Online citations, reference lists, and bibliographies.
← Back to Search

Transcytosis Of Nanoparticle And Dendrimer Delivery Systems: Evolving Vistas.

A. Florence, N. Hussain
Published 2001 · Biology, Medicine

Cite This
Download PDF
Analyze on Scholarcy
Share
The translocation of particulate matter across the gastrointestinal tract is now a well documented phenomenon offering new potential for the delivery of drugs with poor dissolution profiles and labile chemistries via encapsulation in biodegradable nanoparticles. The last few years have seen an acceleration in the number of publications describing the varying facets of this approach and the multidisciplinary nature of this field. This review delineates data from this rather fragmented area and from cognate fields to provide a physicochemical viewpoint of the importance of surface chemistries of oral drug delivery vehicles and their interactions in and with gut contents prior to uptake. The role of lymphoid and non-lymphoid tissues is examined, and the role of bioadhesion is discussed. The exciting potential of molecular encapsulation of drugs via dendrimers and star branched molecules is discussed in the context of nanotechnological applications for the oral route. Evolving vistas include a better understanding of the plasticity of the intestinal epithelium and M-cell induction as well as the influence of disease states on particulate uptake. In this review we address a number of issues deemed vital to an understanding of the subject including (i) some background knowledge on particulate uptake (the subject of several reviews), (ii) factors affecting uptake such as diameter and surface charge and character, (iii) the dynamic nature of particle interactions in the gut, (iv) the dynamic nature of the processes of capture, adhesion, uptake, transcytosis and translocation, and (v) the influence of surface ligands.
This paper references
10.3109/10611869509015936
Factors affecting the oral uptake and translocation of polystyrene nanoparticles: histological and analytical evidence.
A. Florence (1995)
10.1016/S0169-409X(01)00116-8
Mathematical modeling of bioerodible, polymeric drug delivery systems.
J. Siepmann (2001)
10.1128/IAI.34.1.234-240.1981
Role of chemotaxis in the association of motile bacteria with intestinal mucosa: in vivo studies.
R. Freter (1981)
10.1126/SCIENCE.277.5328.949
Conversion by Peyer's patch lymphocytes of human enterocytes into M cells that transport bacteria.
S. Kernéis (1997)
10.3109/10611860008996860
Cellular Uptake of PEO Surface-Modified Nanoparticles: Evaluation of Nanoparticles Made of PLA: PEO Diblock and Triblock Copolymers
F. Jaeghere (2000)
10.1080/107175400455173
Positively charged gelatin microspheres as gastric mucoadhesive drug delivery system for eradication of H. pylori.
J. Wang (2000)
10.1023/A:1011935406664
Synthesis and Physicochemical Properties of Lipophilic Polyamide Dendrimers
T. Sakthivel (2004)
10.1016/S0960-894X(99)00480-1
A direct method for the formation of peptide and carbohydrate dendrimers.
J. P. Mitchell (1999)
10.1016/S0928-0987(97)10007-0
Binding and uptake of biodegradable poly-DL-lactide micro- and nanoparticles in intestinal epithelia.
S. McClean (1998)
10.1016/S0928-0987(97)10004-5
Bioadhesive drug delivery systems. I. Characterisation of mucoadhesive properties of systems based on glyceryl mono-oleate and glyceryl monolinoleate.
L. S. Nielsen (1998)
10.1016/0092-8674(87)90335-7
Identification of invasin: A protein that allows enteric bacteria to penetrate cultured mammalian cells
R. Isberg (1987)
10.1023/A:1015804816582
Bioadhesion by Means of Specific Binding of Tomato Lectin
C. Lehr (2004)
10.1126/science.271.5252.1095
Self-Assembling Dendrimers
S. Zimmerman (1996)
10.3109/10611869509015934
A commentary on morphological and quantitative aspects of microparticle translocation across the gastrointestinal mucosa.
G. M. Hodges (1995)
10.1006/JAUT.1999.0342
Immune potentiation of ultrafine dietary particles in normal subjects and patients with inflammatory bowel disease.
J. Powell (2000)
10.1002/JPS.2600620111
In vitro dissolution and in vivo absorption of nitrofurantoin from deoxycholic acid coprecipitates.
R. Stoll (1973)
10.1016/S0378-5173(00)00627-X
Comparison of two methods of encapsulation of an oligonucleotide into poly(D,L-lactic acid) particles.
F. Delié (2001)
10.1111/j.2042-7158.1989.tb06377.x
The Uptake and Translocation of Latex Nanospheres and Microspheres after Oral Administration to Rats
P. Jani (1989)
10.1164/AJRCCM.162.5.9909009
Cystic fibrosis sputum: a barrier to the transport of nanospheres.
