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Management Of Sarcoma In The Asia-Pacific Region: Resource-stratified Guidelines.

J. Lewin, A. Puri, R. Quek, R. Ngan, A. P. Alcasabas, D. Wood, D. Thomas
Published 2013 · Medicine

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Sarcomas are a rare and diverse set of cancers that disproportionately affect young people. The best possible outcome depends on access to highly specialised, multidisciplinary care. Although advances have been made in therapeutic techniques, access to some treatments might be limited by cost implications. This Review proposes an evidence-based, consensus recommendation for optimum management of bone and soft-tissue sarcoma across the Asia-Pacific region, taking into account variation in health-care resources, stratified according to the Breast Health Global Initiative resource levels. A web-based survey of 89 clinicians involved in the care of patients with sarcoma from 18 Asia-Pacific countries generated the recommendations for diagnosis, staging, and management, including supportive and palliative care, and research.
This paper references
10.1007/s003300050314
Scintigraphically negative skip metastasis in osteosarcoma
S. Bhagia (1997)
10.1007/s002590000301
FDG-PET for detection of osseous metastases from malignant primary bone tumours: comparison with bone scintigraphy
C. Franzius (2000)
Clinical value of [18-F]] fluorodeoxyglucose positron emission tomography imaging in soft tissue sarcomas.
Matthias Schwarzbach (2000)
10.1371/journal.pone.0017127
High-Dose Chemotherapy Followed by Autologous Stem Cell Transplantation for Metastatic Rhabdomyosarcoma—A Systematic Review
F. Peinemann (2011)
10.1097/PDM.0b013e3181a06f66
Molecular Diagnosis of Ewing Sarcoma Family of Tumors: A Comparative Analysis of 560 Cases With FISH and RT-PCR
I. Machado (2009)
10.1016/S1470-2045(09)70290-6
Management of endometrial cancer in Asia: consensus statement from the Asian Oncology Summit 2009.
S. Tangjitgamol (2009)
10.1200/JCO.1987.5.6.840
Randomized comparison of three adriamycin regimens for metastatic soft tissue sarcomas.
E. Borden (1987)
10.1002/cncr.23592
A systematic meta‐analysis of randomized controlled trials of adjuvant chemotherapy for localized resectable soft‐tissue sarcoma
N. Pervaiz (2008)
10.1093/ANNONC/MDH431
Neo-adjuvant chemotherapy for primary high-grade extremity soft tissue sarcoma.
S. Grobmyer (2004)
10.1634/THEONCOLOGIST.11-5-503
Ewing's sarcoma family of tumors: current management.
M. Bernstein (2006)
10.1016/S0140-6736(12)60651-5
Pazopanib for metastatic soft-tissue sarcoma (PALETTE): a randomised, double-blind, placebo-controlled phase 3 trial
W. Graaf (2012)
10.1200/JCO.2011.41.5703
Randomized controlled trial of interval-compressed chemotherapy for the treatment of localized Ewing sarcoma: a report from the Children's Oncology Group.
R. Womer (2012)
10.1016/S1470-2045(09)70266-9
Management of the neck after chemoradiotherapy for head and neck cancers in Asia: consensus statement from the Asian Oncology Summit 2009.
J. Wee (2009)
10.1200/JCO.1997.15.6.2378
High-dose ifosfamide in bone and soft tissue sarcomas: results of phase II and pilot studies--dose-response and schedule dependence.
S. Patel (1997)
10.1200/JCO.2008.17.3146
Phase II trial of weekly paclitaxel for unresectable angiosarcoma: the ANGIOTAX Study.
N. Penel (2008)
10.1016/J.RADONC.2004.12.020
Late radiation morbidity following randomization to preoperative versus postoperative radiotherapy in extremity soft tissue sarcoma.
A. Davis (2005)
10.1200/JCO.2008.21.0088
Efficacy and safety of trabectedin in patients with advanced or metastatic liposarcoma or leiomyosarcoma after failure of prior anthracyclines and ifosfamide: results of a randomized phase II study of two different schedules.
