Online citations, reference lists, and bibliographies.
← Back to Search

Alginate Microparticles As Oral Colon Drug Delivery Device: A Review.

L. Agüero, Dionisio Zaldivar-Silva, L. Pena, M. L. Dias
Published 2017 · Medicine, Chemistry

Cite This
Download PDF
Analyze on Scholarcy
Share
The increase in the research interest on alginate microparticles in pharmaceutical and biomedical areas confirms its potential use as an effective matrix for drug and cell delivery. Among the well known alginate properties, pH sensitivity remains as an attractive option for targeting of drug in the colon region. This essential aspect is advantageous to enhance therapeutic efficacy of treatment of inflammatory bowel diseases, which require multi-drug administration frequently in a long period. As consequence, severe side effect appears leading to discontinuation of therapy and affecting quality of patient life. This review gives an overview of relevant properties of alginate as oral colon delivery systems and the recent innovative strategies of using alginate with other polymers as well as microencapsulation techniques. At the same time, it describes the several advantages of coating processes involving alginate over microparticles in order to design better material with sustained release characteristic for colon-targeted delivery.
This paper references
10.1016/j.addr.2012.09.007
Protein release from alginate matrices.
Wee (1998)
10.1016/J.JCONREL.2004.10.015
Microencapsulation by solvent extraction/evaporation: reviewing the state of the art of microsphere preparation process technology.
S. Freitas (2005)
10.1080/10408398.2014.965773
Alginate gel particles–A review of production techniques and physical properties
Su Hung Ching (2017)
10.1002/jbm.a.34863
Considerations in binding diblock copolymers on hydrophilic alginate beads for providing an immunoprotective membrane
M. Spasojević (2014)
10.1002/JBM.A.30541
Evaluation of alginate purification methods: effect on polyphenol, endotoxin, and protein contamination.
J. Dusseault (2006)
10.1016/S0169-409X(98)00040-4
Specific and non-specific bioadhesive particulate systems for oral delivery to the gastrointestinal tract.
Ponchel (1998)
10.1002/APP.38576
Synthesis and characterization of polyelectrolyte complex microparticles for drug release
Lissette Agüero (2013)
10.1186/s12896-015-0115-2
A novel psychrophilic alkaline phosphatase from the metagenome of tidal flat sediments
D. Lee (2015)
CYTOTOXIC POTENTIAL AND PHYTOCHEMICAL ANALYSIS OF JUSTICIA BEDDOMEI AND ITS ENDOPHYTIC ASPERGILLUS SP
D. Prabavathy (2013)
10.1007/s13167-010-0001-x
Drug delivery systems: Advanced technologies potentially applicable in personalized treatments
J. Coelho (2010)
10.1007/s40204-016-0051-9
Development and evaluation of a calcium alginate based oral ceftriaxone sodium formulation
N. Patel (2016)
10.2174/156720108785915014
Novel pH-sensitive interpenetrating network hydrogel beads of carboxymethylcellulose-(polyacrylamide-grafted-alginate) for controlled release of ketoprofen: preparation and characterization.
R. Kulkarni (2008)
10.1016/j.nano.2015.02.018
Advances in oral nano-delivery systems for colon targeted drug delivery in inflammatory bowel disease: selective targeting to diseased versus healthy tissue.
Susan Hua (2015)
10.3390/md14020034
Marine Origin Polysaccharides in Drug Delivery Systems
M. J. Cardoso (2016)
10.1208/s12249-013-0035-1
Eudragit L/HPMCAS Blend Enteric-Coated Lansoprazole Pellets: Enhanced Drug Stability and Oral Bioavailability
Y. Fang (2013)
10.1002/PEN.23415
Covalently cross‐linked and hydrophobically modified alginic acid hydrogels and their application as drug carriers
M. Wu (2013)
10.1002/bab.1369
Carboxymethyl starch/alginate microspheres containing diamine oxidase for intestinal targeting
Lindsay Blémur (2016)
10.1016/j.actbio.2010.11.040
In situ forming IPN hydrogels of calcium alginate and dextran-HEMA for biomedical applications.
