← Back to Search
Biocompatible Stabilizers In The Preparation Of PLGA Nanoparticles: A Factorial Design Study.
J. Vandervoort, A. Ludwig
Published 2002 · Medicine, Chemistry
Download PDFAnalyze on Scholarcy
Poly(lactic-co-glycolic-acid) nanoparticles are often produced using the w/o/w emulsification solvent evaporation method. In most cases poly(vinyl alcohol) (PVA) is used as stabilizer of the emulsion. The goal of this study was to compare a series of polymers to PVA in a 2(2) full factorial design study. The influence of the concentration of PVA and the polymers tested on particle size and zeta potential value was evaluated before and after freeze-drying of the prepared particles. Nanoparticles were obtained with most polymers when they were used in combination with PVA. Leaving PVA out of the formulation, however, increased the size of the particles over 1 microm. Two exceptions are poloxamer and carbopol, which can be considered as valuable alternatives to PVA. Zeta potential values were usually slightly negative, the most extreme zeta potential values were measured when poloxamer and carbopol were employed. The use of gelatin type A made it possible to achieve positive values. The original 2(2) full factorial design study was further expanded to a central composite design for poloxamer and carbopol, in order to fit the measured data to a quadratic model and to calculate response surfaces.
This paper references
Influence of the co-encapsulation of different non-ionic surfactants on the properties of PLGA insulin-loaded microspheres.
G. Rosa (2000)
Preparation factors affecting the properties of polylactide nanoparticles: a factorial design study.
J. Vandervoort (2001)
Preparation of biodegradable microspheres and microcapsules: 2. Polyactides and related polyesters
R. Arshady (1991)
A mechanistic study of antibiotic release from biodegradable poly(d,1-lactide) cylinders
X. Zhang (1994)
Detection and determination of surface levels of poloxamer and PVA surfactant on biodegradable nanospheres using SSIMS and XPS.
P. Scholes (1999)
Protein-loaded poly(dl-lactide-co-glycolide) microparticles for oral administration: formulation, structural and release characteristics
H. Rafati (1997)
Preparation of microspheres by the solvent evaporation technique.
Study of the mechanism of interaction of poly(ϵ-caprolactone) nanocapsules with the cornea by confocal laser scanning microscopy
P. Calvo (1994)
Effects of emulsifiers on the controlled release of paclitaxel (Taxol) from nanospheres of biodegradable polymers.
S. Feng (2001)
Respirable PLGA Microspheres Containing Rifampicin for the Treatment of Tuberculosis: Manufacture and Characterization
P. O'Hara (2004)
Statistics for Experimenters: An Introduction to Design, Data Analysis, and Model Building.
Gordon D. Booth (1979)
Influence of manufacturing parameters on the size characteristics and the release profiles of nifedipine from poly(DL-lactide-co-glycolide) microspheres
P. Sansdrap (1992)
Mucoadhesive nanoparticulate systems for peptide drug delivery.
H. Takeuchi (2001)
Chemical and physical parameters of tears relevant for the design of ocular drug delivery formulations.
V. Baeyens (1997)
Influence of the stabilizer coating layer on the purification and freeze-drying of poly(D,L-lactic acid) nanoparticles prepared by an emulsion-diffusion technique.
D. Quintanar-Guerrero (1998)
Studies on the transport pathway of PBCA nanoparticles in ocular tissues.
A. Zimmer (1991)
Ganciclovir-loaded polymer microspheres in rabbit eyes inoculated with human cytomegalovirus.
A. A. Veloso (1997)
Biodegradable microspheres containing adriamycin in the treatment of proliferative vitreoretinopathy.
T. Moritera (1992)
Colchicine encapsulation within poly(ethylene glycol)-coated poly(lactic acid)/poly(epsilon-caprolactone) microspheres-controlled release studies.
G. Das (2000)
Topical application of acyclovir-loaded microparticles: quantification of the drug in porcine skin layers.
E. G. de Jalón (2001)
Biodegradation and biocompatibility of PLA and PLGA microspheres.
Preparation of drug delivery systems using supercritical fluid technology.
U. Kompella (2001)
Stealth PLA-PEG Nanoparticles as Protein Carriers for Nasal Administration
M. Tobío (2004)
Ketoprofen-poly(D,L-lactic-co-glycolic acid) microspheres: influence of manufacturing parameters and type of polymer on the release characteristics.
F. Gabor (1999)
Microspheres of biodegradable polymers as a drug-delivery system in the vitreous.
T. Moritera (1991)
Multiple emulsion technology for the design of microspheres containing peptides and oligopeptides.
