Online citations, reference lists, and bibliographies.
Please confirm you are human
(Sign Up for free to never see this)
← Back to Search

Tracking Antigen-specific Helper T Cell Responses.

M. Mcheyzer-Williams, J. Altman, M. Davis
Published 1996 · Biology, Medicine

Save to my Library
Download PDF
Analyze on Scholarcy
Share
T-cell receptor transgenic animals provide an excellent source of T cells for the analysis of antigen-specific helper T-cell development. Alternatively, studies in normal animals continue to focus on specific immune responses dominated by T cells using restricted sets of antigen receptors. These complementary strategies provide direct access to the dynamics of helper T-cell differentiation in vivo.
This paper references
10.1038/376181A0
CD95 (Fas)-dependent elimination of self-reactive B cells upon interaction with CD4+T cells
J. Rathmell (1995)
10.1126/SCIENCE.8451641
TH1 and TH2 cell antigen receptors in experimental leishmaniasis.
S. Reiner (1993)
10.1016/1074-7613(94)90086-8
The ups and downs of T cell costimulation.
M. Jenkins (1994)
Flow cytometric analysis for cytokine production identifies T helper 1, T helper 2, and T helper 0 cells within the human CD4+CD27- lymphocyte subpopulation.
L. Elson (1995)
10.1038/375334A0
Antigen-induced B-cell death and elimination during germinal-centre immune responses
K. Shokat (1995)
Antigen-dependent clonal expansion of a trace population of antigen-specific CD4+ T cells in vivo is dependent on CD28 costimulation and inhibited by CTLA-4.
E. Kearney (1995)
10.1084/JEM.182.5.1579
The effect of antigen dose on CD4+ T helper cell phenotype development in a T cell receptor-alpha beta-transgenic model
N. Hosken (1995)
10.1073/PNAS.89.13.6065
Differential regulation of T helper phenotype development by interleukins 4 and 10 in an alpha beta T-cell-receptor transgenic system.
C. Hsieh (1992)
Costimulator dependence of lymphokine secretion by naive and activated CD4+ T lymphocytes from TCR transgenic mice.
A. J. McKnight (1994)
10.1111/j.1600-065X.1996.tb00693.x
Enumeration and Characterization of Memory Cells in the TH Compartment
M. Mcheyzer-Williams (1996)
10.1182/BLOOD.V86.4.1408.BLOODJOURNAL8641408
Direct demonstration of cytokine synthesis heterogeneity among human memory/effector T cells by flow cytometry.
L. Picker (1995)
10.1016/1074-7613(94)90044-2
Generation and in vivo persistence of polarized Th1 and Th2 memory cells.
S. Swain (1994)
10.1084/JEM.180.3.861
Public and private V beta T cell receptor repertoires against hen egg white lysozyme (HEL) in nontransgenic versus HEL transgenic mice
R. Cibotti (1994)
10.1084/JEM.182.4.915
Successful T cell priming in B cell-deficient mice
M. Epstein (1995)
10.1126/SCIENCE.7535476
Antigen-specific development of primary and memory T cells in vivo.
M. Mcheyzer-Williams (1995)
10.1016/1074-7613(94)90084-1
Visualization of peptide-specific T cell immunity and peripheral tolerance induction in vivo.
E. Kearney (1994)
10.1111/j.1749-6632.1995.tb44477.x
T‐Cell Receptor V‐Region Usage and Antigen Specificity
Mark M. Davis (1995)
10.1002/EJI.1830241128
The expansion of a CD4+ T cell population bearing a distinctive β chain in MRL lpr/lpr mice suggests a role for the fas protein in peripheral T cell selection
P. Musette (1994)
10.1038/NBT1093-1138
Use of Peptide Libraries to Map the Substrate Specificity of a Peptide-Modifying Enzyme: A 13 Residue Consensus Peptide Specifies Biotinylation in Escherichia coli
P. Schatz (1993)
10.1016/0092-8674(95)90349-6
B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 developmental pathways: Application to autoimmune disease therapy
V. Kuchroo (1995)
10.1016/0167-5699(95)80004-2
Th1 and Th2 subsets: paradigms lost?
A. Kelso (1995)
10.1016/1074-7613(94)90067-1
The fas antigen is involved in peripheral but not thymic deletion of T lymphocytes in T cell receptor transgenic mice.
G. Singer (1994)
10.1182/BLOOD.V84.8.2815.2815
In vivo T-cell clonal amplification at time of acute graft-versus-host disease.
P. Y. Dietrich (1994)
10.1084/JEM.182.5.1591
Extent of T cell receptor ligation can determine the functional differentiation of naive CD4+ T cells
S. Constant (1995)
Distinct phenotypes of antigen-selected CD8 T cells emerge at different stages of an in vivo immune response.
