Online citations, reference lists, and bibliographies.
← Back to Search

Strategies For The Nanoencapsulation Of Hydrophilic Molecules In Polymer-based Nanoparticles.

S. Vrignaud, J. Benoit, P. Saulnier
Published 2011 · Materials Science, Medicine

Cite This
Download PDF
Analyze on Scholarcy
Share
Hydrophilic drug delivery still remains a challenge; this either being attributed to the fragility and poor cellular penetration of macromolecules, or to the unsuitable pharmacokinetics and toxicity of small drugs, for instance anticancer agents. By offering more favourable pharmacokinetics and protection of the drug, encapsulation in polymer nanoparticles constitutes an attractive possibility to overcome these problems. This review provides an overview of the strategies that have been developed for encapsulating hydrophilic molecules in polymer-containing nanoparticles, e.g. nanospheres and nanocapsules. Polymer nanospheres are loaded either by drug entrapment (by pH modification, use of reverse micelles or the addition of a polyanion) and generally produce a poor level of entrapment efficiency, or molecule sorption onto the nanosphere surface (by pH modification, use of high drug concentration, or ion-pair formation) with the drawbacks of a less-well protected drug from degradation and a faster drug release. Another strategy consists of the use of aqueous-core nanocapsules, generally surrounded by a thin polymer layer, in which hydrophilic molecules are directly solubilised in internal water, and are thus entrapped within the nanocapsule core, assuring drug protection and sustained release. Nanocapsules require less polymer compared to nanospheres; on the other hand, when the drug is entrapped, it has to be added before or during the formulation process, and is thus likely to be degraded. Overall, drug encapsulation in polymer nanoparticles provides a better pharmacokinetic profile and bioavailability, enhanced anticancer activity, reduced drug toxicity and modified drug distribution as compared to free drugs.
This paper references
Formation and stability of nano-emulsions prepared using the phase inversion temperature method. Langmuir 2002;18:26e30
P Izquierdo (2002)
10.1517/17425240902870413
Poly(alkycyanoacrylate) nanoparticles for enhanced delivery of therapeutics – is there real potential?
A. Graf (2009)
10.1016/S0378-5173(97)00138-5
Ciproflexacin-loaded polyisobutylcyanoacrylate nanoparticles: Preparation and characterization
F. Fawaz (1997)
10.1016/J.JCONREL.2006.09.016
Hybrid polymer nanocapsules enhance in vitro delivery of azidothymidine-triphosphate to macrophages.
H. Hillaireau (2006)
10.1021/CM8012792
Hydrophilic Nanoreservoirs Embedded into Polymeric Micro/Nanoparticles: An Approach To Compatibilize Polar Molecules with Hydrophobic Matrixes
H. Gao (2008)
10.1002/MABI.200500178
Polymeric nanocapsules containing an antiseptic agent obtained by controlled nanoprecipitation onto water-in-oil miniemulsion droplets.
Umaporn Paiphansiri (2006)
10.1016/J.JCONREL.2006.04.017
Polyionic hydrocolloids for the intestinal delivery of protein drugs: alginate and chitosan--a review.
M. George (2006)
10.1080/02652040600776424
Alkylcyanoacrylate nanocapsules prepared from mini-emulsions: A comparison with the conventional approach
N. Altinbas (2006)
10.1002/APP.32789
Doxorubicin loading and in vitro release from poly(alkylcyanoacrylate) nanoparticles produced by redox radical emulsion polymerization
Khairallah Alhareth (2011)
10.1016/S0169-409X(03)00041-3
Poly(alkylcyanoacrylates) as biodegradable materials for biomedical applications.
