← Back to Search
Biodegradable And Thermoreversible PCLA-PEG-PCLA Hydrogel As A Barrier For Prevention Of Post-operative Adhesion.
Z. Zhang, Jian Ni, L. Chen, Lin Yu, J. Xu, J. Ding
Published 2011 · Materials Science, Medicine
Download PDFAnalyze on Scholarcy
Biodegradable polymers can serve as barriers to prevent the post-operative intestinal adhesion. Herein, we synthesized a biodegradable triblock copolymer poly(ɛ-caprolactone-co-lactide)-b-poly(ethylene glycol)-b-poly(ɛ-caprolactone-co-lactide) (PCLA-PEG-PCLA). The concentrated polymeric aqueous solution was injectable, and a hydrogel could be rapidly formed due to percolation of a self-assembled micelle network at the body temperature without requirement of any chemical reactions. This physical hydrogel retained its integrity in vivo for a bit more than 6 weeks and was eventually degraded due to hydrolysis. The synthesized polymer exhibited little cytotoxicity and hemolysis; the acute inflammatory response after implanting the hydrogel was acceptable, and the degradation products were less acidic than those of other polyester-containing materials. A rabbit model of sidewall defect-bowel abrasion was employed, and a significant reduction of post-operative peritoneal adhesion has been found in the group of in situ formed PCLA-PEG-PCLA hydrogels.
This paper references
Prevention of postsurgical peritoneal adhesion formation by intraperitoneal administration of ibuprofen
Hiroyuku Orita (1987)
A thermosensitive chitosan-based hydrogel barrier for post-operative adhesions' prevention.
C. Wei (2009)
The prevention of peritoneal adhesions by in situ cross-linking hydrogels of hyaluronic acid and cellulose derivatives.
Taichi Ito (2007)
Use of chitosan membrane associated with polypropylene mesh to prevent peritoneal adhesion in rats.
N. Paulo (2009)
Mixing a sol and a precipitate of block copolymers with different block ratios leads to an injectable hydrogel.
Lin Yu (2009)
Composite prostheses used to repair abdominal wall defects: physical or chemical adhesion barriers?
J. Bellón (2005)
Optimization of photopolymerized bioerodible hydrogel properties for adhesion prevention.
A. S. Sawhney (1994)
Thermogelling Poly(caprolactone-b-ethylene glycol-b-caprolactone) Aqueous Solutions
S. J. Bae (2005)
Impact of order and disorder in RGD nanopatterns on cell adhesion.
Jinghuan Huang (2009)
Peritoneal adhesion prevention with an in situ cross-linkable hyaluronan gel containing tissue-type plasminogen activator in a rabbit repeated-injury model.
Y. Yeo (2007)
In situ cross-linkable hyaluronic acid hydrogels prevent post-operative abdominal adhesions in a rabbit model.
Y. Yeo (2006)
Local release of fibrinolytic agents for adhesion prevention.
J. L. Hill-West (1995)
Contemporary adhesion prevention.
G. Dizerega (1994)
A subtle end-group effect on macroscopic physical gelation of triblock copolymer aqueous solutions.
Lin Yu (2006)
Biodegradable and thermoreversible hydrogels of poly(ethylene glycol)-poly(epsilon-caprolactone-co-glycolide)-poly(ethylene glycol) aqueous solutions.
Zhi-Qiang Jiang (2008)
Poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) as an injectable implant system for prevention of post-surgical tissue adhesion.
Zhong-W. Dai (2009)
Postoperative pericardial adhesion prevention using Carbylan-SX in a rabbit model.
R. Connors (2007)
Evaluation of a bioabsorable polylactide film in a large animal model for the reduction of retrosternal adhesions.
J. Iliopoulos (2004)
Effects of porosity and pore size on in vitro degradation of three-dimensional porous poly(D,L-lactide-co-glycolide) scaffolds for tissue engineering.
Linbo Wu (2005)
Injectable block copolymer hydrogels for sustained release of a PEGylated drug.
