Online citations, reference lists, and bibliographies.
← Back to Search

DNA Copy Number Changes In Familial Malignant Mesothelioma.

V. Ascoli, Y. Aalto, C. Carnovale-Scalzo, F. Nardi, D. Falzetti, C. Mecucci, S. Knuutila
Published 2001 · Biology, Medicine

Cite This
Download PDF
Analyze on Scholarcy
Malignant mesothelioma (MM) is predominantly a sporadic malignancy linked to exposure to asbestos. Clustering of MM in families suggests genetic susceptibility as a contributing factor. We performed comparative genomic hybridization (CGH) analysis on tumor samples from members of a family with MM of the pleura and a history of parental cancer. Our specific aim was to find a recurrent copy number loss indicating the chromosomal area to which a gene underlying the development of MM could be assigned according to the Knudson two-hit hypothesis. We found losses at 1p, 6q, 9p, 13q, and 14q. The copy number changes were very similar to those reported in sporadic cases. Our findings and results from sporadic cases highlight the importance of cloning the genes in the loss sites at 1p, 6q, 14q, and 22q.
This paper references
Parental cancer and genetic predisposition in malignant pleural mesothelioma: a case-control study.
M. Huncharek (1996)
DNA copy number amplifications in human neoplasms: review of comparative genomic hybridization studies.
S. Knuutila (1998)
Is there a "genetic model" in the genesis of malignant pleural mesothelioma?
J. A. Precerutti (1990)
Somatic genetic alterations in human malignant mesothelioma (review).
W. Lee (1999)
Familial mesothelioma: review and family study.
Henry T. Lynch (1985)
Familial clustering of malignant mesothelioma
B. Risberg (1980)
DNA copy number losses in human neoplasms.
S. Knuutila (1999)
Asbestos-related familial mesothelioma.
C. Bianchi (1993)
Malignant Mesothelioma in Subjects with Marfan’s Syndrome and Ehlers-Danlos Syndrome: Only an Apparent Association?
M. Bisconti (2000)
Familial mesothelioma. Details of 17 cases with histopathologic findings and mineral analysis
A. Dawson (1992)
Detection and mapping of amplified DNA sequences in breast cancer by comparative genomic hybridization.
A. Kallioniemi (1994)
Malignant mesothelioma: clustering in a family producing asbestos cement in their home.
K. Otte (1990)
Familial pleural malignant mesothelioma: clustering in three sisters and one cousin.
V. Ascoli (1998)
Gains and losses of DNA sequences in malignant mesothelioma by comparative genomic hybridization.
P. Kivipensas (1996)
Familial mesothelioma after intense asbestos exposure at home.
F. Li (1978)
Malignant mesothelioma in two pairs of siblings: is there a hereditary predisposing factor?
G. Mårtensson (1984)
Mesothelioma, asbestos, and reported history of cancer in first‐degree relatives
E. F. Heineman (1996)
Optimization of comparative genomic hybridization using fluorochrome conjugated to dCTP and dUTP nucleotides.
W. El-Rifai (1997)
Inherited GSTM1 and NAT2 defects as concurrent risk modifiers in asbestos-related human malignant mesothelioma.
A. Hirvonen (1995)
Familial mesothelioma: a report of two families.
S. Hammar (1989)

This paper is referenced by
Comparative genomic hybridisation in malignant deciduoid mesothelioma
A. Scattone (2006)
1. Comment évaluer une exposition à l’amiante et identifier une population à risque?
J. Pairon (2006)
Molecular Epidemiology and Biology of Mesothelioma
R. Puntoni (2006)
Mesothelioma in blood related subjects: report of 11 clusters among 1954 Italy cases and review of the literature.
V. Ascoli (2007)
Neoplasms of the Pleura
S. Hammar (2008)
A Molecular Epidemiology Case Control Study on Pleural Malignant Mesothelioma
C. Bolognesi (2005)
Hereditary cancer: family history, diagnosis, molecular genetics, ecogenetics, and management strategies.
H. Lynch (2002)
Diffuse malignant pleural mesothelioma: Part I. An overview of diagnosis, staging, and treatment options.
C. Brueggen (2003)
Genetic susceptibility and familial malignant mesothelioma
V. Ascoli (2001)
Gene expression profiles in asbestos-exposed epithelial and mesothelial lung cell lines
P. Nymark (2006)
Cytogenetic and molecular genetic changes in malignant mesothelioma.
M. Musti (2006)
Ultrastructural and chromosomal studies on manganese superoxide dismutase in malignant mesothelioma.
V. Kinnula (2004)
Familial aggregation of malignant mesothelioma in former workers and residents of Wittenoom, Western Australia
N. de Klerk (2013)
Familial mesothelioma of the pleura--a report of 40 cases.
C. Bianchi (2004)
Identification of a mesothelioma phenotype.
J. Ohar (2007)
MALIGNANT MESOTHELIOMA an experimental study with emphasis on proteoglycans in mesothelial cell growth and differentiation
K. Dobra (2002)
Etiology of specific molecular alterations in human malignancies
H. Vauhkonen (2007)
Current therapy for malignant mesothelioma
W. Smythe (2002)
Updates on the cytogenetics and molecular genetics of bone and soft tissue tumors. Mesothelioma.
A. Sandberg (2001)
Comparative Genomic Hybridization Studies on Mesothelioma Show a Parallel Fate of 1p21-1p22 and 9p21 Bands and a Chromosomally Stable Sub-Group
M. Ombretta (2013)
A one-generation cluster of malignant mesothelioma within a family reveals exposure to asbestos-contaminated jute bags in Naples, Italy
V. Ascoli (2004)
A cluster of familial malignant mesothelioma with del(9p) as the sole chromosomal anomaly.
M. Musti (2002)
Implementation of a molecular epidemiology approach to human pleural malignant mesothelioma.
R. Puntoni (2003)
Modélisation génétique de l'oncogenèse mésothéliale induite par les fibres minérales
C. Boulangé-Lecomte (2004)
Familial Mesothelioma of the Pleura
C. Bianchi (2004)
Malignant Mesothelioma: Molecular Markers
E. Kettunen (2014)
Identification of BAP1 as a predisposing gene for malignant mesothelioma
Masaki Nasu (2012)
YAP1 is involved in mesothelioma development and negatively regulated by Merlin through phosphorylation.
T. Yokoyama (2008)
Inherited predisposition to cancer: A historical overview
H. Lynch (2004)
An asbestos-exposed family with multiple cases of pleural malignant mesothelioma without inheritance of a predisposing BAP1 mutation.
M. Cheung (2015)
Mesothelial differentiation, mesothelioma and tumor markers in serous cavities
M. Gulyás (2003)
Case report: malignant peritoneal mesothelioma in two siblings.
A. Picklesimer (2005)
See more
Semantic Scholar Logo Some data provided by SemanticScholar