C. Vauthier (2003)
10.1208/s12248-008-9013-z
Nanoparticles Containing Anti-inflammatory Agents as Chemotherapy Adjuvants: Optimization and In Vitro Characterization
X. Lu (2008)
10.1023/A:1018908421434
Biodegradable Nanoparticles Containing Doxorubicin-PLGA Conjugate for Sustained Release
H. Yoo (2004)
A new nanocapsule formulation with hydrophilic core : Application to the oral administration of salmon calcitonin in rats
H. Vranckx (1996)
10.1155/2011/939851
A Review on Composite Liposomal Technologies for Specialized Drug Delivery
M. S. Mufamadi (2011)
10.1016/J.NANO.2005.12.003
Nanoencapsulation I. Methods for preparation of drug-loaded polymeric nanoparticles.
C. Reis (2006)
10.1016/j.jconrel.2008.02.007
Design and production of nanoparticles formulated from nano-emulsion templates-a review.
N. Anton (2008)
10.1023/A:1007582332491
Polyisobutylcyanoacrylate Nanocapsules Containing an Aqueous Core as a Novel Colloidal Carrier for the Delivery of Oligonucleotides
G. Lambert (2004)
Methods for preparation of drug - loaded polymeric nanoparticles
C PintoReis (2006)
10.1615/CRITREVTHERDRUGCARRIERSYST.V19.I2.10
Nanocapsule technology: a review.
P. Couvreur (2002)
10.1016/j.ejps.2009.04.004
Quantifying drug release from PLGA nanoparticulates.
O. Corrigan (2009)
10.1002/CHIN.201120269
Techniques for Efficient Entrapment of Pharmaceuticals in Biodegradable Solid Micro/Nanoparticles
T. Ishihara (2011)
10.1016/J.ADDR.2007.04.007
Solid lipid nanoparticles as a drug delivery system for peptides and proteins.
A. Almeida (2007)
10.2174/156720105774370267
Engineering of nanoemulsions for drug delivery.
Dipak K. Sarker (2005)
10.1021/MA100481S
Controlled Release from Polyurethane Nanocapsules via pH-, UV-Light- or Temperature-Induced Stimuli
Eva-Maria Rosenbauer (2010)
10.1016/0378-5173(90)90024-X
Design of nanoparticles of less than 50 nm diameter: preparation, characterization and drug loading
B. Seijo (1990)
10.1021/LA010808C
Formation and Stability of Nano-Emulsions Prepared Using the Phase Inversion Temperature Method
P. Izquierdo (2002)
10.1002/mabi.200800293
Fluorescent polyurethane nanocapsules prepared via inverse miniemulsion: surface functionalization for use as biocarriers.
Umaporn Paiphansiri (2009)
10.1016/j.ijpharm.2010.08.022
Chitosan as a carrier for targeted delivery of small interfering RNA.
W. Rudzinski (2010)
10.1517/17425240802680169
Current approaches to stabilising and analysing proteins during microencapsulation in PLGA
C. F. van der Walle (2009)
Preparation and in vitro-in vivo evaluation of salmon calcitonin-loaded polymeric nanoparticles
E Glowka (2010)
Excitation-contraction coupling in heart. 3. Evidence against the involvement of adenosine cyclic 3',5'-monophosphate in calcium transport by sarcotubular vesicles of canine myocardium.
P. Sulakhe (1970)
10.1016/j.ijpharm.2010.03.063
Nanoparticles with dextran/chitosan shell and BSA/chitosan core--doxorubicin loading and delivery.
Jianing Qi (2010)
10.1016/S0168-3659(00)00339-4
Biodegradable polymeric nanoparticles as drug delivery devices.
K. Soppimath (2001)
10.1021/mp900015y
The first targeted delivery of siRNA in humans via a self-assembling, cyclodextrin polymer-based nanoparticle: from concept to clinic.
M. Davis (2009)
10.1080/10611860903105739
Polymeric nanoparticulate system augmented the anticancer therapeutic efficacy of gemcitabine
J. L. Arias (2009)
10.1016/S0142-9612(00)00286-6
Poly n-butyl cyanoacrylate nanoparticles: a mechanistic study of polymerisation and particle formation.