L. Pescosolido (2011)
10.1016/j.drudis.2011.01.003
Intestinal delivery of non-viral gene therapeutics: physiological barriers and preclinical models.
Martin O'Neill (2011)
10.1007/S11434-016-1056-4
Nanoparticle-based oral delivery systems for colon targeting: principles and design strategies
Lei Lu (2016)
10.1098/rsif.2010.0114.focus
Spray-freeze-drying of nanosuspensions: the manufacture of insulin particles for needle-free ballistic powder delivery
H. Schiffter (2010)
FORMULATION AND EVALUATION OF MELOXICAM LOADED MICROSPHERES FOR COLON TARGETED DRUG DELIVERY
S. K. Ms (2013)
10.1021/am403966x
Strengthening alginate/polyacrylamide hydrogels using various multivalent cations.
C. Yang (2013)
A STUDY ON THE EFFECT OF DIFFERENT POLYMERS AND FORMULATION VARIABLES ON ENCAPSULATION EFFICIENCY, MORPHOLOGY AND RELEASE CHARACTERISTICS OF ACECLOFENAC LOADED CALCIUM ALGINATE MICROSPHERES PREPARED BY IONOTROPIC GELATION TECHNIQUE
D. Devanna (2013)
10.3390/ma7010275
Alginate-Poly(ethylene glycol) Hybrid Microspheres for Primary Cell Microencapsulation
R. Mahou (2014)
10.2478/v10007-012-0034-x
Eudragit S-100 coated sodium alginate microspheres of naproxen sodium: Formulation, optimization and in vitro evaluation / Alginatne mikrosfere naproksen natrija obložene Eudragitom S-100: Priprava, optimizacija i in vitro vrednovanje
Anuj Chawla (2012)
10.1016/S0142-9612(02)00118-7
Biocompatibility of microcapsules for cell immobilization elaborated with different type of alginates.
G. Orive (2002)
10.3109/03639045.2014.917657
Alginate drug delivery systems: application in context of pharmaceutical and biomedical research
Dharmendra Jain (2014)
10.1016/j.ijbiomac.2014.07.008
Alginate composites for bone tissue engineering: a review.
J. Venkatesan (2015)
10.2174/092986710791111170
New drug delivery systems in inflammatory bowel disease: MMX and tailored delivery to the gut.
G. Fiorino (2010)
10.1007/s10856-011-4512-3
Encapsulation of Huh-7 cells within alginate-poly(ethylene glycol) hybrid microspheres
R. Mahou (2011)
10.1016/j.jsps.2011.08.004
Emulsification/internal gelation as a method for preparation of diclofenac sodium-sodium alginate microparticles.
M. M. Ahmed (2013)
10.1007/s10856-012-4798-9
Development of pH-sensitive pectinate/alginate microspheres for colon drug delivery
Fu-Yin Hsu (2012)
10.1017/S0022029900015193
Preparation and properties of β-casein from buffalo's milk
M. H. El-Salam (1975)
10.1016/J.COLSURFA.2009.09.005
Preparation of uniformly sized alginate microspheres using the novel combined methods of microchannel emulsification and external gelation
A. M. Chuah (2009)
10.1016/j.colsurfb.2013.01.013
Aceclofenac-loaded chitosan-tamarind seed polysaccharide interpenetrating polymeric network microparticles.
Sougata Jana (2013)
10.1002/jps.24554
Design and In Vivo Anti-Inflammatory Effect of Ketoprofen Delayed Delivery Systems.
Andrea Cerciello (2015)
10.1016/j.addr.2012.10.003
Advanced materials and processing for drug delivery: the past and the future.
Y. Zhang (2013)
Pharmaceutical minitablets, its advantages and different enteric coating processes
A. Mounika (2015)
10.1002/APP.40444
Gastro‐resistant controlled release of OTC encapsulated in alginate/chitosan matrix coated with acryl‐EZE® MP in fluidized bed
S. A. Kleinubing (2014)
10.2147/JIR.S65979
Inflammatory bowel disease: clinical aspects and treatments
Marc Fakhoury (2014)
10.1016/j.jconrel.2010.05.011
Issues in long-term protein delivery using biodegradable microparticles.