Influence of formulation methods on the in vitro controlled release of protein from poly (ester) microspheres
H. Wang (1991)
This paper is referenced by
The effect of process parameters on the size and morphology of poly(D,L-lactide-co-glycolide) micro/nanoparticles prepared by an oil in oil emulsion/solvent evaporation technique
H. Mahdavi (2009)
Chapter 2 Nanoparticles Types , Classifi cation , Characterization , Fabrication Methods and Drug Delivery Applications
The Stabilizer Influence on Morphological Characteristics of Poly-(DL-Lactide-Co-Glycolide) Nanospheres
M. Stevanović (2007)
silymarin nanoparticle prevents paracetamol-induced hepatotoxicity suvadra
B Das (2011)
Ocular sustained release nanoparticles containing stereoisomeric dipeptide prodrugs of acyclovir.
J. Jwala (2011)
Biodegradable Polymers (PLA and PLGA) Based Nanoparticles in Protein and Plasmid DNA Delivery
Kautilya Kumar Jena (2011)
SN38 polymeric nanoparticles: in vitro cytotoxicity and in vivo antitumor efficacy in xenograft balb/c model with breast cancer versus irinotecan.
N. Sepehri (2014)
The influence of the use of viscosifying agents as dispersion media on the drug release properties from PLGA nanoparticles.
K. Dillen (2004)
Engineered PLGA nanoparticles: an emerging delivery tool in cancer therapeutics.
A. Jain (2011)
Influence of Polysorbate 60 on Formulation Properties and Bioavailability of Morin-Loaded Nanoemulsions with and without Low-Saponification-Degree Polyvinyl Alcohol.
Yuri Ikeuchi-Takahashi (2018)
Translating the fabrication of protein-loaded poly(lactic-co-glycolic acid) nanoparticles from bench to scale-independent production using microfluidics
Carla B. Roces (2020)
Influence of emulsifiers on the formation and in vitro anticancer activity of epirubicin loaded PLGA nanoparticles
Ozgur Esim (2020)
Development and Characterization of Furosemide Loaded Nanoparticles
J. M. Meeran (2014)
Formulation and characterization of fast dissolving oral films containing buspirone hydrochloride nanoparticles using design of experiment
K. Bharti (2019)
Synthesis and characterization of temperature-responsive copolymer of PELGA modified poly(N-isopropylacrylamide)
H. Ding (2006)
Flurbiprofen loaded biodegradable nanoparticles for ophtalmic administration.
E. Vega (2006)
Optimization of epirubicin nanoparticles using experimental design for enhanced intravesical drug delivery.
Li-Ching Chang (2009)
Purification of Drug Loaded PLGA Nanoparticles Prepared by Emulsification Solvent Evaporation Using Stirred Cell Ultrafiltration Technique
S. K. Paswan (2017)
Sustained Release of Water-Soluble Blue Dextran from PLGA Nanoparticles
Sang-Hwa Ryu (2006)
Preclinical development of drug delivery systems for paclitaxel-based cancer chemotherapy.
Feihu Wang (2017)
Fabrication of garlic composites nano-biotics and investigating their anti-bacterial activities
S. A. Fahmy (2015)
Investigation of nanoparticulate formulation intended for caffeine delivery to hair follicles
PLGA Nanoparticles as Subconjunctival Injection for Management of Glaucoma
H. A. Salama (2017)
Mesophase and size manipulation of itraconazole liquid crystalline nanoparticles produced via quasi nanoemulsion precipitation.
Naila A. Mugheirbi (2015)
Solid Lipid Nanoparticles of a Water Soluble Drug, Ciprofloxacin Hydrochloride
M. Shah (2012)
Silymarin nanoparticle prevents paracetamol-induced hepatotoxicity
S. Das (2011)
Effect of Solid Lipid Nanoparticles Formulation Compositions on Their Size, Zeta Potential and Potential for In Vitro pHIS-HIV-Hugag Transfection
Rathapon Asasutjarit (2007)
A detailed analysis of biodegradable nanospheres by different techniques--a combined approach to detect particle sizes and size distributions.
C. Augsten (2008)
Poly(lactic-co-glycolic acid) as a particulate emulsifier.
Catherine P. Whitby (2012)
Studies on solvent systems for enhanced skin permeation of venlafaxine hydrochloride
Pramod S. Salve (2019)
Improved delivery of the natural anticancer drug tetrandrine.
C. Shi (2015)
Natural bioadhesive biodegradable nanoparticles-based topical ophthalmic formulations for sustained celecoxib release: in vitro study
M. M. Ibrahim (2013)See more