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Reagent-free Synthesis Of 2,3,4-polysubstituted Tetrahydroquinolines: Application To The Formal Synthesis Of (+/-)-martinellic Acid And Martinelline

Zhouting Rong, Q. Li, Wenhan Lin, Y. Jia
Published 2013 · Chemistry

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The simple and one-pot method for the synthesis of polysubstituted tetrahydroquinolines from readily available anilines and aldehydes under reagent-free conditions has been developed. The scope of the transformation has been demonstrated. This method has been successfully applied to the rapid formal synthesis of (±)-martinellic acid and martinelline.
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