Mingli Ye (2010)
10.1016/j.carbpol.2014.11.053
Microfluidic fabrication of shape-tunable alginate microgels: effect of size and impact velocity.
Yuandu Hu (2015)
10.1016/j.carbpol.2013.11.023
Influence of ionic strength on the flexibility of alginate studied by size exclusion chromatography.
F. G. D. Baños (2014)
10.1021/BM010008G
Molecular basis of C(2+)-induced gelation in alginates and pectins: the egg-box model revisited.
I. Braccini (2001)
10.1039/B603595G
Microencapsulation using natural polysaccharides for drug delivery and cell implantation
W. Wang (2006)
10.1590/S1984-82502010000100002
Mucoadhesive drug delivery systems
F. Carvalho (2010)
10.1128/AEM.01724-12
Role of Calcium Alginate and Mannitol in Protecting Bifidobacterium
D. Dianawati (2012)
10.1016/0378-5173(89)90229-9
A novel in situ method to test polymers and coated microparticles for bioadhesion
K. Rao (1989)
10.1016/j.biomaterials.2015.01.048
Versatile click alginate hydrogels crosslinked via tetrazine-norbornene chemistry.
Rajiv M Desai (2015)
10.1590/S1516-14392014005000095
Strontium Incorporation on Microspheres of Alginate/β-tricalcium Phosphate as Delivery Matrices
Ana Paula Duarte Moreira (2014)
10.1002/PEN.23259
Development, optimization, and evaluation of emulsion‐gelled floating beads using natural polysaccharide‐blend for controlled drug release
Amit kumar Nayak (2013)
10.1016/J.JCONREL.2006.04.017
Polyionic hydrocolloids for the intestinal delivery of protein drugs: alginate and chitosan--a review.
M. George (2006)
10.1016/j.actbio.2013.12.006
Injectable alginate hydrogels for cell delivery in tissue engineering.
S. J. Bidarra (2014)
10.1016/j.ijpharm.2014.07.009
pH-sensitive nanoparticles for colonic delivery of curcumin in inflammatory bowel disease.
A. Beloqui (2014)
10.1007/S13594-015-0223-8
Preparation and properties of milk proteins-based encapsulated probiotics: a review
Mohamed Abd El-Salam (2015)
10.1039/B606424H
Manipulating the generation of Ca-alginate microspheres using microfluidic channels as a carrier of gold nanoparticles.
K. Huang (2006)
10.3390/md14050090
Effect of Experimental Parameters on Alginate/Chitosan Microparticles for BCG Encapsulation
Liliana Aranha Caetano (2016)
10.1016/J.EJPS.2006.06.008
Insulin encapsulation in reinforced alginate microspheres prepared by internal gelation.
Catarina M. Silva (2006)
10.1208/pt070247
Characterization of 5-fluorouracil microspheres for colonic delivery
Z. Rahman (2008)
10.3797/scipharm.1004-24
Sodium Alginate Based Mucoadhesive System for Gatifloxacin and Its In Vitro Antibacterial Activity
K. Kesavan (2010)
10.1016/j.cis.2014.03.009
Preparation methods of alginate nanoparticles.
J. P. Paques (2014)
10.1016/J.PROGPOLYMSCI.2011.06.003
Alginate: properties and biomedical applications.
K. Lee (2012)
10.1021/acsami.6b03245
Dual-Cross-Linked Methacrylated Alginate Sub-Microspheres for Intracellular Chemotherapeutic Delivery.
Spencer L. Fenn (2016)
10.1016/J.AJPS.2014.07.005
A quality by design (QbD) case study on enteric- coated pellets: Screening of critical variables and establishment of design space at laboratory scale
Shuling Kan (2014)
Preparation and In-vitro characterization of ethylcellulose coated pectin alginate microspheres of 5-fluorouracil for colon targeting
G. Ramana (2011)
Formulation and evaluation of meloxicam loaded microspheres for colon targeted drug
M. S. Kumar (2013)
10.1080/17425247.2016.1214564
Preparation methods and applications behind alginate-based particles
M. Lopes (2017)
10.1016/j.addr.2013.10.001
Drug delivery strategies in the therapy of inflammatory bowel disease.
