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Nanomedicine: An Unresolved Regulatory Issue.
V. W. Chan
Published 2006 · Medicine
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Nanomedicine is a science that uses nanotechnology to maintain and improve human health at the molecular scale. Current and potential applications of nanotechnology in medicine range from research involving diagnostic devices, drug delivery vehicles to enhanced gene therapy and tissue engineering procedures. Its advantage over conventional medicine lies on its size. Particle size has effect on serum lifetime and pattern of deposition. This allows drugs of nanosize be used in lower concentration and has an earlier onset of therapeutic action. It also provides materials for controlled drug delivery by directing carriers to a specific location. Major efforts are underway, however, very little attention is devoted to assessment of health risks to human or to the ecosystem. Inhaled nanoparticles have already been related to lung injury. It is recognized that physico-chemical properties in conjunction with environmental factors and stability of the nanomaterial all contribute to the overall toxicological responses. Nanotoxicological information, currently insufficient, will be vital in aiding academia, industry and regulatory bodies in elucidating the mechanisms of action, balancing its risk and benefit, thus maximizing the utility of these materials in medicine without compromising public health and environmental integrity.
This paper references
The role of ultrasound in molecular imaging.
H-D Liang (2003)
Enhanced Ocular Anti-Inflammatory Activity of Ibuprofen Carried by an Eudragit RS100® Nanoparticle Suspension
C. Bucolo (2002)
Ultrafine carbon black particles inhibit human lung fibroblast-mediated collagen gel contraction.
H. Kim (2003)
Accumulation of manganese in rat brain following intranasal administration.
G. Gianutsos (1997)
Multicenter phase II trial of ABI-007, an albumin-bound paclitaxel, in women with metastatic breast cancer.
N. Ibrahim (2005)
Toxicity and tissue distribution of magnetic nanoparticles in mice.
J. Kim (2006)
Arterial uptake of biodegradable nanoparticles: effect of surface modifications.
V. Labhasetwar (1998)
Further histological evidence of the gastrointestinal absorption of polystyrene nanospheres in the rat
P. U. Jani (1992)
Acute toxicological effects of copper nanoparticles in vivo.
Z. Chen (2006)
Work in Brief
D. Loomis (2006)
Comparative pulmonary toxicity assessment of single-wall carbon nanotubes in rats.
D. Warheit (2004)
Reduction of the Uptake by a Macrophagic Cell Line of Nanoparticles Bearing Heparin or Dextran Covalently Bound to Poly(methyl methacrylate)
N. Jaulin (2000)
Titanium dioxide (rutile) particle uptake from the rat GI tract and translocation to systemic organs after oral administration
P. U. Jani (1994)
Less is more in medicine.
A. Alivisatos (2001)
Principles for characterizing the potential human health effects from exposure to nanomaterials: elements of a screening strategy
G. Oberdörster (2005)
Visualization of Hybridization in Nanocarbon Systems
A. S. Barnard (2005)
Nanotoxicology: An Emerging Discipline Evolving from Studies of Ultrafine Particles
G. Oberdörster (2005)
Pulmonary toxicity of single-wall carbon nanotubes in mice 7 and 90 days after intratracheal instillation.
C. Lam (2004)
Drug delivery to the brain--realization by novel drug carriers.
R. Mueller (2004)
NANOPARTICLES: HEALTH IMPACTS?
D. Warheit (2004)
Nanotechnology: A Gentle Introduction to the Next Big Idea
M. Ratner (2002)
Manufactured Nanomaterials (Fullerenes, C60) Induce Oxidative Stress in the Brain of Juvenile Largemouth Bass
E. Oberdörster (2004)
Immune potentiation of ultrafine dietary particles in normal subjects and patients with inflammatory bowel disease.
