Online citations, reference lists, and bibliographies.

Design And Fabrication Of Magnetic Nanoparticles For Targeted Drug Delivery And Imaging.

O. Veiseh, Jonathan W Gunn, M. Zhang
Published 2010 · Medicine, Chemistry
Cite This
Download PDF
Analyze on Scholarcy
Share
Magnetic nanoparticles (MNPs) represent a class of non-invasive imaging agents that have been developed for magnetic resonance (MR) imaging. These MNPs have traditionally been used for disease imaging via passive targeting, but recent advances have opened the door to cellular-specific targeting, drug delivery, and multi-modal imaging by these nanoparticles. As more elaborate MNPs are envisioned, adherence to proper design criteria (e.g. size, coating, molecular functionalization) becomes even more essential. This review summarizes the design parameters that affect MNP performance in vivo, including the physicochemical properties and nanoparticle surface modifications, such as MNP coating and targeting ligand functionalizations that can enhance MNP management of biological barriers. A careful review of the chemistries used to modify the surfaces of MNPs is also given, with attention paid to optimizing the activity of bound ligands while maintaining favorable physicochemical properties.
This paper references
MRmolecular imaging of the Her- 2/neu receptor in breast cancer cells using targeted iron oxide nanoparticles
D. Artemov (2003)
10.1002/mrm.10406
MR molecular imaging of the Her-2/neu receptor in breast cancer cells using targeted iron oxide nanoparticles.
D. Artemov (2003)
10.1016/S0169-409X(01)00202-2
Design and gene delivery activity of modified polyethylenimines.
R. Kircheis (2001)
10.1016/j.jallcom.2006.08.311
Biomedical applications of superparamagnetic iron oxide nanoparticles encapsulated within chitosan
E. Kim (2007)
10.1038/nature06917
Imaging in the era of molecular oncology
R. Weissleder (2008)
10.1002/jbm.a.30781
Folic acid-PEG conjugated superparamagnetic nanoparticles for targeted cellular uptake and detection by MRI.
C. Sun (2006)
10.1161/01.RES.0000155722.17881.dd
Detection of Vascular Adhesion Molecule-1 Expression Using a Novel Multimodal Nanoparticle
K. Kelly (2005)
10.1007/s10856-007-3130-6
Surface modified superparamagnetic iron oxide nanoparticles: as a new carrier for bio-magnetically targeted therapy
Sheng Liang (2007)
10.1002/mrm.1910290504
Monocrystalline iron oxide nanocompounds (MION): physicochemical properties.
T. Shen (1993)
10.1158/0008-5472.CAN-06-4762
Dendrimer-modified magnetic nanoparticles enhance efficiency of gene delivery system.
Bifeng Pan (2007)
10.1177/0284185172012S31604
Radiology
S. Wilson (1938)
10.1016/0022-1759(82)90007-2
Immunospecific ferromagnetic iron-dextran reagents for the labeling and magnetic separation of cells.
R. Molday (1982)
10.1016/j.addr.2006.09.012
Brain cancer diagnosis and therapy with nanoplatforms.
Yong-Eun Lee Koo (2006)
10.1016/S0958-1669(02)00294-X
Non-viral gene delivery systems.
M. Davis (2002)
10.1088/0022-3727/36/13/201
Applications of magnetic nanoparticles in biomedicine
Q. Pankhurst (2003)
siRNA delivery by magnetofection.
O. Mykhaylyk (2008)
10.1038/nrn1827
Neuroscience nanotechnology: progress, opportunities and challenges
G. Silva (2006)
10.1016/0169-409X(95)00043-7
Mechanisms of splenic clearance of blood cells and particles: Towards development of new splenotropic agents
Seyed Moein Moghimi (1995)
10.1016/j.geb.2003.09.006
Preparation
M. Voorneveld (2004)
10.1088/0957-4484/19/40/405102
Magnetic nanoparticles as gene delivery agents: enhanced transfection in the presence of oscillating magnet arrays.
S C McBain (2008)
Nanotoxicology -Interactions of Nanomaterials with Biological Systems
(2006)
Transport of molecules
R. K. Jain (1999)
10.1158/1535-7163.MCT-06-0172
Discovery and development of anticancer aptamers
C. Ireson (2006)
Preparation of ultra fi ne silicaand PEGcoated magnetite particles , Colloids and Surfaces
S. S. Davis (2004)
Bioconjugate Techniques
G. T. Hermanson (2008)
10.1096/fj.06-8070com
Magnetically driven plasmid DNA delivery with biodegradable polymeric nanoparticles.
M. Chorny (2007)
10.1016/S0168-3659(99)00248-5
Tumor vascular permeability and the EPR effect in macromolecular therapeutics: a review.
H. Maeda (2000)
10.1021/la801138e
Controlled rupture of magnetic polyelectrolyte microcapsules for drug delivery.
Shang-Hsiu Hu (2008)
10.1002/cmmi.87
Specific E-selectin targeting with a superparamagnetic MRI contrast agent.
S. Boutry (2006)
10.1634/theoncologist.2007-0180
Concept and clinical evaluation of carrier-mediated anticancer agents.
W. Zamboni (2008)
10.1016/j.addr.2006.09.013
Recent advances in iron oxide nanocrystal technology for medical imaging.
C. Corot (2006)
10.1016/j.addr.2012.09.015
Nanoparticulate systems for brain delivery of drugs.
J. Kreuter (2001)
European Biophysics Journal with Biophysics Letters
M Decuyper (1988)
Long-circulating and target-specific nanoparticles: theory to practice.
S. Moghimi (2001)
10.1517/17425247.5.1.69
Past and future evolution in colloidal drug delivery systems
Ben J Boyd (2008)
Computer modeling of several ligands binding to multiple receptors.
Peter J. Munson (1979)
10.1021/JP075235C
Structure and Properties of Iron Oxide Nanoparticles Encapsulated by Phospholipids with Poly(ethylene glycol) Tails
E. Shtykova (2007)
10.1006/jcis.2001.7762
Superparamagnetic latex via inverse emulsion polymerization
K. Wormuth (2001)
Magnetic properties of biological materials
J. Dobson (2007)
Nalwa (Eds.), Nanotoxicology - Interactions of Nanomaterials with Biological Systems, American Scientific Publishers, Stevenson Ranch
H.S.Y. Zhao (2006)
10.1002/ADMA.200800004
Magnetic Iron Oxide Nanoworms for Tumor Targeting and Imaging.