N. Sanders (2000)
10.1016/0168-3659(87)90071-X
MECHANISTIC STUDIES IN THE SIMULTANEOUS FLOW AND ADSORPTION OF POLYMER-COATED LATEX PARTICLES ON INTESTINAL MUCUS I: METHODS AND PHYSICAL MODEL DEVELOPMENT#
C.L.C. Teng (1987)
10.1016/S0962-8924(98)80017-2
Trojan peptides: the penetratin system for intracellular delivery.
D. Derossi (1998)
Influence of colloid stabilizing agents on interactions between nanoparticles and mucus
C. Durrer (1999)
99mTc-sulfur colloid gastroesophageal scintigraphy with late lung imaging to evaluate patients with posterior laryngitis.
A. Bestetti (2000)
Uptake by enterocytes and subsequent translocation to internal organs, eg, the thymus, of Percoll microspheres administered per os to suckling mice.
K. Matsuno (1983)
10.1021/JS9703380
Migration of adhesive and nonadhesive particles in the rat intestine under altered mucus secretion conditions.
B. Tirosh (1998)
10.1016/S0264-410X(00)00537-5
Oral immunisation with peptide and protein antigens by formulation in lipid vesicles incorporating bile salts (bilosomes).
M. Conacher (2001)
10.1016/S1367-5931(97)80052-X
Synthetic methods of glycopeptide assembly, and biological analysis of glycopeptide products.
M. Meldal (1997)
10.1038/7385
Oral gene delivery with chitosan–DNA nanoparticles generates immunologic protection in a murine model of peanut allergy
K. Roy (1999)
10.1016/0142-9612(96)86742-1
Degradation of poly(D,L-lactic acid) nanoparticles coated with albumin in model digestive fluids (USP XXII).
F. Landry (1996)
10.1209/EPL/I2000-00517-6
Weakly adhering vesicles in shear flow: Tanktreading and anomalous lift force
B. Lorz (2000)
10.1016/S0168-3659(00)00358-8
In vitro uptake of polystyrene microspheres: effect of particle size, cell line and cell density.
W. Zauner (2001)
10.1021/BC0000583
Synthesis of polyamidoamine dendrimers having poly(ethylene glycol) grafts and their ability to encapsulate anticancer drugs.
C. Kojima (2000)
10.1016/S0168-3659(99)00237-0
Oral uptake and translocation of a polylysine dendrimer with a lipid surface.
A. Florence (2000)
10.1016/S0092-8674(01)00328-2
Multi-Organ, Multi-Lineage Engraftment by a Single Bone Marrow-Derived Stem Cell
D. Krause (2001)
10.1248/BPB.17.1272
Oral delivery of poly(lactide-co-glycolide) microspheres containing ovalbumin as vaccine formulation: particle size study.
T. Uchida (1994)
10.1016/S0925-4439(00)00095-8
The measured level of prion infectivity varies in a predictable way according to the aggregation state of the infectious agent.
J. Masel (2001)
10.1023/A:1018926605871
PAMAM Dendrimers as Delivery Agents for Antisense Oligonucleotides
H. Yoo (2004)
10.1007/978-1-4757-2046-4_18
Vaccine-containing biodegradable microspheres specifically enter the gut-associated lymphoid tissue following oral administration and induce a disseminated mucosal immune response.
J. Eldridge (1989)
10.1097/00001813-199909000-00010
Dendrimer-platinate: a novel approach to cancer chemotherapy.
N. Malik (1999)
10.1016/S0142-9612(00)00231-3
Chitosan microparticles for oral vaccination: preparation, characterization and preliminary in vivo uptake studies in murine Peyer's patches.
I. M. van der Lubben (2001)
10.1016/S0168-3659(98)00097-2
Chitosan and depolymerized chitosan oligomers as condensing carriers for in vivo plasmid delivery.
F. Maclaughlin (1998)
10.1016/S0168-3659(99)00144-3
A mechanistic analysis of carrier-mediated oral delivery of protein therapeutics.
B. R. Stoll (2000)
10.1016/0304-4165(86)90020-6
Pinocytosis and phagocytosis: the effect of size of a particulate substrate on its mode of capture by rat peritoneal macrophages cultured in vitro.
M. Pratten (1986)
10.1007/978-1-4615-4143-1_2
Bacterial translocation from the gastrointestinal tract.
R. Berg (1992)
10.1023/A:1018968011169
Mucoadhesion of Latexes. I. Analytical Methods and Kinetic Studies
C. Durrer (2004)
10.1111/J.1600-0722.1993.TB01129.X
Reflectometry: a new method for quantitative determinations of intraoral film formation.
N. Vassilakos (1993)
10.1128/IAI.65.12.5309-5319.1997
Internalin of Listeria monocytogenes with an intact leucine-rich repeat region is sufficient to promote internalization.
