Online citations, reference lists, and bibliographies.
Please confirm you are human
(Sign Up for free to never see this)
← Back to Search

Biomimicry Of Microbial Polysaccharide Hydrogels For Tissue Engineering And Regenerative Medicine - A Review.

Jian Yao Ng, Sybil Obuobi, Mei Ling Chua, C. Zhang, Shiqi Hong, Y. Kumar, R. Gokhale, Pui Lai Rachel Ee
Published 2020 · Chemistry, Medicine

Save to my Library
Download PDF
Analyze on Scholarcy
Share
Hydrogels as artificial biomaterial scaffolds offer a much favoured 3D microenvironment for tissue engineering and regenerative medicine (TERM). Towards biomimicry of the native ECM, polysaccharides from Nature have been proposed as ideal surrogates given their biocompatibility. In particular, derivatives from microbial sources have emerged as economical and sustainable biomaterials due to their fast and high yielding production procedures. Despite these merits, microbial polysaccharides do not interact biologically with human tissues, a critical limitation hampering their translation into paradigmatic scaffolds for in vitro 3D cell culture. To overcome this, chemical and biological functionalization of polysaccharide scaffolds have been explored extensively. This review outlines the most recent strategies in the preparation of biofunctionalized gellan gum, xanthan gum and dextran hydrogels fabricated exclusively via material blending. Using inorganic or organic materials, we discuss the impact of these approaches on cell adhesion, proliferation and viability of anchorage-dependent cells for various TERM applications.'
This paper references
10.1126/science.1168243
Drug Discovery and Natural Products: End of an Era or an Endless Frontier?
J. W. Li (2009)
10.1016/j.carbpol.2018.02.002
Synergistic effect of κ-carrageenan and gelatin blends towards adipose tissue engineering.
L. Tytgat (2018)
10.1039/C6TB01488G
Recent progress in gellan gum hydrogels provided by functionalization strategies.
Ana H. Bacelar (2016)
10.1002/term.363
Gellan gum‐based hydrogels for intervertebral disc tissue‐engineering applications
J. Silva-Correia (2011)
10.1038/nmat3339
Extracellular-matrix tethering regulates stem-cell fate.
Britta Trappmann (2012)
10.1039/9781847559425
Compendium of polymer terminology and nomenclature : IUPAC recommendations 2008
R. Jones (2009)
10.1248/CPB.58.1423
Chitosan nanoparticles: a promising system in novel drug delivery.
K. Nagpal (2010)
10.4103/2277-9175.188486
Evaluate the growth and adhesion of osteoblast cells on nanocomposite scaffold of hydroxyapatite/titania coated with poly hydroxybutyrate
Babak Pourmollaabbassi (2016)
10.1016/J.MATLET.2017.11.085
Polysaccharide based hydrogels reinforced with halloysite nanotubes via polyelectrolyte complexation
K. M. Rao (2018)
10.1016/j.biomaterials.2017.11.035
Does soft really matter? Differentiation of induced pluripotent stem cells into mesenchymal stromal cells is not influenced by soft hydrogels.
Roman Goetzke (2018)
10.1073/pnas.142063399
Tissue-nonspecific alkaline phosphatase and plasma cell membrane glycoprotein-1 are central antagonistic regulators of bone mineralization
L. Hessle (2002)
10.1016/j.carbpol.2017.01.078
Biosynthesis of agar in red seaweeds: A review.
Wei-Kang Lee (2017)
10.1089/ten.TEB.2017.0081
Tissue Engineering and Regenerative Medicine: New Trends and Directions-A Year in Review.
M. Gomes (2017)
10.1038/nrd1657
The evolving role of natural products in drug discovery
F. Koehn (2005)
10.1016/B978-0-08-100079-3.00021-1
Organic/inorganic nanocomposite hydrogels
J. Du (2015)
10.3389/fmicb.2015.01012
Present and future medical applications of microbial exopolysaccharides
M. Moscovici (2015)
10.1016/J.MATLET.2017.01.143
Xanthan gum/bioactive silica glass hybrid scaffolds reinforced with cellulose nanocrystals: Morphological, mechanical and in vitro cytocompatibility study
A. Kumar (2017)
10.15406/ATROA.2017.02.00022
Use of polysaccharide hydrogels in drug delivery and tissue engineering
R. K. Upadhyay (2017)
10.1016/J.MSEC.2019.109904
Blended alginate/collagen hydrogels promote neurogenesis and neuronal maturation
Samuel R Moxon (2019)
10.1016/0141-0229(94)90058-2
A new process for the production of clinical dextran by mixed-culture fermentation of Lipomyces starkeyi and Leuconostoc mesenteroides.