N. Behan (2001)
10.1016/J.ADDR.2007.04.008
Chemotherapy with anticancer drugs encapsulated in solid lipid nanoparticles.
H. L. Wong (2007)
10.1517/17425240902870413
Poly(alkylcyanoacrylate) nanoparticles for enhanced delivery of therapeutics - is there real potential?
A. Graf (2009)
10.1007/s11095-008-9763-4
Design of Biodegradable Nanoparticles for Oral Delivery of Doxorubicin: In vivo Pharmacokinetics and Toxicity Studies in Rats
D. R. Kalaria (2008)
10.1021/la9017097
Surface-active monomer as a stabilizer for polyurea nanocapsules synthesized via interfacial polyaddition in inverse miniemulsion.
Eva-Maria Rosenbauer (2009)
10.1016/j.ejps.2008.01.013
Protein delivery using nanoparticles based on microemulsions with different structure-types.
A. Graf (2008)
10.1016/B978-075065148-6/50001-5
Introduction to plastics
T. Szabo (2005)
10.1007/S00396-004-1173-5
In vitro release of protein from poly(butylcyanoacrylate) nanocapsules with an aqueous core
S. Li (2005)
10.1016/S0376-7388(01)00385-4
Formation of aqueous core polyamide microcapsules obtained via interfacial polycondensation
N. Zydowicz (2001)
10.1002/CHIN.199349286
Development of a New Drug Carrier Made from Alginate.
M. Rajaonarivony (1993)
10.1211/0022357044418
Development of a single‐dose stabilized poly(d,l‐lactic‐co‐glycolic acid) microspheres‐based vaccine against hepatitis B
K. S. Jaganathan (2004)
10.1007/s11095-006-9203-2
Surfactant-polymer Nanoparticles: A Novel Platform for Sustained and Enhanced Cellular Delivery of Water-soluble Molecules
M. Chavanpatil (2006)
10.1016/j.ejpb.2010.11.008
High loading efficiency and sustained release of siRNA encapsulated in PLGA nanoparticles: quality by design optimization and characterization.
D. Cun (2011)
10.1016/S0168-3659(01)00218-8
PEGylated PLGA nanoparticles as protein carriers: synthesis, preparation and biodistribution in rats.
Y. Li (2001)
10.1016/J.MEMSCI.2008.09.002
Interfacial polycondensation—modeling of kinetics and film properties
S. Dhumal (2008)
Anthracycline-induced cardiotoxicity and the cardiac-sparing effect of liposomal formulation
A. Rahman (2007)
10.1002/MASY.200750508
Antiseptic Nanocapsule Formation via Controlling Polymer Deposition onto Water‐in‐Oil Miniemulsion Droplets
Umaporn Paiphansiri (2007)
10.1007/2882_2008_089
Synthesis of Poly(butylcyanoacrylate) Nanocapsules by Interfacial Polymerization in Miniemulsions for the Delivery of DNA Molecules
A. Musyanovych (2008)
10.1021/la901565q
Aqueous-core lipid nanocapsules for encapsulating fragile hydrophilic and/or lipophilic molecules.
N. Anton (2009)
10.1016/S0168-3659(97)00246-0
Biodegradable polyalkylcyanoacrylate nanoparticles for the delivery of oligonucleotides.
E. Fattal (1998)
10.1080/10611860701539584
Enhanced permeability and retention of macromolecular drugs in solid tumors: A royal gate for targeted anticancer nanomedicines
K. Greish (2007)
10.1016/S0376-7388(96)00171-8
Release rates from semi-crystalline polymer microcapsules formed by interfacial polycondensation
S. Yadav (1997)
10.1016/J.JCONREL.2007.09.013
Nano/micro technologies for delivering macromolecular therapeutics using poly(D,L-lactide-co-glycolide) and its derivatives.
R. C. Mundargi (2008)
10.1016/J.NANO.2006.04.009
Nanoencapsulation II. Biomedical applications and current status of peptide and protein nanoparticulate delivery systems.