J. Park (2008)
10.1016/j.addr.2008.03.018
Magnetic nanoparticles in MR imaging and drug delivery.
C. Sun (2008)
10.1016/S0168-3659(02)00045-7
Physical properties and in vitro transfection efficiency of gene delivery vectors based on complexes of DNA with synthetic polycations.
Tomas Reschel (2002)
10.1016/J.EJPB.2007.02.024
Effect of cell media on polymer coated superparamagnetic iron oxide nanoparticles (SPIONs): colloidal stability, cytotoxicity, and cellular uptake studies.
A. Petri-Fink (2008)
10.1016/j.addr.2008.02.004
Efficient construction of therapeutics, bioconjugates, biomaterials and bioactive surfaces using azide-alkyne "click" chemistry.
J. Lutz (2008)
Multivalent Binding in the Design of Bioactive Compounds
Dennis Wright and Lynn Usher (2001)
10.1002/CBIC.200700323
Smart "turn-on" magnetic resonance contrast agents based on aptamer-functionalized superparamagnetic iron oxide nanoparticles.
M. V. Yigit (2007)
10.1002/mrm.1910170229
Magnetic resonance in medicine.
J. M. Taveras (1985)
10.1201/9781315186580
Bioengineering and biophysical aspects of electromagnetic fields
F. Barnes (2006)
10.1227/01.NEU.0000311058.80249.6B
NEUROSURGERY IN THE REALM OF 10−9, PART 1: STARDUST AND NANOTECHNOLOGY IN NEUROSCIENCE
J. B. Elder (2008)
10.1162/15353500200202103
Annexin V–CLIO: A Nanoparticle for Detecting Apoptosis by MRI
Eyk A Schellenberger (2002)
PET/MRI dualmodality tumor imaging using arginine-glycine-aspartic (RGD)-conjugated radiolabeled iron oxide nanoparticles
H. Y. Lee (2008)
Click chemistry
C. D. Hein (2008)
10.1189/jlb.0205074
Nanotechnology for the biologist.
S. Mcneil (2005)
10.1038/nrd725
Drug and gene targeting to the brain with molecular trojan horses
W. Pardridge (2002)
10.2217/17435889.3.4.567
Nanotechnology for regenerative medicine: nanomaterials for stem cell imaging.
Aniruddh Solanki (2008)
10.1016/j.jmmm.2005.01.053
A method for synthesis and functionalization of ultrasmall superparamagnetic covalent carriers based on maghemite and dextran
S. Mornet (2005)
10.1021/ja0516460
Generation of superparamagnetic liposomes revealed as highly efficient MRI contrast agents for in vivo imaging.
Marie-Sophie Martina (2005)
Physicochemical characterization of ultrasmall superparamagnetic iron oxide particles (USPIO) for biomedical application as MRI contrast agents
M. Di Marco (2007)
10.1021/nl0502569
Optical and MRI multifunctional nanoprobe for targeting gliomas.
O. Veiseh (2005)
10.1021/mp800032f
Preclinical studies to understand nanoparticle interaction with the immune system and its potential effects on nanoparticle biodistribution.
M. Dobrovolskaia (2008)
NONINVASIVE
F. F. Jobsis (1977)
10.1002/ddr.20067
Magnetic nanoparticles for drug delivery
J. Dobson (2006)
10.1021/cr068445e
Magnetic iron oxide nanoparticles: synthesis, stabilization, vectorization, physicochemical characterizations, and biological applications.
S. Laurent (2008)
10.1073/pnas.96.9.5177
Tracking the intracellular path of poly(ethylenimine)/DNA complexes for gene delivery.
W. Godbey (1999)
10.1016/0304-8853(95)00317-7
Synthesis of very fine maghemite particles
A. Bee (1995)
10.1038/nm1101-1241
Non-invasive detection of apoptosis using magnetic resonance imaging and a targeted contrast agent
M. Zhao (2001)
10.1074/mcp.R400001-MCP200
Targeted Therapy in Breast Cancer
J. Ross (2004)
10.1002/nbm.1011
Lipid-based nanoparticles for contrast-enhanced MRI and molecular imaging.
W. Mulder (2006)
10.1016/j.ijpharm.2006.12.002
Differential tumor cell targeting of anti-HER2 (Herceptin) and anti-CD20 (Mabthera) coupled nanoparticles.
A. Cirstoiu-Hapca (2007)
10.1007/s00775-007-0265-3
Multimodal MRI contrast agents
Luca Frullano (2007)
American Journal of Roentgenology
R Weissleder (1989)
Synthesis and characterization of the iron oxide magnetic particles Please cite this article as: O
K. Donadel (2008)
10.1593/neo.05769
Nanoparticle imaging of integrins on tumor cells.
X. Montet (2006)
E.Duguet,Magneticnanoparticledesign formedical diagnosis and therapy
S.Mornet (2004)
10.2310/7290.2006.00013
“Clickable” Nanoparticles for Targeted Imaging
E. Y. Sun (2006)
10.1038/nnano.2008.30
Nanoparticle-mediated cellular response is size-dependent.
W. Jiang (2008)
10.1021/ja052337c
In vivo magnetic resonance detection of cancer by using multifunctional magnetic nanocrystals.
Y. Huh (2005)
10.1002/smll.200700595
Cytotoxicity of nanoparticles.
Nastassja Lewinski (2008)
10.1038/nbt720
Magnetic relaxation switches capable of sensing molecular interactions
J. M. Pérez (2002)
10.1146/annurev.bioeng.1.1.241
Transport of molecules, particles, and cells in solid tumors.
R. Jain (1999)
10.1515/9783111576855-016
K
Martin P. Catherwood (1824)
10.1088/0957-4484/19/46/465608
The development of stable aqueous suspensions of PEGylated SPIONs for biomedical applications.
