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Efficient Synthesis Of Resin-Bound α-TMSdiazoketones And Their Use In Solid-Phase Organic Synthesis

Y. Iso, Hirohisa Shindo, H. Hamana
Published 2000 · Chemistry

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Abstract α-TMSdiazoketones on a solid support could be simply and efficiently prepared by reaction of the corresponding resin-bound acid chlorides with excess TMSdiazomethane, without any bases. These α-TMSdiazoketones were used via carbenes or carbenoids for a variety of solid-phase reactions. These useful solid-phase reactions allow efficient construction of diverse compound libraries by use of combinatorial chemistry, due to the high reactivity and wide applications of the carbenes or carbenoids.
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