D. Kim (1994)
10.1007/978-3-319-39196-0_8
Protein-Based Hydrogels for Tissue Engineering.
Ashley C. Schloss (2016)
10.1016/J.PROGSOLIDSTCHEM.2004.07.001
Calcium phosphates as substitution of bone tissues
M. Vallet-Regí (2004)
10.1016/B978-1-78242-338-6.00010-7
Biomimetic mineralization of hydrogels
T. Douglas (2016)
10.3390/ma11010014
The Components of Bone and What They Can Teach Us about Regeneration
B. Le (2017)
10.1016/j.carbpol.2015.06.013
Injectable thermo-responsive hydrogel composed of xanthan gum and methylcellulose double networks with shear-thinning property.
Z. Liu (2015)
10.1067/MJW.2002.129073
Honey: A Potent Agent for Wound Healing?
P. Lusby (2002)
10.1242/jcs.023820
The extracellular matrix at a glance
Christian Frantz (2010)
10.1002/term.2062
Composites of gellan gum hydrogel enzymatically mineralized with calcium–zinc phosphate for bone regeneration with antibacterial activity
T. Douglas (2017)
10.2147/IJN.S37953
A nanoparticulate injectable hydrogel as a tissue engineering scaffold for multiple growth factor delivery for bone regeneration
D. Dyondi (2013)
10.1016/s1369-7021(05)70988-3
Bio-based polymers and composites
R. P. Wool (2005)
10.1039/c8bm00478a
Enhanced healing activity of burn wound infection by a dextran-HA hydrogel enriched with sanguinarine.
Qiyu Zhu (2018)
10.1016/J.CHROMA.2006.01.133
Preparation of glycerol dimethacrylate-based polymer monolith with unusual porous properties achieved via viscoelastic phase separation induced by monodisperse ultra high molecular weight poly(styrene) as a porogen.
H. Aoki (2006)
10.1016/S0142-9612(03)00340-5
Hydrogels for tissue engineering: scaffold design variables and applications.
Jeanie L Drury (2003)
10.1016/S0169-409X(01)00239-3
Hydrogels for biomedical applications.
A. Hoffman (2002)
10.1016/j.yexmp.2008.12.004
Nanoparticle-based targeted drug delivery.
R. Singh (2009)
10.1016/j.msec.2017.05.096
A mini review on hydrogels classification and recent developments in miscellaneous applications.
K. Varaprasad (2017)
10.3390/gels5020030
Challenges for Natural Hydrogels in Tissue Engineering
E. Jabbari (2019)
10.1016/j.actbio.2019.05.070
 Mechanisms of pore formation in hydrogel scaffolds textured by freeze-drying.
Jérôme Grenier (2019)
10.1016/j.toxlet.2017.05.007
Toxicity of silver nanoparticles in biological systems: Does the complexity of biological systems matter?
R. Vazquez-Muñoz (2017)
10.3390/pharmaceutics9040053
An Overview of Chitosan Nanoparticles and Its Application in Non-Parenteral Drug Delivery
M. Mohammed (2017)
10.1002/(SICI)1097-4636(200007)51:1<107::AID-JBM14>3.0.CO;2-F
In vitro and in vivo biocompatibility of chitosan-xanthan polyionic complex.
F. Chellat (2000)
10.1177/0885328214553959
Combining xanthan and chitosan membranes to multipotent mesenchymal stromal cells as bioactive dressings for dermo-epidermal wounds
M. Z. Bellini (2015)
10.1002/PAT.1134
Progress in the development of interpenetrating polymer network hydrogels.
D. Myung (2008)
10.1021/BM0700800
Novel hydrogels via click chemistry: synthesis and potential biomedical applications.
V. Crescenzi (2007)
10.1021/am504520j
Gellan gum-hyaluronic acid spongy-like hydrogels and cells from adipose tissue synergize promoting neoskin vascularization.
M. T. Cerqueira (2014)
10.1038/srep46050
Knockdown of toll-like receptor 4 signaling pathways ameliorate bone graft rejection in a mouse model of allograft transplantation
Jeng-Long Hsieh (2017)
10.1016/j.carbpol.2014.07.049
Evaluation of the ability of xanthan gum/gellan gum/hyaluronan hydrogel membranes to prevent the adhesion of postrepaired tendons.
S. M. Kuo (2014)
10.1002/term.2273
Enzymatic, urease‐mediated mineralization of gellan gum hydrogel with calcium carbonate, magnesium‐enriched calcium carbonate and magnesium carbonate for bone regeneration applications
T. Douglas (2017)
10.1016/j.ijbiomac.2018.07.031
Radiation fabrication of Xanthan-based wound dressing hydrogels embedded ZnO nanoparticles: In vitro evaluation.