Christian Lautenschläger (2014)
10.1080/10717544.2016.1178824
Comparative pharmaceutical study on colon targeted micro-particles of celecoxib: in-vitro–in-vivo evaluation
Lamyaa Bazan (2016)
10.1021/BM060010D
Effect of Ca2+, Ba2+, and Sr2+ on alginate microbeads.
Ý. Mørch (2006)
10.3390/md13052890
Alginate Hydrogels Coated with Chitosan for Wound Dressing
M. C. Straccia (2015)
Microencapsulation: A promising technique for controlled drug delivery
M. Singh (2010)
10.3390/ma6041285
Alginate-Based Biomaterials for Regenerative Medicine Applications
Jinchen Sun (2013)
10.1208/s12249-007-9005-9
Development of Enteric Coated Flurbiprofen Tablets using Opadry/acryl-eze System—A Technical Note
Durriya Hashmat (2007)
10.1016/J.REACTFUNCTPOLYM.2004.01.002
Investigation of swelling/degradation behaviour of alginate beads crosslinked with Ca2+ and Ba2+ ions
S. K. Bajpai (2004)
Formulation and evaluation of anti-inflammatory drug microspheres for colon targeted drug delivery
R. Pramod (2014)
10.1080/03639040500214647
Alginate-Coated Alginate-Polyethyleneimine Beads for Prolonged Release of Furosemide in Simulated Intestinal Fluid
C. Mallikarjuna Setty (2005)
10.3109/1061186X.2015.1128941
Polysaccharide-based micro/nanocarriers for oral colon-targeted drug delivery
Lin Zhang (2016)
10.1186/s12896-015-0147-7
Rheological characterization of an injectable alginate gel system
B. E. Larsen (2015)
10.1016/j.jsps.2014.10.001
Microparticles as controlled drug delivery carrier for the treatment of ulcerative colitis: A brief review
Nidhi (2016)
10.1590/S1984-82502012000100008
Development and evaluation of a hot-melt coating technique for enteric coating
Arun T. Patil (2012)
10.3390/POLYM7020161
Direct Determination of Chitosan-Mucin Interactions Using a Single-Molecule Strategy: Comparison to Alginate-Mucin Interactions
Kristin E. Haugstad (2015)
10.1002/JBM.A.30763
Novel alginate-acrylic polymers as a platform for drug delivery.
P. Laurienzo (2006)
10.1016/j.biomaterials.2012.01.007
Alginate derivatization: a review of chemistry, properties and applications.
S. Pawar (2012)
10.1002/MASY.201200099
Combined Electrostatic and Covalent Polymer Networks for Cell Microencapsulation
R. Mahou (2013)
10.1208/pt050118
Experimental design for the formulation and optimization of novel cross-linked oilispheres developed for in vitro site-specific release ofMentha piperita oil
W. Sibanda (2008)
Colon Specific Drug Delivery Systems: A Review on Various Pharmaceutical Approaches.
Prasanth (2012)
10.1016/J.CEJ.2014.01.065
Design and applications of interpenetrating polymer network hydrogels. A review
E. Dragan (2014)
10.1208/s12249-014-0147-2
Encapsulation of Sorbitan Ester-Based Organogels in Alginate Microparticles
S. S. Sagiri (2014)
10.1016/S2222-1808(12)60151-0
Fabrication and Evaluation of Tinidazole Microbeads for Colon Targeting
A. K. Pandey (2012)
10.1007/S00396-007-1807-5
Adhesion and growth of goat mammary epithelial cells on novel polyelectrolyte complex
O. Valdés (2008)
10.1016/J.JCONREL.2007.09.012
Polymer blends for controlled release coatings.
F. Siepmann (2008)
10.1016/j.addr.2013.04.016
Crosslinked ionic polysaccharides for stimuli-sensitive drug delivery.
C. Alvarez-Lorenzo (2013)
10.1517/17425247.5.4.417
Recent advances and perspectives on coated alginate microspheres for modified drug delivery.
P. Matricardi (2008)
10.1016/J.BIOMATERIALS.2006.05.011
Cell-compatible covalently reinforced beads obtained from a chemoenzymatically engineered alginate.
