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Direct C2-trifluoromethylation Of Indole Derivatives Catalyzed By Copper Acetate

R. Shimizu, H. Egami, Tatsuya Nagi, J. Chae, Y. Hamashima, M. Sodeoka
Published 2010 · Chemistry

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Direct C2-selective trifluoromethylation of indole derivatives was achieved with Togni’s hypervalent iodine reagent and CuOAc as a catalyst in MeOH under mild conditions, affording the desired C2-trifluoromethylated indoles in good yield (up to 90%).
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