K. Herve (2008)
Plank, siRNA delivery by magnetofection
O Mykhaylyk (2008)
Magnetic nanoparticles: Synthesis
A. H. Lu (2007)
10.1007/bf00256482
Magnetoliposomes. Formation and structural characterization.
M. de Cuyper (1988)
10.2217/17435889.3.4.495
Tumor-targeted drug delivery and MRI contrast enhancement by chlorotoxin-conjugated iron oxide nanoparticles.
C. Sun (2008)
10.1021/cr030441b
Chitosan chemistry and pharmaceutical perspectives.
M. Kumar (2004)
10.1021/bc060035+
Imaging pancreatic cancer with a peptide-nanoparticle conjugate targeted to normal pancreas.
X. Montet (2006)
10.1118/1.2966595
Towards new functional nanostructures for medical imaging.
N. Matsuura (2008)
10.1016/j.jinorgbio.2005.02.009
C-MALISA (cellular magnetic-linked immunosorbent assay), a new application of cellular ELISA for MRI.
Carmen Burtea (2005)
10.1002/ANIE.200703554
Multifunctional magneto-polymeric nanohybrids for targeted detection and synergistic therapeutic effects on breast cancer.
Jaemoon Yang (2007)
10.1002/(SICI)1522-2586(199902)9:2<329::AID-JMRI27>3.0.CO;2-Z
Short- vs. long-circulating magnetoliposomes as bone marrow-seeking MR contrast agents.
Jeff W. M. Bulte (1999)
10.1056/NEJMoa022749
Noninvasive detection of clinically occult lymph-node metastases in prostate cancer.
M. Harisinghani (2003)
Nanotubular probes as ultrasensitive MR contrast agent
J. Gao (2008)
Neuroscience nanotechnology: Progress
G. A. Silva (2006)
10.1016/j.addr.2008.03.014
Multifunctional magnetic nanoparticles for targeted imaging and therapy.
J. Mccarthy (2008)
10.1081/DDC-120001481
Nanoparticle Technology for Drug Delivery Across the Blood-Brain Barrier
P. Lockman (2002)
10.1021/bc049905i
Magneto/optical annexin V, a multimodal protein.
Eyk A Schellenberger (2004)
10.2214/ajr.152.1.167
Superparamagnetic iron oxide: pharmacokinetics and toxicity.
R. Weissleder (1989)
10.1021/ja026501x
Size-controlled synthesis of magnetite nanoparticles.
S. Sun (2002)
10.1021/nn800072t
Multifunctional inorganic nanoparticles for imaging, targeting, and drug delivery.
M. Liong (2008)
10.1007/s11095-008-9616-1
Click Chemistry, A Powerful Tool for Pharmaceutical Sciences
Christopher D. Hein (2008)
10.1055/S-2007-963409
Aptamer-based isolation and subsequent imaging of mesenchymal stem cells in ischemic myocard by magnetic resonance imaging.
R. Schaefer (2007)
Synthesis and surfacemodifications of iron oxide magnetic nanoparticles and applications on separation and analysis
Z. L. Zhao (2006)
Magneticnanoparticledesign formedical diagnosis and therapy
S. Vasseur (2002)
10.1016/J.JMMM.2008.02.115
Magnetic and relaxometric properties of polyethylenimine-coated superparamagnetic MRI contrast agents
Maurizio Corti (2008)
10.1002/JPS.21249
Magnetic colloids as drug vehicles.
J. D. Durán (2008)
10.1021/ja801482d
Ligand-directed nanobialys as theranostic agent for drug delivery and manganese-based magnetic resonance imaging of vascular targets.
D. Pan (2008)
10.1002/anie.200602866
Magnetic nanoparticles: synthesis, protection, functionalization, and application.
A. Lu (2007)
10.1016/S0142-9612(01)00267-8
Surface modification of superparamagnetic magnetite nanoparticles and their intracellular uptake.
Y. Zhang (2002)
10.1016/S0162-0134(03)00068-0
Formation of spherical iron(III) oxyhydroxide nanoparticles sterically stabilized by chitosan in aqueous solutions.
P. Sipos (2003)
10.1080/02656730802104757
Clinical applications of magnetic nanoparticles for hyperthermia
B. Thiesen (2008)
10.1126/science.1057553
Molecular Rulers for Scaling Down Nanostructures
A. Hatzor (2001)
10.1021/la052990d
Maghemite nanoparticles protectively coated with poly(ethylene imine) and poly(ethylene oxide)-block-poly(glutamic acid).
A. Thünemann (2006)
10.1016/0169-409X(95)00041-5
Exploiting bone marrow microvascular structure for drug delivery and future therapies
S. Moghimi (1995)
10.1016/j.biomaterials.2008.10.003
A ligand-mediated nanovector for targeted gene delivery and transfection in cancer cells.
O. Veiseh (2009)
Super - paramagnetic iron oxide nanoparticleaptamer bioconjugates for combined prostate cancer imaging and therapy
S. Y. Jon (2004)
10.1016/j.jmmm.2004.11.093
Synthesis of ferrofluid with magnetic nanoparticles by sonochemical method for MRI contrast agent
E. Kim (2005)
10.1021/bc980125h
High-efficiency intracellular magnetic labeling with novel superparamagnetic-Tat peptide conjugates.
L. Josephson (1999)
10.1016/J.ACTBIO.2007.05.011
Magnetic drug-targeting carrier encapsulated with thermosensitive smart polymer: core-shell nanoparticle carrier and drug release response.
J. Zhang (2007)
10.5040/9781474284028.0024
S
Ashish Kumar (1824)
Magneto/optical annexin V
E. A. Schellenberger (2004)
10.1021/bm0607527
One-pot synthesis of pegylated ultrasmall iron-oxide nanoparticles and their in vivo evaluation as magnetic resonance imaging contrast agents.
J. Lutz (2006)
10.1016/j.parkreldis.2007.11.012
Potential applications of nanotechnologies to Parkinson's disease therapy.
G. Linazasoro (2008)
10.1593/neo.05751
Fluorescent nanoparticle uptake for brain tumor visualization.