George D. Demetri (2009)
10.2214/AJR.146.4.749
MRI and CT evaluation of primary bone and soft-tissue tumors.
A. Aisen (1986)
10.1016/j.ejca.2011.05.030
Chemotherapeutic adjuvant treatment for osteosarcoma: where do we stand?
J. Anninga (2011)
10.1002/14651858.CD006325.PUB3
Methotrexate for high‐grade osteosarcoma in children and young adults
E. C. V. Dalen (2011)
10.1002/1098-2264(2000)9999:9999<::AID-GCC1056>3.0.CO;2-G
Molecular mechanisms underlying human synovial sarcoma development.
N. R. Santos (2001)
10.1016/S0140-6736(10)61507-3
Health and health-care systems in southeast Asia: diversity and transitions
V. Chongsuvivatwong (2011)
Predictive pathology: a pathologist's perspective
P. Waring (2003)
10.1097/CCO.0b013e32832c95e2
Utilization of positron emission tomography in the management of patients with sarcoma
M. Benz (2009)
10.1093/annonc/mdp155
Ewing's sarcoma of the bone: ESMO clinical recommendations for diagnosis, treatment and follow-up.
M. Paulussen (2009)
Immunohistochemical analysis of Ewing's sarcoma cell surface antigen p30/32MIC2.
E. Fellinger (1991)
Pathology and genetics of tumours of soft tissue and bone
C. D. Fletcher (2002)
10.1080/028418600431076
Neoadjuvant chemotherapy for Ewing's sarcoma of bone in patients older than thirty-nine years.
G. Bacci (2000)
10.1200/JCO.1996.14.3.859
Long-term results of a prospective randomized trial of adjuvant brachytherapy in soft tissue sarcoma.
P. W. Pisters (1996)
10.1016/S1470-2045(12)70424-2
Management of colon cancer: resource-stratified guidelines from the Asian Oncology Summit 2012.
G. Ku (2012)
10.1016/S1470-2045(12)70346-7
Adjuvant chemotherapy with doxorubicin, ifosfamide, and lenograstim for resected soft-tissue sarcoma (EORTC 62931): a multicentre randomised controlled trial.
P. J. Woll (2012)
10.1023/A:1011111322376
FDG-PET for detection of pulmonary metastases from malignant primary bone tumors: comparison with spiral CT.
C. Franzius (2001)
10.1093/annonc/mdp154
Osteosarcoma: ESMO clinical recommendations for diagnosis, treatment and follow-up.
S. Bielack (2009)
10.1002/IJC.2910420408
The international incidence of childhood cancer
D. Parkin (1988)
10.1002/pbc.24155
Chemotherapy compliance in patients with osteosarcoma
J. Bajpai (2013)
10.1016/S1470-2045(09)70265-7
Management of T-cell and natural-killer-cell neoplasms in Asia: consensus statement from the Asian Oncology Summit 2009.
Y. Kwong (2009)
10.1016/J.IJROBP.2003.11.037
Intensity-modulated radiotherapy for soft tissue sarcoma of the thigh.
L. Hong (2004)
10.1002/pbc.24468
SIOP‐PODC recommendations for graduated‐intensity treatment of retinoblastoma in developing countries
G. Chantada (2013)
10.2214/AJR.150.3.615
Soft-tissue sarcomas of the extremities: comparison of MR and CT in determining the extent of disease.
B. Demas (1988)
10.1200/JCO.1992.10.10.1579
A comparison of two short intensive adjuvant chemotherapy regimens in operable osteosarcoma of limbs in children and young adults: the first study of the European Osteosarcoma Intergroup.
V. Bramwell (1992)
10.1200/JCO.2003.08.132
Primary metastatic osteosarcoma: presentation and outcome of patients treated on neoadjuvant Cooperative Osteosarcoma Study Group protocols.
L. Kager (2003)
10.1016/J.CTRV.2003.07.004
The value of FDG-PET in the detection, grading and response to therapy of soft tissue and bone sarcomas; a systematic review and meta-analysis.
