Online citations, reference lists, and bibliographies.
← Back to Search

Increased Adipose Tissue Lipoprotein Lipase Activity During The Development Of The Genetically Obese Rat (fa/fa).

R. Gruen, E. Hietanen, M. Greenwood
Published 1978 · Biology, Medicine

Cite This
Download PDF
Analyze on Scholarcy
Share
Lipoprotein lipase (LPL) enzyme activity in epididymal adipose tissue from obese and lean Zucker rats was measured. At 5, 10, 13, and 20 wk of age obese rats have heavier fat pads, larger fat cells, and more LPL per epididymal fat pad and per fat cell than do their lean littermate controls. Although LPL per fat cell increased as fat cell size increased in lean rats, the increased LPL activity in the obese could not be attributed solely to increased fat cell size. When obese and lean rats had similar cell sizes, LPL per fat cell was still significantly increased in the obese compared to lean. Furthermore LPL activity was increased in "preobese" (fa/fa) rats compared to either lean genotype (Fa/fa or Fa/Fa) during the second postnatal week. The data suggest that early increments in LPL activity in adipose tissue of the "pre-obese" rat may significantly contribute to the early fat cell hypertrophy seen during the development of this genetic obesity. Furthermore, early increased LPL activity may prove useful as a predictor of the onset of obesity.
This paper references
10.3181/00379727-139-36078
Insulin Resistance and Pancreatic Insulin Release in the Genetically Obese Zucker Rat 1
J. Stern (1972)
10.1152/PHYSREV.1971.51.3.598
Genetically transmitted obesity in rodents.
G. Bray (1971)
Cellularity of adipose depots in six strains of genetically obese mice.
P. Johnson (1972)
Characterization of the plasma lipoproteins of the genetically obese hyperlipoproteinemic Zucker fatty rat.
G. Schonfeld (1974)
10.1021/BI00649A024
Lipoprotein lipase: evidence for high- and low-affinity enzyme sites.
C. Fielding (1976)
10.7748/en.15.5.4.s10
The obese patient.
G. Bray (1976)
A rapid assay for lipoprotein lipase.
M. Schotz (1970)
Evaluation of body composition of young obese and lean Zucker rats.
Bell Ge (1977)
10.1021/BI00733A026
Cofactor activity of protein components of human very low density lipoproteins in the hydrolysis of triglycerides by lipoproteins lipase from different sources.
R. Havel (1973)
A comparison of lipoprotein lipase activity and adipocyte differentiation in growing male rats.
E. Hietanen (1977)
10.1016/S0140-6736(78)92465-0
INCREASED ADIPOSE-TISSUE LIPOPROTEIN-LIPASE ACTIVITY IN MODERATELY OBESE MEN AFTER WEIGHT REDUCTION
R. Schwartz (1978)
10.1016/S0026-0495(78)80011-0
Adipose tissue hyperplasia and hyperinsulinemia on Zucker obese female rats: a developmental study.
P. Johnson (1978)
10.1093/OXFORDJOURNALS.JHERED.A107093
FATTY, A NEW MUTATION IN THE RAT
L. Zucker (1961)
Cellular and enzymatic changes in porcine adipose tissue during growth.
D. Anderson (1973)
10.3928/0090-4481-19750501-05
Can obesity be prevented?
J. Knittle (1975)
Cellularity of adipose depots in the genetically obese Zucker rat.
P. Johnson (1971)
Experimental obesity in man.
E. Sims (1968)
10.1210/endo-90-5-1320
Insulin and obesity in the Zucker genetically obese rat "fatty".
L. Zucker (1972)
10.1016/0026-0495(71)90084-9
Sjöström L,+SJOSTROM L: Number and size of adipose tissue fat cells in relation to metabolism in human obesity.
P. Björntorp (1971)
Protein measurement with the Folin phenol reagent.
O. H. Lowry (1951)
10.1016/S0022-3476(72)80231-2
Obesity in childhood: a problem in adipose tissue cellular development.
J. Knittle (1972)
Methods for the determination of adipose cell size in man and animals.
J. Hirsch (1968)
Trends in fatness and the origins of obesity Ad Hoc Committee to Review the Ten-State Nutrition Survey.
S. Garn (1976)
Lipoprotn lipase content and triglyceride fatty acid uptake in adipose tissue of rats of differing body weights.
P. Nestel (1969)
10.1111/j.1749-6632.1965.tb34807.x
GENETIC FACTORS IN HUMAN OBESITY
J. Mayer (1965)
10.1093/JN/103.5.738
Effect of early nutrition on adipose cellularity and pancreatic insulin release in the Zucker rat.
P. Johnson (1973)