A. M. Rokstad (2006)
Effect of Ca, Ba, and Sr on alginate
Ý.A. Mørch (2006)
10.6227/JFDA.2012200202
Preparation of Microparticles for Acid-Iabile Lansoprazole by Solvent Evaporation Method Combined with a Spray Drying Process
Wei-Zhe Sun (2012)
10.1016/S0142-9612(00)00201-5
Ionically crosslinked alginate hydrogels as scaffolds for tissue engineering: part 1. Structure, gelation rate and mechanical properties.
C. K. Kuo (2001)
10.4103/0975-1483.51869
Colon targeted drug delivery: Different approaches
S. Jose (2009)
10.1016/j.ejpb.2011.08.002
Quality by design approach for developing chitosan-Ca-alginate microspheres for colon delivery of celecoxib-hydroxypropyl-β-cyclodextrin-PVP complex.
N. Mennini (2012)
10.1016/j.jconrel.2013.09.004
Mucoadhesive intestinal devices for oral delivery of salmon calcitonin.
V. Gupta (2013)
10.1016/J.EURPOLYMJ.2013.04.033
Designing polymeric microparticles for biomedical and industrial applications
E. Campos (2013)
10.1002/APP.26619
Synthesis and Characterization of Poly(acryloxyethyl-trimethylammonium chloride-co-2-hydroxyethyl methacrylate) : A Study of its Interaction with Sodium Alginate
O. Valdés (2008)
10.3390/molecules170910094
Activity of Spray-dried Microparticles Containing Pomegranate Peel Extract against Candida albicans
Eliana H Endo (2012)
10.1016/j.carbpol.2015.10.074
Development of edible films and coatings from alginates and carrageenans.
Elham Tavassoli-Kafrani (2016)
10.1016/J.EJPB.2007.06.007
Chitosan coated Ca-alginate microparticles loaded with budesonide for delivery to the inflamed colonic mucosa.
M. Simonoska Crcarevska (2008)
10.1016/J.CARBPOL.2011.11.012
Alginates as a useful natural polymer for microencapsulation and therapeutic applications
C. H. Goh (2012)
10.1002/PEN.23962
Preparation and characterization of pH‐sensitive microparticles based on polyelectrolyte complexes for antibiotic delivery
L. Agüero (2015)
10.1016/J.JFOODENG.2013.02.018
Smart porous microparticles based on gelatin/sodium alginate polyelectrolyte complex
N. Devi (2013)



This paper is referenced by
10.1111/JFPP.13851
Nanoparticles based on sodium alginate and β-conglycinin: Self-assembly and delivery of Phyllanthus urinaria phenolic compounds: XXXX
Yong Liu (2019)
10.1016/J.FOODHYD.2018.08.001
Convenient one-step approach based on stimuli-responsive sol-gel transition properties to directly build chitosan-alginate core-shell beads
Chaoran Qin (2019)
10.3390/molecules25071688
Synthesis, Characterization, and Histological Evaluation of Chitosan-Ruta Graveolens Essential Oil Films
Carlos David Grande Tovar (2020)
10.1016/j.carbpol.2017.11.049
A review on carbohydrate embedded polyurethanes: An emerging area in the scope of biomedical applications.
Archana Solanki (2018)
10.1039/c8fo01216d
A colon-specific delivery system for quercetin with enhanced cancer prevention based on co-axial electrospinning.
P. Wen (2018)
10.1016/J.JDDST.2018.07.027
In vitro and in vivo evaluation of coated capsules for colonic delivery
S. Handali (2018)
10.22159//IJAP.2018V10I1.21935
THE ROLE OF MATRIX TABLET IN DRUG DELIVERY SYSTEM
Nita Mondal (2018)
10.1002/jsfa.10219
Development of Functional Pasta With Microencapsulated Spirulina: Technological and Sensorial Effects.