Marc Lecuit (1997)
10.1038/386410A0
Biologically erodable microspheres as potential oral drug delivery systems
E. Mathiowitz (1997)
10.1002/BIT.1085
Limited adhesion of biodegradable microspheres to E- and P-selectin under flow.
J. Dickerson (2001)
10.1016/S0927-7765(99)00157-5
The role of PEG on the stability in digestive fluids and in vivo fate of PEG-PLA nanoparticles following oral administration.
Tobío (2000)
10.1006/SMIM.1999.0176
Plasticity of the gastrointestinal epithelium: the M cell paradigm and opportunism of pathogenic microorganisms.
S. Kernéis (1999)
10.1007/s002030000187
Gliding motility in cyanobacteria: observations and possible explanations
E. Hoiczyk (2000)
10.1093/NAR/28.21.4225
Enhanced delivery of antisense oligonucleotides with fluorophore-conjugated PAMAM dendrimers.
H. Yoo (2000)
10.1111/j.2042-7158.1990.tb07033.x
Nanoparticle Uptake by the Rat Gastrointestinal Mucosa: Quantitation and Particle Size Dependency
P. Jani (1990)
10.1023/A:1018920128007
Mucoadhesion of Latexes. II. Adsorption Isotherms and Desorption Studies
C. Durrer (2004)
10.1201/b14099-16
BACTERIAL INVASION FACTORS AND LECTINS AS SECOND-GENERATION BIOADHESIVES
James H. Easson (1999)
10.1016/S0006-3495(01)76144-9
Particle diameter influences adhesion under flow.
V. R. Shinde Patil (2001)
10.1016/S0169-409X(01)00152-1
Recent advances in the understanding of uptake of microparticulates across the gastrointestinal lymphatics.
N. Hussain (2001)
10.1038/sj.gt.3300886
Activated polyamidoamine dendrimers, a non-viral vector for gene transfer to the corneal endothelium
T. Hudde (1999)
10.1006/BBRC.2000.4038
Expression of specific markers and particle transport in a new human intestinal M-cell model.
E. Gullberg (2000)
10.1007/BF00652384
Binding of salivary proteins and oral bacteria to hydrophobic and hydrophilic surfaces in vivo and in vitro
B. Lassen (1994)
10.1006/TAAP.2001.9128
Impairment of alveolar macrophage phagocytosis by ultrafine particles.
L. Renwick (2001)
10.1016/S1359-6446(00)01600-7
Innovations in oral gene delivery: challenges and potentials.
D. T. Page (2001)
10.18388/ABP.2001_5123
Translocation of polysialic acid across model membranes: kinetic analysis and dynamic studies.
T. Janas (2001)
10.1016/S0378-5173(00)00552-4
A unique dosage form to evaluate the mechanical destructive force in the gastrointestinal tract.
M. Kamba (2000)
10.1016/S0006-3495(90)82597-2
Specific adhesion of glycophorin liposomes to a lectin surface in shear flow.
M. R. Wattenbarger (1990)
10.1128/AEM.67.1.293-299.2001
Evaluation of Biological and Physical Protection against Nuclease Degradation of Clay-Bound Plasmid DNA
S. Demanèche (2001)
10.1111/J.1365-2842.1995.TB01053.X
Surface and colloid chemical aspects of saliva particle interactions.
P. O. Glantz (1995)
10.1111/J.1600-0722.1992.TB01719.X
Retention of streptococci to defined solid surfaces in the presence of saliva secretions.
C. Christersson (1992)
10.1046/j.1365-2958.1996.6461357.x
Coating the surface: a model for expression of capsular polysialic acid in Escherichia coli K1
J. M. Bliss (1996)
10.1111/j.2042-7158.1989.tb06429.x
The transport of microspheres from the gastro‐intestinal tract to inflammatory air pouches in the rat
H. O. Alpar (1989)
10.3109/10611869808996837
Peroral administration of 14C-poly(D,L-lactic acid) nanoparticles coated with human serum albumin or polyvinyl alcohol to guinea pigs.
F. Landry (1998)
10.1201/b14099-19
NOVEL FORMULATION APPROACHES TO ORAL MUCOADHESIVE DRUG DELIVERY SYSTEMS
Y. Akiyama (1999)
10.1038/78523
Enhancement of transfection by physical concentration of DNA at the cell surface
D. Luo (2000)
10.1038/sj.gt.3301347
Plasmid DNA adsorbed onto cationic microparticles mediates target gene expression and antigen presentation by dendritic cells
K. Denis-Mize (2000)
10.1006/VIRO.1999.0093
Oral DNA vaccination promotes mucosal and systemic immune responses to HIV envelope glycoprotein.
H. Kaneko (2000)



This paper is referenced by
10.1201/9781420004014.CH23
Nanoparticles for Drug Delivery
A. Lowman (2006)
10.1007/978-3-642-00477-3_2
Nanoparticle technologies for cancer therapy.
