Online citations, reference lists, and bibliographies.
← Back to Search

Single Trial FMRI Reveals Significant Contralateral Bias In Responses To Laser Pain Within Thalamus And Somatosensory Cortices

U. Bingel, M. Quante, R. Knab, B. Bromm, C. Weiller, C. Büchel
Published 2003 · Computer Science, Psychology, Medicine

Cite This
Download PDF
Analyze on Scholarcy
Pain is processed in multiple brain areas, indicating the complexity of pain perception. The ability to locate pain plays a pivotal role in immediate defense and withdrawal behavior. However, how the brain localizes nociceptive information without additional information from somatotopically organized mechano-receptive pathways is not well understood. We used single-trial functional magnetic resonance imaging (fMRI) to assess hemodynamic responses to right and left painful stimulation. Thulium-YAG-(yttrium-aluminium-granate)-laser-evoked pain stimuli, without concomitant tactile component, were applied to either hand in a randomized order. A contralateral bias of the BOLD response was investigated to determine areas involved in the coding of the side of stimulation, which we observed in primary (SI) and secondary (SII) somatosensory cortex, insula, and the thalamus. This suggests that these structures provide spatial information of selective nociceptive stimuli. More importantly, this contralateral bias of activation allowed functionally segregated activations within the SII complex, the insula, and the thalamus. Only distinct subregions of the SII complex, the posterior insula and the lateral thalamus, but not the remaining SII complex, the anterior insula and the medial thalamus, showed a contralaterally biased representation of painful stimuli. This result supports the hypothesis that sensory-discriminative attributes of painful stimuli, such as those related to body side, are topospecifically represented within the forebrain projections of the nociceptive system and highlights the concept of functional segregation and specialization within these structures.
This paper references
Pain processing during three levels of noxious stimulation produces differential patterns of central activity
S. Derbyshire (1997)
Exploring the pain “neuromatrix”
S. Derbyshire (2000)
Parallel activation of primary and secondary somatosensory cortices in human pain processing.
M. Ploner (1999)
Human brain activation under controlled thermal stimulation and habituation to noxious heat: An fMRI study
L. Becerra (1999)
Subcortical structures involved in pain processing: evidence from single-trial fMRI
U. Bingel (2002)
Painful stimuli evoke different stimulus-response functions in the amygdala, prefrontal, insula and somatosensory cortex: a single-trial fMRI study.
K. Bornhoevd (2002)
Right-hemisphere preponderance of responses to painful CO2 stimulation of the human nasal mucosa
R. Hari (1997)
A Comparative fMRI Study of Cortical Representations for Thermal Painful, Vibrotactile, and Motor Performance Tasks
P. A. Gelnar (1999)
fMRI of Thermal Pain: Effects of Stimulus Laterality and Attention
J. Brooks (2002)
Pain perception: is there a role for primary somatosensory cortex?
M. Bushnell (1999)
Cognitive Conjunction: A New Approach to Brain Activation Experiments
C. Price (1997)
Haemodynamic brain responses to acute pain in humans: sensory and attentional networks.
R. Peyron (1999)
Spatial registration and normalization of images
Karl J. Friston (1995)
Insula of the old world monkey. III: Efferent cortical output and comments on function
M. Mesulam (1982)
A thalamic nucleus specific for pain and temperature sensation
A. Craig (1994)
Nociceptive responses of trigeminal neurons in SII-7b cortex of awake monkeys
Willie K. Dong (1989)
Differential coding of pain intensity in the human primary and secondary somatosensory cortex.
L. Timmermann (2001)
Multiple representations of pain in human cerebral cortex.
J. Talbot (1991)
Cortical representation of pain
Per Roland (1992)
Computational approaches to network analysis in functional brain imaging
F. Gonzalez-Lima (1994)
Comparison of human cerebral activation pattern during cutaneous warmth, heat pain, and deep cold pain.
K. Casey (1996)
Clinical evaluation criteria for the assessment of impaired pain sensitivity by thulium-laser evoked potentials
J. Spiegel (2000)
Hemispheric lateralization of somatosensory processing.
R. Coghill (2001)
Primary somatosensory cortex is actively involved in pain processing in human
M. Kanda (2000)
Temporal and intensity coding of pain in human cortex.
C. Porro (1998)
Somatotopic organization of cortical fields in the lateral sulcus of Homo sapiens: Evidence for SII and PV
E. Disbrow (2000)
Distributed processing of pain and vibration by the human brain
R. Coghill (1994)
Dissociable Neural Responses Related to Pain Intensity, Stimulus Intensity, and Stimulus Awareness within the Anterior Cingulate Cortex: A Parametric Single-Trial Laser Functional Magnetic Resonance Imaging Study
C. Büchel (2002)
Functional imaging of brain responses to pain. A review and meta-analysis (2000)
R. Peyron (2000)
Statistical parametric maps in functional imaging: A general linear approach
Karl J. Friston (1994)
Meta-Analysis of thirty-four independent samples studied using PET reveals a significantly attenuated central response to noxious stimulation in clinical pain patients
S. Derbyshire (1999)
Thermosensory activation of insular cortex
A. Craig (2000)
Cortical areas within the lateral sulcus connected to cutaneous representations in areas 3b and 1: A revised interpretation of the second somatosensory area in macaque monkeys
H. Burton (1995)
Pain affect encoded in human anterior cingulate but not somatosensory cortex.
P. Rainville (1997)
Somatotopic organization of human secondary somatosensory cortex.
J. Ruben (2001)
Responses of human cutaneous afferents to CO2 laser stimuli causing pain
B. Bromm (2004)
Second somatic sensory cortical area (sii) in a prosimian primate, galago crassicaudatus
H. Burton (1986)
Modeling the thalamocortical loop.
De Carvalho La (1994)
Sensations evoked by intraneural microstimulation of C nociceptor fibres in human skin nerves.
J. Ochoa (1989)
The detection and perceived intensity of noxious thermal stimuli in monkey and in human.
D. Kenshalo (1989)
Somatotopic organization along the central sulcus, for pain localization in humans, as revealed by positron emission tomography
J. Andersson (1997)
Temporal and spatial dynamics of human forebrain activity during heat pain: analysis by positron emission tomography.
K. Casey (2001)
Dissociation of sensory and affective dimensions of pain using hypnotic modulation
P. Rainville (1999)
Responses of neurons in primate ventral posterior lateral nucleus to noxious stimuli.
D. Kenshalo (1980)
Somatic submodality distribution within the second somatosensory (SII), 7b, retroinsular, postauditory, and granular insular cortical areas of M. fascicularis
C. Robinson (1980)
Functional MRI study of thalamic and cortical activations evoked by cutaneous heat, cold, and tactile stimuli.
K. Davis (1998)
Functional localization of pain perception in the human brain studied by PET
X. Xu (1997)
Pain intensity processing within the human brain: a bilateral, distributed mechanism.
R. Coghill (1999)
Cortical representation of pain: functional characterization of nociceptive areas near the lateral sulcus
Rolf-Detlef Treede (2000)
Local maxima and the expected Euler characteristic of excursion sets of
Fields K. j. Worsley (1994)
Right-lateralised central processing for pain of nitroglycer-induced cluster headache
J. Hsieh (1996)