Cindiele Karen Zen (2019)
10.1016/J.COLSURFA.2019.04.082
Nanostructured lipid carriers incorporated in alginate hydrogel: Enhanced stability and modified behavior in gastrointestinal tract
R. C. Sun (2019)
10.5798/DICLETIP.362435
Mikroenkapsüle edilen paratiroid hücrelerinin in-vitro optimizasyonu
E. Yucesan (2017)
10.1007/s13233-019-7033-4
Preparation of Mesalazine-Clay Composite Encapsulated Alginate (MCA) Bead for Targeted Drug Delivery: Effect of Composite Content and CaCl2 Concentration
Hye-Jin Hong (2018)
10.1016/j.tifs.2020.04.028
Dietary fiber-based colon-targeted delivery systems for polyphenols
Hsi-Yang Tang (2020)
10.1039/d0ra01427c
Synthesis of polyacrylonitrile nanoflowers and their controlled pH-sensitive drug release behavior
Qi Lian (2020)
10.1039/c9cc08207g
Antimicrobial gum bio-based nanocomposites and their industrial and biomedical applications.
Ehsan Nazarzadeh Zare (2019)
10.1016/j.ijbiomac.2019.10.233
Fabrication of alginate microspheres for drug delivery: a review.
Nguyễn Thị Thanh Uyên (2019)
10.1016/j.carbpol.2019.115121
Nano- and microstructural evolution of alginate beads in simulated gastrointestinal fluids. Impact of M/G ratio, molecular weight and pH.
Laura G Gómez-Mascaraque (2019)
10.13057/BIODIV/D200432
A novel Bacillus sp. isolated from rotten seaweed: Identification and characterization alginate lyase it is produced
Dewi Seswita Zilda (2019)
10.1016/j.addr.2018.10.009
Local delivery of macromolecules to treat diseases associated with the colon
A. Bak (2018)
10.3390/nano10020183
Multifunctional Nanocarriers for Lung Drug Delivery
Jorge F. Pontes (2020)
10.1016/j.carbpol.2018.10.091
Exploring the hydrogen-bond structures in sodium alginate through two-dimensional correlation infrared spectroscopy.
L. Hou (2019)
10.1016/J.MOLSTRUC.2019.03.080
Advanced molecular interaction in Cu2+-alginate beads with high M/G ratio for the intercalation of Li+ and Mg2+ ions
Sung Ho Park (2019)
10.1016/J.LWT.2019.05.118
Calcium alginate beads loaded with Mg(OH)2 improve L. casei viability under simulated gastric condition
I. M. Arenales-Sierra (2019)
10.1016/J.COLSURFA.2019.05.013
Development and characterization of dual sensitive poly(N,N-diethyl acrylamide) grafted alginate microparticles
N. Işıklan (2019)
10.1016/j.ijbiomac.2020.07.157
Formation and characteristics of alginate and anthocyanin complexes.
Dovile Liudvinaviciute (2020)
10.1016/J.PROCBIO.2019.05.024
Immobilized fungal laccase as "green catalyst" for the decolourization process – State of the art
M. Deska (2019)
10.1039/c8bm00478a
Enhanced healing activity of burn wound infection by a dextran-HA hydrogel enriched with sanguinarine.
Qiyu Zhu (2018)
10.3390/ma11091522
Calcium Chloride Modified Alginate Microparticles Formulated by the Spray Drying Process: A Strategy to Prolong the Release of Freely Soluble Drugs
Marta Szekalska (2018)
10.1007/s00217-020-03496-x
An overview of microencapsulation in the food industry: opportunities, challenges, and innovations
Marta Arenas-Jal (2020)
10.1016/j.fbp.2020.04.011
In vitro evaluation of microparticles with Laurus nobilis L. extract prepared by spray-drying for application in food and pharmaceutical products
Michael Chaumun (2020)
10.1016/j.ijbiomac.2018.11.252
pH-Thermosensitive hydrogel based on polyvinyl alcohol/sodium alginate/N-isopropyl acrylamide composite for treating re-infected wounds.
A. Montaser (2019)
10.1016/j.jddst.2020.101551
pH-responsive double network alginate/kappa-carrageenan hydrogel beads for controlled protein release: Effect of pH and crosslinking agent
Selin Sarıyer (2020)
10.1016/j.foodhyd.2020.106142
Molecular characterisation of hot moulded alginate gels as a delivery vehicle for the release of entrapped caffeine
Courtney Morrish (2020)
See more
Semantic Scholar Logo Some data provided by SemanticScholar