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Effective Approach To Ureas Through Organocatalyzed One-pot Process
M. Wang, Jilai Han, Xiaojia Si, Y. Hu, Jidong Zhu, Xun Sun
Published 2017 · Chemistry
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Abstract An efficient approach to N, N′-unsymmetrically substituted ureas 9 has been developed through the ammonolysis process of N-Boc protected anilines 7 with amines prompted by 1,5,7-triazabicyclo[4.4.0]dec-5-ene (TBD). Moreover, a convenient protocol for the synthesis of the symmetric N, N'-substituted ureas 12 by one-pot diammonolysis process of Boc2O with amines catalyzed by DABCO has also been achieved. With broad substrate scope and mild conditions, these two methods demonstrate practical preparation of both unsymmetrical and symmetrical ureas.
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