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Single And Repeated Dose Toxicity Of Mesoporous Hollow Silica Nanoparticles In Intravenously Exposed Mice.
Tianlong Liu, L. Li, X. Teng, Xinglu Huang, H. Liu, D. Chen, J. Ren, J. He, F. Tang
Published 2011 · Materials Science, Medicine
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Mesoporous hollow silica nanoparticles (MHSNs) are emerging as one of the new and promising nanomaterials for biomedical applications, but the biocompatibility of MHSNs in vivo has received little attention. In the present study, the systematic single and repeated dose toxicity, biodistribution and clearance of MHSNs in vivo were demonstrated after intravenous injection in mice. For single dose toxicity, lethal dose 50 (LD(50)) of 110 nm MHSNs was higher than 1000 mg/kg. Further repeated dose toxicity studies indicated no death was observed when mice were exposed to MHSNs at 20, 40 and 80 mg/kg by continuous intravenous administration for 14 days. These results suggest low toxicity of MHSNs when intravenous injection at single dose or repeated administrations. ICP-OES and TEM results show that the MHSNs mainly accumulate in mononuclear phagocytic cells in liver and spleen. In addition, these particles could be excreted from the body and the entire clearance time of the particles should be over 4 weeks. These findings would be useful for future development of nanotechnology-based drug delivery system and other biomedical applications.
This paper references
Silica nanoparticles as hepatotoxicants.
H. Nishimori (2009)
The biocompatibility of mesoporous silicates.
S. Hudson (2008)
Facile and Scalable Synthesis of Tailored Silica “Nanorattle” Structures
D. Chen (2009)
Effect of surface functionalization of MCM-41-type mesoporous silica nanoparticles on the endocytosis by human cancer cells.
I. Slowing (2006)
Ultrasmall, well-dispersed, hollow siliceous spheres with enhanced endocytosis properties.
J. Zhu (2010)
Ceramic-based nanoparticles entrapping water-insoluble photosensitizing anticancer drugs: a novel drug-carrier system for photodynamic therapy.
I. Roy (2003)
Biomedical applications and potential health risks of nanomaterials: molecular mechanisms.
S. Lanone (2006)
The biocompatibility of porous silicon in tissues of the eye.
S. Low (2009)
In vivo tissue response to resorbable silica xerogels as controlled-release materials.
S. Radin (2005)
Mesoporous silica nanoparticles inhibit cellular respiration.
Zhimin Tao (2008)
Co-delivery of doxorubicin and Bcl-2 siRNA by mesoporous silica nanoparticles enhances the efficacy of chemotherapy in multidrug-resistant cancer cells.
A. M. Chen (2009)
Photoinduced intracellular controlled release drug delivery in human cells by gold-capped mesoporous silica nanosphere.
Juan L Vivero-Escoto (2009)
Mesoporous silica nanoparticles for reducing hemolytic activity towards mammalian red blood cells.
I. Slowing (2009)
Nanomedicine: current status and future prospects
S. Moghimi (2005)
Clinical toxicities of nanocarrier systems.
K. R. Vega-Villa (2008)
Silica binding and toxicity in alveolar macrophages.
R. Hamilton (2008)
A polyamidoamine dendrimer-capped mesoporous silica nanosphere-based gene transfection reagent.
D. R. Radu (2004)
Nanotechnology and Nanotoxicology
J. Curtis (2006)
Hollow/rattle-type mesoporous nanostructures by a structural difference-based selective etching strategy.
Y. Chen (2010)
A template route to the preparation of mesoporous amorphous calcium silicate with high in vitro bone-forming bioactivity.
X. Li (2007)
Five-day inhalation toxicity study of three types of synthetic amorphous silicas in Wistar rats and post-exposure evaluations for up to 3 months.
J. Arts (2007)
Rattle-type Fe(3)O(4)@SiO(2) hollow mesoporous spheres as carriers for drug delivery.
Y. Zhu (2010)
Effects of nanomaterial physicochemical properties on in vivo toxicity.
Kristin L Aillon (2009)
Inclusion of poorly soluble drugs in highly ordered mesoporous silica nanoparticles.
M. Thomas (2010)
Nanotoxicity: the growing need for in vivo study.
H. C. Fischer (2007)
Nanomedicines and nanotoxicology: some physiological principles.
