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Recent Applications Of Magnesium- And Zinc-TMP Amides In The Synthesis Of Bioactive Targets

R. H. V. Nishimura, R. H. V. Nishimura, A. D. L. Vaz, L. A. Bozzini, Valter E. Murie, Giuliano C Clososki, Giuliano C Clososki
Published 2019 · Chemistry

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Abstract Magnesium- and zinc-TMP amides have come out from relative obscurity to be recognized as important tools in modern synthetic chemistry. Development of LiCl-activated metal amides like TMPMgCl·LiCl and TMP2Zn·2MgCl2·2LiCl has been important to obtain new organometallic reagents through highly chemo- and regioselective reactions. Herein, we review how these reagents are applied in the synthesis of important bioactive targets such as natural products and drugs.
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