E. Bastiaannet (2004)
10.1016/S1470-2045(12)70380-7
Supportive, palliative, and end-of-life care for patients with cancer in Asia: resource-stratified guidelines from the Asian Oncology Summit 2012.
S. Payne (2012)
Impact of megatherapy in children with high-risk Ewing's tumours in complete remission: a report from the EBMT Solid Tumour Registry.
R. Ladenstein (1995)
10.1200/JCO.2001.19.11.2812
High-dose melphalan, etoposide, total-body irradiation, and autologous stem-cell reconstitution as consolidation therapy for high-risk Ewing's sarcoma does not improve prognosis.
P. Meyers (2001)
10.1016/S0360-3016(02)04510-8
Preoperative vs. postoperative radiation therapy for soft tissue sarcoma: a retrospective comparative evaluation of disease outcome.
G. Zagars (2003)
10.1200/JCO.2004.00.5785
Neoadjuvant chemotherapy with high-dose Ifosfamide, high-dose methotrexate, cisplatin, and doxorubicin for patients with localized osteosarcoma of the extremity: a joint study by the Italian and Scandinavian Sarcoma Groups.
S. Ferrari (2005)
10.1002/cncr.23842
Guideline implementation for breast healthcare in low‐ and middle‐income countries
C. Yip (2008)
10.1200/JCO.1989.7.1.126
Response to ifosfamide and mesna: 124 previously treated patients with metastatic or unresectable sarcoma.
K. Antman (1989)
10.1093/annonc/mdn526
Decreased occurrence of osteonecrosis of the jaw after implementation of dental preventive measures in solid tumour patients with bone metastases treated with bisphosphonates. The experience of the National Cancer Institute of Milan.
C. Ripamonti (2009)
10.1093/ANNONC/MDQ223
Bone sarcomas: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up.
P. Hogendoorn (2012)
10.1158/1078-0432.CCR-08-3185
Clinical and Biological Significance of CDK4 Amplification in Well-Differentiated and Dedifferentiated Liposarcomas
A. Italiano (2009)
10.1016/S0140-6736(02)09292-9
Preoperative versus postoperative radiotherapy in soft-tissue sarcoma of the limbs: a randomised trial
B. O'Sullivan (2002)
10.1002/14651858.CD006669.pub2
High-dose chemotherapy for children and young adults with stage IV rhabdomyosarcoma.
R. Admiraal (2010)
10.1200/JCO.2008.26.15_SUPPL.10525
The end of adjuvant chemotherapy (adCT) era with doxorubicin-based regimen in resected high-grade soft tissue sarcoma (STS): Pooled analysis of the two STBSG-EORTC phase III clinical trials
A. Cesne (2008)
10.1186/1477-7819-10-191
Suboptimal chemotherapy is an adverse prognostic factor in osteosarcoma
B. Yong (2012)
10.1007/s11999-009-0965-9
Biopsy of Soft Tissue Masses: Evidence-based Medicine for the Musculoskeletal Tumor Society
B. Rougraff (2009)
10.1016/j.ejca.2008.06.004
Imaging strategy for detecting lung metastases at presentation in patients with soft tissue sarcomas.
M. Christie-Large (2008)
10.1155/2010/317462
UK Guidelines for the Management of Bone Sarcomas
R. Grimer (2010)
10.1155/2010/506182
Guidelines for the Management of Soft Tissue Sarcomas
R. Grimer (2010)
10.1200/JCO.2005.07.088
Molecular and clinical analysis of locally advanced dermatofibrosarcoma protuberans treated with imatinib: Imatinib Target Exploration Consortium Study B2225.
G. McArthur (2005)
10.1002/pbc.24118
Rhabdomyosarcoma: Review of the Children's Oncology Group (COG) soft‐tissue Sarcoma committee experience and rationale for current COG studies
S. Malempati (2012)
10.1097/RTI.0b013e3182010bf9
ACR Appropriateness Criteria® screening for pulmonary metastases.
T. Mohammed (2011)
10.1016/S1470-2045(09)70241-4
Management of hepatocellular carcinoma in Asia: consensus statement from the Asian Oncology Summit 2009.
