Online citations, reference lists, and bibliographies.
← Back to Search

Localization And Spatiotemporal Expression Of IDO Following Transient Forebrain Ischemia In Gerbils

A. Taguchi, A. Hara, K. Saito, M. Hoshi, H. Mori
Published 2008 · Biology, Medicine

Save to my Library
Download PDF
Analyze on Scholarcy
Share
Indoleamine 2,3-dioxygenase (IDO) is the rate-limiting enzyme in the kynurenine pathway that converts L-tryptophan to L-kynurenine. Transient forebrain ischemia initiates a series of cellular events that lead to the delayed neuronal degeneration of several brain regions. The goal of this study was to determine the localization of IDO in gerbil brain, and analyze the spatiotemporal expression of IDO in a transient forebrain ischemic model. Expression of IDO in the normal gerbil brain was observed by using immunohistochemistry. Time-course of the expression of IDO following transient forebrain ischemic gerbils was examined by immunohistochemistry, combined with hematoxylin and eosin staining for morphological analysis, and in situ terminal dUTP-biotin nick end labeling of DNA fragments (TUNEL) method. In normal gerbils, IDO immunostaining was observed in thalamus, hypothalamus and amygdaloid nucleus. IDO expression was negative in the cingulate cortex, hippocampal CA1 region and parietal cortex. Following transient ischemia, we observed a time-dependent increase of IDO expression in CA1, cingulate cortex and hypothalamus. The peak of IDO expression in CA1 and cingulate cortex occurred at 48 h after ischemic insult and diminished by 2 weeks. TUNEL staining was observed only in the CA1 region at 72 and 96 h after transient ischemia. Thus, IDO protein is present in specific regions in gerbil brain, and dynamic changes of IDO expression was observed in some neurons following transient ischemia.
This paper references
10.1016/J.EJPHAR.2005.01.043
In vivo neuroprotective effects of the novel imidazolyl nitrone free-radical scavenger (Z)-alpha-[2-thiazol-2-yl)imidazol-4-yl]-N-tert-butylnitrone (S34176).
B. Lockhart (2005)
10.1017/S0317167100037872
Hypothesis: a role for quinolinic acid in the neuropathology of glutaric aciduria type I.
M. Heyes (1987)
10.1016/S0092-8674(00)81874-7
Apoptosis by Death Factor
S. Nagata (1997)
10.1016/0378-4347(91)80406-3
Determination of 3-hydroxykynurenine in human brain and plasma by high-performance liquid chromatography with electrochemical detection. Increased concentrations in hepatic encephalopathy.
S. Pearson (1991)
10.1073/PNAS.91.17.8117
Apoptosis in substantia nigra following developmental striatal excitotoxic injury.
A. Macaya (1994)
10.1152/AJPRENAL.00044.2007
Proapoptotic activity of indoleamine 2,3-dioxygenase expressed in renal tubular epithelial cells.
K. Mohib (2007)
10.1016/0006-8993(91)91171-V
Chronic effects of γ-interferon on quinolinic acid and indoleamine-2,3-dioxygenase in brain of C57BL6 mice
K. Saito (1991)
10.1161/01.STR.23.1.75
Protective Effects of Human Recombinant Superoxide Dismutase on Transient Ischemic Injury of CA1 Neurons in Gerbils
O. Uyama (1992)
10.1124/JPET.102.034439
Manipulation of Brain Kynurenines: Glial Targets, Neuronal Effects, and Clinical Opportunities
R. Schwarcz (2002)
10.1016/0006-8993(96)00200-4
Stimulation of N-methyl-d-aspartate receptors induces apoptosis in rat brain
Z. Qin (1996)
10.1111/j.1471-4159.1993.tb05836.x
Mechanism of Delayed Increases in Kynurenine Pathway Metabolism in Damaged Brain Regions Following Transient Cerebral Ischemia
K. Saito (1993)
10.1002/glia.20090
Expression of indoleamine 2,3‐dioxygenase and production of quinolinic acid by human microglia, astrocytes, and neurons
G. Guillemin (2005)
10.1016/0006-8993(82)90833-2
Delayed neuronal death in the gerbil hippocampus following ischemia
T. Kirino (1982)
10.1097/00004647-199808000-00001
Protective Effect of Apoptosis-Inhibitory Agent, N-Tosyl-l-Phenylalanyl Chloromethyl Ketone against Ischemia-Induced Hippocampal Neuronal Damage
A. Hara (1998)
10.1016/S0006-8993(98)00753-7
Transport of fragmented DNA in apical dendrites of gerbil CA1 pyramidal neurons following transient forebrain ischemia
A. Hara (1998)
10.1179/135100002125000550
Implications of the kynurenine pathway and quinolinic acid in Alzheimer's disease
G. Guillemin (2002)
10.1083/JCB.119.3.493
Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation
Y. Gavrieli (1992)
10.1002/ANA.410110509
Temporal profile of neuronal damage in a model of transient forebrain ischemia
W. Pulsinelli (1982)
10.1007/BF00304636
Delayed neuronal death and delayed neuronal recovery in the human brain following global ischemia
M. Horn (2004)
10.1111/j.1471-4159.2005.03070.x
Tryptophan metabolism and oxidative stress in patients with Huntington's disease
N. Stoy (2005)
10.1016/S0891-5849(98)00257-3
Involvement of free radicals in cerebral vascular reperfusion injury evaluated in a transient focal cerebral ischemia model of rat.
M. Nakashima (1999)
10.1212/WNL.42.9.1702
Kynurenine pathway abnormalities in Parkinson's disease
T. Ogawa (1992)
10.1111/j.1471-4159.1993.tb07443.x
Kynurenine Pathway Enzymes in Brain: Responses to Ischemic Brain Injury Versus Systemic Immune Activation
K. Saito (1993)
10.1042/BJ3200595
Human microglia convert l-tryptophan into the neurotoxin quinolinic acid.
M. Heyes (1996)
10.1111/j.1471-4159.1993.tb09843.x
Rapid Communication: Regional Variability in DNA Fragmentation After Global Ischemia Evidenced by Combined Histological and Gel Electrophoresis Observations in the Rat Brain
A. Héron (1993)
10.1016/S0304-3940(01)01559-2
Caspase activation as an apoptotic evidence in the gerbil hippocampal CA1 pyramidal cells following transient forebrain ischemia
M. Niwa (2001)
10.1016/S1385-299X(99)00012-4
Neuronal apoptosis studied by a sequential TUNEL technique: a method for tract-tracing.
A. Hara (1999)
10.1016/j.neulet.2005.07.010
Neuronal localization of indoleamine 2,3-dioxygenase in mice
E. Roy (2005)
10.1016/0006-8993(95)00902-3
DNA fragmentation in granular cells of human cerebellum following global ischemia
A. Hara (1995)
10.1016/S0006-8993(98)00324-2
Relationship between magnitude of hypothermia during ischemia and preventive effect against post-ischemic DNA fragmentation in the gerbil hippocampus
M. Niwa (1998)
10.1016/0006-8993(94)01363-M
Temporal profile of nuclear DNA fragmentation in situ in gerbil hippocampus following transient forebrain ischemia
Tomohiko Iwai (1995)
10.1523/JNEUROSCI.15-02-01001.1995
Delayed neuronal death in the CA1 pyramidal cell layer of the gerbil hippocampus following transient ischemia is apoptosis
T. Nitatori (1995)
10.1038/jcbfm.1984.28
Delayed Neuronal Recovery and Neuronal Death in Rat Hippocampus following Severe Cerebral Ischemia: Possible Relationship to Abnormalities in Neuronal Processes
C. Petito (1984)
10.1016/s0021-9258(17)40209-2
Indoleamine 2,3-dioxygenase. Potassium superoxide as substrate.
T. Ohnishi (1977)