A. Raafat (2018)
10.1038/boneres.2015.29
Nanomaterials and bone regeneration
T. Gong (2015)
10.1038/nature21392
Enzymatic mineralization generates ultrastiff and tough hydrogels with tunable mechanics
Nicolas Rauner (2017)
10.1016/J.FOODHYD.2012.01.004
Gelation of gellan – A review
E. Morris (2012)
10.1016/j.jmbbm.2017.04.006
The production of injectable hydrazone crosslinked gellan gum-hyaluronan-hydrogels with tunable mechanical and physical properties.
Jennika Karvinen (2017)
10.1039/c6cs00052e
Hydrogel scaffolds for differentiation of adipose-derived stem cells.
Qiutong Huang (2017)
10.1016/j.jcis.2014.09.041
Poly(vinylamine) microgel-dextran composite hydrogels: characterisation; properties and pH-triggered degradation.
Judith Mccann (2015)
10.1038/boneres.2017.14
Injectable hydrogels for cartilage and bone tissue engineering
Mei Liu (2017)
10.1088/1748-6041/10/4/045002
Neuronal adhesion, proliferation and differentiation of embryonic stem cells on hybrid scaffolds made of xanthan and magnetite nanoparticles.
T. Glaser (2015)
10.1016/j.nano.2017.11.011
Nanocellulose reinforced gellan-gum hydrogels as potential biological substitutes for annulus fibrosus tissue regeneration.
D. R. Pereira (2018)
10.1016/j.actbio.2010.03.031
Evaluation of mesoporous silicon/polycaprolactone composites as ophthalmic implants.
Soheila Kashanian (2010)
10.1016/J.RBMRET.2005.04.006
Polysaccharides as scaffolds for bone regeneration
M. Barbosa (2005)
10.1016/j.carbpol.2013.10.080
Mineralization of hydroxyapatite upon a unique xanthan gum hydrogel by an alternate soaking process.
H. Izawa (2014)
10.1016/j.biomaterials.2010.06.035
Modified Gellan Gum hydrogels with tunable physical and mechanical properties.
Daniela F. Coutinho (2010)
10.1016/J.MATLET.2016.12.122
Bioinspired, biomimetic, double-enzymatic mineralization of hydrogels for bone regeneration with calcium carbonate
M. Lopez-Heredia (2016)
10.11138/ADS/2014.5.3.108
Nano-hydroxyapatite and its applications in preventive, restorative and regenerative dentistry: a review of literature.
Erlind Pepla (2014)
10.1002/adhm.201200256
Biocompatibility evaluation of ionic- and photo-crosslinked methacrylated gellan gum hydrogels: in vitro and in vivo study.
J. Silva-Correia (2013)
10.1016/j.colsurfb.2018.06.048
Xanthan gum-functionalised span nanoparticles for gene targeting to endothelial cells.
I. Fernandez-Piñeiro (2018)
10.2217/nnm.10.12
Engineering hydrogels as extracellular matrix mimics.
Hikmet Geçkil (2010)
10.1089/ten.TEA.2016.0430
* Synthesis and Characterization of Electroactive Gellan Gum Spongy-Like Hydrogels for Skeletal Muscle Tissue Engineering Applications.
F. Berti (2017)
10.1021/acsami.7b19730
Three-Dimensional Bioprinting of Oppositely Charged Hydrogels with Super Strong Interface Bonding.
H. Li (2018)
10.1016/S0032-3861(97)00266-8
Annealing induced gelation of xanthan/water systems
T. Yoshida (1998)
10.1002/CM.20041
Effects of substrate stiffness on cell morphology, cytoskeletal structure, and adhesion.
T. Yeung (2005)
10.3390/ma9040267
Composite Hydrogels for Bone Regeneration
G. Tozzi (2016)
10.1016/S0144-8617(96)00093-8
Rheological and thermal studies of gel-sol transition in gellan gum aqueous solutions
E. Miyoshi (1996)
10.1351/pac200476111985
Definition of terms related to polymer blends, composites, and multiphase polymeric materials (IUPAC Recommendations 2004)
W. J. Work (2004)
10.1007/BF02996744
Screening of matrix suitable for immobilization of microbial cells
I. Takata (1977)
10.1002/jbm.a.32574
Gellan gum: a new biomaterial for cartilage tissue engineering applications.
J. T. Oliveira (2010)
10.1016/J.BJOMS.2006.09.013
Manuka honey dressing: An effective treatment for chronic wound infections.
B. Visavadia (2008)
10.1038/nrm3896
Mechanotransduction and extracellular matrix homeostasis
J. Humphrey (2014)
10.1016/j.kjms.2016.11.004
Achyranthes bidentate saponins protect rat articular chondrocytes against interleukin‐1β‐induced inflammation and apoptosis in vitro
X. Xu (2017)
10.1016/j.phytochem.2016.11.012
Triterpenoid saponins with anti-inflammatory activities from Ilex pubescens roots.
