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Anatomical And Physiological Parameters Affecting Gastrointestinal Absorption In Humans And Rats.

J. DeSesso, C. F. Jacobson
Published 2001 · Biology, Medicine

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Anatomical and physiological parameters of the gastrointestinal (GI) tract dramatically affect the rate and extent of absorption of ingested compounds. These parameters must be considered by nutritionists, pharmacologists and toxicologists when describing or modeling absorption. Likewise, interspecies extrapolation (e.g. from rat to human) requires species-to-species comparison of these parameters. The present paper (1) describes the alimentary canal and the barrier to absorption; (2) relates the major sites of absorption; (3) compares the dimensions and surface areas of human and rat intestinal tracts; (4) discusses motility of the gut and transit times through regions of the alimentary canal; (5) explains how luminal contents are altered by physical, chemical and metabolic processes; and (6) describes the flow of blood and lymph from the GI tract to the systemic circulation, including the enterohepatic circulation. Despite strong morphological similarities between humans and rats at the microscopic level, gross anatomical differences in the relative absorptive surface areas provide a basis for concluding that the human GI tract is capable of absorbing materials faster and to a greater extent than that of the rat. Differences in the environment of the GI lumen of the two species make it possible to infer which substances are more likely to be present in a dissolved/non-ionized state for each species. Taken together, these differences may be of sufficient magnitude to alter the assessment of risks/benefits for a given compound when those risks/benefits are based on interspecies extrapolations.
This paper references
Bacteria and gastrointestinal secretion and motility.
Borriello Sp (1984)
Paracellular intestinal absorption of glucose, creatinine, and mannitol in normal animals: relation to body size.
J. Pappenheimer (1990)
The Cardiovascular System
N. Simionescu (1983)
Animal models for oral drug absorption
J. Dressman (1991)
CHAPTER 10 – The Significance of the Gut Flora in Safety Testing of Food Additives
B. Drasar (1970)
Interactions of xenobiotics with the gastrointestinal flora
K. Pelkonen (1986)
Segmental variations in the surface architecture of the normal rat colonic mucosa
S. Gutschmidt (1983)
Feeding, Digestion and Assimilation in Animals
J. Jennings (1972)
Lymphatic Vessels and Lymph Nodes
L. Weiss (1983)
Anatomical relationships of urinary bladders compared: their potential role in the development of bladder tumours in humans and rats.
J. M. D. Sesso (1995)
Dynamic anatomy & physiology
L. Langley (1974)
The relevance to humans of animal models for inhalation studies of cancer in the nose and upper airways.
DeSesso Jm (1993)
Structure and function in man
S. Jacob (1971)
Gastrointestinal absorption of drugs.
Kararli Tt (1989)
Intestinal Absorptive Surface in Mammals of Different Sizes
D. R. L. Snipes (1997)
Stress effects on gastrointestinal transit in the rat.
P. Enck (1989)
Casarett and Doull's Toxicology. The Basic Science of Poisons
C. Klaassen (1981)
Textbook of Medical Physiology
A. Guyton (1961)
Clinical Gastrointestinal Physiology
D. Granger (1985)
Cell and tissue biology : a textbook of histology
L. Weiss (1988)
Principles of animal extrapolation
E. Calabrese (1983)
A physiologically based model for gastrointestinal absorption and excretion of chemicals carried by lipids.
W. L. Roth (1993)
Human Physiology: The Mechanism of Body Function
A. Vander (1975)
Report of the task group on reference man
W. Snyder (1979)
Vibrio cholerae produces a second enterotoxin, which affects intestinal tight junctions.
A. Fasano (1991)
Dukes' Physiology of domestic animals
M. J. Swenson (1942)
Effect of nicotine on the morphology of the rat gastric mucosa.
L. Jarvis (1980)
The gastrointestinal circulation.
E. Jacobson (1968)
Comparison of the gastrointestinal anatomy, physiology, and biochemistry of humans and commonly used laboratory animals
T. Kararli (1995)
Use of radioyttrium to study food movement in the small intestine of the rat.
C. Marcus (1962)
Digestion and the Structure and Function of the Gut
D. F. Magee (1986)
Gray's Anatomy
H. Gray (1858)
Metabolic aspects of food safety
F. Roe (1970)
Anatomy and embryology of the laboratory rat
R. Hebel (1986)
Pathology of the Gastrointestinal Tract
Si-Chun Ming (1992)
Small intestinal cytochromes P450.
L. Kaminsky (1991)

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J. Richter (2018)
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A. Nokhodchi (2014)
Assessment of the carcinogenicity associated with oral exposures to hydrogen peroxide.
J. DeSesso (2000)
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G. Williamson (2004)
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Hilda Amekyeh (2016)
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The Impact of Solubility and Dissolution Assessment on Formulation Strategy and Implications for Oral Drug Disposition
J. Alsenz (2012)
Minor effect of the dietary combination of probiotic Pediococcus acidilactici with fructooligosaccharides or polysaccharidases on beneficial changes in the cecum of rats
J. Juśkiewicz (2007)
Diagnosis of Type 2 Diabetes Using Electrogastrograms: Extraction and Genetic Algorithm–Based Selection of Informative Features
Paramasivam Alagumariappan (2020)
PEG‐PGA enveloped octaarginine‐peptide nanocomplexes: An oral peptide delivery strategy
Zhigao Niu (2018)
Exposure of lead on intestinal structural integrity and the diversity of gut microbiota of common carp.
Y. Zhang (2020)
Is "nano safe to eat or not"? A review of the state-of-the art in soft engineered nanoparticle (sENP) formulation and delivery in foods.
X. Liu (2019)
On being the right size: scaling effects in designing a human-on-a-chip.
C. Moraes (2013)
Investigation of surfactant-drug pharmacokinetic interactions
L. Erasmus (2018)
GIT Anatomy and Physiology and Drug Oral Bioavailability: Impact of Species Differences
A. El-Kattan (2017)
Bioavailability and Bioactivity of Green Tea Catechins in Skin
K. A. Clarke (2013)
Passivation of irregular surfaces accessed by diffusion
M. Filoche (2008)
Modeling the dynamic flow-fiber interaction for microscopic biofluid systems.
X. Yin (2013)
Polymeric formulations for innovative drug delivery systems of nitric oxide in the treatment of inflammatory bowel diseases: formulation and bioavailability assessment
Shefaat Ullah Shah (2015)
Comparison of gastrointestinal absorption between human and rat: the role of intestinal absorptive surface area and unstirred aqueous layer.
T. C. Wu (2002)
Use of brush border membrane vesicles to simulate the human intestinal digestion
G. Picariello (2016)
Chapter 4 – Morphophysiology
John Hofstetter (2006)
In vitro and in vivo performance of monoacyl phospholipid‐based self‐emulsifying drug delivery systems
T. Tran (2017)
Effect of oleanolic acid on small intestine morphology and enzymes of glutamine metabolism in diabetic rats.
M. B. Isah (2017)
The physiological roles of dietary fibre
I. Brownlee (2011)
Contrasting the Gastrointestinal Tracts of Mammals: Factors that Influence Absorption
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