Online citations, reference lists, and bibliographies.
← Back to Search

Preparation Of PLGA Nanoparticles Containing Estrogen By Emulsification–diffusion Method

Hye young Kwon, J. Lee, S. Choi, Y. Jang, J. Kim
Published 2001 · Chemistry

Cite This
Download PDF
Analyze on Scholarcy
Share
Abstract Nano-sized poly ( d , l lactide-co-glycolide) (PLGA) particles, widely used as a biodegradable polymeric carrier, containing estrogen were prepared employing emulsification–diffusion method. Estrogen was chosen as a model drug. The preparation method consists of emulsifying a solution of polymer and drug in the aqueous phase containing stabilizer, previously saturated, followed by adding excess water. Influence of process variables on the mean particle size of nanoparticles has been studied. It was clarified that the type and concentrations of stabilizer, homogenizer speed, polymer concentration determined the size of PLGA nanoparticles. Especially when didodecyl dimethyl ammonium bromide (DMAB) was used as a stabilizer, estrogen containing nanoparticles of smaller than 100 nm was obtained.
This paper references
10.1021/JS980021F
Arterial uptake of biodegradable nanoparticles: effect of surface modifications.
V. Labhasetwar (1998)
10.3109/02652049009028421
Microencapsulation using poly (L-lactic acid) II: Preparative variables affecting microcapsule properties.
R. Jalil (1990)
10.1016/S0168-3659(96)01484-8
Formulation and characterization of biodegradable nanoparticles for intravascular local drug delivery
Cunxian Song (1997)
10.1016/0142-9612(96)00049-X
Stability study of nanoparticles of poly(epsilon-caprolactone), poly(D,L-lactide) and poly(D,L-lactide-co-glycolide).
D. Lemoine (1996)
10.1021/bp970128t
Solvent Evaporation Processes for the Production of Controlled Release Biodegradable Microsphere Formulations for Therapeutics and Vaccines
J. Cleland (1998)
10.1016/S0168-3659(96)01475-7
Protein-loaded poly(dl-lactide-co-glycolide) microparticles for oral administration: formulation, structural and release characteristics
H. Rafati (1997)
10.1161/01.CIR.89.2.770
Contrasting Effects of the Intermittent and Continuous Administration of Heparin in Experimental Restenosis
E. Edelman (1994)
10.1016/S0378-5173(96)04854-5
Influence of the Degrees of Hydrolyzation and Polymerization of Poly(vinylalchol)on the Preparation and Properties of Poly(DL-lactide-co-glycolide)nanoparticle.
Murakami (1997)
10.1016/0168-3659(93)90097-O
Preparations of biodegradable nanospheres of water-soluble and insoluble drugs with D, L-lactide/glycolide copolymer by a novel spontaneous emulsification solvent diffusion method, and the drug release behavior.
T. Niwa (1993)
10.1016/S0378-5173(97)00116-6
Preparation and characterisation of poly (D,L-lactic-co-glycolic acid) microspheres containing desferrioxamine
E. Schlicher (1997)
10.1016/0378-5173(96)04486-9
Steric stabilization of nanoparticles: Size and surface properties
C. Lourenço (1996)
10.1016/0168-3659(95)00164-6
Biodegradable nanoparticles — From sustained release formulations to improved site specific drug delivery
J. Leroux (1996)
10.1161/01.CIR.91.3.785
Enhanced intracoronary thrombolysis with urokinase using a novel, local drug delivery system. In vitro, in vivo, and clinical studies.
J. Mitchel (1995)
10.1016/S0378-5173(96)04697-2
Influence of stabilizing agents and preparative variables on the formation of poly(d,l-lactic acid) nanoparticles by an emulsification-diffusion technique
D. Quintanar-Guerrero (1996)
10.1002/JPS.2600841202
Pharmacokinetics of a novel HIV-1 protease inhibitor incorporated into biodegradable or enteric nanoparticles following intravenous and oral administration to mice.
J. C. Leroux (1995)
10.1016/S0168-3659(98)00016-9
Arterial uptake of biodegradable nanoparticles for intravascular local drug delivery: results with an acute dog model.
C. Song (1998)
10.1161/01.CIR.94.6.1441
Local intraluminal infusion of biodegradable polymeric nanoparticles. A novel approach for prolonged drug delivery after balloon angioplasty.
L. A. Guzman (1996)



