← Back to Search
Transcytosis Of Nanoparticle And Dendrimer Delivery Systems: Evolving Vistas.
A. Florence, N. Hussain
Published 2001 · Biology, Medicine
Download PDFAnalyze on Scholarcy
The translocation of particulate matter across the gastrointestinal tract is now a well documented phenomenon offering new potential for the delivery of drugs with poor dissolution profiles and labile chemistries via encapsulation in biodegradable nanoparticles. The last few years have seen an acceleration in the number of publications describing the varying facets of this approach and the multidisciplinary nature of this field. This review delineates data from this rather fragmented area and from cognate fields to provide a physicochemical viewpoint of the importance of surface chemistries of oral drug delivery vehicles and their interactions in and with gut contents prior to uptake. The role of lymphoid and non-lymphoid tissues is examined, and the role of bioadhesion is discussed. The exciting potential of molecular encapsulation of drugs via dendrimers and star branched molecules is discussed in the context of nanotechnological applications for the oral route. Evolving vistas include a better understanding of the plasticity of the intestinal epithelium and M-cell induction as well as the influence of disease states on particulate uptake. In this review we address a number of issues deemed vital to an understanding of the subject including (i) some background knowledge on particulate uptake (the subject of several reviews), (ii) factors affecting uptake such as diameter and surface charge and character, (iii) the dynamic nature of particle interactions in the gut, (iv) the dynamic nature of the processes of capture, adhesion, uptake, transcytosis and translocation, and (v) the influence of surface ligands.
This paper references
Factors affecting the oral uptake and translocation of polystyrene nanoparticles: histological and analytical evidence.
A. Florence (1995)
Mathematical modeling of bioerodible, polymeric drug delivery systems.
J. Siepmann (2001)
Role of chemotaxis in the association of motile bacteria with intestinal mucosa: in vivo studies.
R. Freter (1981)
Conversion by Peyer's patch lymphocytes of human enterocytes into M cells that transport bacteria.
S. Kernéis (1997)
Cellular Uptake of PEO Surface-Modified Nanoparticles: Evaluation of Nanoparticles Made of PLA: PEO Diblock and Triblock Copolymers
F. Jaeghere (2000)
Positively charged gelatin microspheres as gastric mucoadhesive drug delivery system for eradication of H. pylori.
J. Wang (2000)
Synthesis and Physicochemical Properties of Lipophilic Polyamide Dendrimers
T. Sakthivel (2004)
A direct method for the formation of peptide and carbohydrate dendrimers.
J. P. Mitchell (1999)
Binding and uptake of biodegradable poly-DL-lactide micro- and nanoparticles in intestinal epithelia.
S. McClean (1998)
Bioadhesive drug delivery systems. I. Characterisation of mucoadhesive properties of systems based on glyceryl mono-oleate and glyceryl monolinoleate.
L. S. Nielsen (1998)
Identification of invasin: A protein that allows enteric bacteria to penetrate cultured mammalian cells
R. Isberg (1987)
Bioadhesion by Means of Specific Binding of Tomato Lectin
C. Lehr (2004)
S. Zimmerman (1996)
A commentary on morphological and quantitative aspects of microparticle translocation across the gastrointestinal mucosa.
G. M. Hodges (1995)
Immune potentiation of ultrafine dietary particles in normal subjects and patients with inflammatory bowel disease.
J. Powell (2000)
In vitro dissolution and in vivo absorption of nitrofurantoin from deoxycholic acid coprecipitates.
R. Stoll (1973)
Comparison of two methods of encapsulation of an oligonucleotide into poly(D,L-lactic acid) particles.
F. Delié (2001)
The Uptake and Translocation of Latex Nanospheres and Microspheres after Oral Administration to Rats
P. Jani (1989)
Cystic fibrosis sputum: a barrier to the transport of nanospheres.
N. Sanders (2000)
MECHANISTIC STUDIES IN THE SIMULTANEOUS FLOW AND ADSORPTION OF POLYMER-COATED LATEX PARTICLES ON INTESTINAL MUCUS I: METHODS AND PHYSICAL MODEL DEVELOPMENT#
C.L.C. Teng (1987)
Trojan peptides: the penetratin system for intracellular delivery.
D. Derossi (1998)
Influence of colloid stabilizing agents on interactions between nanoparticles and mucus
C. Durrer (1999)
99mTc-sulfur colloid gastroesophageal scintigraphy with late lung imaging to evaluate patients with posterior laryngitis.
A. Bestetti (2000)
Uptake by enterocytes and subsequent translocation to internal organs, eg, the thymus, of Percoll microspheres administered per os to suckling mice.
K. Matsuno (1983)
Migration of adhesive and nonadhesive particles in the rat intestine under altered mucus secretion conditions.
B. Tirosh (1998)
Oral immunisation with peptide and protein antigens by formulation in lipid vesicles incorporating bile salts (bilosomes).
M. Conacher (2001)
Synthetic methods of glycopeptide assembly, and biological analysis of glycopeptide products.
