis Of The Tylophora Alkaloids Rusplinone, 13aα-secoantofine, And Antofine Using A Multicatalytic Oxidative Aminochlorocarbonylation/Friedel–Crafts Reaction

Lisa M. Ambrosini, Tim A. Cernak, T. Lambert
Published 2010 · Chemistry

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Abstract A rapid synthetic approach to the tylophora alkaloids antofine and 13aα-secoantofine is presented that makes use of a multicatalytic oxidative aminochlorocarbonylation/Friedel–Crafts reaction as the key step. This reaction, along with a one-pot, three-step telescoped process offers a three or four-pot sequence to access the title compounds in high overall yield.
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