R. Tréhin (2006)
10.1021/la020322b
Synthesis and Magnetic Characterization of Zinc Ferrite Nanoparticles with Different Environments: Powder, Colloidal Solution, and Zinc Ferrite−Silica Core−Shell Nanoparticles
F. Grasset (2002)
10.1002/JMRI.21194
Coating thickness of magnetic iron oxide nanoparticles affects R2 relaxivity.
L. LaConte (2007)
10.1007/s10439-005-8976-5
A Theoretical Model for the Margination of Particles within Blood Vessels
P. Decuzzi (2005)
10.1038/nbt1340
Renal clearance of quantum dots
H. Choi (2007)
10.1002/smll.200600009
Methotrexate-immobilized poly(ethylene glycol) magnetic nanoparticles for MR imaging and drug delivery.
N. Kohler (2006)
10.3322/CA.2007.0003
Application of nanotechnology in cancer therapy and imaging.
X. Wang (2008)
10.1021/bc800077y
In vivo tumor cell targeting with "click" nanoparticles.
G. von Maltzahn (2008)
10.1515/9783111548050-024
M
M. Sankar (1824)
10.1016/j.mri.2004.01.050
MR imaging of the her2/neu and 9.2.27 tumor antigens using immunospecific contrast agents.
M. Funovics (2004)
Synthesis and surface-modifications of iron oxide magnetic nanoparticles and applications on separation and analysis
ZL Zhao (2006)
10.1002/smll.200701103
A multimodal targeting nanoparticle for selectively labeling T cells.
Jonathan W Gunn (2008)
One-pot synthesis of PEGylatedultrasmall iron-oxidenanoparticles and their invivoevaluationasmagnetic resonance imaging contrast agents
J. F. Lutz (2006)
Ef fi cient construction of therapeutics , bioconjugates , biomaterials and bioactive surfaces using azidealkyne " click " chemistry
Z. Zarafshani (2001)
10.2967/jnumed.108.051243
PET/MRI Dual-Modality Tumor Imaging Using Arginine-Glycine-Aspartic (RGD)–Conjugated Radiolabeled Iron Oxide Nanoparticles
Ha-young Lee (2008)
10.1002/(SICI)1521-3773(19981102)37:20<2754::AID-ANIE2754>3.0.CO;2-3
Polyvalent Interactions in Biological Systems: Implications for Design and Use of Multivalent Ligands and Inhibitors.
M. Mammen (1998)
10.2174/157341308783591861
Magnetic Nanoparticles for Cancer Therapy
G. F. Goya (2008)
10.1016/j.tibtech.2008.04.005
Multifunctional nanoparticles--properties and prospects for their use in human medicine.
Nuria Sanvicens (2008)
10.1016/j.carbpol.2007.01.006
N-Acylated chitosan stabilized iron oxide nanoparticles as a novel nano-matrix and ceramic modification
S. Bhattarai (2007)
10.2217/17435889.3.5.703
Clearance properties of nano-sized particles and molecules as imaging agents: considerations and caveats.
M. Longmire (2008)
10.1002/jgm.577
Insights into the mechanism of magnetofection using PEI-based magnetofectins for gene transfer.
S. Huth (2004)
10.1002/ADFM.200801844
PEI-PEG-Chitosan Copolymer Coated Iron Oxide Nanoparticles for Safe Gene Delivery: synthesis, complexation, and transfection.
Forrest M Kievit (2009)
10.1016/j.jmmm.2006.10.1194
Characterization of PEI-coated superparamagnetic iron oxide nanoparticles for transfection: Size distribution, colloidal properties and DNA interaction
B. Steitz (2007)
10.1089/cbr.2007.0410
Development of multivalent radioimmunonanoparticles for cancer imaging and therapy.
A. Natarajan (2008)
Lipidbased nanoparticles for contrast-enhanced MRI and molecular imaging
W.J.M. Mulder (2006)
Langmuir
S.-H Hu (2008)
10.1002/cbic.200300741
Optimal modification of annexin V with fluorescent dyes.
Eyk A Schellenberger (2004)
10.1177/153303460500400606
The Molecular Analysis of Breast Cancer Utilizing Targeted Nanoparticle Based Ultrasound Contrast Agents
Jason Sakamoto (2005)
10.1148/radiol.2301021493
Hepatocellular carcinoma: regional therapy with a magnetic targeted carrier bound to doxorubicin in a dual MR imaging/ conventional angiography suite--initial experience with four patients.
M. Wilson (2004)
10.1016/J.BIOMATERIALS.2007.08.050
Iron oxide nanoparticles as a drug delivery vehicle for MRI monitored magnetic targeting of brain tumors.
B. Chertok (2008)
10.1016/S0169-409X(00)00123-X
Polysaccharide colloidal particles as delivery systems for macromolecules.
K. Janes (2001)
10.1080/10611860701231810
Targeted nanoparticle-based drug delivery and diagnosis
D. Emerich (2007)
10.1016/j.addr.2006.09.009
Multifunctional nanocarriers.
V. Torchilin (2006)
10.1007/s00418-008-0511-y
Molecular imaging with nanoparticles: giant roles for dwarf actors
P. Debbage (2008)
Methotrexateimmobilized poly(ethylene glycol) magnetic nanoparticles for MR imaging and drug delivery
N. Kohler (2006)
10.1016/j.addr.2004.10.004
Nuclear delivery of macromolecules: barriers and carriers.
M. Belting (2005)
10.1158/0008-5472.CAN-03-3230
In Vivo Targeting of Underglycosylated MUC-1 Tumor Antigen Using a Multimodal Imaging Probe
A. Moore (2004)
10.1039/B810061F
Magnetic and pH-responsive nanocarriers with multilayer core–shell architecture for anticancer drug delivery
Miao Guo (2008)
10.1039/b617402g
Polyethyleneimine functionalized iron oxide nanoparticles as agents for DNA delivery and transfection
S. C. McBain (2007)
10.1007/s10439-005-9072-6
The Effective Dispersion of Nanovectors Within the Tumor Microvasculature
P. Decuzzi (2005)
10.1038/nnano.2007.70
Shape effects of filaments versus spherical particles in flow and drug delivery.