P. Wu (2017)
10.1016/j.ijpharm.2014.03.038
Application of gellan gum in pharmacy and medicine.
Tomasz Osmałek (2014)
10.3390/ijms15033640
An Overview of Poly(lactic-co-glycolic) Acid (PLGA)-Based Biomaterials for Bone Tissue Engineering
P. Gentile (2014)
10.1016/j.msec.2014.01.002
Synthesis and characterization of xanthan-hydroxyapatite nanocomposites for cellular uptake.
V. Bueno (2014)
10.1016/j.actbio.2014.07.009
Engineering cell-adhesive gellan gum spongy-like hydrogels for regenerative medicine purposes.
Lucília P da Silva (2014)
10.1016/j.carbpol.2017.11.081
Preparation and properties of wet-spun agar fibers.
J. Liu (2018)
10.5301/ijao.5000667
Polysaccharide-based hydrogels with tunable composition as 3D cell culture systems
R. Gentilini (2018)
10.1088/0957-4484/21/22/225606
Enzyme-triggered self-assembly of a small molecule: a supramolecular hydrogel with leaf-like structures and an ultra-low minimum gelation concentration.
Huaimin Wang (2010)
10.1007/s13233-019-7085-5
Evaluation of Cartilage Regeneration in Gellan Gum/agar Blended Hydrogel with Improved Injectability
Jong Seon Baek (2019)
10.1007/s13233-018-6094-0
Evaluation of Saponin Loaded Gellan Gum Hydrogel Scaffold for Cartilage Regeneration
Ha Yan Jeon (2018)
10.1016/0378-5173(91)90034-L
Rheological evaluation of deacetylated gellan gum (Gelrite) for pharmaceutical use
P. Deasy (1991)
10.1089/TEN.2006.12.1197
Electrospinning of polymeric nanofibers for tissue engineering applications: a review.
Quynh P. Pham (2006)
10.1128/AAC.01250-17
Single-Center Evaluation of an Agar-Based Screening for Azole Resistance in Aspergillus fumigatus by Using VIPcheck
J. Buil (2017)
10.1016/j.matlet.2019.126891
Thiolated gellan gum hydrogels as a peptide delivery system for 3D neural stem cell culture
Yue Yu (2020)
10.1016/j.jare.2017.01.005
A review on polymeric hydrogel membranes for wound dressing applications: PVA-based hydrogel dressings
E. Kamoun (2017)
10.1016/j.actbio.2016.11.016
3D culture of human pluripotent stem cells in RGD-alginate hydrogel improves retinal tissue development.
N. Hunt (2017)
10.1016/b978-0-12-814033-8.00010-2
Hydrogel Nanocomposite Systems
R. Conte (2019)
10.1007/s10973-016-5757-3
Thermal behavior of polyvinyl alcohol–gellan gum–Al3+ composite hydrogels with improved network structure and mechanical property
F. Wang (2016)
10.1016/j.carbpol.2012.02.036
Curcumin/xanthan-galactomannan hydrogels: rheological analysis and biocompatibility.
Eneida Janiscki Da-Lozzo (2013)
10.1002/term.1959
Biological performance of cell‐encapsulated methacrylated gellan gum‐based hydrogels for nucleus pulposus regeneration
R. Tsaryk (2017)
10.1016/j.msec.2015.03.023
Biocompatible xanthan/polypyrrole scaffolds for tissue engineering.
V. Bueno (2015)
10.1093/bmb/ldn025
Articular cartilage: structure, injuries and review of management.
A. Bhosale (2008)
10.2174/138955710793564115
Microbial exo-polysaccharides for biomedical applications.
I. Shih (2010)
10.1021/bm301332z
Microfluidic fabrication of self-assembled peptide-polysaccharide microcapsules as 3D environments for cell culture.
A. C. Mendes (2012)
10.1016/j.msec.2019.110444
Advances in cartilage repair: The influence of inorganic clays to improve mechanical and healing properties of antibacterial Gellan gum-Manuka honey hydrogels.
M. A. Bonifacio (2020)
10.1038/nrc1391
Hyaluronan: from extracellular glue to pericellular cue
B. Toole (2004)
10.1016/S0268-005X(09)80200-2
Effect of monovalent and divalent cations on the rheological properties of gellan gels
Hatsue Moritaka (1991)
Bone regeneration: molecular and cellular interactions with calcium phosphate ceramics
F. Barrère (2006)
10.1016/j.biomaterials.2011.12.050
The mechanical properties and cytotoxicity of cell-laden double-network hydrogels based on photocrosslinkable gelatin and gellan gum biomacromolecules.