D. Poon (2009)
10.1016/S1470-2045(09)70238-4
First-line systemic treatment of advanced stage non-small-cell lung cancer in Asia: consensus statement from the Asian Oncology Summit 2009.
R. Soo (2009)
10.1002/cncr.20995
National survival trends of young adults with sarcoma
A. Bleyer (2005)
10.1016/S0959-8049(02)00491-4
Results of randomised studies of the EORTC Soft Tissue and Bone Sarcoma Group (STBSG) with two different ifosfamide regimens in first- and second-line chemotherapy in advanced soft tissue sarcoma patients.
A. V. van Oosterom (2002)
10.1002/14651858.CD003293
Doxorubicin-based chemotherapy for the palliative treatment of adult patients with locally advanced or metastatic soft tissue sarcoma.
V. H. Bramwell (2003)
10.1200/JCO.1994.12.6.1137
Adjuvant CYVADIC chemotherapy for adult soft tissue sarcoma--reduced local recurrence but no improvement in survival: a study of the European Organization for Research and Treatment of Cancer Soft Tissue and Bone Sarcoma Group.
V. Bramwell (1994)
10.1002/cncr.22821
Analysis of prognostic factors in ewing sarcoma family of tumors
C. Rodriguez-Galindo (2007)
10.1056/NEJM199408043310503
The Ewing family of tumors--a subgroup of small-round-cell tumors defined by specific chimeric transcripts.
O. Delattre (1994)
10.1002/(SICI)1097-0142(19990215)85:4<869::AID-CNCR14>3.0.CO;2-8
Pelvic Ewing sarcoma
C. Hoffmann (1999)
10.1200/JCO.2002.03.084
Function and health status outcomes in a randomized trial comparing preoperative and postoperative radiotherapy in extremity soft tissue sarcoma.
A. Davis (2002)
10.1007/s11864-009-0087-3
The Multidisciplinary Management of Osteosarcoma
N. Federman (2009)
10.1200/JCO.2008.16.5720
Results of the EICESS-92 Study: two randomized trials of Ewing's sarcoma treatment--cyclophosphamide compared with ifosfamide in standard-risk patients and assessment of benefit of etoposide added to standard treatment in high-risk patients.
M. Paulussen (2008)
10.1023/A:1013103511633
Computed tomography of pulmonary metastases from osteosarcoma: the less poor technique. A study of 51 patients with histological correlation.
P. Picci (2001)
10.1200/JCO.2006.05.7059
Impact of high-dose busulfan plus melphalan as consolidation in metastatic Ewing tumors: a study by the Société Française des Cancers de l'Enfant.
O. Oberlin (2006)
10.1200/JCO.1998.16.1.197
Randomized prospective study of the benefit of adjuvant radiation therapy in the treatment of soft tissue sarcomas of the extremity.
J. Yang (1998)
10.1016/S0140-6736(13)60826-0
India's patent case victory rattles Big Pharma
P. Chatterjee (2013)
10.7314/APJCP.2012.13.9.4281
Incidence and survival rates among pediatric osteogenic sarcoma cases in Khon Kaen, Thailand, 1985-2010.
Pattara Wiromrat (2012)
10.1016/J.CTRV.2007.01.001
International patterns of cancer incidence in adolescents.
C. Stiller (2007)
10.1111/J.1365-3016.1994.TB00439.X
International variations in the incidence of childhood soft-tissue sarcomas.
C. Stiller (1994)
10.1056/NEJMOA020890
Addition of ifosfamide and etoposide to standard chemotherapy for Ewing's sarcoma and primitive neuroectodermal tumor of bone.
H. Grier (2003)
10.1177/107327480501200104
Advanced-technology radiation therapy in the management of bone and soft tissue sarcomas.
T. Delaney (2005)
10.1111/j.1445-2197.2005.03332.x
ACCURACY OF COMPUTED TOMOGRAPHY GUIDED CORE NEEDLE BIOPSY OF MUSCULOSKELETAL TUMOURS
Altay O. Altuntas (2005)
10.1787/9789264088368-3-EN
Growth, employment and inequality in Brazil, China, India and South Africa: An overview
E. Arnal (2010)
10.1016/J.EJCA.2003.08.022
Long-term outcome for patients with non-metastatic Ewing's sarcoma treated with adjuvant and neoadjuvant chemotherapies. 402 patients treated at Rizzoli between 1972 and 1992.