Y. Geng (2007)
10.1016/j.jmmm.2005.01.086
Synthesis of polyacrylamide modified magnetic nanoparticles and radiolabeling with 188Re for magnetically targeted radiotherapy
Chunfu Zhang (2005)
10.1016/S0378-5173(02)00267-3
Preparation, characterization and biodistribution of ultrafine chitosan nanoparticles.
Tanima Banerjee (2002)
10.1073/pnas.0509009103
Tissue biodistribution and blood clearance rates of intravenously administered carbon nanotube radiotracers.
R. Singh (2006)
10.1002/smll.200800646
Inhibition of tumor-cell invasion with chlorotoxin-bound superparamagnetic nanoparticles.
O. Veiseh (2009)
10.1016/j.ejca.2005.12.020
Clinical applications of newer radionuclide therapies.
B. Brans (2006)
10.1002/anie.200800857
Drug-loaded superparamagnetic iron oxide nanoparticles for combined cancer imaging and therapy in vivo.
M. Yu (2008)
Development and comparison of iron dextran products.
R. Lawrence (1998)
SUPERPARAMAGNETIC IRON-OXIDE - CLINICAL-APPLICATION AS A CONTRASTAGENTFORMRIMAGINGOFTHELIVER,Radiology168 (1988)297–301
D. D. Stark (1988)
10.1038/sj.bjc.6602668
Monoclonal antibody A7-superparamagnetic iron oxide as contrast agent of MR imaging of rectal carcinoma
Atsushi Toma (2005)
MR imaging of the her 2 / neu and 9 . 2 . 27 tumor antigens using immunospeci fi c contrast agents
H. S. Su (2005)
10.1002/mrm.1910290108
Selective MR imaging of labeled human peripheral blood mononuclear cells by liposome mediated incorporation of dextran-magnetite particles.
J. Bulte (1993)
10.1002/smll.200801789
Systematic surface engineering of magnetic nanoworms for in vivo tumor targeting.
J. Park (2009)
10.1016/j.addr.2007.11.007
Clinical toxicities of nanocarrier systems.
K. R. Vega-Villa (2008)
10.1038/nbt1159
Cell-specific targeting of nanoparticles by multivalent attachment of small molecules
R. Weissleder (2005)
10.1016/j.jmmm.2005.01.049
Synthesis of SPIO-chitosan microspheres for MRI-detectable embolotherapy
H. S. Lee (2005)
10.1016/j.biomaterials.2008.07.004
Magnetic nanoparticles with dual functional properties: drug delivery and magnetic resonance imaging.
Tapan Jain (2008)
10.1194/jlr.M700598-JLR200
Polyunsaturated phospholipids promote the oxidation and fragmentation of gamma-hydroxyalkenals: formation and reactions of oxidatively truncated ether phospholipids.
Xi Chen (2008)
Multifunctional inorganic nanoparticles for imaging
M. Liong (2008)
10.1002/smll.200700847
Linking proteins with anionic nanoparticles via protamine: ultrasmall protein-coupled probes for magnetic resonance imaging of apoptosis.
E. Schellenberger (2008)
10.1016/j.jmmm.2003.10.022
Preparation and radiolabeling of surface-modified magnetic nanoparticles with rhenium-188 for magnetic targeted radiotherapy
Jinquan Cao (2004)
10.1002/JBM.A.31724
Magnetic nanoparticles for improving cell invasion in tissue engineering.
Takuro Sasaki (2008)
TOPICAL REVIEW: Applications of magnetic nanoparticles in biomedicine
Q. Pankhurst (2003)
10.1515/9783111697888-004
B
B. A. R. Kernfach (1824)
10.1016/0730-725X(95)02106-4
In vivo evaluation of magnetite nanoparticles for use as a tumor contrast agent in MRI.
L. Tiefenauer (1996)
10.1016/j.chembiol.2006.11.015
The binding avidity of a nanoparticle-based multivalent targeted drug delivery platform.
Seungpyo Hong (2007)
10.1016/S0168-3659(01)00306-6
Delivery of molecular medicine to solid tumors: lessons from in vivo imaging of gene expression and function.
R. Jain (2001)
10.1088/0022-3727/36/13/202
The preparation of magnetic nanoparticles for applications in biomedicine
P. Tartaj (2003)
10.1016/j.biomaterials.2004.10.012
Synthesis and surface engineering of iron oxide nanoparticles for biomedical applications.
A. Gupta (2005)
10.1166/jnn.2006.443
Nanoparticles for cellular drug delivery: mechanisms and factors influencing delivery.
M. Chavanpatil (2006)
10.1002/chin.200135279
Click Chemistry: Diverse Chemical Function from a Few Good Reactions
H. Kolb (2001)
A multimodal nanoparticle for preoperative magnetic resonance imaging and intraoperative optical brain tumor delineation.
M. Kircher (2003)
10.1038/nnano.2006.170
In vivo biodistribution and highly efficient tumour targeting of carbon nanotubes in mice.
Z. Liu (2007)
10.1002/adma.200600385
Preparation of biocompatible magnetite nanocrystals for in vivo magnetic resonance detection of cancer
F. Hu (2006)
10.1002/ADMA.200701975
Controlled PEGylation of Monodisperse Fe3O4 Nanoparticles for Reduced Non‐Specific Uptake by Macrophage Cells
J. Xie (2007)
10.1038/nmat1251
Ultra-large-scale syntheses of monodisperse nanocrystals
Jongnam Park (2004)
10.1615/CritRevTherDrugCarrierSyst.v18.i6.30
Capture of stealth nanoparticles by the body's defences.
S. Moghimi (2001)
10.1039/B512605C
Size-controlled preparation of magnetite nanoparticles in the presence of graft copolymers
S. Wan (2006)
10.1021/cm070495s
Synthesis of ultrasensitive magnetic resonance contrast agents for cancer imaging using PEG-fatty acid
Jaemoon Yang (2007)
10.1088/0953-8984/18/38/S24
Drug loaded magnetic nanoparticles for cancer therapy
R. Jurgons (2006)
10.1038/nrc1566
Cancer nanotechnology: opportunities and challenges
M. Ferrari (2005)
10.1016/J.JVIROMET.2007.08.028
Laboratory formulated magnetic nanoparticles for enhancement of viral gene expression in suspension cell line.