C. Reis (2006)
10.1016/j.ijpharm.2008.06.011
State of the art and perspectives for the delivery of antisense oligonucleotides and siRNA by polymeric nanocarriers.
E. Fattal (2008)
10.1111/j.2042-7158.1986.tb04547.x
Polyalkyl cyanoacrylate nanocapsules
M. El-Samaligy (1986)
10.1016/j.cis.2010.02.006
On inverse miniemulsion polymerization of conventional water-soluble monomers.
I. Capek (2010)
10.1016/J.EJPB.2007.04.007
Nanoparticles based on the complex of chitosan and polyaspartic acid sodium salt: preparation, characterization and the use for 5-fluorouracil delivery.
Y. Zheng (2007)
10.1211/jpp.61.02.0001
Review: doxorubicin delivery systems based on chitosan for cancer therapy
M. Tan (2009)
10.1016/S0378-5173(00)00624-4
Polyisobutylcyanoacrylate nanocapsules containing an aqueous core for the delivery of oligonucleotides.
G. Lambert (2001)
10.1016/j.addr.2008.08.002
Hydrogel nanoparticles in drug delivery.
M. Hamidi (2008)
10.1021/la904380k
Narrowly size-distributed cobalt salt containing poly(2-hydroxyethyl methacrylate) particles by inverse miniemulsion.
Z. Cao (2010)
10.1146/ANNUREV.MATSCI.36.032905.091025
SYNTHESIS OF COLLOIDAL PARTICLES IN MINIEMULSIONS
K. Landfester (2006)
10.1007/s11095-009-0043-8
New Core-Shell Nanoparticules for the Intravenous Delivery of siRNA to Experimental Thyroid Papillary Carcinoma
H. Martimprey (2009)
10.1021/LA00074A001
Organized surfactant systems: microemulsions
K. Shinoda (1987)
An introduction to plastics
H. Elias (1993)
10.1016/J.IJPHARM.2006.07.006
Encapsulation of antiviral nucleotide analogues azidothymidine-triphosphate and cidofovir in poly(iso-butylcyanoacrylate) nanocapsules.
H. Hillaireau (2006)
10.1002/JPS.20961
Polymer-surfactant nanoparticles for sustained release of water-soluble drugs.
M. Chavanpatil (2007)
10.1023/A:1016121319668
A Novel Phase Inversion-Based Process for the Preparation of Lipid Nanocarriers
B. Heurtault (2004)
10.1006/BBRC.2000.3963
EWS fli-1 antisense nanocapsules inhibits ewing sarcoma-related tumor in mice.
G. Lambert (2000)
10.1016/J.JBIOTEC.2008.07.311
Formation and stability of new palm-based nanoemulsions
M. Basri (2008)
10.1016/j.ejpb.2008.11.012
Development of new lipid-based paclitaxel nanoparticles using sequential simplex optimization.
X. Dong (2009)
10.1016/j.colsurfb.2009.09.001
Biodegradable polymeric nanoparticles based drug delivery systems.
A. Kumari (2010)
10.1023/A:1007574030674
Preparation of Biodegradable Insulin Nanocapsules from Biocompatible Microemulsions
Suchat Watnasirichaikul (2004)
10.2165/00137696-200402040-00005
Entrapment of bioactive molecules in poly (alkylcyanoacrylate) nanoparticles
K. Krauel (2004)
10.1016/J.CIS.2003.10.023
Formation and stability of nano-emulsions.
T. Tadros (2004)
10.1016/S0378-5173(02)00002-9
Effects of formulation variables on characteristics of poly (ethylcyanoacrylate) nanocapsules prepared from w/o microemulsions.
S. Watnasirichaikul (2002)
10.1016/S0939-6411(01)00245-4
Factors influencing the entrapment of hydrophilic compounds in nanocapsules prepared by interfacial polymerisation of water-in-oil microemulsions.