G. Bacci (2004)
10.1007/978-1-4614-5197-6_27
Soft tissue sarcomas.
J. Cormier (2004)
10.1002/pbc.21596
Imaging guidelines for children with Ewing sarcoma and osteosarcoma: A report from the Children's Oncology Group Bone Tumor Committee
J. Meyer (2008)
10.1155/2011/483154
Liposarcoma: Molecular Genetics and Therapeutics
R. Conyers (2011)
10.1002/jso.21600
The role of core needle biopsy in the diagnosis of suspected soft tissue tumours
D. Strauss (2010)
10.1002/cncr.23844
Guideline implementation for breast healthcare in low‐income and middle‐income countries
B. Anderson (2008)
10.1016/S1470-2045(09)70230-X
Management of HER2-positive breast cancer in Asia: consensus statement from the Asian Oncology Summit 2009.
N. S. Wong (2009)
10.1200/JCO.2002.11.050
Gemcitabine and docetaxel in patients with unresectable leiomyosarcoma: results of a phase II trial.
M. Hensley (2002)
10.1023/A:1008279426654
Phase II study of continuous-infusion high-dose ifosfamide in advanced and/or metastatic pretreated soft tissue sarcomas.
R. Palumbo (1997)
10.1002/ijc.24320
International osteosarcoma incidence patterns in children and adolescents, middle ages and elderly persons
L. Mirabello (2009)
10.1016/S0959-8049(01)00083-1
A randomised phase II study on neo-adjuvant chemotherapy for 'high-risk' adult soft-tissue sarcoma.
E. Gortzak (2001)
10.1111/j.1445-2197.2008.04715.x
PREOPERATIVE CORE BIOPSY OF SOFT TISSUE TUMOURS FACILITATES THEIR SURGICAL MANAGEMENT: A 10‐YEAR UPDATE
Dixon T S Woon (2008)
10.1200/JCO.1990.8.10.1664
Multimodal therapy for the management of primary, nonmetastatic Ewing's sarcoma of bone: a long-term follow-up of the First Intergroup study.
M. Nesbit (1990)
10.1016/J.IJROBP.2005.07.299
Radiation therapy for Ewing's sarcoma: results from Memorial Sloan-Kettering in the modern era.
T. La (2006)
10.6004/JNCCN.2010.0049
Soft tissue sarcoma.
G. Demetri (2010)
10.1016/S0165-4608(97)00287-2
Structural analysis of PAX3 genomic rearrangements in alveolar rhabdomyosarcoma.
F. Barr (1998)
10.1097/00003086-200004000-00011
Fine Needle Aspiration Biopsy of Primary Bone Tumors
W. Ward (2000)
10.1111/j.1743-7563.2012.01560.x
Analysis of prognostic factors in 333 Chinese patients with high‐grade osteosarcoma treated by multidisciplinary combined therapy
D. Min (2013)
10.1056/NEJMOA020461
Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors.
G. Demetri (2002)
10.1016/S1470-2045(11)70128-0
Abandonment of treatment for childhood cancer: position statement of a SIOP PODC Working Group.
S. Mostert (2011)
10.1200/JCO.2010.30.5128
Adolescent and young adult oncology: an emerging field.
D. Thomas (2010)
10.1016/S1470-2045(13)70451-0
Management of prostate cancer in Asia: resource-stratified guidelines from the Asian Oncology Summit 2013.
S. Williams (2013)
10.1093/annonc/mdn678
Neo/adjuvant chemotherapy does not improve outcome in resected primary synovial sarcoma: a study of the French Sarcoma Group.
A. Italiano (2009)
10.1016/S1470-2045(10)70062-0
Sequelae of osteosarcoma medical therapy: a review of rare acute toxicities and late effects.