M. Meldal (1997)
Oral gene delivery with chitosan–DNA nanoparticles generates immunologic protection in a murine model of peanut allergy
K. Roy (1999)
Degradation of poly(D,L-lactic acid) nanoparticles coated with albumin in model digestive fluids (USP XXII).
F. Landry (1996)
Weakly adhering vesicles in shear flow: Tanktreading and anomalous lift force
B. Lorz (2000)
In vitro uptake of polystyrene microspheres: effect of particle size, cell line and cell density.
W. Zauner (2001)
Synthesis of polyamidoamine dendrimers having poly(ethylene glycol) grafts and their ability to encapsulate anticancer drugs.
C. Kojima (2000)
Oral uptake and translocation of a polylysine dendrimer with a lipid surface.
A. Florence (2000)
Multi-Organ, Multi-Lineage Engraftment by a Single Bone Marrow-Derived Stem Cell
D. Krause (2001)
Oral delivery of poly(lactide-co-glycolide) microspheres containing ovalbumin as vaccine formulation: particle size study.
T. Uchida (1994)
The measured level of prion infectivity varies in a predictable way according to the aggregation state of the infectious agent.
J. Masel (2001)
PAMAM Dendrimers as Delivery Agents for Antisense Oligonucleotides
H. Yoo (2004)
Vaccine-containing biodegradable microspheres specifically enter the gut-associated lymphoid tissue following oral administration and induce a disseminated mucosal immune response.
J. Eldridge (1989)
Dendrimer-platinate: a novel approach to cancer chemotherapy.
N. Malik (1999)
Chitosan microparticles for oral vaccination: preparation, characterization and preliminary in vivo uptake studies in murine Peyer's patches.
I. M. van der Lubben (2001)
Chitosan and depolymerized chitosan oligomers as condensing carriers for in vivo plasmid delivery.
F. Maclaughlin (1998)
A mechanistic analysis of carrier-mediated oral delivery of protein therapeutics.
B. R. Stoll (2000)
Pinocytosis and phagocytosis: the effect of size of a particulate substrate on its mode of capture by rat peritoneal macrophages cultured in vitro.
M. Pratten (1986)
Bacterial translocation from the gastrointestinal tract.
R. Berg (1992)
Mucoadhesion of Latexes. I. Analytical Methods and Kinetic Studies
C. Durrer (2004)
Reflectometry: a new method for quantitative determinations of intraoral film formation.
N. Vassilakos (1993)
Internalin of Listeria monocytogenes with an intact leucine-rich repeat region is sufficient to promote internalization.
Marc Lecuit (1997)
Biologically erodable microspheres as potential oral drug delivery systems
E. Mathiowitz (1997)
Limited adhesion of biodegradable microspheres to E- and P-selectin under flow.
J. Dickerson (2001)
The role of PEG on the stability in digestive fluids and in vivo fate of PEG-PLA nanoparticles following oral administration.
Plasticity of the gastrointestinal epithelium: the M cell paradigm and opportunism of pathogenic microorganisms.
S. Kernéis (1999)
Gliding motility in cyanobacteria: observations and possible explanations
E. Hoiczyk (2000)
Enhanced delivery of antisense oligonucleotides with fluorophore-conjugated PAMAM dendrimers.
H. Yoo (2000)
Nanoparticle Uptake by the Rat Gastrointestinal Mucosa: Quantitation and Particle Size Dependency
P. Jani (1990)
Mucoadhesion of Latexes. II. Adsorption Isotherms and Desorption Studies
C. Durrer (2004)
BACTERIAL INVASION FACTORS AND LECTINS AS SECOND-GENERATION BIOADHESIVES
James H. Easson (1999)
Particle diameter influences adhesion under flow.
V. R. Shinde Patil (2001)
Recent advances in the understanding of uptake of microparticulates across the gastrointestinal lymphatics.
N. Hussain (2001)
Activated polyamidoamine dendrimers, a non-viral vector for gene transfer to the corneal endothelium
T. Hudde (1999)
Expression of specific markers and particle transport in a new human intestinal M-cell model.
E. Gullberg (2000)
Binding of salivary proteins and oral bacteria to hydrophobic and hydrophilic surfaces in vivo and in vitro
B. Lassen (1994)
Impairment of alveolar macrophage phagocytosis by ultrafine particles.
L. Renwick (2001)
Innovations in oral gene delivery: challenges and potentials.
D. T. Page (2001)
Translocation of polysialic acid across model membranes: kinetic analysis and dynamic studies.
T. Janas (2001)
A unique dosage form to evaluate the mechanical destructive force in the gastrointestinal tract.
M. Kamba (2000)
Specific adhesion of glycophorin liposomes to a lectin surface in shear flow.
M. R. Wattenbarger (1990)
Evaluation of Biological and Physical Protection against Nuclease Degradation of Clay-Bound Plasmid DNA
S. Demanèche (2001)
Surface and colloid chemical aspects of saliva particle interactions.