H. Shin (2012)
10.1016/j.bcp.2008.07.023
Anoikis: a necessary death program for anchorage-dependent cells.
P. Chiarugi (2008)
10.1016/J.MATLET.2017.12.004
Phytase-mediated enzymatic mineralization of chitosan-enriched hydrogels
Jana Lísková (2018)
10.1016/j.biopha.2017.10.068
Panax quinquefolium saponin inhibits endoplasmic reticulum stress-induced apoptosis and the associated inflammatory response in chondrocytes and attenuates the progression of osteoarthritis in rat.
Jun-jun Xie (2018)
10.1002/term.2058
Three‐dimensional plotting of a cell‐laden alginate/methylcellulose blend: towards biofabrication of tissue engineering constructs with clinically relevant dimensions
K. Schütz (2017)
10.1021/acs.accounts.6b00477
Versatile Functionalization of Polysaccharides via Polymer Grafts: From Design to Biomedical Applications.
Yang Hu (2017)
10.1002/adhm.201700686
Gellan Gum Hydrogels with Enzyme‐Sensitive Biodegradation and Endothelial Cell Biorecognition Sites
Lucília P da Silva (2018)
10.2217/NNM.12.109
Magnetic nanoparticle-based approaches to locally target therapy and enhance tissue regeneration in vivo.
Richard Sensenig (2012)
10.1002/term.1902
Development and characterization of novel agar and gelatin injectable hydrogel as filler for peripheral nerve guidance channels
C. Tonda-Turo (2017)
10.1016/j.ijpharm.2017.06.060
Cysteamine polysaccharide hydrogels: Study of extended ocular delivery and biopermanence time by PET imaging.
Andrea Luaces-Rodríguez (2017)
Cellular Organization of Glycosylation
A. Varki (2009)
10.1016/j.msec.2019.02.035
Bioactive glass ions induce efficient osteogenic differentiation of human adipose stem cells encapsulated in gellan gum and collagen type I hydrogels.
Kaisa Vuornos (2019)
10.1016/S0142-9612(00)00121-6
Scaffolds in tissue engineering bone and cartilage.
D. Hutmacher (2000)
10.1016/0144-8617(87)90004-X
Gelation of gellan gum
H. Grasdalen (1987)
10.1016/j.biomaterials.2010.03.024
The effect of 3D hydrogel scaffold modulus on osteoblast differentiation and mineralization revealed by combinatorial screening.
K. Chatterjee (2010)
10.1016/j.carbpol.2018.01.028
Mechanical reinforcement of gellan gum polyelectrolyte hydrogels by cationic polyurethane soft nanoparticles.
M. Sahraro (2018)
10.3390/nano8110882
Exploring the Role of Nanoparticles in Enhancing Mechanical Properties of Hydrogel Nanocomposites
J. Zaragoza (2018)
10.1016/j.jcis.2019.12.097
Calcium phosphate mineralization through homogenous enzymatic catalysis: Investigation of the early stages.
E. Colaço (2019)
10.1039/B916705F
Synthetic hydrogels for controlled stem cell differentiation
S. Liu (2010)
10.1186/s12989-017-0199-z
Mechanistic understanding of nanoparticles’ interactions with extracellular matrix: the cell and immune system
A. Engin (2017)
10.1557/MRC.2017.59
Three-dimensional cell culture of human mesenchymal stem cells in nanofibrillar cellulose hydrogels
Ioannis Azoidis (2017)
10.3891/ACTA.CHEM.SCAND.45-1018
Infrared spectra of amorphous and crystalline calcium carbonate
F. A. Andersen (1991)
10.1080/03008200390152034
Coexistence of Amorphous and Crystalline Calcium Carbonate in Skeletal Tissues
J. Aizenberg (2003)
10.1016/j.actbio.2014.06.029
Composite pullulan-dextran polysaccharide scaffold with interfacial polyelectrolyte complexation fibers: a platform with enhanced cell interaction and spatial distribution.
Marie F. A. Cutiongco (2014)
10.1021/acsomega.8b00308
Gelatin-Based Hydrogels Blended with Gellan as an Injectable Wound Dressing
Yueyuan Zheng (2018)
10.1002/ADFM.201606273
Self-assembled Hydrogel Fiber Bundles from Oppositely Charged Polyelectrolytes Mimic Micro-/nanoscale Hierarchy of Collagen.
Shilpa Sant (2017)
10.1016/S0008-6215(00)85885-1
Structure of extracellular polysaccharide from Xanthomonas campestris.