K. Janeway (2010)
10.1002/ijc.21867
Docetaxel and gemcitabine combination in 133 advanced soft‐tissue sarcomas: A retrospective analysis
J. Bay (2006)



This paper is referenced by
10.3389/fsurg.2014.00027
Orthopedic Oncology – “The Challenges Ahead”
A. Puri (2014)
10.1155/2015/614179
Wiki-Based Clinical Practice Guidelines for the Management of Adult Onset Sarcoma: A New Paradigm in Sarcoma Evidence
S. J. Neuhaus (2015)
10.21037/cco.2018.08.06
Soft tissue sarcoma in Asia.
E. Poon (2018)
10.1016/j.ejca.2016.02.007
Prognostic significance of (18)F-FDG PET at diagnosis in patients with soft tissue sarcoma and bone sarcoma; systematic review and meta-analysis.
T. Kubo (2016)
10.4103/njps.njps_14_18
Management of lower extremity soft-tissue sarcoma in a sub-Saharan African teaching hospital: Case reports
O. Ayandipo (2019)
10.1200/JCO.2014.60.6376
Toward the Cure of All Children With Cancer Through Collaborative Efforts: Pediatric Oncology As a Global Challenge.
C. Rodríguez-Galindo (2015)
10.1007/978-3-319-43121-5_23
Multidisciplinary Approach to Treatment: An Australian Perspective
S. J. Neuhaus (2017)
10.1038/bjc.2014.537
A phase Ib/II translational study of sunitinib with neoadjuvant radiotherapy in soft-tissue sarcoma
J. Lewin (2014)
10.3892/ol.2014.2803
Rare chondrosarcoma of the breast treated with quadrantectomy instead of mastectomy: A case report
V. Pasta (2015)
10.1254/FPJ.148.329
悪性軟部腫瘍に対するエリブリンメシル酸塩(ハラヴェン®静注1 mg)の臨床効果と抗腫瘍メカニズムについて
Noriyuki Koyama (2016)
10.21037/atm.2020.01.113
Survival-associated alternative splicing signatures in soft tissue sarcomas.
Xianghai Ren (2020)
10.1016/s1470-2045(20)30022-x
Sustainable care for children with cancer: a Lancet Oncology Commission.
R. Atun (2020)
10.1016/j.forsciint.2016.01.001
The medico-legal observation of an aggressive urogenital fibromatosis with isolated development not related to any traumatic event.
E. Muccino (2016)
10.3892/mco.2017.1378
Antitumor activity of yulangsan polysacchrides in mice bearing S180 sarcoma tumors.
Wen'E Cai (2017)
10.1186/s13045-018-0664-7
Anlotinib: a novel multi-targeting tyrosine kinase inhibitor in clinical development
Guoshuang Shen (2018)
10.1155/2017/1837475
Variations of Surveillance Practice for Patients with Bone Sarcoma: A Survey of Australian Sarcoma Clinicians
J. Lewin (2017)
10.1097/MPH.0000000000001506
Age and Tumor Location Predict Survival in Nonmetastatic Osteosarcoma in Upper Egypt
A. M. Morsy (2019)
10.3389/fpubh.2020.00097
Battle Against Musculoskeletal Tumors: Descriptive Data of Military Hospital Experience
Cagri Neyisci (2020)
10.1177/2309499018801168
Giant cell tumor of the small bones of the foot
H. L. Co. (2018)
10.37980/IM.JOURNAL.RMDP.2014160
Estudio descriptivo de las características epidemiológicas, patológicas y de tratamiento en pacientes tratados por Sarcoma en el Instituto Oncológico Nacional de Panamá desde 2004 al 2011.
Yair Ruiz (2014)
Orthopedic oncology - "the challenges ahead"
Vasileios S Nikolaou (2014)
Caraterização Histopatológica e Imuno-histoquímica de Sarcomas e Carcinossarcomas Mamários Caninos
Antonio Ramos (2016)
10.1002/nbm.4426
Texture analysis for chemotherapy response evaluation in osteosarcoma using MR imaging
Esha Baidya Kayal (2020)
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