P. R. Walker (1995)
10.1038/378617A0
Impairment of antigen-specific T-cell priming in mice lacking CD40 ligand
I. Grewal (1995)
10.1002/EJI.1830250506
Evidence for the stochastic acquisition of cytokine profile by CD4+ T cells activated in a T helper type 2‐like response in vivo
A. Kelso (1995)
10.1084/JEM.182.2.459
CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation
M. Krummel (1995)
10.1016/0952-7915(93)90063-X
Homing of naive, memory and effector lymphocytes.
C. Mackay (1993)
10.1038/371389A0
Competition for follicular niches excludes self-reactive cells from the recirculating B-cell repertoire
J. Cyster (1994)
10.1016/S1074-7613(00)80297-6
Single-cell PCR analysis of TCR repertoires selected by antigen in vivo: a high magnitude CD8 response is comprised of very few clones.
J. Maryanski (1996)
10.1126/SCIENCE.7701331
T cell receptor-MHC class I peptide interactions: affinity, kinetics, and specificity
M. Corr (1994)
10.1084/JEM.181.2.713
T cell genetic background determines default T helper phenotype development in vitro
C. Hsieh (1995)
10.1002/EJI.1830221025
Molecular detection and in vivo analysis of the specific T cell response to a protein antigen
M. Cochet (1992)
Activated T cells can induce high levels of CTLA-4 expression on B cells.
H. Kuiper (1995)
10.1038/355224A0
Mapping T-cell receptor–peptide contacts by variant peptide immunization of single-chain transgenics
J. L. Jorgensen (1992)
10.1002/EJI.1830250541
Role of T helper cell precursor frequency on vesicular stomatitis virus neutralizing antibody responses in a T cell receptor β chain transgenic mouse
G. Freer (1995)
10.1084/JEM.177.5.1487
Oligoclonal expansion of major histocompatibility complex class I- restricted cytolytic T lymphocytes during a primary immune response in vivo: direct monitoring by flow cytometry and polymerase chain reaction
H. Macdonald (1993)
10.1016/0092-8674(94)90338-7
T and B memory cells
J. Sprent (1994)
10.1016/0092-8674(94)90335-2
Signals and signs for lymphocyte responses
C. Janeway (1994)
10.1002/EJI.1830240510
Are primed CD4+ T lymphocytes different from unprimed cells?
S. Constant (1994)
Peptide and protein antigens require distinct antigen-presenting cell subsets for the priming of CD4+ T cells.
S. Constant (1995)
10.1016/0378-1119(94)90275-5
Chimeric molecules created by gene amplification interfere with the analysis of somatic hypermutation of murine immunoglobulin genes.
J. E. Ford (1994)
10.1016/0952-7915(94)90128-7
Role of cytokines in determining T-lymphocyte function.
A. O’Garra (1994)
10.1038/378620A0
CD40 ligand-transduced co-stimulation of T cells in the development of helper function
D. Essen (1995)
10.1038/375148A0
Serial triggering of many T-cell receptors by a few peptide–MHC complexes
S. Valitutti (1995)
10.1073/PNAS.90.19.8987
Activation and differentiation requirements of primary T cells in vitro.
C. Sagerström (1993)
10.1126/science.270.5238.985
Lymphoproliferative Disorders with Early Lethality in Mice Deficient in Ctla-4
P. Waterhouse (1995)
10.1016/0952-7915(94)90122-8
Regulation of immunological memory.
Dianna P. Gray (1994)
10.1038/372556A0
Locus-specific somatic hypermutation in germinal centre T cells
B. Zheng (1994)
10.1002/j.1460-2075.1993.tb06189.x
Tracing B cell development in human germinal centres by molecular analysis of single cells picked from histological sections.
R. Küppers (1993)
10.1084/JEM.179.5.1539
Resting and anergic B cells are defective in CD28-dependent costimulation of naive CD4+ T cells
W. Ho (1994)
10.1016/0952-7915(95)80111-1
T helper cell differentiation in immune response.
S. Reiner (1995)
10.1073/PNAS.91.26.12862
Kinetics of T-cell receptor binding to peptide/I-Ek complexes: correlation of the dissociation rate with T-cell responsiveness.
K. Matsui (1994)
10.1016/0167-5699(94)90080-9
The B7 and CD28 receptor families.
C. June (1994)
10.1146/ANNUREV.IY.12.040194.003223
Acquisition of lymphokine-producing phenotype by CD4+ T cells.
R. Seder (1994)



This paper is referenced by
10.1002/1531-8249(199902)45:2<224::AID-ANA13>3.0.CO;2-B
Early‐onset myasthenia gravis: A recurring T‐cell epitope in the adult‐specific acetylcholine receptor ε subunit presented by the susceptibility allele HLA‐DR52a
M. Hill (1999)
10.1093/INTIMM/11.8.1337
Astrocytoma infiltrating lymphocytes include major T cell clonal expansions confined to the CD8 subset.
G. Perrin (1999)
10.1016/S1074-7613(02)00289-3
Tracking salmonella-specific CD4 T cells in vivo reveals a local mucosal response to a disseminated infection.
