Online citations, reference lists, and bibliographies.

Radiation Treatment Planning With An Integrated Positron Emission And Computer Tomography (PET/CT): A Feasibility Study.

I. Frank Ciernik, Elena V Dizendorf, Brigitta Baumert, Béatrice Reiner, Cyrill Burger, J Bernard Davis, Urs Martin Lütolf, Hans C. Steinert, Gustav K. von Schulthess
Published 2003 · Medicine
Cite This
Download PDF
Analyze on Scholarcy
PURPOSE To investigate the usefulness of hardware coregistered PET/CT images for target volume definition. METHODS AND MATERIALS Thirty-nine patients presenting with various solid tumors were investigated. CT and a FDG-PET were obtained in treatment position in an integrated PET/CT scanner, and coregistered images were used for treatment planning. First, volume delineation was performed on the CT data. In a second step, the corresponding PET data were used as an overlay to the CT data to define the target volume. Delineation was done independently by two investigators. RESULTS Coregistered PET/CT showed good fusion accuracy. The GTV increased by 25% or more because of PET in 17% of cases with head-and-neck (2/12) and lung cancer (1/6), and in 33% (7/21) in cancer of the pelvis. The GTV was reduced > or =25% in 33% of patients with head-and-neck cancer (4/12), in 67% with lung cancer (4/6), and 19% with cancer of the pelvis (4/21). Overall, in 56% (22/39) of cases, GTV delineation was changed significantly if information from metabolic imaging was used in the planning process. The modification of the GTV translated into altered PTV changes exceeding >20% in 46% (18/39) of cases. With PET, volume delineation variability between two independent oncologists decreased from a mean volume difference of 25.7 cm(3) to 9.2 cm(3) associated with a reduction of the standard deviation from 38.3 cm(3) to 13.3 cm(3) (p = 0.02). In 16% of cases, PET/CT revealed distant metastasies, changing the treatment strategy from curative to palliative. CONCLUSION Integrated PET/CT for treatment planning for three-dimensional conformal radiation therapy improves the standardization of volume delineation compared with that of CT alone. PET/CT has the potential for reducing the risk for geographic misses, to minimize the dose of ionizing radiation applied to non-target organs, and to change the current practice to three-dimensional conformal radiation therapy planning by taking into account the metabolic and biologic features of cancer. The impact on treatment outcome remains to be demonstrated.

This paper is referenced by
Utilidad de la PET-TAC en la planificación radioterápica en el cáncer de cabeza y cuello. Nuestra experiencia inicial
María Emiliana Bellón Guardia (2010)
PET-CT in Radiation Oncology: The Impact on Diagnosis, Treatment Planning, and Assessment of Treatment Response
Dwight E Heron (2008)
Indications for PET/CT in the head and neck.
Vikas Agarwal (2008)
Nonrigid Image Registration for Head and Neck Cancer Radiotherapy Treatment Planning With PET/CT
Rob H. Ireland (2007)
Towards Biological Target Volumes Definition for Radiotherapy Treatment Planning: Quo Vadis PET/CT?
Slobodan Devic (2013)
Patient and image data management in positron emission tomography-computed tomography for radiation therapy and therapy response assessment.
Todd Faasse (2010)
Clinical Applications of PET-Computed Tomography in Planning General Principles and an Overview
Gregory J Kubicek (2011)
Role and Cost Effectiveness of PET/CT in Management of Patients with Cancer
Muhammad Wasif Saif (2010)
[Utility of PET-CT on radiotherapy planning of head and neck cancer. Our initial experience].
María Emiliana Bellón Guardia (2010)
Radiation treatment planning using positron emission tomography for patients with non-small cell lung cancer
Agata Lewandowska (2006)
Klinische Untersuchungen zum Einsatz der Positronen-Emissions-Tomographie (PET) in der Zielvolumendefinition bei der Bestrahlungsplanung
Ingo G. Steffen (2014)
PET-CT as an Alternative to Fiducial Markers Guidance in Liver Metastasis Treatment.
Fernanda Marques Granato (2017)
Assessment of various strategies for 18F-FET PET-guided delineation of target volumes in high-grade glioma patients
Hansjoerg Vees (2008)
The impact of positron emission tomography/computed tomography in edge delineation of gross tumor volume for head and neck cancers.
Hani Ashamalla (2007)
PET/CT scanner instrumentation, challenges, and solutions.
Adam M. Alessio (2004)
PET/CT in oncology: integration into clinical management of lymphoma, melanoma, and gastrointestinal malignancies.
Heiko Schöder (2004)
Techniques innovantes en radiothérapie des cancers bronchopulmonaires
Georges Noël (2007)
CT-PET guided target delineation in head and neck cancer and implications for improved outcome
Russell N Moule (2010)
Target definition of moving lung tumors in positron emission tomography: correlation of optimal activity concentration thresholds with object size, motion extent, and source-to-background ratio.
Adam C. Riegel (2010)
Economic Evaluation of PET and PET/CT in Oncology: Evidence and Methodologic Approaches
Andreas K. Buck (2010)
Segmentation of positron emission tomography images: some recommendations for target delineation in radiation oncology.
John A. Lee (2010)
Using 18 F-FDG PET/CT to Diagnose and Treat Non-small Cell Lung Cancer
Liu Liu (2019)
PET/CT significance for planning radiotherapy of head and neck cancer.
Iveta Kolářová (2012)
Hybrid PET/MRI-based delineation of gross tumor volume in head and neck cancer and tumor parameter analysis
Jie-tao Ma (2017)
The dilemma of target delineation with PET/CT in radiotherapy planning for malignant tumors
Suyu Zhu (2007)
Instructions for use Title A New Brain Positron Emission Tomography Scanner with Semiconductor Detectors for TargetVolume Delineation and Radiotherapy Treatment Planning in Patients with Nasopharyngeal Carcinoma
Norio Katoh (2017)
Modification of staging and treatment of head and neck cancer by FDG-PET/CT prior to radiotherapy
Andrej Abramyuk (2012)
FDG PET metabolic tumor volume segmentation and pathologic volume of primary human solid tumors.
Praveen Sridhar (2014)
Recent Advances in Hybrid Imaging for Radiation Therapy Planning: The Cutting Edge.
Habib Zaidi (2011)
The Application of PET in Radiation Treatment Planning for Head and Neck Cancer.
Charles B. Woods (2011)
Radiation treatment planning using positron emission and computed tomography for lung and pharyngeal cancers: a multiple-threshold method for [(18)F]fluoro-2-deoxyglucose activity.
Mitsuru Okubo (2010)
Machine-learned target volume delineation of 18F-FDG PET images after one cycle of induction chemotherapy.
Craig Parkinson (2019)
See more
Semantic Scholar Logo Some data provided by SemanticScholar