P. Jansson (1975)
10.1177/0883911519876080
Reduced graphene oxide–reinforced gellan gum thermoresponsive hydrogels as a myocardial tissue engineering scaffold
S. Zargar (2019)
10.1016/S0141-3910(97)00180-8
Properties and applications of xanthan gum
B. Katzbauer (1998)
10.1080/15583720701271278
Polymer Nanocomposites: The “Nano” Effect on Mechanical Properties
A. Crosby (2007)
10.1016/j.carbpol.2018.02.083
Dextran hydrogels incorporated with bioactive glass-ceramic: Nanocomposite scaffolds for bone tissue engineering.
Parisa Nikpour (2018)
10.1016/J.BIOMATERIALS.2006.07.008
Stem cell-based tissue engineering with silk biomaterials.
Y. Wang (2006)
10.1002/jbm.a.34650
Rheological and mechanical properties of acellular and cell-laden methacrylated gellan gum hydrogels.
J. Silva-Correia (2013)
10.1002/jbm.a.36248
Gellan gum-hydroxyapatite composite spongy-like hydrogels for bone tissue engineering.
Marianthi G Manda (2018)
10.1016/J.POLYMERTESTING.2017.08.030
Development of sodium alginate-xanthan gum based nanocomposite scaffolds reinforced with cellulose nanocrystals and halloysite nanotubes
A. Kumar (2017)
10.1016/j.nano.2018.03.011
Development of hybrid scaffold with biomimetic 3D architecture for bone regeneration.
Priya Vashisth (2018)
10.1016/J.JMST.2017.10.003
Polysaccharide-based magnetically responsive polyelectrolyte hydrogels for tissue engineering applications
K. M. Rao (2017)
10.1146/ANNUREV.CB.11.110195.003001
Integrins: emerging paradigms of signal transduction.
M. Schwartz (1995)
10.4137/BTRI.S36138
Hydroxyapatite—Past, Present, and Future in Bone Regeneration
Vivekanand S Kattimani (2016)
10.1016/J.BIORTECH.2006.03.012
Optimization of nutrients for gellan gum production by Sphingomonas paucimobilis ATCC-31461 in molasses based medium using response surface methodology.
R. M. Banik (2007)
10.1016/J.JDDST.2018.03.026
Anticancer drug carriers using dicalcium phosphate/dextran/CMCnanocomposite scaffolds
E. El-Meliegy (2018)
10.1016/j.carbpol.2014.03.041
Xanthan gum stabilized gold nanoparticles: characterization, biocompatibility, stability and cytotoxicity.
D. Pooja (2014)
10.1007/978-1-4939-6840-4_18
Electrospun Nanofiber Scaffolds and Their Hydrogel Composites for the Engineering and Regeneration of Soft Tissues.
O. Manoukian (2017)
10.3390/polym12010099
Xanthan Gum–Konjac Glucomannan Blend Hydrogel for Wound Healing
A. Alves (2020)
10.3390/nano8110960
Scaffold Structural Microenvironmental Cues to Guide Tissue Regeneration in Bone Tissue Applications
Xuening Chen (2018)
10.1021/MA9907587
Structure and Morphology of Freeze/Thawed PVA Hydrogels
C. Hassan (2000)
10.1016/j.actbio.2009.03.005
Preparation and characterization of homogeneous chitosan-polylactic acid/hydroxyapatite nanocomposite for bone tissue engineering and evaluation of its mechanical properties.
Xuan Cai (2009)
10.1016/j.msec.2018.09.045
Mechanically-enhanced polysaccharide-based scaffolds for tissue engineering of soft tissues.
Renata Francielle Bombaldi de Souza (2019)
10.1021/CR000108X
Hydrogels for tissue engineering.
K. Lee (2001)
10.1007/s13233-019-7048-x
Evaluation of Chondrogenic Differentiation Ability of Bone Marrow Mesenchymal Stem Cells in Silk Fibroin/Gellan Gum Hydrogels Using miR-30
E. Y. Shin (2019)
10.1016/j.addr.2015.11.019
ECM and ECM-like materials - Biomaterials for applications in regenerative medicine and cancer therapy.
S. Hinderer (2016)
10.1016/j.biomaterials.2016.01.050
Enzyme responsive GAG-based natural-synthetic hybrid hydrogel for tunable growth factor delivery and stem cell differentiation.
Fraz Anjum (2016)
10.1016/j.compositesb.2020.107937
Calcium silicate scaffolds promoting bone regeneration via the doping of Mg2+ or Mn2+ ion
Zhiyun Du (2020)
10.1088/2053-1591/AAB5F5
3D Nanostructured materials: TiO2 nanoparticles incorporated gellan gum scaffold for photocatalyst and biomedical Applications
M. Razali (2018)
10.1016/J.MATLET.2016.08.043
Polysaccharides based antibacterial polyelectrolyte hydrogels with silver nanoparticles
K. M. Rao (2016)
10.1002/jbm.a.36277
Novel self-gelling injectable hydrogel/alpha-tricalcium phosphate composites for bone regeneration: Physiochemical and microcomputer tomographical characterization.