M. Garnett (2006)
The promotion of human malignant melanoma growth by mesoporous silica nanoparticles through decreased reactive oxygen species.
Xinglu Huang (2010)
Changing the dose metric for inhalation toxicity studies: Short-term study in rats with engineered aerosolized amorphous silica nanoparticles
C. Sayes (2010)
Stimuli-responsive controlled drug release from a hollow mesoporous silica sphere/polyelectrolyte multilayer core-shell structure.
Y. Zhu (2005)
Nanotoxicology: An Emerging Discipline Evolving from Studies of Ultrafine Particles
G. Oberdörster (2005)
The effect of the shape of mesoporous silica nanoparticles on cellular uptake and cell function.
Xinglu Huang (2010)
Novel drug delivery system of hollow mesoporous silica nanocapsules with thin shells: preparation and fluorescein isothiocyanate (FITC) release kinetics.
Y. Liu (2007)
Concepts of Nanoparticle Dose Metric and Response Metric
G. Oberdörster (2007)
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Y. Chen (2013)
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Mingchun Guo (2013)
Construction of a two-in-one liposomal system (TWOLips) for tumor-targeted combination therapy.
Tingting Su (2014)
Assessment of in vivo systemic toxicity and biodistribution of iron-doped silica nanoshells.
N. Mendez (2017)
Iron oxide nanoparticle encapsulated diatoms for magnetic delivery of small molecules to tumors.
T. Todd (2014)
Extra-Large Pore Mesoporous Silica Nanoparticles for Directing in Vivo M2 Macrophage Polarization by Delivering IL-4.
Dohyeong Kwon (2017)
Dual drug loaded vitamin D3 nanoparticle to target drug resistance in cancer
Sandeep Palvai (2014)
A progressive approach on zebrafish toward sensitive evaluation of nanoparticles' toxicity.
Yang Liu (2012)
Structural and Oxidative Changes in the Kidney of Crucian Carp Induced by Silicon-Based Quantum Dots
S. Petrache (2012)
Mimicking red blood cell lipid membrane to enhance the hemocompatibility of large-pore mesoporous silica.
R. Roggers (2014)
Paramagnetic hollow silica nanospheres for in vivo targeted ultrasound and magnetic resonance imaging.
Lu An (2014)
Improved Efficacy and Reduced Toxicity Using a Custom-Designed Irinotecan-Delivering Silicasome for Orthotopic Colon Cancer.
X. Liu (2019)
Composite phospholipid-coated hollow mesoporous silica nanoplatform with multi-stimuli responsiveness for combined chemo-photothermal therapy
Y. Wu (2020)
Efficacy-shaping nanomedicine by loading Calcium Peroxide into Tumor Microenvironment-responsive Nanoparticles for the Antitumor Therapy of Prostate Cancer
Di Wu (2020)
Analysis of SiO2 nanoparticles binding proteins in rat blood and brain homogenate
Kyu Hwan Shim (2014)
Biomedical application of mesoporous silica nanoparticles as delivery systems: a biological safety perspective.
S. Hosseinpour (2020)
The shape effect of mesoporous silica nanoparticles on biodistribution, clearance, and biocompatibility in vivo.
Xinglu Huang (2011)
Alteration of antioxidant enzymes and impairment of DNA in the SiO2 nanoparticles exposed zebra fish (Danio rerio)
R. Ramesh (2012)
Surface chemistry architecture of silica nanoparticles determine the efficiency of in vivo fluorescence lymph node mapping.
Marion Helle (2013)
THE APPLICATION OF NANOMATERIALS IN DIAGNOSIS AND TREATMENT FOR MALIGNANT PRIMARY BRAIN TUMORS
Ruichao Liang (2014)
Mesoporous Silica Nanoparticles: A Comprehensive Review on Synthesis and Recent Advances
Reema Narayan (2018)
Relationship between the glutathione-responsive degradability of thiol-organosilica nanoparticles and the chemical structures
Tomohiro Doura (2019)
Nanomedicine(s) under the microscope.
R. Duncan (2011)
Mesoporous silica nanoparticle is comparatively safer than zinc oxide nanoparticle which can cause profound steroidogenic effects on pregnant mice and male offspring exposed in utero
Nisha Bara (2018)
Hepatic distribution and toxicity of zirconia nanoparticles in vivo and in vitro
Ting Sun (2021)
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