← Back to Search
Microparticle Resins As A Potential Nasal Drug Delivery System For Insulin.
M. Takenaga, Y. Serizawa, Y. Azechi, A. Ochiai, Y. Kosaka, R. Igarashi, Y. Mizushima
Published 1998 · Chemistry, Medicine
Download PDFAnalyze on Scholarcy
The application of various resins for the nasal delivery of insulin was examined in rabbits. Intranasal administration of human insulin (28 U, 1 mg) mixed with fractionated sodium polystyrene sulfonate powder (an anionic resin with a particle size of 20-45 microns) caused a rapid increase of the plasma insulin level 413.0 +/- 71.7 microU/ml (mean +/- S.D.) after 15 min, while intranasal administration of insulin alone caused little increase. The blood glucose level decreased from 118.8 +/- 18.5 mg/dl to 65.8 +/- 13.8 mg/dl at 45 min after administration. These results were superior to those obtained with the unfractionated resin. Styrene-divinylbenzene copolymer (a nonionic resin; 20-45 microns fraction) showed similar enhancement of nasal insulin absorption. In contrast, polyacrylester (a nonionic resin; 20-45 microns fraction) and cholestyramine (a cationic resin) did not promote insulin absorption. These results suggest that some resins may be useful for nasal delivery of insulin.
This paper references
Chitosan as a nasal delivery system: evaluation of insulin absorption enhancement and effect on nasal membrane integrity using rat models
T. Aspden (1996)
Effect of polymers and microspheres on the nasal absorption of insulin in rats
L. Rydén (1992)
Intragastric Distribution of Ion‐exchange Resins: a Drug Delivery System for the Topical Treatment of the Gastric Mucosa
S. Burton (1995)
Structure-function relationship among Quillaja saponins serving as excipients for nasal and ocular delivery of insulin.
D. Pillion (1996)
Hyaluronic acid ester microspheres as a nasal delivery system for insulin
L. Illum (1994)
Protein measurement with the Folin phenol reagent.
O. H. Lowry (1951)
Effect of time, temperature and freezing on the stability of immunoreactive LH, FSH, TSH, growth hormone, prolactin and insulin in plasma.
J. Livesey (1980)
Degradable starch microspheres as a nasal delivery system for insulin
E. Björk (1988)
Starch microspheres induce pulsatile delivery of drugs and peptides across the epithelial barrier by reversible separation of the tight junctions.
E. Björk (1995)
Dextran microspheres as a potential nasal drug delivery system for insulin : in vitro and in vivo properties
Lena Pereswetoff-Morath (1995)
Characterization of degradable starch microspheres as a nasal delivery system for drugs
E. Björk (1990)
This paper is referenced by
Recent strategies and methods for improving insulin delivery
C. Lin (2004)
Inhalation therapy: new delivery systems.
V. Ranade (2001)
Absorption Enhancers for Nasal Drug Delivery
S. Davis (2003)
Conventional and Novel Pharmaceutical Dosage Forms on Prevention of Gastric Ulcers
Işık Özgüney (2011)
Nasal Drug Delivery Systems: An Overview
M. U. Ghori (2015)
Preparation and in vivo evaluation of mucoadhesive microparticles containing amoxycillin-resin complexes for drug delivery to the gastric mucosa.
M. Cuña (2001)
Introduction to Nanotechnology (NT) and Nanomaterials (NMs)
Loutfy H. Madkour (2019)
New strategies to improve the intranasal absorption of insulin.
X. Duan (2010)
In vivo absorption studies of insulin from an oral delivery system.
N. Jerry (2001)
Preparation and characterization of core/shell SiOx/PAM nanospheres with ‘graft from’ method
P. Liu (2005)
The Use of Polyglycol Succinates for the Microencapsulation of Insulin
R. Sariri (2002)
Development of a novel nasal nicotine formulation comprising an optimal pulsatile and sustained plasma nicotine profile for smoking cessation.
Y. Cheng (2002)
Characterization of Ion-Exchange Fibers for Controlled Drug Delivery
Kaisa R Hänninen (2008)
Synthesis of Copoly(amide-imide)s Based on Silica Nano Particles-polyacrylamide
J. Min (2016)
Nanoparticles types and properties – understanding these promising devices in the biomedical area
Ana Luísa Pécurto Cartaxo (2015)
Loading and release of amine drugs by ion-exchange fibers: role of amine type.
Yanan Gao (2014)
In vivo evaluation of nicotine lyophilised nasal insert in sheep.
F. Mcinnes (2005)
Aminated gelatin microspheres as a nasal delivery system for peptide drugs: evaluation of in vitro release and in vivo insulin absorption in rats.
J. Wang (2006)
Peroral and nasal delivery of insulin with PheroidTM technology
Ian Dewald Oberholzer (2009)
Optimization of the size of biodegradable polymeric nanoparticles as intracellular drug delivery devices
Ana Luísa Pécurto Cartaxo (2015)
In Vivo Absorption Studies of Insulin from an Oral Delivery System
N Jerry, Y. Anitha, C. P. Sharma, Poulose Sony (2001)
Transdermal Drug Delivery
Vasant V. Ranade (2011)
Phase inversion emulsification: Current understanding and applications.
A. Perazzo (2015)
Evaluation of starch-maltodextrin-Carbopol 974 P mixtures for the nasal delivery of insulin in rabbits.
C. Callens (2000)
Challenges in nasal drug absorption: how far have we come?
R. Agu (2016)
Formulation of poly(D,L-lactic-co-glycolic acid) microparticles for rapid plasmid DNA delivery.
A. Tinsley-Bown (2000)
Microfluidics of Multiphase Flows
A. Perazzo (2015)
Nasal Delivery of High Molecular Weight Drugs
Y. Ozsoy (2009)
An Overview on Diabetes Mellitus with Emphasis on Non Invasive Techniques of Insulin Delivery
Mukesh K. Nag (2013)
ION EXCHANGE RESINS: PHARMACEUTICAL IMPORTANCE AND RECENT ADVANCEMENT
A DeshmukhHimanshu (2012)
Characterizations of Modified Silica Nanoparticles(I)
Seong Kee Min (2012)
A Novel Stabilizing Approach to Improve the Manufacturing of Biodegradable Microparticles Entrapping Plasticizing Active Molecules: the Case of 4-Methoxychalcone
D. Benvenutti (2018)See more