T. Douglas (2018)
10.1002/term.1616
Enzymatic mineralization of gellan gum hydrogel for bone tissue‐engineering applications and its enhancement by polydopamine
Tel Douglas (2014)
10.1002/bit.22361
Hydrogels as extracellular matrix mimics for 3D cell culture.
Mark W. Tibbitt (2009)
10.1177/0885328207076522
An Initial Evaluation of Gellan Gum as a Material for Tissue Engineering Applications
A. M. Smith (2007)
10.1002/chem.201701906
Chemical Functionalization of Polysaccharides-Towards Biocompatible Hydrogels for Biomedical Applications.
A. Kirschning (2018)
10.1016/j.carbpol.2017.01.064
Insight into halloysite nanotubes-loaded gellan gum hydrogels for soft tissue engineering applications.
M. A. Bonifacio (2017)
10.1021/acsami.6b05698
Enhancing the Mechanical Properties of Biodegradable Polymer Blends Using Tubular Nanoparticle Stitching of the Interfaces.
Yichen Guo (2016)
10.1016/j.ijbiomac.2017.03.080
Polysaccharide based bionanocomposite hydrogels reinforced with cellulose nanocrystals: Drug release and biocompatibility analyses.
K. Madhusudana Rao (2017)
10.1371/journal.pone.0221931
Design of modular gellan gum hydrogel functionalized with avidin and biotinylated adhesive ligands for cell culture applications
Christine Gering (2019)
10.1007/s13726-016-0492-y
Development of a novel glucosamine/silk fibroin–chitosan blend porous scaffold for cartilage tissue engineering applications
Varshini Vishwanath (2016)
10.1016/j.actbio.2019.03.041
Fabrication and mechanical characterization of 3D printed vertical uniform and gradient scaffolds for bone and osteochondral tissue engineering.
Sean M. Bittner (2019)
10.1016/S1369-7021(07)70078-0
ZnO - nanostructures, defects, and devices
L. Schmidt-Mende (2007)
10.1111/IJAG.12252
Bioglass and Bioactive Glasses and Their Impact on Healthcare
J. Jones (2016)
10.1016/J.MATLET.2018.03.204
3D bioprinting of cell-laden scaffolds for intervertebral disc regeneration
Duo Hu (2018)
10.1016/j.biomaterials.2008.09.041
Hydrogel based on interpenetrating polymer networks of dextran and gelatin for vascular tissue engineering.
Yun-xiao Liu (2009)
10.22203/ECM.V026A16
Generation of co-culture spheroids as vascularisation units for bone tissue engineering.
R. Walser (2013)
10.1007/12_100
Functional Polymers Based on Dextran
T. Heinze (2006)
10.1101/cshperspect.a004903
Overview of the matrisome--an inventory of extracellular matrix constituents and functions.
R. Hynes (2012)
Use of Osteoplug polycaprolactone implants as novel burr-hole covers.
S. W. Low (2009)
10.1016/j.biomaterials.2009.05.011
Neurite infiltration and cellular response to electrospun polycaprolactone scaffolds implanted into the brain.
D. Nisbet (2009)
10.1080/00914037.2018.1482468
Hybrid PVA-xanthan gum hydrogels as nucleus pulposus substitutes
G. Leone (2019)
10.1016/j.carbpol.2017.10.009
Application of xanthan gum as polysaccharide in tissue engineering: A review.
A. Kumar (2018)
10.1002/APP.42035
Xanthan gum: a versatile biopolymer for biomedical and technological applications
D. F. Petri (2015)
10.1039/c7bm01101f
Gellan Gum-based luminal fillers for peripheral nerve regeneration: an in vivo study in the rat sciatic nerve repair model.
C. R. Carvalho (2018)
10.2217/nnm.12.149
Engineering dextran-based scaffolds for drug delivery and tissue repair.
G. Sun (2012)
10.1016/j.drudis.2008.07.004
Natural products in drug discovery.
A. Harvey (2008)
10.1128/JB.00965-12
Genome sequence of Xanthomonas campestris JX, an industrially productive strain for Xanthan gum.
Fei Tao (2012)
10.1016/b978-0-08-102906-0.00023-4
Nanocomposite hydrogels for tissue engineering applications
Azadeh Mostafavi (2020)
10.4236/JBNB.2011.23027
Biodegradable Polysaccharide Gels for Skin Scaffolds
S. J. Juris (2011)
10.1089/ten.TEA.2011.0632
Angiogenic potential of gellan-gum-based hydrogels for application in nucleus pulposus regeneration: in vivo study.