This paper is referenced by
10.1007/s11064-010-0187-2
The Role of Tryptophan Catabolism along the Kynurenine Pathway in Acute Ischemic Stroke
R. Brouns (2010)
10.1007/978-1-4614-5836-4_127
Quinolinate and related excitotoxins: mechanisms of neurotoxicity and disease relevance
Jonas Innies Addae (2014)
10.1007/s00210-011-0611-4
Vascular expression, activity and function of indoleamine 2,3-dioxygenase-1 following cerebral ischaemia–reperfusion in mice
K. Jackman (2011)
10.1093/ILAR.52.1.E1
Characteristics of circle of Willis variations in the mongolian gerbil and a newly established ischemia-prone gerbil group.
X. Du (2011)
10.1016/j.neulet.2014.01.051
Indoleamine 2,3-dioxygenase 1 is upregulated in activated microglia in mice cerebellum during acute viral encephalitis
A. Taguchi (2014)
10.1016/j.neures.2008.12.003
Marked increases in hippocampal neuron indoleamine 2, 3-dioxygenase via IFN-γ-independent pathway following transient global ischemia in mouse
M. Hoshi (2009)
10.2174/1381612822666151214125950
The Kynurenine Pathway in the Acute and Chronic Phases of Cerebral Ischemia.
M. I. Cuartero (2016)
10.1016/j.neulet.2012.04.016
PBN fails to suppress in delayed neuronal death of hippocampal CA1 injury following transient forebrain ischemia in gerbils
Wael Goda (2012)
10.1016/j.neuroscience.2011.03.070
Inflammatory stimuli reduce survival of serotonergic neurons and induce neuronal expression of indoleamine 2,3-dioxygenase in rat dorsal raphe nucleus organotypic brain slices
T. Hochstrasser (2011)
10.5483/BMBRep.2020.53.11.114
Tat-indoleamine 2,3-dioxygenase 1 elicits neuroprotective effects on ischemic injury
J. H. Park (2020)
Semantic Scholar Logo Some data provided by SemanticScholar