This paper is referenced by
Parallel spinal pathways generate the middle-latency N1 and the late P2 components of the laser evoked potentials
Massimiliano Valeriani (2007)
Human Brain Anatomy: Prospective, Microgravity, Hemispheric Brain Specialisation and Death of a Person
Z. Idris (2017)
Localization of pain‐related brain activation: A meta‐analysis of neuroimaging data
E. G. Duerden (2013)
Simultaneous recording of laser-evoked brain potentials and continuous, high-field functional magnetic resonance imaging in humans
G. Iannetti (2005)
Somatotopic organisation of the human insula to painful heat studied with high resolution functional imaging
J. Brooks (2005)
Le visage de la douleur : informations efficientes pour la reconnaissance et impacts sur l’observateur
C. Roy (2012)
Differential involvement of the anterior cingulate and primary sensorimotor cortices in sensory and affective functions of pain.
C. Kuo (2009)
Altered intrinsic brain activity in patients with toothaches using the amplitude of low-frequency fluctuations: a resting-state fMRI study
J. Yang (2019)
Functional deactivations: Multiple ipsilateral brain areas engaged in the processing of somatosensory information
C. Klingner (2011)
Hand dominancy—A feature affecting sensitivity to pain
D. Pud (2009)
Basal opioid receptor binding is associated with differences in sensory perception in healthy human subjects: A [18F]diprenorphine PET study
C. Mueller (2010)
Imaging of Pain
L. Chen (2007)
Funktionelle Magnetresonanztomographie zur Darstellung zerebraler Aktivierungen bei thermischen Schmerzreizen ohne Medikation sowie nach Gabe von Remifentanil und Metamizol
P. Prahs (2004)
Regional intensive and temporal patterns of functional MRI activation distinguishing noxious and innocuous contact heat.
E. Moulton (2005)
Affective Processing in Major Depressive Disorder: Neuroanatomical Correlates of State and Trait Abnormailities
J. Konarski (2010)
Distribution of trigeminothalamic and spinothalamic lamina I terminations in the macaque monkey
A. Craig (2004)
Capsaicin-induced thermal hyperalgesia and sensitization in the human trigeminal nociceptive pathway: An fMRI study
E. Moulton (2007)
Increased Prefrontal Activation During Pain Perception in Major Depression
K. Bär (2007)
Somatotopic representation of nociceptive information in the putamen: an event-related fMRI study.
U. Bingel (2004)
Placebo Effect on Modulating Empathic Pain: Reduced Activation in Posterior Insula
Y. Zhao (2020)
he Neural Bases of lacebo Effects in Anticipation and Pain or
Dale Wager ()
Functional human brain connectivity during labor and its alteration under epidural analgesia
F. Yang (2020)
A positron emission tomographic study in spontaneous migraine.
S. Afridi (2005)
Imaging Pain in the Human Brain
M. Loggia (2014)
An MR-compatible device for automated and safe application of laser stimuli in experiments employing nociceptive stimulation
P. Pott (2010)
Diffuse optical tomography of pain and tactile stimulation: Activation in cortical sensory and emotional systems
L. Becerra (2008)
Pain: Evidence for Contralateral Mechanisms Attenuation of Sensory and Affective Responses to Heat
Marie-Claire Albanese (2013)
Brain activity for spontaneous pain of postherpetic neuralgia and its modulation by lidocaine patch therapy
P. Geha (2007)
Apallic syndrome is not apallic: is vegetative state vegetative?
B. Kotchoubey (2005)
Kalorische Stimulation in der funktionellen Magnetresonanztomographie (fMRT) : Detektion vestibulär assoziierter Kortexareale und deren hämodynamische Antwort durch die Independent Component Analysis
Claudia med. Flatz (2013)
fMRI of pain studies using laser-induced heat on skin with and without the loved one near the subject – a pilot study on 'love hurts'
Tengku Ida Sofina (2014)
Touch or pain? Spatio-temporal patterns of cortical fMRI activity following brief mechanical stimuli
F. Lui (2008)
See more
Semantic Scholar Logo Some data provided by SemanticScholar