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Short-term Motor Improvement After Sub-threshold 5-Hz Repetitive Transcranial Magnetic Stimulation Of The Primary Motor Hand Area In Parkinson’s Disease

H. Siebner, C. Rossmeier, C. Mentschel, A. Peinemann, B. Conrad
Published 2000 · Medicine, Psychology

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Ten unmedicated patients with Parkinson's disease received sub-threshold 5-Hz repetitive transcranial magnetic stimulation (rTMS) over the primary motor hand area (M1(HAND)) contralaterally to the more affected upper limb. Compared to a midfrontal sham-rTMS, real-rTMS over M1(HAND) was associated with a significant decrease in the global motor UPDRS score 1 h after the cessation of rTMS. This was mainly due to a clinical improvement in the arm contralaterally to the stimulated M1(HAND). These preliminary data suggest that focal rTMS of M1(HAND) may have a therapeutic potential in PD.
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