S. Bhattarai (2008)
10.1016/S1567-2719(05)16005-3
chapter 5 Synthesis, Properties and Biomedical Applications of Magnetic Nanoparticles
P. Tartaj (2006)
Nanotoxicology - Interactions of Nanomaterials with Biological Systems American Scientific Publishers
Y. Zhao (2006)
Aptamerbased isolation and subsequent imaging of mesenchymal stem cells in ischemic myocard by magnetic resonance imaging
R Schafer (2007)
Drug - loaded superparamagnetic iron oxide nanoparticles for combined cancer imaging and therapy invivo , AngewandteChemie
Y. Y. Jeong (2008)
10.1158/1535-7163.MCT-06-0141
Nanotechnology in cancer therapeutics: bioconjugated nanoparticles for drug delivery
Rajni Sinha (2006)
10.1002/smll.200700784
In vivo MRI detection of gliomas by chlorotoxin-conjugated superparamagnetic nanoprobes.
C. Sun (2008)
10.1016/j.jmmm.2006.01.250
In situ hybridization to chitosan/magnetite nanocomposite induced by the magnetic field
B. Li (2006)
10.1016/j.apradiso.2004.03.114
Preparation and radiolabeling of human serum albumin (HSA)-coated magnetite nanoparticles for magnetically targeted therapy.
Zhang Chun-fu (2004)
10.1021/nl052396o
Determining the size and shape dependence of gold nanoparticle uptake into mammalian cells.
B. Chithrani (2006)
10.1038/nm1486
In vivo imaging of siRNA delivery and silencing in tumors
Z. Medarova (2007)
10.1227/01.neu.0000315995.73269.c3
Neurosurgery in the realm of 10(-9), Part 2: applications of nanotechnology to neurosurgery--present and future.
J. B. Elder (2008)
10.1016/j.jconrel.2007.05.027
Nanofabricated particles for engineered drug therapies: a preliminary biodistribution study of PRINT nanoparticles.
Stephanie E. A. Gratton (2007)
10.1039/B402025A
Magnetic nanoparticle design for medical diagnosis and therapy
S. Mornet (2004)
10.1016/J.IJPHARM.2007.05.018
Sterically stabilized superparamagnetic liposomes for MR imaging and cancer therapy: pharmacokinetics and biodistribution.
V. Plassat (2007)
10.1007/978-1-60761-901-7
Molecular Imaging
Kathryn E Luker (2011)
LHRHconjugated magnetic iron oxide nanoparticles for detection of breast cancer metastases
C. Leuschner (2006)
10.1002/cmdc.200800091
Superparamagnetic iron oxide nanoparticle-aptamer bioconjugates for combined prostate cancer imaging and therapy.
A. Wang (2008)
ULTRASMALL SUPERPARAMAGNETIC IRON-OXIDE - AN INTRAVENOUS etic nanoparticles for targeted drug delivery and imaging
R. Weissleder (1990)
Turn-on" magnetic resonance contrast agents based on aptamer-functionalized superparamagnetic iron oxide nanoparticles
M V Yigit (2007)
10.2217/17435889.2.2.153
Targeted delivery of multifunctional magnetic nanoparticles.
J. Mccarthy (2007)
10.1021/la702887m
Design and synthesis of novel magnetic core-shell polymeric particles.
Kin Man Ho (2008)
10.1021/bc000079x
Improvement of MRI probes to allow efficient detection of gene expression.
D. Högemann (2000)
10.1021/bc7003928
MRI detection of thrombin with aptamer functionalized superparamagnetic iron oxide nanoparticles.
M. V. Yigit (2008)
10.1016/S0304-8853(00)01255-5
Characterization and MRI study of surfactant-coated superparamagnetic nanoparticles administered into the rat brain
D. Kim (2001)
10.1088/0957-4484/19/30/305101
Physical characterization methods for iron oxide contrast agents encapsulated within a targeted liposome-based delivery system.
J. Dagata (2008)
10.1021/la0503451
Methotrexate-modified superparamagnetic nanoparticles and their intracellular uptake into human cancer cells.
N. Kohler (2005)
10.1002/jgm.419
IONP-PLL: a novel non-viral vector for efficient gene delivery.
Juan-Juan Xiang (2003)
10.2174/157341308783591843
Nanoprobes for Medical Diagnosis: Current Status of Nanotechnology in Molecular Imaging
E. Jones (2008)
10.3109/10611869808997890
Superparamagnetic agents in magnetic resonance imaging: physicochemical characteristics and clinical applications. A review.
B. Bonnemain (1998)
10.1016/0168-3659(90)90127-F
The clinical efficacy of poly(ethylene glycol)-modified proteins
Friedericka Fuertges (1990)
10.1166/JNN.2008.399
Magnetic nanoparticles for drug delivery applications.
Mini Namdeo (2008)
10.1126/science.1057553
Colloidal nanocrystal shape and size control: the case of cobalt.
V. Puntes (2001)
10.1201/9780203492321
Biomaterials for Delivery and Targeting of Proteins and Nucleic Acids
R. Mahato (2009)
Journal of Magnetism and Magnetic Materials. Volumes 198-199, 1 June 1999,
A. Freeman (1999)
Magnetic iron oxide nanoparticles: Synthesis
S. Laurent (2008)
10.1002/chin.200046244
Synthesis and Magnetic Studies of Uniform Iron Nanorods and Nanospheres.
†. Park (2000)
Efficient construction of therapeutics
J. F. Lutz (2008)
10.1016/J.BIOMATERIALS.2007.10.018
Determination of nanoparticle vehicle unpackaging by MR imaging of a T(2) magnetic relaxation switch.
In-Kyu Park (2008)
10.2217/17435889.2.1.23
Recent advances on surface engineering of magnetic iron oxide nanoparticles and their biomedical applications.
