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Implantable Controlled Release Devices For BMP-7 Delivery And Suppression Of Glioblastoma Initiating Cells.

Elaine Reguera-Nuñez, C. Roca, Eugenio Hardy, M. de la Fuente, N. Csaba, M. Garcia-Fuentes
Published 2014 · Materials Science, Medicine

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Designing therapeutic devices capable of manipulating glioblastoma initiating cells (GICs) is critical to stop tumor recurrence and its associated mortality. Previous studies have indicated that bone morphogenetic protein-7 (BMP-7) acts as an endogenous suppressor of GICs, and thus, it could become a treatment for this cancer. In this work, we engineer an implantable microsphere system optimized for the controlled release of BMP-7 as a bioinspired therapeutic device against GICs. This microsphere delivery system is based on the formation of a heparin-BMP-7 nanocomplex, first coated with Tetronic(®) and further entrapped in a biodegradable polyester matrix. The obtained microspheres can efficiently encapsulate BMP-7, and release it in a controlled manner with minimum burst effect for over two months while maintaining protein bioactivity. Released BMP-7 showed a remarkable capacity to stop tumor formation in a GICs cell culture model, an effect that could be mediated by forced reprogramming of tumorigenic cells towards a non-tumorigenic astroglial lineage.
This paper references
10.1016/j.ccr.2007.12.018
BMPing off glioma stem cells.
I. Nakano (2008)
10.1016/S0168-3659(02)00009-3
Pluronic block copolymers as novel polymer therapeutics for drug and gene delivery.
A. Kabanov (2002)
10.1098/rsif.2010.0223
Growth factor delivery-based tissue engineering: general approaches and a review of recent developments
Kangwon Lee (2010)
10.1093/brain/awq128
Bone morphogenetic protein-7 release from endogenous neural precursor cells suppresses the tumourigenicity of stem-like glioblastoma cells.
S. R. Chirasani (2010)
10.1016/j.neulet.2009.09.013
Neuroprotective effects of bone morphogenetic protein 7 (BMP7) treatment after spinal cord injury
J. D. R. Vaccari (2009)
10.1158/0008-5472.CAN-11-1674
Intracellular ATP levels are a pivotal determinant of chemoresistance in colon cancer cells.
Y. Zhou (2012)
10.1023/A:1006091608586
Brain tumor survival: Results from the National Cancer Data Base
T. S. Surawicz (2004)
10.1038/nature03128
Identification of human brain tumour initiating cells
S. Singh (2004)
10.1007/S00396-009-2131-Z
Protein-loaded PLGA–PEO blend nanoparticles: encapsulation, release and degradation characteristics
M. J. Santander-Ortega (2010)
10.1038/nm0412-474a
Companies hope for rare win with cancer stem cell therapies
A. Azvolinsky (2012)
10.3109/10717549809031385
Direct intracerebral delivery of carboplatin from PLGA microspheres against experimental malignant glioma in rats.
W. Chen (1998)
10.1126/SCIENCE.1553558
Generation of neurons and astrocytes from isolated cells of the adult mammalian central nervous system.
B. Reynolds (1992)
10.1038/nrc2499
Cancer stem cells in solid tumours: accumulating evidence and unresolved questions
J. Visvader (2008)
A restricted cell population propagates glioblastoma growth after chemotherapy
J. Chen (2012)
10.1016/J.JCONREL.2004.10.015
Microencapsulation by solvent extraction/evaporation: reviewing the state of the art of microsphere preparation process technology.
S. Freitas (2005)
10.1021/JS960363Q
A new strategy to determine the actual protein content of poly(lactide-co-glycolide) microspheres.
H. Sah (1997)
10.1016/j.ccr.2007.12.005
Epigenetic-mediated dysfunction of the bone morphogenetic protein pathway inhibits differentiation of glioblastoma-initiating cells.
J. Lee (2008)
10.1385/MN:34:3:153
Strengths and limitations of the neurosphere culture system
Josephine B. Jensen (2007)
10.1016/J.DRUDIS.2006.10.013
Blood-brain barrier delivery.