This paper is referenced by
10.1533/9781845694210.3.297
12 – Encapsulation and controlled release of antioxidants and vitamins
C. M. Sabliov (2008)
10.1155/2015/794601
Recent trends in preparation of poly(lactide- co -glycolide) nanoparticles by mixing polymeric organic solution with antisolvent
Edel Sah (2015)
NMR and Gas Sorption Studies of Structure-Transport Relationships in Porous Media
Elenica Shiko (2013)
10.1080/10611860600565987
Sustained release nanoparticulate formulation containing antioxidant-ellagic acid as potential prophylaxis system for oral administration
I. Bala (2006)
10.3390/ijms151223909
PLGA Biodegradable Nanoparticles Containing Perphenazine or Chlorpromazine Hydrochloride: Effect of Formulation and Release
Mohammed Halayqa (2014)
10.1016/B978-0-323-46143-6.00011-7
Polymeric micro- and nanoparticles for controlled and targeted drug delivery
Magdalena Stevanović (2017)
10.3762/bjnano.10.201
Incorporation of doxorubicin in different polymer nanoparticles and their anticancer activity
Sebastian Pieper (2019)
10.1007/s10904-012-9818-1
Polymer Assisted Co-precipitation Synthesis and Characterization of Polyethylene Glycol (PEG)/CoFe2O4 Nanocomposite
R. Topkaya (2013)
10.1002/ADV.21295
Optimizing the Process Parameters for Encapsulation of Linamarin into PLGA Nanoparticles Using Double Emulsion Solvent Evaporation Technique
A. Hussein (2013)
10.1080/02652048.2016.1208296
Preparation, statistical optimisation and in vitro characterisation of poly (3-hydroxybutyrate-co-3-hydroxyvalerate)/poly (lactic-co-glycolic acid) blend nanoparticles for prolonged delivery of teriparatide
Nika Bahari Javan (2016)
Curcumin containing chitosan-pectinate nanoparticulate drug delivery system for colon cancer treatment
Enas Alkhader (2018)
10.1016/j.ijpharm.2020.119090
Nanoparticles formulation and in vitro efficacy testing of the mitoNEET ligand NL-1 for drug delivery in a brain endothelial model of ischemic reperfusion-injury.
Pushkar Saralkar (2020)
10.1007/S11746-011-1960-3
Nanoencapsulation of Alpha-linolenic Acid with Modified Emulsion Diffusion Method
Salam M. Habib (2012)
Dosetaksel İçeren Nanopartiküllerin Formülasyonu ve in Vitro Değerlendirilmesi
Dila Demir (2013)
10.4172/2161-0398.1000143
Promazine Hydrochloride/PLGA Biodegradable Nanoparticles Formulation and Release
U. Domańska (2014)
10.1016/J.JSCS.2011.06.009
Synthesis and characterization of copper nanoparticles by reducing agent
S. Chandra (2014)
10.1155/2015/341848
Caffeic acid phenethyl ester loaded PLGA nanoparticles: effect of various process parameters on reaction yield, encapsulation efficiency, and particle size
S. Derman (2015)
10.1002/APP.31595
The effect of process parameters on the size and morphology of poly(D,L-lactide-co-glycolide) micro/nanoparticles prepared by an oil in oil emulsion/solvent evaporation technique
H. Mahdavi (2009)
10.1016/J.COLSURFA.2012.12.022
Ferrofluid based on polyethylene glycol-coated iron oxide nanoparticles: Characterization and properties
Sonia García-Jimeno (2013)
Development of nanoscale delivery systems for breast cancer treatment
Y. Zhang (2015)
10.1080/02652040500162766
Preparation and characterization of PLGA nanospheres for the targeted delivery of NR2B-specific antisense oligonucleotides to the NMDA receptors in the brain
A. Kılıç (2005)
10.3844/AJASSP.2009.1352.1358
Coating and Encapsulation of Nanoparticles using Supercritical Antisolvent
Gun Hean Chong (2009)
10.1208/s12248-010-9184-2
Online Monitoring of PLGA Microparticles Formation Using Lasentec Focused Beam Reflectance (FBRM) and Particle Video Microscope (PVM)
A. Zidan (2010)
10.1109/ICBME.2011.6168534
Chitosan-surface modified poly(lactide-co-glycolide) nanoparticles as an effective drug delivery system
Newsha Jalali (2011)
10.1186/s40580-016-0061-2
Polymeric nanoparticles containing diazepam: preparation, optimization, characterization, in-vitro drug release and release kinetic study
Sarvesh Bohrey (2016)
10.1063/1.4976767
Characterization of polylactic co-glycolic acid nanospheres modified with PVA and DDAB
Kamarza Mulia (2017)
10.3109/21691401.2016.1147453
The use of experimental design in the optimization of risperidone biodegradable nanoparticles: in vitro and in vivo study
Ali F. A. Alzubaidi (2017)
10.1007/s10924-016-0789-0
Effects of Emulsifier and Continuous Phase on Biodegradable Poly(Propylene Carbonate) Emulsion
Li-sha Pan (2016)
10.1016/J.JMMM.2003.12.416
Nanoparticles of Magnetic Ferric Oxides Encapsulated with Poly(D,L Laticde-Co Glycolide) and Their Applications to Magnetic Resonance Imaging Contrast Agent.
S. J. Lee (2003)
10.22028/D291-22546
Cationically-modified nanoparticles for the pulmonary delivery of the telomerase inhibitor 2';-O-Methyl RNA for the treatment of lung cancer
N. Nafee (2008)
10.1080/17425247.2016.1182487
Plant extracts: from encapsulation to application
Brenda Armendáriz-Barragán (2016)
10.1016/j.msec.2017.06.004
Polymeric nanoparticles: A study on the preparation variables and characterization methods.
Carina Crucho (2017)
See more
Semantic Scholar Logo Some data provided by SemanticScholar