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Effects Of Fructose Infusion On Lactate And Uric Acid Metabolism.

H. Sahebjami, R. Scalettar
Published 1971 · Medicine

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Abstract Ten healthy volunteers received 10% intravenous fructose (0·5 g. per kg. body-weight per hour) for two hours following a one-hour control period in which physiological saline solution was infused intravenously. Blood-lactate rose significantly during fructose administration; and this change was accompanied by a fall in serum-bicarbonate and a rise in serum-glucose, which fell to hypoglycaemic concentrations an hour after infusion of fructose. Blood-uric-acid did not appreciably change; urinary urate excretion, urate clearance, and the ratio of urate to creatinine clearance increased during fructose infusion with no alteration of urinary pH. The lack of hyperuricaemia suggests that the hyperuricaemic effect of fructose previously reported is dose-related and associated only with larger than physiological concentrations of fructose infused under experimental conditions. While fructose seems to remain contraindicated in clinical settings where lactate accumulation must be avoided (diabetic ketoacidosis, hypoxia, postoperative period, and uraemia), it can be safely administered in physiological concentrations without fear of hyperuricaemia.
This paper references
10.1172/JCI104643
Interrelation of uric acid and ethanol metabolism in man.
C. Lieber (1962)
10.1016/S0140-6736(67)90494-1
FRUCTOSE-INDUCED HYPERURICÆMIA
P.-U. Heuckenkamp (1967)
10.1001/JAMA.1924.02650340012004
INCREASE OF URIC ACID IN THE BLOOD DURING PROLONGED STARVATION
William G. Lennox (1924)
10.1111/J.0954-6820.1968.TB02471.X
Lactic acid accumulation in connection with fructose infusion.
J. Bergström (1968)
10.1111/J.0954-6820.1967.TB11503.X
Synthesis of muscle glycogen in man after glucose and fructose infusion.
J. Bergström (1967)
10.1039/AN9659000736
An automated micro determination of blood-glucose with the autoanalyzer.
D. Faulkner (1965)
10.1172/jci105872
Enzymes of fructose metabolism in human liver.
F. Heinz (1968)
10.1126/science.161.3847.1253
Liver Adenine Nuldeotides: Fructose-Induced Depletion and Its Effect on Protein Synthesis
Pekka H. M�enp�� (1968)
10.1093/AJCN/21.3.245
Fructose metabolism. I. The fructose metabolic pathway.
R. H. Heman (1968)
10.1016/S0140-6736(70)92436-0
Absence of fructose-induced hyperuricaemia in men.
P. Curreri (1970)
10.1016/0003-2697(65)90271-X
AUTOMATED LACTIC ACID DETERMINATION IN SERUM AND TISSUE EXTRACTS.
N. J. Hochella (1965)
10.1136/pgmj.41.474.227-c
Control of Glycogen Metabolism
W. J. Whelan (1965)
10.1056/NEJM196209132671102
Hyperuricemia in diabetic ketoacidosis.
J. Padova (1962)
Simultaneous measurement of glucose and fructose.
W. L. Brown (1957)
10.1172/JCI102569
Metabolism of intravenous fructose and glucose in normal and diabetic subjects.
M. Miller (1952)
FRUCTOSE AND GLUCOSE TOLERANCE IN UREMIA.
R. Luke (1964)
10.1056/NEJM196312122692401
HEREDITARY FRUCTOSE INTOLERANCE.
M. Cornblath (1963)
10.1172/JCI105830
An experimental renal acidification defect in patients with hereditary fructose intolerance: I. Its resemblance to renal tubular acidosis
Morris Rc (1968)