A. Gupta (2007)
10.1021/JP8029083
Reexamining the Effects of Particle Size and Surface Chemistry on the Magnetic Properties of Iron Oxide Nanocrystals: New Insights into Spin Disorder and Proton Relaxivity
Hongwei Duan (2008)
Synthesis and surface engineering of superparamagnetic nanoparticles
Randy De Palma (2005)
10.1016/j.colsurfb.2008.07.004
Biodistribution of colloidal gold nanoparticles after intravenous administration: effect of particle size.
Ganeshchandra Sonavane (2008)
10.1117/12.841168
Multifunctional inorganic nanoparticles for imaging, targeting, and drug delivery
Travis A. Pecorelli (2010)
10.1016/j.addr.2007.06.008
Endocytic mechanisms for targeted drug delivery.
Lisa Bareford (2007)
10.2214/ajr.152.1.175
The diagnosis of splenic lymphoma by MR imaging: value of superparamagnetic iron oxide.
R. Weissleder (1989)
10.2214/ajr.149.6.1161
Ferrite-enhanced MR imaging of hepatic lymphoma: an experimental study in rats.
R. Weissleder (1987)
10.1007/s10549-006-9199-7
LHRH-conjugated Magnetic Iron Oxide Nanoparticles for Detection of Breast Cancer Metastases
C. Leuschner (2006)
10.1016/j.biomaterials.2006.05.024
The adhesive strength of non-spherical particles mediated by specific interactions.
P. Decuzzi (2006)
USPTO. US Patent Application
J. Gao (2008)
10.3109/02652049609026013
Development of superparamagnetic nanoparticles for MRI: effect of particle size, charge and surface nature on biodistribution.
C. Chouly (1996)
10.1148/radiology.175.2.2326475
Ultrasmall superparamagnetic iron oxide: an intravenous contrast agent for assessing lymph nodes with MR imaging.
R. Weissleder (1990)
Synthesis and magnetic characterization of zinc ferrite nanoparticles with different environments: Powder
F. Grasset (2002)
10.1016/j.addr.2006.09.011
Nanomedicine: developing smarter therapeutic and diagnostic modalities.
O. Farokhzad (2006)
10.1073/pnas.95.8.4607
Regulation of transport pathways in tumor vessels: role of tumor type and microenvironment.
S. Hobbs (1998)
10.1179/095066004225021882
Chemically prepared magnetic nanoparticles
M. Willard (2004)
10.1002/mrm.1910400209
Targeting of ultrasmall superparamagnetic iron oxide (USPIO) particles to tumor cells in vivo by using transferrin receptor pathways.
M. Kresse (1998)
10.1053/j.ajkd.2008.08.001
Safety of ferumoxytol in patients with anemia and CKD.
A. Singh (2008)
10.1038/nrd1033
Effect of pegylation on pharmaceuticals
J. Harris (2003)
10.1016/j.tibtech.2008.01.002
Targeting tumors with peptides from natural sources.
Sujit K Bhutia (2008)
10.1038/nm1467
Artificially engineered magnetic nanoparticles for ultra-sensitive molecular imaging
Jaehyun Lee (2007)
10.1179/174328408X341690
Magnetic nanoparticle carrier for targeted drug delivery: perspective, outlook and design
R. Misra (2008)
10.1088/0957-4484/19/36/365603
Highly water-dispersible PEG surface modified ultra small superparamagnetic iron oxide nanoparticles useful for target-specific biomedical applications.
J. Park (2008)
10.1016/j.jconrel.2006.06.004
Template synthesis of multifunctional nanotubes for controlled release.
S. Son (2006)
10.1023/A:1011081210142
Development of Systems for Targeting the Regional Lymph Nodes for Diagnostic Imaging: In Vivo Behaviour of Colloidal PEG-Coated Magnetite Nanospheres in the Rat Following Interstitial Administration
L. Illum (2004)
10.1002/chin.200249024
Colloidal Synthesis and Self-Assembly of CoPt3 Nanocrystals.
E. Shevchenko (2002)
10.1016/j.addr.2008.04.013
Radionuclides delivery systems for nuclear imaging and radiotherapy of cancer.
M. Hamoudeh (2008)
10.1002/JBM.A.31752
Targeted folic acid-PEG nanoparticles for noninvasive imaging of folate receptor by MRI.
Ting-Jung Chen (2008)
10.1016/j.pharmthera.2004.08.001
Delivery of therapeutic agents to the central nervous system: the problems and the possibilities.
D. Begley (2004)
10.1021/cm049205n
Size-Controlled Synthesis of Magnetite Nanoparticles in the Presence of Polyelectrolytes
S. Si (2004)
10.1021/jm060515m
Multivalent effects of RGD peptides obtained by nanoparticle display.
X. Montet (2006)
10.1126/science.929199
Noninvasive, infrared monitoring of cerebral and myocardial oxygen sufficiency and circulatory parameters.
F. Jöbsis (1977)
10.1021/ja049195r
A bifunctional poly(ethylene glycol) silane immobilized on metallic oxide-based nanoparticles for conjugation with cell targeting agents.
N. Kohler (2004)
10.1016/S0927-7757(00)00633-6
Preparation of ultrafine silica- and PEG-coated magnetite particles
M. Butterworth (2001)
10.1016/0304-8853(93)91115-N
Colloidal magnetic resonance contrast agents: effect of particle surface on biodistribution
M. Papisov (1993)
10.2214/ajr.149.4.723
MR imaging of splenic metastases: ferrite-enhanced detection in rats.
R. Weissleder (1987)
10.1038/nrd2614
Nanoparticle therapeutics: an emerging treatment modality for cancer
M. Davis (2008)
10.1515/9783111548050-035
Z
Axel M. Gressner (2012)
10.1515/9783111576855-012
G
G.V.T.V. Weerasooriya (1824)
10.1007/978-0-387-85600-1_20
Applications of Magnetic Nanoparticles in Biomedicine
C. Bárcena (2003)
10.1002/CHIN.200837219
Synthesis, Properties and Biomedical Applications of Magnetic Nanoparticles.
P. Tartaj (2008)
10.1016/S1076-6332(03)80210-6
Crosslinked iron oxides (CLIO): a new platform for the development of targeted MR contrast agents.