This paper is referenced by
10.3177/JNSV.39.365
Increased 120 kDa protein in liver cytosol of genetically obese Zucker rats.
Hiroshi Maeda (1993)
10.1111/j.1749-6632.1990.tb22739.x
Obesity A Biobehavioral Point of View a
M. Katahn (1990)
10.1111/J.0954-6820.1987.TB05931.X
Mechanisms associating body fat distribution to glucose intolerance and diabetes mellitus: window with a view.
A. Kissebah (1988)
10.1074/jbc.272.27.17182
Induced Mutant Mice Expressing Lipoprotein Lipase Exclusively in Muscle Have Subnormal Triglycerides yet Reduced High Density Lipoprotein Cholesterol Levels in Plasma*
S. Levak-Frank (1997)
10.1210/JCEM-57-2-304
Relationship of androgenic activity to body fat topography, fat cell morphology, and metabolic aberrations in premenopausal women.
D. Evans (1983)
Near-Infrared and Infrared Imaging Analysis of Lipid Metabolism and Energy Expenditure
L. Cassis (2011)
10.1093/JN/114.2.447
Exercise and detraining: effect on food intake, adiposity and lipogenesis in Osborne-Mendel rats made obese by a high fat diet.
E. Applegate (1984)
10.1016/0031-9384(80)90123-7
Development of food motivated behavior in free feeding and food restricted zucker fatty (fa/fa) rats
J. Vasselli (1980)
10.1210/endo.138.3.4984
Influence of Estrogenic Status on the Lipolytic Activity of Parametrial Adipose Tissue in Vivo: an in Situ Microdialysis Study.
C. Darimont (1997)
10.1530/JOE-12-0455
Testosterone: a metabolic hormone in health and disease.
D. M. Kelly (2013)
10.1093/JN/113.6.1150
The influence of starvation and refeeding on the lipoprotein lipase activity of skeletal muscle and adipose tissue of lean and obese Zucker rats.
D. W. Quig (1983)
10.1016/0031-9384(86)90411-7
The effects of repeated cycles of weight loss and regain in rats
K. Brownell (1986)
10.1016/B978-0-12-715950-8.50027-5
OBESITY — LESSONS FROM EXPERIMENTAL MEDICINE
G. Bray (1984)
10.1016/0026-0495(80)90172-9
Postreceptor alterations in the states of insulin resistance.
M. Crettaz (1980)
10.1097/CCM.0000000000000999
Modification of the &bgr;-Adrenoceptor Stimulation Pathway in Zucker Obese and Obese Diabetic Rat Myocardium*
C. Jiang (2015)
10.1016/0026-0495(85)90114-3
Adipocyte precursor clones vary in capacity for differentiation.
P. Djian (1985)
10.1037//0735-7044.98.3.375
Mechanisms of energy balance in obesity.
M. R. McMinn (1984)
10.1016/0026-0495(81)90046-9
Onset and development of hypertriglyceridemia in the Zucker rat (fa/fa).
A. Boulangé (1981)
10.1002/DMR.5610050202
Biology of regional body fat distribution: relationship to non-insulin-dependent diabetes mellitus.
A. Kissebah (1989)
10.2527/JAS1986.633741X
Postnatal expression of adipose tissue metabolic activity associated with a porcine genetic obesity.
H. Mersmann (1986)
10.1161/01.ATV.15.10.1688
Overexpression of human lipoprotein lipase protects diabetic transgenic mice from diabetic hypertriglyceridemia and hypercholesterolemia.
M. Shimada (1995)
10.1016/0091-3057(83)90316-7
Effects of a glucosidase inhibitor (acarbose, BAY g 5421) on the development of obesity and food motivated behavior in Zucker (fafa) rats
J. Vasselli (1983)
10.1186/1471-2350-10-99
Genetic association study of selected candidate genes (ApoB, LPL, Leptin) and telomere length in obese and hypertensive individuals
B. Das (2008)
10.1002/9781444325546.CH32
Role of Marine Foods in Prevention of Obesity
Shigeru Nakajima (2010)
10.1016/0031-9384(86)90442-7
Ontogeny of brain monoamines in lean and obese female Zucker rats
M. Orosco (1986)
10.1007/978-3-0348-6540-1_5
Energy fuel and hormonal profile in experimental obesities.
B. Jeanrenaud (1983)
10.1007/s11745-002-0960-9
Impaired lipoprotein metabolism in obese offspring of streptozotocin-induced diabetic rats
H. Merzouk (2002)
10.1152/AJPENDO.1979.236.5.E508
Developmental changes in thymidine kinase, DNA, and fat cellularity in Zucker rats.
M. Cleary (1979)
10.1007/BF02535038
Glycerolipid biosynthesis in rat adipose tissue: VIII. Effect of obesity and cell size on [14C]acetate incorporation into lipids
S. Jamdar (2006)
10.1016/0026-0495(83)90123-3
Lipogenesis in primary cultures of adipoblasts derived from genetically obese Zucker rats.
F. Bourgeois (1983)
10.1111/J.1432-1033.1986.TB09494.X
Processing of human choriogonadotropin and its receptors by cultured pig Leydig cells. Role of cyclic AMP and protein synthesis.
M. Bernier (1986)
Adipose tissue cellularity and histochemistry in fetal swine as affected by genetic selection for high or low backfat.
G. Hausman (1983)
See more
Semantic Scholar Logo Some data provided by SemanticScholar