Lin Yu (2008)
Complement activation on surfaces modified with ethylene glycol units.
Yusuke Arima (2008)
RNA interference targeting hypoxia inducible factor 1alpha reduces post-operative adhesions in rats.
T. Segura (2007)
Prevention of postsurgical abdominal intestinal adhesion by a novel biodegradable thermosensitive PECE hydrogel
B Yang (2010)
Prevention of postsurgical tissue adhesion by anti-inflammatory drug-loaded pluronic mixtures with sol-gel transition behavior.
S. Oh (2005)
Materials in surgery: a review of biomaterials in postsurgical tissue adhesion and seroma prevention.
Peter N. Zawaneh (2008)
Roles of Hydrophilic Homopolymers on the Hydrophobic-Association-Induced Physical Gelling of Amphiphilic Block Copolymers in Water
Huan Zhang (2008)
Comparison of covalently and physically cross-linked polyethylene glycol-based hydrogels for the prevention of postoperative adhesions in a rat model.
J. West (1995)
A-part gel-an efficient adhesion prevention barrier.
C. Weis (2007)
Prevention of peritoneal adhesions with an in situ cross-linkable hyaluronan hydrogel delivering budesonide.
Y. Yeo (2007)
Design of an injectable synthetic and biodegradable surgical biomaterial
Peter N. Zawaneh (2010)
Biodegradability and biocompatibility of thermoreversible hydrogels formed from mixing a sol and a precipitate of block copolymers in water.
Lin Yu (2010)
Nanostructured interfaces with RGD arrays to control cell–matrix interaction
Jinghuan Huang (2010)
Protein repellent properties of covalently attached PEG coatings on nanostructured SiO2-based interfaces. Biomaterials 2007;28:4739e47
J Blummel (2007)
Frequency- and Temperature-Dependent Rheological Properties of an Amphiphilic Block Co-polymer in Water and Including Cell-Culture Media
H. Zhang (2010)
A thermoreversible hydrogel as a biosynthetic bandage for corneal wound repair.
C. Pratoomsoot (2008)
Synthesis and characterization of biodegradable poly (ethylene glycol) and poly (caprolactone diol) end capped poly (propylene fumarate) cross linked amphiphilic hydrogel as tissue engineering scaffold material
L. Krishna (2009)
In vitro degradation of three-dimensional porous poly(D,L-lactide-co-glycolide) scaffolds for tissue engineering.
Linbo Wu (2004)
Polymers in the prevention of peritoneal adhesions.
Y. Yeo (2008)
Efficacy of adhesion barriers. Resorbable hydrogel, oxidized regenerated cellulose and hyaluronic acid.
J. West (1996)
Tissue anti-adhesion potential of ibuprofen-loaded PLLA-PEG diblock copolymer films.
J. Lee (2005)
The prevention of peritoneal intestinal adhesion by in situ cross - linking hydrogels of hyaluronic acid and cellulose derivatives
T Ito (2007)
The regulation of stem cell differentiation by cell-cell contact on micropatterned material surfaces.
Jian Tang (2010)
Biodegradable block copolymers as injectable drug-delivery systems
B. Jeong (1997)
Thermoreversible Gelation of PEG−PLGA−PEG Triblock Copolymer Aqueous Solutions
B. Jeong (1999)
Prevention of post-surgical abdominal adhesions by a novel biodegradable thermosensitive PECE hydrogel.
B. Yang (2010)
Prevention of postoperative pericardial adhesions using tissue-protective solutions.
J. Seeger (1997)
Injectable in situ cross-linking hydrogels for local antifungal therapy.
S. Hudson (2010)
Injectable hydrogels as unique biomedical materials.
Lin Yu (2008)
Synthesis, swelling behavior, and biocompatibility of novel physically cross-linked polyurethane-block-poly(glycerol methacrylate) hydrogels.
