← Back to Search
Oral Particulate Delivery: Status And Future Trends.
Published 1998 · Medicine
Download PDFAnalyze on Scholarcy
Oral delivery of complex molecules such as peptides and proteins is one of the most intensively studied research subjects. However, its success has been hampered by the degradation of these molecules in the gastrointestinal tract. As a result, various types of particulate systems such as biodegradable microspheres and liposomes have been proposed as potential delivery vehicles to protect these drugs in the gastrointestinal tract. Unfortunately, these particulates generally display low oral absorption efficiencies. This renders most encapsulated drugs ineffective after oral administration and therefore remains as the main obstacle to their practical application as oral delivery vehicles. In attempts to improve particle absorption efficiency, strategies such as using mucoadhesive polymers and targeted delivery systems have been studied in animals. In this chapter, the usefulness of these strategies are briefly reviewed. Potential applications and future prospects of particulates in oral delivery of complex molecules are also highlighted.
This paper references
Uptake of alginate microspheres by Peyer's patches
T. Bowersock (1994)
Peroral administration of nanoparticles
J. Kreuter (1991)
New Approach for Oral Administration of Insulin With Polyalkylcyanoacrylate Nanocapsules as Drug Carrier
C. Damgé (1988)
Further histological evidence of the gastrointestinal absorption of polystyrene nanospheres in the rat
P. U. Jani (1992)
Polymerized liposomes as potential oral vaccine carriers: Stability and bioavailability
Hongming Chen (1996)
Crystallized dextran nanospheres with entrapped antigen and their use as adjuvants.
U. Schröder (1984)
Differential expression of lectin-binding sites defines mouse intestinal M-cells.
M. A. Clark (1993)
Effects of the Mucoadhesive Polymer Polycarbophil on the Intestinal Absorption of a Peptide Drug in the Rat
C. Lehr (1992)
Biologically erodable microspheres as potential oral drug delivery systems
E. Mathiowitz (1997)
Generation and characterization of monoclonal antibodies recognizing follicle epithelial M cells in rabbit gut-associated lymphoid tissues.
J. Pappo (1989)
Bioadhesive microspheres. I: A novel electrobalance-based method to study adhesive interactions between individual microspheres and intestinal mucosa
Donald E. Chickering (1995)
Gamma-ray polymerization of phospholipids having diene or triene groups as liposomes
H. Ohno (1986)
Comparative, quantitative study of lymphoid and non-lymphoid uptake of 60 nm polystyrene particles.
A. M. Hillery (1994)
Effects of bile salts on the structural integrity of liposomes.
M. Richards (1978)
The phenomenon of persorption.
G. Volkheimer (1968)
Polymerization of liposomes composed of diene-containing lipids by UV and radical initiators: evidence for the different chemical environment of diene groups on 1- and 2-acyl chains
H. Ohno (1987)
Intestinal Uptake of Fluorescent Microspheres in Young and Aged Mice 1
M. Lefevre (1989)
Biodegradable microspheres. III: some immunological properties of polyacryl starch microparticles.
P. Artursson (1986)
Uptake and translocation of fluorescent latex particles by rabbit Peyer's patch follicle epithelium: a quantitative model for M cell uptake.
J. Pappo (1989)
Can intact liposomes be absorbed in the gut?
D. S. Deshmukh (1981)
Co-polymerised peptide particles II: Oral uptake of a novel co-polymeric nanoparticulate delivery system for peptides
A. M. Hillery (1996)
Novel Delivery Systems for Oral Vaccines
D. O'hagan (1994)
The preparation, characterization and pre-clinical evaluation of an orally administered HIV-I vaccine, consisting of a branched peptide immunogen entrapped in controlled release microparticles
D. O'hagan (1995)
Persorption of particles: physiology and pharmacology.
G. Volkheimer (1977)
Design and production of single-immunization vaccines using polylactide polyglycolide microsphere systems.
J. Cleland (1995)
Lectin-bearing Polymerized Liposomes as Potential Oral Vaccine Carriers
Hongming Chen (2004)
Differential surface characteristics of M cells from mouse intestinal Peyer's and caecal patches
M. A. Clark (2004)
HEMATOGENOUS DISSEMINATION OF INGESTED POLYVINYL CHLORIDE PARTICLES
G. Volkheimer (1975)
Salivary, gut, vaginal and nasal antibody responses after oral immunization with biodegradable microparticles.
S. Challacombe (1997)
Nanocapsules as carriers for oral peptide delivery
C. Damgé (1990)
Enhanced secretory IgA and systemic IgG antibody responses after oral immunization with biodegradable microparticles containing antigen.
S. Challacombe (1992)
An in‐vitro investigation of mucosa‐adhesive materials for use in controlled drug delivery
J. Smart (1984)
A study of particulate intestinal absorption and hepatocellular uptake. Use of polystyrene latex particles.
E. Sanders (1961)
Bioadhesive microspheres: III. An in vivo transit and bioavailability study of drug-loaded alginate and poly(fumaric-co-sebacic anhydride) microspheres
Donald E. Chickering (1997)
The iscom: an immunostimulating system.