J. Powell (2000)
In Vitro Cytotoxicity of Nanoparticles in Mammalian Germ-Line Stem Cell
M. Vinardell (2005)
CURRENT STATUS OF NANOMEDICINE AND MEDICAL NANOROBOTICS
Freitas Robert A.Jr (2005)
Long-circulating and target-specific nanoparticles: theory to practice.
S. Moghimi (2001)
Nanoengineered device for drug delivery application
Piyush M. Sinha (2004)
Health and environmental impact of nanotechnology: toxicological assessment of manufactured nanoparticles.
K. Dreher (2004)
Serum exposed to nanoparticle carbon black displays increased potential to induce macrophage migration.
P. G. Barlow (2005)
The world of nanotechnology
M. Sherman (2006)
Size-dependent proinflammatory effects of ultrafine polystyrene particles: a role for surface area and oxidative stress in the enhanced activity of ultrafines.
D. Brown (2001)
Enhanced anti-inflammatory activity of a liposomal intercellular adhesion molecule-1 antisense oligodeoxynucleotide in an acute model of contact hypersensitivity.
S. Klimuk (2000)
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R. Rajagopalan (2017)
Nanocarrier possibilities for functional targeting of bioactive peptides and proteins: state-of-the-art
C. Moutinho (2012)
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B. Laube (2014)
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S. Gopalakrishnan (2014)
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M. Zhang (2013)
NANOTECHNOLOGY IN MEDICINE AND HEALTH SCIENCES
E. Denkbaş (2008)
Near-Field Light Scattering Techniques for Measuring Nanoparticle-Surface Interaction Energies and Forces
Perry Schein (2015)
Fingermarks, Bitemarks and Other Impressions (Barefoot, Ears, Lips)
A. Becue (2007)
Extracellular Vesicles as Natural Nanosized Delivery Systems for Small-Molecule Drugs and Genetic Material: Steps towards the Future Nanomedicines.
Mustafa Kotmakci (2015)
Economic and societal dimensions of nanotechnology-enabled drug delivery
Haico te Kulve (2013)
Nano-interventions for neurodegenerative disorders.
Clara Fernandes (2010)
Octanol-water distribution of engineered nanomaterials
K. Hristovski (2011)
Identifying recent trends in nanomedicine development
S. Darshan (2010)
A poly(vinyl alcohol) nanoparticle platform for kinetic studies of inhaled particles
M. Gul (2009)
Recent trends in nanomaterials immobilised enzymes for biofuel production
M. L. Verma (2016)
Bezpieczeństwo nanoproduktów leczniczych: nowe obszary badań toksykologicznych
I. P. Grudziński (2011)
Gamma-irradiation applied in the synthesis of metallic and organic nanoparticles: A short review
G. G. Flores-Rojas (2020)
Toxicological Assessment of Nanomedicine
H. Nehoff (2013)
Advances in antimicrobial photodynamic inactivation at the nanoscale
N. Kashef (2017)
Nanomedicine: Principles, Properties, and Regulatory Issues
S. Soares (2018)
Réflexion sur la gestion des risques émergents : l'exemple des nanotechnologies
Mathieu Moslonka-Lefebvre (2009)
Development of a magnetic system for the treatment of Helicobacter pylori infections
Érica L. Silva (2009)
Impact of nanoscience and nanotechnology on controlled drug delivery.
B. Youan (2008)
Nanomaterials for regenerative medicine
Shalini Verma (2011)
Pluronic based nano-delivery systems; Prospective warrior in war against cancer
Pouya Dehghankelishadi (2016)
BIODISTRIBUTION AND TOXICITY OF METALLIC NANOPARTICLES:IN VIVO STUDIES IN MICE
M. D. Maglie (2017)
Epithelial cell adhesion molecule aptamer functionalized PLGA-lecithin-curcumin-PEG nanoparticles for targeted drug delivery to human colorectal adenocarcinoma cells
L. Li (2014)
NANOCRYSTAL TECHNOLOGY AND DRUG DELIVERY
Biman Bhuyan (2014)See more