W. Pardridge (2007)
10.1158/0008-5472.CAN-04-1364
Isolation and Characterization of Tumorigenic, Stem-like Neural Precursors from Human Glioblastoma
R. Galli (2004)
10.1593/NEO.101540
Imaging bone morphogenetic protein 7 induced cell cycle arrest in experimental gliomas.
A. Klose (2011)
10.1023/A:1018820507379
A Novel System Based on a Poloxamer/ PLGA Blend as a Tetanus Toxoid Delivery Vehicle
M. Tobío (2004)
10.1163/1568562041753098
Design and characterisation of new nanoparticulate polymer blends for drug delivery
N. Csaba (2004)
10.1016/j.actbio.2009.07.016
An injectable scaffold: rhBMP-2-loaded poly(lactide-co-glycolide)/hydroxyapatite composite microspheres.
H. Shen (2010)
10.1021/mp1001262
Nanoparticles based on PLGA:poloxamer blends for the delivery of proangiogenic growth factors.
I. d'Angelo (2010)
10.1038/444687A
Cancer: Stem cells and brain tumours
P. Dirks (2006)
10.1016/j.canlet.2012.12.024
Understanding high grade glioma: molecular mechanism, therapy and comprehensive management.
Y. Wang (2013)
10.1016/0142-9612(93)90151-Q
Biodegradation and brain tissue reaction to poly(D,L-lactide-co-glycolide) microspheres.
P. Menei (1993)
Biodegradation and brain tissue reaction to poly(D,L-lactide-coglycolide) microspheres. Biomaterials 1993;14:470e8
P Menei (1993)
10.1002/(SICI)1097-0142(19990715)86:2<325::AID-CNCR17>3.0.CO;2-S
Local and sustained delivery of 5‐fluorouracil from biodegradable microspheres for the radiosensitization of glioblastoma
P. Menei (1999)
Targeting cancer stem cells for more effective therapies: Taking out cancer
RJ Winquist (2009)
10.1038/nature05349
Bone morphogenetic proteins inhibit the tumorigenic potential of human brain tumour-initiating cells
S. G. M. Piccirillo (2006)
10.1016/J.ADDR.2007.08.038
Controlled drug delivery in tissue engineering.
Marco Biondi (2008)
10.1371/journal.pone.0006206
Molecular Mechanisms of HIF-1α Modulation Induced by Oxygen Tension and BMP2 in Glioblastoma Derived Cells
F. Pistollato (2009)
10.1016/j.biomaterials.2010.03.002
The use of submicron/nanoscale PLGA implants to deliver paclitaxel with enhanced pharmacokinetics and therapeutic efficacy in intracranial glioblastoma in mice.
Sudhir H. Ranganath (2010)
10.1002/mabi.201000206
Affinity-based drug delivery.
N. X. Wang (2011)
10.1016/j.bcp.2009.03.020
Targeting cancer stem cells for more effective therapies: Taking out cancer's locomotive engine.
R. Winquist (2009)
10.1016/j.ejps.2010.09.008
PLGA:poloxamer blend micro- and nanoparticles as controlled release systems for synthetic proangiogenic factors.
Yolanda Parajó (2010)
10.1038/71916
Stabilization of proteins encapsulated in injectable poly (lactide-co-glycolide)
Gaozhong Zhu (2000)
10.1021/BM049577P
PLGA:poloxamer and PLGA:poloxamine blend nanoparticles: new carriers for gene delivery.
N. Csaba (2005)



This paper is referenced by
10.1016/j.addr.2015.04.008
Drug encapsulated polymeric microspheres for intracranial tumor therapy: A review of the literature.
J. Floyd (2015)
10.1021/acsbiomaterials.7b01037
Engineered Coatings for Titanium Implants To Present Ultralow Doses of BMP-7
Mohammed Al-Jarsha (2018)
10.4137/TOG.S22256
Genomic Analysis of the BMP Family in Glioblastomas
Laura D. Hover (2015)
10.1155/2014/549742
BMPs as Therapeutic Targets and Biomarkers in Astrocytic Glioma
P. González-Gómez (2014)
10.1016/j.bbagen.2017.07.001
A synthetic BMP-2 mimicking peptide induces glioblastoma stem cell differentiation.