B. Morein (1990)
Monoclonal antibody-directed targeting of fluorescent polystyrene microspheres to Peyer's patch M cells.
J. Pappo (1991)
Retention of Ingested Latex Particles in Peyer's Patches of Germfree and Conventional Mice 1
M. Lefevre (1985)
Physico-chemical properties of water insoluble polymers important to mucin/epithelial adhesion☆
H. Park (1985)
Nanoparticles as carriers for oral peptide absorption: Studies on particle uptake and fate
A. T. Florence (1995)
Controlled vaccine release in the gut-associated lymphoid tissues. I. Orally administered biodegradable microspheres target the peyer's patches
J. Eldridge (1990)
Accumulation of Latex in Peyer's Patches and Its Subsequent Appearance in Villi and Mesenteric Lymph Nodes 1 2
M. Lefevre (1978)
Cochleate lipid cylinders: formation by fusion of unilamellar lipid vesicles.
D. Papahadjopoulos (1975)
This paper is referenced by
ZEIN: NOVEL NATURAL POLYMER FOR NANOPARTICLE- AND FILM- MEDIATED GENE DELIVERY
Jessica K. D. Taylor (2013)
STIMULI RESPONSIVE LAYER BY LAYER SELF-ASSEMBLY A NOVEL APPROACHS IN CURRENT DRUG DELIVERY: REVIEW
L. Jo (2015)
Radioactive Microspheres for Medical Applications
U. Häfeli (2001)
ZEIN NANOSPHERES FOR GENE DELIVERY
Mary C Regier (2011)
Analysis of the Delivery of an Oral Heparin Formulation
B. Rogers (2001)
Development of gemcitabine-adsorbed magnetic gelatin nanoparticles for targeted drug delivery in lung cancer
Şenay Hamarat Şanlıer (2016)
Cancer research andtherapy:W herearewetoday?
Sampada Sawant (2014)
Nanoparticles: a boon for modernisation of drug delivery: a review
Mohammed Shuaib Khan (2011)
Investigation into the production of calcium pectinate particles for oral delivery to the colon
Patrick McCarry (2011)
Solubilization of cyclosporin A in dextran-g-polyethyleneglycolalkyl ether polymeric micelles.
M. Francis (2003)
Review : Radioactive Microspheres for Medical Applications
U. Häfeli (2002)
The Development, Evaluation and In Vitro Release Study of the Terbinafine Transdermal Patch
Vikas G. Rajurkar (2016)
Evaluation of the Antibody Response and Uptake of Ca-Alginate Microspheres Containing Model Antigen After Oral Immunization
Nidn. Dewi Melani Hariyadi (2016)
In Vivo Phage Display to Identify M Cell-Targeting Ligands
Lisa M. Higgins (2004)
The effect of inorganic salt type and concentration on hydrophilic drug loading into microspheres using the emulsion/solvent diffusion method
Göksu Yağ (2014)
An approach to the design of a particulate system for oral protein delivery. I. In vitro stability of various poly (α-hydroxy acids)-microspheres in simulated gastrointestinal fluids
Nastaran Nafissi-varcheh (2008)
Pharmacokinetic analysis and formulation development of therapeutic proteins
Kimberley Temeca Hill (2004)
Novel Starch-PVA Polymer for Microparticle Preparation and Optimization Using Factorial Design Study
Helen Chattopadhyay (2015)
Recent advances in mucosal vaccine development.
H. Chen (2000)
Development of potent oral nanoparticulate formulation of coenzyme Q10 for treatment of hypertension: can the simple nutritional supplements be used as first line therapeutic agents for prophylaxis/therapy?
D. Ankola (2007)
Microencapsulation of saffron anthocyanins using β glucan and β cyclodextrin: Microcapsule characterization, release behaviour & antioxidant potential during in-vitro digestion.
M. Ahmad (2018)
Characterization of niosomes prepared with various nonionic surfactants for paclitaxel oral delivery.
Z. S. Bayindir (2010)
Preparation and in vitro evaluation of thiolated chitosan microparticles
K. Maculotti (2005)
Controlled drug release behavior of 5-aminosalicylic acid using polyacrylamide grafted oatmeal (OAT-g-PAM): a pH-sensitive drug carrier
Srijita Bharti (2018)
Increasing bioavailability of silymarin using a buccal liposomal delivery system: preparation and experimental design investigation.
M. El-Samaligy (2006)
International Journal of Drug Research and Technology
Hemant H. Gangurde (2012)
Alginate microparticles produced by spray-drying for oral insulin delivery
Kristen Bowey (2009)
Synthesis and Characterization of Luteinizing Hormone-Releasing Hormone (LHRH)-Functionalized Mini-Dendrimers
A. Rafiee (2013)
Overview of the main methods used to combine proteins with nanosystems: absorption, bioconjugation, and encapsulation
M. Di Marco (2010)
Size dependent immune response after subcutaneous, oral and intranasal administration of BSA loaded nanospheres.
I. Gutierro (2002)
Validation and quantitation of an in vitro M-cell model.
P. Tyrer (2002)
Oral delivery of peptides and proteins using lipid-based drug delivery systems
P. Li (2012)See more