T. Pitaksuteepong (2002)
10.3109/02652041003638158
Influence of the chitosan nature on the transfection efficacy of DNA-loaded nanoparticles after hydrodynamic administration in mice
Miguel N. Centelles (2010)
10.1007/s10269-009-1842-6
Nanotechnologies et cancer
G. Dine (2009)
10.3109/02652040902751125
Preparation and in vitro–in vivo evaluation of salmon calcitonin-loaded polymeric nanoparticles
Eliza Główka (2010)
10.1016/j.peptides.2010.10.003
Development of peptide and protein nanotherapeutics by nanoencapsulation and nanobioconjugation
S. C. Yadav (2011)
10.1049/iet-nbt.2009.0014
Hepatocyte growth factor incorporated chitosan nanoparticles differentiate murine bone marrow mesenchymal stem cell into hepatocytes in vitro.
S. Pulavendran (2010)
10.1016/S0076-6879(05)91004-5
The liposomal formulation of doxorubicin.
S. Abraham (2005)
10.1211/jpp/60.12.0004
Comparison of chitosan nanoparticles and chitosan hydrogels for vaccine delivery.
S. Gordon (2008)
10.1007/s11095-006-9901-9
Efficacy of siRNA Nanocapsules Targeted Against the EWS–Fli1 Oncogene in Ewing Sarcoma
N. Toub (2006)
10.1021/bm800664c
Physicochemical characteristics and preliminary in vivo biological evaluation of nanocapsules loaded with siRNA targeting estrogen receptor alpha.
C. Bouclier (2008)
10.1111/j.1476-5381.2009.00148.x
Nanotechnologies and controlled release systems for the delivery of antisense oligonucleotides and small interfering RNA
E. Fattal (2009)
10.1016/S0168-3659(01)00397-2
Poly(lactic acid)-poly(ethylene glycol) nanoparticles as new carriers for the delivery of plasmid DNA.
C. Pérez (2001)
10.1016/J.COLSURFB.2007.09.018
Poly(alkylcyanoacrylate) colloidal particles as vehicles for antitumour drug delivery: a comparative study.
J. L. Arias (2008)
10.1016/J.MSEC.2005.10.022
Simultaneous emulsification and interfacial polycondensation for the preparation of colloidal suspensions of nanocapsules
K. Bouchemal (2006)
10.1016/0169-409X(95)00026-4
The controlled intravenous delivery of drugs using PEG-coated sterically stabilized nanospheres.
R. Gref (1995)
10.3748/WJG.V5.I1.57
Preparation and distribution of 5-fluorouracil (125)I sodium alginate-bovine serum albumin nanoparticles.
Yi-Mu Yi (1999)
10.1111/j.2042-7158.1979.tb13510.x
Polycyanoacrylate nanocapsules as potential lysosomotropic carriers: preparation, morphological and sorptive properties
P. Couvreur (1979)
10.1081/DDC-100102197
Encapsulation of hydrophilic and lipophilic drugs in PLGA nanoparticles by the nanoprecipitation method.
J. Barichello (1999)
10.1016/J.IJPHARM.2006.12.023
Ftorafur loading and controlled release from poly(ethyl-2-cyanoacrylate) and poly(butylcyanoacrylate) nanospheres.
J. L. Arias (2007)
10.1002/1097-4628(20001017)78:3<517::AID-APP60>3.0.CO;2-3
DOXORUBICIN-LOADED POLY(BUTYLCYANOACRYLATE) NANOPARTICLES PRODUCED BY EMULSIFIER-FREE EMULSION POLYMERIZATION
S. C. Yang (2000)
10.1021/MA050661M
An effective method for preparing polymer nanocapsules with hydrophobic acrylic shell and hydrophilic interior by inverse emulsion radical polymerization
D. Sarkar (2005)
10.1016/J.JCONREL.2005.04.013
Using different structure types of microemulsions for the preparation of poly(alkylcyanoacrylate) nanoparticles by interfacial polymerization.
