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The Topographic Representation Of Esophageal Motor Function On The Human Cerebral Cortex.

Q. Aziz, J. Rothwell, S. Hamdy, J. Barlow, D. Thompson
Published 1996 · Medicine

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BACKGROUND & AIMS Corticofugal pathways to the human esophagus have been recently identified in humans using transcranial magnetic stimulation. The aim of this study was to determine the topographic representation of the esophagus on the cerebral cortex. METHODS Focal magnetic stimulation of 1-cm areas was performed over both hemispheres in 10 healthy subjects. Esophageal electromyographic responses were recorded 2 cm below the upper esophageal sphincter. The studies were repeated to determine reproducibility in 3 subjects; in 2 subjects, esophageal topography was compared with thenar muscle topography. RESULTS In all subjects, esophageal electromyographic responses were evoked by stimulation of either the right or left hemisphere. Largest amplitude responses were obtained anterior to those of the thenar muscles, indicating that the esophagus may be represented on either the anterior aspect of the motor cortex or on the premotor cortex. In all subjects, the area of response was asymmetric, being more extensive on the right hemisphere than on the left hemisphere in 8 subjects. In 2 subjects, the area of response on the left hemisphere was more extensive than on the right. Repeat studies showed that this asymmetry was consistent. CONCLUSIONS Esophageal motor function shows bilateral cortical representation with consistent interhemispheric asymmetry.



This paper is referenced by
10.1097/01.wnp.0000209578.08391.e2
Assessing the Temporal Reproducibility of Human Esophageal Motor-Evoked Potentials to Transcranial Magnetic Stimulation
P. Paine (2006)
10.1016/S0166-2236(97)01212-5
Gut feelings about recovery after stroke: the organization and reorganization of human swallowing motor cortex
S. Hamdy (1998)
10.1016/J.BPG.2004.06.004
Alterations of sensori-motor functions of the digestive tract in the pathophysiology of irritable bowel syndrome.
M. Delvaux (2004)
10.1007/978-3-642-57194-7_14
Motilitätsstörungen von Pharynx und Ösophagus
T. Frieling (2000)
Invited review Neurophysiology of swallowing
C. Ertekin (2003)
10.1111/j.1469-7793.1998.857bv.x
Sensorimotor modulation of human cortical swallowing pathways
S. Hamdy (1998)
10.1016/S0022-3999(99)00050-1
From gut to brain and back--a new perspective into functional gastrointestinal disorders.
Y. Ringel (1999)
10.1097/00004836-199904000-00001
Treatment of patients with functional esophageal symptoms: is there a role for a psychotherapeutic approach?
Y. Ringel (1999)
10.1136/JNNP.72.3.391
Peripheral facial palsy and dysfunction of the oropharynx
Y. Seçil (2002)
10.1016/j.jpeds.2016.10.065
Feeding Methods at Discharge Predict Long‐Term Feeding and Neurodevelopmental Outcomes in Preterm Infants Referred for Gastrostomy Evaluation
S. Jadcherla (2017)
10.1016/J.BJPS.2019.05.023
Impact of lower motor neurone facial palsy on oro-motor function and its remediation.
V. Venables (2019)
10.1161/STROKEAHA.109.566133
Relevance of Subcortical Stroke in Dysphagia
M. Cola (2010)
10.1016/j.clinph.2008.06.006
Reliability of transcranial magnetic stimulation for mapping swallowing musculature in the human motor cortex
E. K. Plowman-Prine (2008)
10.1016/j.neucli.2015.12.005
Central and peripheral motor drive to the palatal muscles
R. Ahdab (2016)
10.1023/A:1018838710214
Intersubject and Interswallow Variability in Topography of Esophageal Motility
R. Clouse (2004)
10.1002/1531-8249(199909)46:3<281::AID-ANA2>3.0.CO;2-L
The functional neuroanatomy of voluntary swallowing
D. Zald (1999)
Orthodontic tooth movement is associated with orofacial mechanical and thermal hypersensitivities and face sensorimotor cortex neuroplasticity
Mandeep Sood (2014)
10.1159/000443656
The Role of the Endoscopist in the Stroke Unit
T. Frieling (2016)
10.1007/978-1-4614-3794-9_22
Esophageal Motor Physiology
W. Paterson (2013)
10.1007/978-3-540-71905-2_10
Motorisch evozierte Potenziale der axialen und proximalen Muskeln
A. Ferbert (2007)
10.1002/9781444346220.CH5
Functional Anatomy and Physiology of Swallowing and Esophageal Motility
N. E. Diamant (2012)
10.1136/gut.52.12.1671
Cognitive modulation of the cerebral processing of human oesophageal sensation using functional magnetic resonance imaging
L. J. Gregory (2003)
10.2298/ACI0901017S
Current concepts in the anatomy and origin of pharyngeal diverticula.
O. Skrobić (2009)
10.1016/j.clinph.2013.12.110
Effects of transcranial direct current stimulation on esophageal motility in patients with gastroesophageal reflux disease
S. Vigneri (2014)
10.1016/S0016-5085(99)70547-0
The cortical topography of human anorectal musculature.
G. Turnbull (1999)
10.1111/j.1365-2982.2005.00662.x
The upper oesophageal sphincter
S. Singh (2005)
10.1007/978-1-4614-3794-9_5
Cerebral Cortical Control of Deglutition
D. Vasant (2013)
10.1016/S1567-4231(04)04028-6
Electrophysiological evaluation of oropharyngeal dysphagia in ALS
C. Ertekin (2004)
10.1007/s10072-019-04120-x
Transcranial direct current stimulation improves the swallowing function in patients with cricopharyngeal muscle dysfunction following a brainstem stroke
Zhi-yong Wang (2019)
10.1044/2019_AJSLP-19-00068
Cortical and Subcortical Control of Swallowing-Can We Use Information From Lesion Locations to Improve Diagnosis and Treatment for Patients With Stroke?
J. Wilmskoetter (2020)
THE EFFECTS OF CARBONATED FLUIDS ON THE HUMAN CORTICAL SWALLOWING MOTOR SYSTEM
O. Elshukri (2013)
10.1016/S1567-4231(03)03026-0
Magnetic stimulation in the definition of eloquent cortical areas
K. J. Werhahn (2003)
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