This paper is referenced by
10.1093/BJA/87.2.316
Another feature of TURP syndrome: hyperglycaemia and lactic acidosis caused by massive absorption of sorbitol.
C. A. Trépanier (2001)
10.1007/BF02019649
The effect of intravenous carbohydrates on various parameters in blood
H. Förster (1972)
10.1136/adc.46.250.855
Intravenous feeding in infants.
J. Harries (1971)
17 Aspects of intravenous feeding in childhood
J. T. H. Rries (1978)
10.1111/J.0954-6820.1972.TB05324.X
Fructose and purine metabolism.
K. O. Raivio (1972)
10.1007/978-3-642-85459-0_93
Ernährungstherapie der Hyperurikämie — Wissenschaftliche Grundlagen und praktische Konsequenzen
W. Loeffler (1986)
10.1203/00006450-197510000-00005
Fructose-induced Hyperuricemia: Observations in Normal Children and in Patients with Hereditary Fructose Intolerance and Galactosemia
M. D. Kogut (1975)
10.3109/09637488009143450
Parenteral nutrition in paediatric practice: a review.
D. Candy (1980)
10.1177/003591577306600818
Management of prolonged intravenous feeding.
I. D. Johnston (1973)
10.1007/BF02020648
Harnsäureverhalten nach Infusion von Kohlenhydraten
G. Berg (1973)
10.1249/MSS.0b013e3181eb6147
Isomaltulose Improves Postexercise Glycemia by Reducing CHO Oxidation in T1DM.
D. West (2011)
10.1007/BF02019384
Vergleich von Nebenwirkungen bei Infusion von Glukose und von Glukoseaustauschstoffen
H. Förster (1978)
10.1042/0264-6021:3490539
Hepatic intralobular mapping of fructose metabolism in the rat liver.
S. Burns (2000)
10.1007/978-3-642-47087-5_415
Einfluß von Fructose auf die Purin de novo-Synthese der Rattenleber
J. Schwarzmeier (1973)
10.3109/00365521.2012.741618
Metabolic preconditioning with fructose prior to organ recovery attenuates ischemia-reperfusion injury in the isolated perfused rat liver
Katharina Lehne (2013)
10.1007/BF01486854
Fett- und Harnsäurestoffwechsel unter der akuten Wirkung von Xylit
D. Mertz (2005)
10.1007/BF01468334
Sorbitelimination bei Patienten mit akuter Hepatitis
D. Brachtel (2005)
10.1007/BF01940847
Effect of fructose administration on serum urate levels in the uricase inhibited rat
B. Stavric (2005)
10.1007/BF01851705
Fructose induced hyperuricemia
J. Schwarzmeier (1974)
10.2165/11591610-000000000-00000
Medical Management of Chronic Liver Diseases in Children (Part I)
M. El-Shabrawi (2011)
10.1016/0028-2243(77)90021-1
The effect of fructose infusions in the course of labor upon parturient and fetus.
V. Sabata (1977)
10.1016/S0065-2423(08)60174-2
Biochemical consequences of intravenous nutrition in the newborn.
G. Dale (1977)
This material is the copyright of the original publisher. Unauthorised copying and distribution is prohibited. Medical Management of Chronic Liver Diseases in Children (Part I) Focus on Curable or Potentially Curable Diseases
M. El-Shabrawi (2011)
10.1093/rheumatology/kew293
Drug-induced hyperuricaemia and gout.
C. Ben Salem (2017)
10.1016/S0140-6736(72)92791-2
Dangers of intravenous fructose.
H. Woods (1972)
10.4172/JBB.1000173
Effects on Uric Acid Metabolism of the Drugs except the Antihyperuricemics
Y. Moriwaki (2014)
10.1111/j.1651-2227.1975.tb03912.x
INTRAVENOUS FEEDING OF YOUNG INFANTS WITH PERSISTENT DIARRHOEA
A. Banister (1975)
10.3390/nu9020164
Metabolic Effects of Glucose-Fructose Co-Ingestion Compared to Glucose Alone during Exercise in Type 1 Diabetes
L. Bally (2017)
Intermediary metabolism of fructose 3
P. Mayes (2005)
10.1007/978-3-662-41451-4_5
Säure-Basen-Haushalt bei Dauerinfusion von Xylit, Fructose, Glucose und Kohlenhydratmischungen
G. Berg (1973)
10.1016/0921-4488(91)90067-Z
Influence of intravenous fructose loading on metabolism in sheep
M. Leontowicz (1991)
10.1007/BF02019385
Vergleich von Stoffwechselwirkungen bei Infusion von Glukose und von Glukoseaustauschstoffen in unterschiedlicher Dosierung
H. Förster (1978)
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