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The First Bismuth(III)-catalyzed Guanylation Of Thioureas

Silvio Henriques Cunha, M. T. Rodrigues
Published 2006 · Chemistry

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Abstract This work describes the first catalytic bismuth-promoted synthesis of polysubstituted guanidines in good yields through the guanylation reaction of N -benzoyl or N -phenylthioureas with primary and secondary amines, but now employing equimolar amounts of each organic reagent. Both bismuth iodine and bismuth nitrate were efficient as inorganic thiophiles at only 5 mol % in relation to substrates, being the first example of inorganic thiophiles acting in guanylation at catalytic levels.
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