K. Krauel (2005)
10.1080/10611860701603372
Design aspects of poly(alkylcyanoacrylate) nanoparticles for drug delivery
C. Vauthier (2007)
10.1016/S0168-3659(01)00294-2
Chitosan nanoparticles as delivery systems for doxorubicin.
K. Janes (2001)
10.1002/anie.200900723
Miniemulsion polymerization and the structure of polymer and hybrid nanoparticles.
K. Landfester (2009)
10.1007/S11743-005-0368-9
Influence of surfactants on the parameters of polylactide nanocapsules containing insulin
Y. Zhu (2005)
10.1248/CPB.58.1423
Chitosan nanoparticles: a promising system in novel drug delivery.
K. Nagpal (2010)
10.1016/j.addr.2012.09.018
Microemulsion-based media as novel drug delivery systems.
M. Lawrence (2000)
10.1016/j.molmed.2010.08.001
Small-molecule delivery by nanoparticles for anticancer therapy.
Z. Chen (2010)
10.1016/J.IJPHARM.2006.10.031
Encapsulation of mono- and oligo-nucleotides into aqueous-core nanocapsules in presence of various water-soluble polymers.
H. Hillaireau (2007)
10.1021/bm901414k
Cross-linked starch capsules containing dsDNA prepared in inverse miniemulsion as "nanoreactors" for polymerase chain reaction.
Grit Baier (2010)
10.1016/j.jconrel.2010.10.029
Release and bioactivity of PACA nanoparticles containing D-Lys⁶-GnRH for brushtail possum fertility control.
Alexandra P Kafka (2011)
10.1021/JS970124I
Poly(alkyl cyanoacrylate) nanospheres for oral administration of insulin.
C. Damgé (1997)



This paper is referenced by
10.1016/j.ijpharm.2013.12.050
Encapsulation and controlled release of hydrophilic pesticide in shell cross-linked nanocapsules containing aqueous core.
Chuxiang Sun (2014)
10.3389/fbioe.2020.00437
Strategies to Obtain Encapsulation and Controlled Release of Small Hydrophilic Molecules
Q. Li (2020)
10.1039/D0RA05597B
Potent in vivo antimalarial activity of water-soluble artemisinin nano-preparations
Praveesh Valissery (2020)
10.1016/B978-0-08-099939-5.00005-7
The Impact of Nanotechnology on Chitin and Chitosan Biomaterials Research
Eugene Khor (2014)
10.2217/nnm.12.78
From nano- to macro-scale: nanotechnology approaches for spatially controlled delivery of bioactive factors for bone and cartilage engineering.
V. E. Santo (2012)
10.1002/btpr.1835
Dopamine‐loaded poly(d,l‐lactic‐co‐glycolic acid) microspheres: New strategy for encapsulating small hydrophilic drugs with high efficiency
Mikyung Shin (2014)
10.3402/nano.v5.24381
Perspectives on the application of nanotechnology in photodynamic therapy for the treatment of melanoma
Victoria Monge-Fuentes (2014)
10.1016/j.actbio.2013.09.013
pH-sensitive Laponite(®)/doxorubicin/alginate nanohybrids with improved anticancer efficacy.
M. Gonçalves (2014)
10.3390/molecules23112906
Co-Delivery of Gemcitabine and Paclitaxel in cRGD-Modified Long Circulating Nanoparticles with Asymmetric Lipid Layers for Breast Cancer Treatment
J. Zhang (2018)
10.1111/cbdd.12748
β‐lactoglobulin–pectin Nanoparticle‐based Oral Drug Delivery System for Potential Treatment of Colon Cancer
Zhila Izadi (2016)
10.1016/j.jcis.2017.08.049
Microparticle templating as a route to nanoscale polymer vesicles with controlled size distribution for anticancer drug delivery.