K. Mequanint (2006)
Critical areas of cell adhesion on micropatterned surfaces.
C. Yan (2011)
Effects of contractubex on the prevention of postoperative peritoneal adhesion.
E. Aysan (2010)
Evaluation of the antiadhesion potential of UV cross-linked gelatin films in a rat abdominal model.
S. Matsuda (2002)
Temperature‐induced spontaneous sol–gel transitions of poly(D,L‐lactic acid‐co‐glycolic acid)‐b‐poly(ethylene glycol)‐b‐poly(D,L‐lactic acid‐co‐glycolic acid) triblock copolymers and their end‐capped derivatives in water
L. Yu (2007)
Comparison of covalently and physically cross-linked polyethylene glycol-based hydrogels for the prevention of postoperative intestinal adhesion in a rat model. Biomaterials 1995;16:1153e6
JL West (1995)
Evaluation of a bioresorbable polylactide sheet for the reduction of pelvic soft tissue attachments in a porcine animal model.
W. Walsh (2006)
Biodegradable in situ gel-forming controlled drug delivery system based on thermosensitive PCL-PEG-PCL hydrogel. Part 2: sol-gel-sol transition and drug delivery behavior.
C. Gong (2009)
Poloxamer 407 as an Intraperitoneal Barrier Material for the Prevention of Postsurgical Adhesion Formation and Reformation in Rodent Models for Reproductive Surgery
A. Steinleitner (1991)
Thermogelling hydrogels of poly(ε‐caprolactone‐co‐D,L‐lactide)–poly(ethylene glycol)–poly(ε‐caprolactone‐co‐D,L‐lactide) and poly(ε‐caprolactone‐co‐L‐lactide)–poly(ethylene glycol)–poly(ε‐caprolactone‐co‐L‐lactide) aqueous solutions
Zhi-Qiang Jiang (2007)
Acute toxicity evaluation of biodegradable in situ gel-forming controlled drug delivery system based on thermosensitive PEG-PCL-PEG hydrogel.
C. Gong (2009)
The prevention of peritendinous adhesions by a phospholipid polymer hydrogel formed in situ by spontaneous intermolecular interactions.
N. Ishiyama (2010)
Effects of immobilizing sites of RGD peptides in amphiphilic block copolymers on efficacy of cell adhesion.
Z. Zhang (2010)
The biological performance of cell-containing phospholipid polymer hydrogels in bulk and microscale form.
Y. Xu (2010)
cacy of adhesion barriers - Resorbable hydrogel , oxidized regenerated cellulose and hyaluronic acid
JL West (1996)
Protein repellent properties of covalently attached PEG coatings on nanostructured SiO(2)-based interfaces.
J. Blümmel (2007)
Poly(vinyl alcohol) membranes for adhesion prevention.
C. Weis (2004)
In situ cross - linkable hyaluronic acid hydrogels prevent post - operative abdominal intestinal adhesion in a rabbit model
Y Yeo (2006)
Dextran-based in situ cross-linked injectable hydrogels to prevent peritoneal adhesions.
Taichi Ito (2007)
Peritoneal adhesion prevention with an in situ cross-linkable hyaluronan gel containing tissuetype plasminogen activator in a rabbit repeated-injury model. Biomaterials 2007;28:3704e13
Y Yeo (2007)
Biodegradable block copolymers for delivery of proteins and water-insoluble drugs.
G. Zentner (2001)
Novel macromolecular crosslinking hydrogel to reduce intra-abdominal adhesions.
Christine A. Falabella (2010)
This paper is referenced by
Peritoneal Adhesions: Occurrence, Prevention and Experimental Models.
Jingyi Tang (2020)
Biodegradation and In Vitro Biocompatibility of Polyperoxides: Alternating Co-Polymers of Vinyl Monomers and Molecular Oxygen
Sunirmal Pal (2012)
Polymer hybrid magnetic nanocapsules encapsulating IR820 and PTX for external magnetic field-guided tumor targeting and multifunctional theranostics.
