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Transcriptional And Transforming Activities Of The Adenovirus E1A Proteins.
T. Shenk, J. Flint
Published 1991 · Biology, Medicine
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Publisher Summary The products of the adenovirus E1A gene play key roles in both the productive and transforming cycles of infection. During productive growth in human cells, the E1A proteins activate expression of adenovirus genes at the level of transcription. The E1A proteins are also oncoproteins that cooperate with the adenovirus E1B gene products to oncogenically transform rodent cells. The 289R E1A protein is primarily responsible for the transactivation of viral gene expression. This protein and CR3 peptide stimulate transcription when added to uninfected cell-nuclear extracts in vitro . It is, therefore, unlikely that transactivation is generally a result of E1A protein-induced increases in the absolute concentration of cellular transcriptional components. A mechanism invoking E1A protein-dependent modification of cellular transcriptional components to increase one or more of their activities has a number of virtues. The E1A gene has been reported to transform established NIH 3T3 cells in the absence of a cooperating oncogene when it is expressed at high levels under the control of a heterologous promoter. However, the results obtained with established cell lines are difficult to interpret because such lines may harbor mutant recessive oncogenes, such as p53, that could influence the transforming activity of E1A proteins.
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Modelling and treating Huntington’s disease: Generation of high-capacity adenovirus vectors to express normal and mutant huntingtin and to block huntingtin expression by short hairpin interference RNA
B. Huang (2008)
Cyclin-dependent kinases phosphorylate the adenovirus E1A protein, enhancing its ability to bind pRb and disrupt pRb-E2F complexes.
A. Mal (1996)
Adenovirus E1A Targets the DREF Nuclear Factor To Regulate Virus Gene Expression, DNA Replication, and Growth
Sandi Radko (2014)
Identification of a Portable Repression Domain and an E1A-Responsive Activation Domain in Pax4: a Possible Role of Pax4 as a Transcriptional Repressor in the Pancreas
Y. Fujitani (1999)
Viral Oncoproteins as Probes for Tumor Suppressor Function
S. Chellappan (2001)
Adenovirus E 1 A-Regulated Transcription Factor p 120 E 4 F Inhibits Cell Growth and Induces the Stabilization of the cdk Inhibitor p 21 WAF 1
E. R. Fernandes (1997)
Apoptosis and signal transduction: clues to a molecular mechanism.
S. Lee (1993)
Preliminary characterisation of the adenovirus type 40 E1A region
Fb Stevenson (2000)
Adenovirus vectors deleted for genes essential for viral DNA replication.
J. Schaack (2005)
Acetylation of the Adenovirus-transforming Protein E1A Determines Nuclear Localization by Disrupting Association with Importin-α*
D. Madison (2002)
DNA synthesis-dependent relief of repression of transcription from the adenovirus type 2 IVa(2) promoter by a cellular protein.
W. Huang (2003)
The development, implementation and evaluation of a real-time PCR-based diagnostic service for viral causes of infectious intestinal disease
R. Gunson (2008)
Zinc finger and carboxyl regions of adenovirus E1A 13S CR3 are important for transactivation of the cytomegalovirus major immediate early promoter by adenovirus.
T. A. Sanchez (2000)
Superimposed Promoter Sequences of the Adenoviral E2 Early RNA Polymerase III and RNA Polymerase II Transcription Units*
D Ellsworth (2001)
Immunization with DNA, adenovirus or both in biodegradable alginate microspheres: effect of route of inoculation on immune response.
S. Mittal (2000)
The adenovirus E1A oncoprotein N-terminal transcriptional repression domain enhances p300 autoacetylation and inhibits histone H3 Lys18 acetylation
Ling-Jun Zhao (2015)See more