Weichang Li (2017)
10.1002/POLB.23671
The accessibility of a unimolecular micelle's core to environmental ions: Exploration with a xanthene dye
Honghai Liu (2015)
10.1016/j.biomaterials.2020.120297
Nanomedicine progress in thrombolytic therapy.
Alina Zenych (2020)
10.1016/j.biomaterials.2012.02.038
The intranuclear release of a potential anticancer drug from small nanoparticles that are derived from intracellular dissociation of large nanoparticles.
Y. Fan (2012)
10.1016/j.jcis.2014.02.025
Dynamic encapsulation of hydrophilic nisin in hydrophobic poly (lactic acid) particles with controlled morphology by a single emulsion process.
Shaowen Ji (2014)
10.1063/1.4978106
Molecular docking and ADME-toxicity studies of potential compounds of medicinal plants grown in Indonesia as an anti-rheumatoid arthritis
Rizki Awaluddin (2017)
10.1016/j.biomaterials.2014.05.061
Amphiphilic dendritic derivatives as nanocarriers for the targeted delivery of antimalarial drugs.
Julie Movellan (2014)
10.1039/C4NJ02053G
Nanocapsules for 5-fluorouracil delivery decorated with a poly(2-ethylhexyl methacrylate-co-7-(4-trifluoromethyl)coumarin acrylamide) cross-linked wall
M. Sierant (2015)
10.1016/j.biomaterials.2014.02.053
Counterion-enhanced cyanine dye loading into lipid nano-droplets for single-particle tracking in zebrafish.
V. Kilin (2014)
10.1016/j.nano.2013.12.013
Crucial CD8(+) T-lymphocyte cytotoxic role in amphotericin B nanospheres efficacy against experimental visceral leishmaniasis.
S. C. Costa Lima (2014)
10.1016/j.ijpharm.2013.01.031
Drug carriers in osteoporosis: preparation, drug encapsulation and applications.
K. Miladi (2013)
10.1039/C6RA12616B
Monoclonal antibody-tagged polyethylenimine (PEI)/poly(lactide) (PLA) nanoparticles for the enhanced delivery of doxorubicin in HER-positive breast cancers
N. Cui (2016)
10.3390/PR5020025
Design of Cross-Linked Starch Nanocapsules for Enzyme-Triggered Release of Hydrophilic Compounds
Fernanda R. Steinmacher (2017)
10.1155/2012/673291
Nanobiotechnological Nanocapsules Containing Polyhemoglobin-Tyrosinase: Effects on Murine B16F10 Melanoma Cell Proliferation and Attachment
Y. Wang (2012)
Development of multifunctional polymeric nanoparticles by nano-emulsion templating as advanced nanocarriers targeting the blood-brain barrier
Cristina Fornaguera Puigvert (2015)
10.1039/c5bm00039d
Polymeric biomaterials for the delivery of platinum-based anticancer drugs.
J. Kim (2015)
10.3109/10837450.2014.882940
PLGA micro and nanoparticles in delivery of peptides and proteins; problems and approaches
S. Mohammadi-Samani (2015)
10.7150/thno.44259
Engineering Circulating Tumor Cells as Novel Cancer Theranostics
Katie M. Parkins (2020)
Development of spider silk protein particles for pharmaceutical applications
M. Hofer (2013)
10.1021/ACS.MACROMOL.5B01531
Hydration of Hydrophobic Iron–Carbonyl Homopolymers via Water–Carbonyl Interaction (WCI): Creation of Uniform Organometallic Aqueous Vesicles with Exceptionally High Encapsulation Capacity
Kai Cao (2015)
10.1039/C3BM00175J
One-step fabrication of core-shell structured alginate-PLGA/PLLA microparticles as a novel drug delivery system for water soluble drugs.
M. Lim (2013)
10.1016/j.ijpharm.2016.01.020
Strategies for encapsulation of small hydrophilic and amphiphilic drugs in PLGA microspheres: State-of-the-art and challenges.
F. Ramazani (2016)
See more
Semantic Scholar Logo Some data provided by SemanticScholar