P. Wunderbaldinger (2002)
10.1148/radiology.168.2.3393649
Superparamagnetic iron oxide: clinical application as a contrast agent for MR imaging of the liver.
David D. Stark (1988)
10.1016/J.MSEC.2007.06.004
Synthesis and characterization of the iron oxide magnetic particles coated with chitosan biopolymer
K. Donadel (2008)



This paper is referenced by
10.1016/J.COLSURFA.2011.06.017
Preparation and characterization of fluorescent silica coated magnetic hybrid nanoparticles
Kaliyaperumal Viswanathan (2011)
10.1201/B14594-5
Bioreceptor Functionalization of Gold-Coated Sensor Surfaces
Daria Prilutsky (2013)
10.1142/S2251237313500019
DOPAMINE SERVES AS A STABLE SURFACE MODIFIER FOR IRON OXIDE NANOPARTICLES
Xiaoqin Chi (2013)
10.2217/nnm.13.146
Thermal potentiation of chemotherapy by magnetic nanoparticles.
Madeline Torres-Lugo (2013)
10.1155/2013/680712
Use of Magnetic Folate-Dextran-Retinoic Acid Micelles for Dual Targeting of Doxorubicin in Breast Cancer
Jaleh Varshosaz (2013)
10.1007/s11051-014-2393-3
β-Cyclodextrin polymer brushes decorated magnetic colloidal nanocrystal clusters for the release of hydrophobic drugs
Shaonan Lv (2014)
10.1039/C4CE00582A
Fabrication and characterization of novel magnetic/luminescent multifunctional nanocomposites for controlled drug release
Shiyong Yu (2014)
10.1016/B978-1-78242-017-0.00006-4
Absorbable, drug-loaded, extruded fiber for implantation
K. Douglas Nelson (2015)
10.1016/J.JMMM.2014.04.006
Synthesis of magnetic multicomponent nanoparticles CuxNi1−xFe2O4
A. Bingolbali (2015)
10.3390/md12126038
Glycol Chitosan-Based Fluorescent Theranostic Nanoagents for Cancer Therapy
Jin-Kyu Rhee (2014)
10.1016/B978-0-444-59453-2.00004-4
Chapter 4 – Toxicity of Metal and Metal Oxide Nanoparticles
Hanna L Karlsson (2015)
10.1021/jp512782e
Cell Penetrating Peptide Adsorption on Magnetite and Silica Surfaces: A Computational Investigation.
Gianvito Grasso (2015)
10.1016/j.jconrel.2010.08.027
To exploit the tumor microenvironment: Passive and active tumor targeting of nanocarriers for anti-cancer drug delivery.
Fabienne Danhier (2010)
10.1038/s41598-020-69591-x
Plasma polymerized nanoparticles effectively deliver dual siRNA and drug therapy in vivo
P. Michael (2020)
10.1088/0957-4484/22/35/355602
Magnetic carbon nanotubes with particle-free surfaces and high drug loading capacity.
Eleni C. Vermisoglou (2011)
10.1021/JP210423A
Dual-Wavelength Detection of Rotational Diffusion of Single Anisotropic Nanocarriers on Live Cell Membranes
Ji Won Ha (2012)
10.1002/pmic.201500383
Highly efficient and selective enrichment of glycopeptides using easily synthesized magG/PDA/Au/l-Cys composites.
Runqing Wu (2016)
10.1109/NEMS.2017.8017116
Understanding drug delivery from a system perspective: Concept and demonstration
R. X. Yin (2017)
10.1007/s40843-017-9049-0
Magnetic drug delivery systems
Y. Liu (2017)
10.1016/J.JMMM.2015.10.007
Exchange spring like magnetic behavior in cobalt ferrite nanoparticles
M. Jay Chithra (2016)
10.1039/C6RA01557C
Marriage of antibody–drug conjugate with gold nanorods to achieve multi-modal ablation of breast cancer cells and enhanced photoacoustic performance
F. Cao (2016)
10.7150/thno.16562
Inhibition by Multifunctional Magnetic Nanoparticles Loaded with Alpha-Synuclein RNAi Plasmid in a Parkinson's Disease Model
Shuiqin Niu (2017)
10.3390/molecules24132509
Hemodynamic Effects on Particle Targeting in the Arterial Bifurcation for Different Magnet Positions
Sandor Bernad (2019)
10.1021/acsami.7b00459
Targeted Self-Healing by Magnetically Guiding Microcapsules.
Matthew D. Crall (2017)
10.1002/adfm.201909049
Recent Advances in Host–Guest Self‐Assembled Cyclodextrin Carriers: Implications for Responsive Drug Delivery and Biomedical Engineering
Jitendra Wankar (2020)
10.1039/c7sm01238a
Metal-based magnetic fluids with core-shell structure FeB@SiO2 amorphous particles.
Mengchun Yu (2017)
10.1080/09205063.2017.1409048
LyP-1-conjugated Fe3O4 nanoparticles suppress tumor growth by magnetic induction hyperthermia
Peishan Teo (2018)
10.1007/s13204-018-0798-5
Cyclodextrin–PEG conjugate-wrapped magnetic ferrite nanoparticles for enhanced drug loading and release
Israel V. M. V. Enoch (2018)
10.1016/J.JMMM.2017.11.009
Soapnut extract mediated synthesis of nanoscale cobalt substituted NdFeB ferromagnetic materials and their characterization
G. V. S. Rao (2018)
10.1088/0957-4484/24/1/015603
Preparation and in vitro evaluation of folate-receptor-targeted SPION-polymer micelle hybrids for MRI contrast enhancement in cancer imaging.
S. Mahajan (2013)
Design , fabrication and characterization of drug delivery systems based on lab-ona-chip technology
N. D. Nguyena (2013)
CRYSTALLINE STARCH CITRATE BIOPOLYMER NANORODS AS POTENTIAL STABILIZERS IN NANO AND MICRO EMULSIONS
Oluwaseyi D. Saliu (2017)
See more
Semantic Scholar Logo Some data provided by SemanticScholar