S. McSorley (2002)
10.1097/00007890-199906270-00002
The visualization of T cell responses.
J. Barbará (1999)
10.1016/S0079-6123(01)32110-6
Immune escape of gliomas.
P. R. Walker (2001)
10.1016/J.HUMIMM.2005.06.011
Direct ex vivo detection of HLA-DR3-restricted cytomegalovirus- and Mycobacterium tuberculosis-specific CD4+ T cells.
C. Bronke (2005)
10.1016/S1074-7613(00)80573-7
Virus-specific CD8+ T cells in primary and secondary influenza pneumonia.
K. Flynn (1998)
Differentiation Cytokine-Driven Expansion and Antigen-Dependent and Late Naive CD 4 T Cells to Effectors , Early Two Distinct Stages in the Transition from
Susan L Swain (2000)
10.4049/jimmunol.165.9.5017
Two Distinct Stages in the Transition from Naive CD4 T Cells to Effectors, Early Antigen-Dependent and Late Cytokine-Driven Expansion and Differentiation1
D. Jelley-Gibbs (2000)
Tracking memory CD4 T cells in vivo: requirements for the generation, survival and re-activation of memory cells
Megan K. MacLeod (2005)
10.1111/j.0105-2896.2006.00387.x
Control of CD4+ T‐cell memory by cytokines and costimulators
H. Dooms (2006)
10.1016/j.virol.2008.04.031
Persistence of restricted CD4 T cell expansions in SIV-infected macaques resistant to SHIV89.6P superinfection.
M-D Salha (2008)
10.1016/S0165-2478(97)00105-3
Enrichment of antigen-specific T lymphocytes by panning on immobilized MHC-peptide complexes.
P. Bousso (1997)
Direct Measurement of CD41 and CD81 T-Cell Responses to CMV in HIV-1-Infected Subjects
Krishna V. Komanduri (2001)
This information is current as Diversity of Responding CTL Immunodominance , In Vitro Proliferation , and MHC Class I / Peptide Stability : Implications for
D. Busch (1998)
Vitro and In Vivo UpRegulate Cell Surface Expression of CD 4 In Following Antigen Challenge , T Cells
William Ridgway (1998)
10.1007/978-1-4615-0757-4_2
Development of antigen-specific helper T cell responses in vivo: antigen-specific Th cell subsets.
L. McHeyzer-Williams (2002)
10.1155/2003/214034
T cell costimulatory molecules in anti-viral immunity: Potential role in immunotherapeutic vaccines.
T. Watts (2003)
10.1007/BF02899917
Molecular cancer vaccines: Tumor therapy using antigen-specific immunizations
T. Schweighoffer (2008)
10.1385/IR:22:2-3:223
Antigen-specific immunity
M. Mcheyzer-Williams (2000)
MHC class I/peptide stability: implications for immunodominance, in vitro proliferation, and diversity of responding CTL.
D. Busch (1998)
10.1146/ANNUREV.IMMUNOL.23.021704.115732
Antigen-specific memory B cell development.
L. McHeyzer-Williams (2005)
10.1006/VIRO.2000.0697
Direct measurement of CD4+ and CD8+ T-cell responses to CMV in HIV-1-infected subjects.
K. Komanduri (2001)
10.1084/JEM.192.12.1719
T Cell Receptor (Tcr)-Mediated Repertoire Selection and Loss of Tcr Vβ Diversity during the Initiation of a Cd4+ T Cell Response in Vivo
M. Fassò (2000)
10.3929/ETHZ-A-003840267
Analysis of the CD4+ T cell immune response in vivo using CD4 up-regulation as an activation marker
M. Fassò (1999)
10.13028/ZJ0E-XX59
The Virus-Specific CD4+ T Cell Response During Acute Lymphocytic Choriomeningitis Virus Infection and into Long Term Memory: a Dissertation
S. Varga (1999)
Following antigen challenge, T cells up-regulate cell surface expression of CD4 in vitro and in vivo.
W. Ridgway (1998)
10.1111/j.0105-2896.2005.00307.x
The relationship between immunodominance, DM editing, and the kinetic stability of MHC class II:peptide complexes
A. Sant (2005)
10.1016/S1286-4579(00)00324-5
Generation of MHC-peptide tetramers: a new opportunity for dissecting T-cell immune responses.
P. Bousso (2000)
10.1097/00007890-200002270-00028
Visualization of the in vivo generation of donor antigen-specific effector CD8+ T cells during mouse cardiac allograft rejection: in vivo effector CD8+ T cell generation during allograft rejection.
B. Gilot (2000)
10.1016/S0165-0173(03)00141-3
T-cell immune responses in the brain and their relevance for cerebral malignancies
P. R. Walker (2003)
10.1111/j.1600-065X.1999.tb01299.x
Interplays between mouse mammary tumor virus and the cellular and humoral immune response
H. Acha-Orbea (1999)
See more
Semantic Scholar Logo Some data provided by SemanticScholar