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Efficient Synthesis And Antioxidant Activity Of Coelenterazine Analogues

Yueting Lu, R. Hendra, A. Oakley, P. Keller
Published 2014 · Chemistry

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Abstract A convenient and highly convergent method for the synthesis of new imidazo[1,2- a ]pyridine-based coelenterazine analogues is reported. The imidazo[1,2- a ]pyridine core was constructed through a condensation between 2-aminopyridine analogues and arylglyoxals. Additionally, a new approach to the synthesis of benzylglyoxals was introduced. The imidazo[1,2- a ]pyridines display moderate antioxidant activities at a low micromolar level in 2,2-diphenyl-1-picrylhydrazyl (DPPH).
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