E. Rampazzo (2017)
Les cellules initiatrices de tumeurs à l'origine de l'hétérogénéité d'expression de l'intégrine α5β1 dans les glioblastomes
Marie-Cécile Mercier (2018)
10.1016/j.ijpharm.2014.12.014
Biocompatibility of poly(D,L-lactic-co-hydroxymethyl glycolic acid) microspheres after subcutaneous and subcapsular renal injection.
F. Kazazi-Hyseni (2015)
Biocompatibility of monodisperse mi- crospheres composed of a biodegradable poly(DL-lactide-PEG)-b-poly(L-Lactide) multiblock copolymer
(2015)
10.1007/s11523-015-0378-5
Targeting Glioblastoma with the Use of Phytocompounds and Nanoparticles
F. Pistollato (2015)
Implications of the endothelial cell response in glioblastoma to stimulation by mesenchymal stem cells and ionizing radiation
Tansy Zhao (2017)
10.1016/j.ijpharm.2016.12.013
Biomaterials to suppress cancer stem cells and disrupt their tumoral niche.
Carla Garcia-Mazas (2017)
10.1016/j.febslet.2015.04.058
Transforming growth factor β and bone morphogenetic protein actions in brain tumors
L. Caja (2015)
10.1016/j.jconrel.2020.05.012
Development and in vivo evaluation of Irinotecan-loaded Drug Eluting Seeds (iDES) for the localised treatment of recurrent glioblastoma multiforme.
Matthew Gawley (2020)
10.1201/B20045-19
Biodegradable Polyester-Based Multi-Compartmental Delivery Systems for Oral Nucleic Acid Therapy
M. R. Kumar (2017)
10.1039/C5RA17901G
Preparation and characterization of enzyme-responsive emamectin benzoate microcapsules based on a copolymer matrix of silica–epichlorohydrin–carboxymethylcellulose
Mingcheng Guo (2015)
10.4018/978-1-4666-9811-6.CH003
Bioinspired Nanoparticles for Efficient Drug Delivery System
B. Al-Najar (2016)
10.1016/j.cytogfr.2015.11.009
Mechanisms of action of bone morphogenetic proteins in cancer.
Hayley Davis (2016)
10.1038/s41418-018-0149-9
BMP9 counteracts the tumorigenic and pro-angiogenic potential of glioblastoma
E. Porcù (2018)
10.31031/RDMS.2018.05.000625
Protein Release Systems for Bone Regeneration
D. D. Pérez (2018)
10.7717/peerj.1277
Pore size is a critical parameter for obtaining sustained protein release from electrochemically synthesized mesoporous silicon microparticles
Ester L. Pastor (2015)
10.7497/j.issn.2095-3941.2015.0020
Development of targeted therapies in treatment of glioblastoma
Y. Xu (2015)
10.1016/j.ijpharm.2015.07.072
Hot melt extruded and injection moulded disulfiram-loaded PLGA millirods for the treatment of glioblastoma multiforme via stereotactic injection.
C. McConville (2015)
10.18632/ONCOTARGET.3459
Controlled release microspheres loaded with BMP7 suppress primary tumors from human glioblastoma
P. González-Gómez (2015)
10.1124/pr.115.011247
Pharmacology of Heparin and Related Drugs
B. Mulloy (2016)
10.7314/APJCP.2015.16.16.6813
Overview of Transforming Growth Factor β Superfamily Involvement in Glioblastoma Initiation and Progression.
André Wendindondé Nana (2015)
10.2217/FNL.14.56
Glioblastoma stem cells: new insights in therapeutic strategies
N. Goffart (2014)
BMP signaling in high grade gliomas
Laura D. Hover (2016)
10.1016/j.ejpb.2016.12.021
New scaffolds encapsulating TGF‐&bgr;3/BMP‐7 combinations driving strong chondrogenic differentiation
J. Crecente-Campo (2017)
10.1002/jps.24304
Development of disulfiram-loaded poly(lactic-co-glycolic acid) wafers for the localised treatment of glioblastoma multiforme: a comparison of manufacturing techniques.
Iwona Zembko (2015)
10.1002/adtp.201800126
Structure‐Optimized Interpolymer Polyphosphazene Complexes for Effective Gene Delivery against Glioblastoma
Wei‐Hsin Hsu (2019)
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