J. Liao (2017)
Emerging Perspectives in the Synthesis of Novel Degradable Biomedical Copolymers
Xiong-Yan Zhao (2015)
Sustained subconjunctival delivery of cyclosporine A using thermogelling polymers for glaucoma filtration surgery.
J. Sun (2017)
Intra-articular Drug Delivery Systems for the Treatment of Osteoarthritis
M. Sandker (2019)
Biomimetic honeycomb-patterned surface as the tunable cell adhesion scaffold.
S. Chen (2015)
Design and Characterization of a PVLA-PEG-PVLA Thermosensitive and Biodegradable Hydrogel
A. Vidyasagar (2017)
A methylcellulose and collagen based temperature responsive hydrogel promotes encapsulated stem cell viability and proliferation in vitro
Christina M Payne (2016)
FRET-enabled monitoring of the thermosensitive nanoscale assembly of polymeric micelles into macroscale hydrogel and sequential cognate micelles release.
P. Huang (2017)
Biodegradable Polymeric Films and Membranes Processing and Forming for Tissue Engineering
R. Suntornnond (2015)
Comparative studies of thermogels in preventing post-operative adhesions and corresponding mechanisms.
Lin Yu (2014)
Sol–gel transition of PEG–PAF aqueous solution and its application for hGH sustained release
U. P. Shinde (2012)
Injectable Hydrogels by Physical Crosslinking
Matthew J. Glassman (2016)
A postoperative anti-adhesion barrier based on photoinduced imine-crosslinking hydrogel with tissue-adhesive ability.
Yunlong Yang (2017)
Effects of cell-cell contact and oxygen tension on chondrogenic differentiation of stem cells.
B. Cao (2015)
A hydrolytically‐tunable photocrosslinked PLA‐PEG‐PLA/PCL‐PEG‐PCL dual‐component hydrogel that enhances matrix deposition of encapsulated chondrocytes
Sydney Peng (2017)
Metal and light free “click” hydrogels for prevention of post-operative peritoneal adhesions
W. Zhu (2014)
Thermosensitive methyl cellulose-based injectable hydrogels for post-operation anti-adhesion.
Y. Zhang (2014)
Soft Artificial Bladder Detrusor
X. Yang (2018)
Functional and Biomimetic Materials for Engineering of the Three-Dimensional Cell Microenvironment.
G. Huang (2017)
Polycaprolactone: a biodegradable polymer with its application in the field of self-assembly study
Piyali Mandal (2020)
Prevention of intra-abdominal adhesion using electrospun PEG/PLGA nanofibrous membranes.
J. Li (2017)
Injectable implants for the sustained release of protein and peptide drugs.
P. Agarwal (2013)
Hydrogels For Peptide Hormones Delivery: Therapeutic And Tissue Engineering Applications
Mohsen Doostmohammadi (2019)
Ibuprofen-Loaded Hyaluronic Acid Nanofibrous Membranes for Prevention of Postoperative Tendon Adhesion through Reduction of Inflammation
C. Chen (2019)
Barriers to Prevent Tissue Adhesion
Shuko Suzuki (2012)
Reducing the Oxidation Level of Dextran Aldehyde in a Chitosan/Dextran-Based Surgical Hydrogel Increases Biocompatibility and Decreases Antimicrobial Efficacy
Maggie Chan (2015)
Tissue engineering scaffolds of mesoporous magnesium silicate and poly(ε-caprolactone)–poly(ethylene glycol)–poly(ε-caprolactone) composite
D. He (2014)
5-Fluorouracil loaded thermosensitive PLGA–PEG–PLGA hydrogels for the prevention of postoperative tendon adhesion
Baoming Yuan (2015)
Pansement pour la cicatrisation de plaies compromises
Felisa Reyes Ortega (2013)
Smart Hydrogels – Synthetic Stimuli-Responsive Antitumor Drug Release Systems
Adam Kasiński (2020)See more