F. Alexis (2010)
10.1016/j.ijpharm.2006.10.043
Factors influencing intestinal microparticle uptake in vivo.
M. Doyle-McCullough (2007)
10.1007/s10953-018-0739-7
Interaction of a Surface-Active Ionic Liquid with an Antidepressant Drug: Micellization and Spectroscopic Studies
U. Farooq (2018)
10.1007/s11095-008-9769-y
Synthesis and Evaluation of Pegylated Dendrimeric Nanocarrier for Pulmonary Delivery of Low Molecular Weight Heparin
Shuhua Bai (2008)
10.1016/j.ijbiomac.2020.08.014
Modified karaya gum colloidal particles for the management of systemic hypertension.
M. Dhua (2020)
10.1186/1477-3155-2-12
Nanoparticles – known and unknown health risks
P. Hoet (2004)
Novel Photodynamic Cancer Therapy Agent and Biochemical Phosphate Sensor Based on Nanomaterials
Alaa Fadhel (2016)
10.1016/j.ijpharm.2009.10.026
Cellular uptake and toxicity of microparticles in a perspective of polymyxin B oral administration.
G. Coppi (2010)
10.2165/00063030-200822040-00002
Strategies Toward the Improved Oral Delivery of Insulin Nanoparticles via Gastrointestinal Uptake and Translocation
Camile B. Woitiski (2012)
10.1201/9781420008449.CH19
Gastrointestinal Applications of Nanoparticulate Drug-Delivery Systems
M. Gasco (2007)
10.1016/J.MOLLIQ.2016.07.076
Binding interactions of anesthetic drug with surface active ionic liquid
A. Pal (2016)
10.17863/CAM.14072
Toxicology of nanoparticles after cellular uptake
C. Cheng (2010)
Mannose-rich guar gum nanoparticles as a novel therapeutic drug against inflammatory diseases
N. Ghosh (2018)
10.1159/000110009
Nanoparticle-Based Oral Drug Delivery System for an Injectable Antibiotic – Streptomycin
R. Pandey (2007)
10.1016/S1367-5931(02)00400-3
Biological applications of dendrimers.
M. Cloninger (2002)
10.3390/COLLOIDS2030034
Micellar Parameters of Aqueous Solutions of Tween 20 and 60 at Different Temperatures: Volumetric and Viscometric Study
K. Szymczyk (2018)
10.1007/s00592-019-01403-9
Lipid nanoparticles as vehicles for oral delivery of insulin and insulin analogs: preliminary ex vivo and in vivo studies
E. Muntoni (2019)
Engineering lipid nanocapsule systems for intracellular delivery of anticancer drugs
P. Moreno (2014)
10.1080/10611860410001693760
Use of Targeting Agents to Increase Uptake and Localization of Drugs to the Intestinal Epithelium
G. J. Russell-Jones (2004)
10.1016/j.ijpharm.2017.09.040
Rifampicin Lipid-Polymer hybrid nanoparticles (LIPOMER) for enhanced Peyer's patch uptake.
S. S. Bachhav (2017)
10.1007/978-3-319-28609-9_14
Targeting Immunomodulatory Agents to the Gut-Associated Lymphoid Tissue
Atheer Zgair (2016)
10.1016/S1071-9091(02)00009-8
A forward look at therapy for pediatric movement disorders.
M. Pranzatelli (2003)
10.1163/15685620360511146
Amphiphilic copolymers of ε-caprolactone and γ-substituted ε-caprolactone. Synthesis and functionalization of poly(D,L-lactide) nanoparticles
S. Gautier (2003)
10.1016/J.EJPS.2005.02.008
A comparative study of the potential of solid triglyceride nanostructures coated with chitosan or poly(ethylene glycol) as carriers for oral calcitonin delivery.
M. Garcia-Fuentes (2005)
10.1002/9781118444726.CH4
Solid Lipid Nanoparticles for Drug Delivery
S. Joseph (2013)
10.1007/978-1-59745-225-0_11
Nanocarriers and Drug Delivery
S. Gelperina (2007)
NANO EXPRESS Open Access
J. Lorbeer (2014)
10.1016/j.colsurfb.2019.04.064
Novel propyl karaya gum nanogels for bosentan: In vitro and in vivo drug delivery performance.
Bibek Laha (2019)
10.1002/jps.23087
Optimization, in vitro-in vivo evaluation, and short-term tolerability of novel levofloxacin-loaded PLGA nanoparticle formulation.
G. Kumar (2012)
10.1021/acs.molpharmaceut.5b00335
Nanotechnology Approaches for the Delivery of Exogenous siRNA for HIV Therapy.
S. Adesina (2015)
10.1002/jps.21270
Nanovehicular intracellular delivery systems.
A. Prokop (2008)
See more
Semantic Scholar Logo Some data provided by SemanticScholar