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Synthesis Of Novel Dinucleosides Via Tandem Cross-metathesis And Ring-closing Metathesis

Shi Zhong, M. Mondon, S. Pilard, C. Len
Published 2006 · Chemistry

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Abstract Two novel cyclic dinucleosides having two butylene linkers between the 5′-OH and N-3 positions (thereby generating a 24-membered ring) were synthesized from uridine via tandem cross-metathesis and ring-closing metathesis. Selective synthesis of one dinucleoside with a link between the two N-3 atoms and a link between the two 5′-OH groups was achieved.
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