P. O. Glantz (1995)
Retention of streptococci to defined solid surfaces in the presence of saliva secretions.
C. Christersson (1992)
Coating the surface: a model for expression of capsular polysialic acid in Escherichia coli K1
J. M. Bliss (1996)
The transport of microspheres from the gastro‐intestinal tract to inflammatory air pouches in the rat
H. O. Alpar (1989)
Peroral administration of 14C-poly(D,L-lactic acid) nanoparticles coated with human serum albumin or polyvinyl alcohol to guinea pigs.
F. Landry (1998)
NOVEL FORMULATION APPROACHES TO ORAL MUCOADHESIVE DRUG DELIVERY SYSTEMS
Y. Akiyama (1999)
Enhancement of transfection by physical concentration of DNA at the cell surface
D. Luo (2000)
Plasmid DNA adsorbed onto cationic microparticles mediates target gene expression and antigen presentation by dendritic cells
K. Denis-Mize (2000)
Oral DNA vaccination promotes mucosal and systemic immune responses to HIV envelope glycoprotein.
H. Kaneko (2000)
This paper is referenced by
Nanoparticles for Drug Delivery
A. Lowman (2006)
Nanoparticle technologies for cancer therapy.
F. Alexis (2010)
Factors influencing intestinal microparticle uptake in vivo.
M. Doyle-McCullough (2007)
Interaction of a Surface-Active Ionic Liquid with an Antidepressant Drug: Micellization and Spectroscopic Studies
U. Farooq (2018)
Synthesis and Evaluation of Pegylated Dendrimeric Nanocarrier for Pulmonary Delivery of Low Molecular Weight Heparin
Shuhua Bai (2008)
Modified karaya gum colloidal particles for the management of systemic hypertension.
M. Dhua (2020)
Nanoparticles – known and unknown health risks
P. Hoet (2004)
Novel Photodynamic Cancer Therapy Agent and Biochemical Phosphate Sensor Based on Nanomaterials
Alaa Fadhel (2016)
Cellular uptake and toxicity of microparticles in a perspective of polymyxin B oral administration.
G. Coppi (2010)
Strategies Toward the Improved Oral Delivery of Insulin Nanoparticles via Gastrointestinal Uptake and Translocation
Camile B. Woitiski (2012)
Gastrointestinal Applications of Nanoparticulate Drug-Delivery Systems
M. Gasco (2007)
Binding interactions of anesthetic drug with surface active ionic liquid
A. Pal (2016)
Toxicology of nanoparticles after cellular uptake
C. Cheng (2010)
Mannose-rich guar gum nanoparticles as a novel therapeutic drug against inflammatory diseases
N. Ghosh (2018)
Nanoparticle-Based Oral Drug Delivery System for an Injectable Antibiotic – Streptomycin
R. Pandey (2007)
Biological applications of dendrimers.
M. Cloninger (2002)
Micellar Parameters of Aqueous Solutions of Tween 20 and 60 at Different Temperatures: Volumetric and Viscometric Study
K. Szymczyk (2018)
Lipid nanoparticles as vehicles for oral delivery of insulin and insulin analogs: preliminary ex vivo and in vivo studies
E. Muntoni (2019)
Engineering lipid nanocapsule systems for intracellular delivery of anticancer drugs
P. Moreno (2014)
Use of Targeting Agents to Increase Uptake and Localization of Drugs to the Intestinal Epithelium
G. J. Russell-Jones (2004)
Rifampicin Lipid-Polymer hybrid nanoparticles (LIPOMER) for enhanced Peyer's patch uptake.
S. S. Bachhav (2017)
Targeting Immunomodulatory Agents to the Gut-Associated Lymphoid Tissue
Atheer Zgair (2016)
A forward look at therapy for pediatric movement disorders.
M. Pranzatelli (2003)
Amphiphilic copolymers of ε-caprolactone and γ-substituted ε-caprolactone. Synthesis and functionalization of poly(D,L-lactide) nanoparticles
S. Gautier (2003)
A comparative study of the potential of solid triglyceride nanostructures coated with chitosan or poly(ethylene glycol) as carriers for oral calcitonin delivery.
M. Garcia-Fuentes (2005)
Solid Lipid Nanoparticles for Drug Delivery
S. Joseph (2013)
Nanocarriers and Drug Delivery
S. Gelperina (2007)
NANO EXPRESS Open Access
J. Lorbeer (2014)
Novel propyl karaya gum nanogels for bosentan: In vitro and in vivo drug delivery performance.
Bibek Laha (2019)
Optimization, in vitro-in vivo evaluation, and short-term tolerability of novel levofloxacin-loaded PLGA nanoparticle formulation.
G. Kumar (2012)
Nanotechnology Approaches for the Delivery of Exogenous siRNA for HIV Therapy.
S. Adesina (2015)
Nanovehicular intracellular delivery systems.
A. Prokop (2008)See more