J. Silva-Correia (2012)
10.1016/J.JCYT.2018.02.241
Age-dependent modulation of the extracellular microenvironment of human adipose-derived stem cells
K. Hamel (2018)
10.1016/j.carbpol.2018.06.115
Antibacterial effectiveness meets improved mechanical properties: Manuka honey/gellan gum composite hydrogels for cartilage repair.
M. A. Bonifacio (2018)
10.1016/j.actbio.2009.11.013
Electrospun microfiber meshes of silicon-doped vaterite/poly(lactic acid) hybrid for guided bone regeneration.
A. Obata (2010)
10.1016/j.carbpol.2018.12.006
Mineralized layered films of xanthan and chitosan stabilized by polysaccharide interactions: A promising material for bone tissue repair.
A. Aguiar (2019)
10.1016/B978-0-12-816506-5.00009-7
Synthesis of hydrogels and their emerging role in pharmaceutics
Hamna Yasin (2019)
Production, properties and applications of Xanthan
J. Kennedy (1984)
10.3109/10408449609012524
Toxicological aspects of topical silver pharmaceuticals.
M. Hollinger (1996)
10.1016/S0142-9612(00)00151-4
Surface-immobilized dextran limits cell adhesion and spreading.
S. Massia (2000)
10.1021/acs.jafc.7b00985
Potential Anti-inflammatory Steroidal Saponins from the Berries of Solanum nigrum L. (European Black Nightshade).
Yihai Wang (2017)
10.1016/j.ijbiomac.2020.01.191
Osteochondral and bone tissue engineering scaffold prepared from Gallus var domesticus derived demineralized bone powder combined with gellan gum for medical application.
D. Kim (2020)
10.1016/j.addr.2013.04.002
Interpenetrating Polymer Networks polysaccharide hydrogels for drug delivery and tissue engineering.
P. Matricardi (2013)
10.1016/j.stem.2018.02.001
Understanding the Extracellular Matrix to Enhance Stem Cell-Based Tissue Regeneration.
L. Niklason (2018)
10.1038/nrm2236
The third dimension bridges the gap between cell culture and live tissue
F. Pampaloni (2007)
10.1088/1758-5090/8/2/025011
A tailored three-dimensionally printable agarose-collagen blend allows encapsulation, spreading, and attachment of human umbilical artery smooth muscle cells.
Marius Köpf (2016)
10.1016/j.biomaterials.2014.06.047
Influence of the stiffness of three-dimensional alginate/collagen-I interpenetrating networks on fibroblast biology.
Cristiana Branco da Cunha (2014)
10.1016/J.JFOODENG.2011.03.035
Production, recovery and applications of xanthan gum by Xanthomonas campestris
A. Palaniraj (2011)
10.1016/0169-409X(93)90029-4
Hydrogel delivery systems based on polymer blends, block co-polymers or interpenetrating networks
Y. Bae (1993)
10.1016/J.POLYMER.2007.06.070
Biomimetic strain hardening in interpenetrating polymer network hydrogels
D. Myung (2007)
10.1016/bs.ctdb.2018.02.002
The Physical and Biochemical Properties of the Extracellular Matrix Regulate Cell Fate.
Jonathon M. Muncie (2018)
10.1016/j.actbio.2018.12.008
Degradable conductive self-healing hydrogels based on dextran-graft-tetraaniline and N-carboxyethyl chitosan as injectable carriers for myoblast cell therapy and muscle regeneration.
B. Guo (2019)
10.1016/j.biomaterials.2016.01.036
Planar and tubular patterning of micro and nano-topographies on poly(vinyl alcohol) hydrogel for improved endothelial cell responses.
Marie F.A. Cutiongco (2016)
10.1002/jbm.a.36408
Layer-by-layer buildup of polysaccharide-containing films: Physico-chemical properties and mesenchymal stem cells adhesion.
V. Kulikouskaya (2018)
10.1016/j.biomaterials.2017.06.020
Polysaccharide matrices used in 3D in vitro cell culture systems.
Dorina Diekjürgen (2017)



This paper is referenced by
10.1016/j.ijbiomac.2020.07.071
Azobenzene-grafted carboxymethyl cellulose hydrogels with photo-switchable, reduction-responsive and self-healing properties for a controlled drug release system.
Y. Kim (2020)
10.3390/pharmaceutics12100983
An Overview of Biopolymeric Electrospun Nanofibers Based on Polysaccharides for Wound Healing Management
Andreea-Teodora Iacob (2020)
10.1021/acsomega.0c02678
Three Dimensional Quercetin-Functionalized Patterned Scaffold: Development, Characterization, and In Vitro Assessment for Neural Tissue Engineering
Priya Vashisth (2020)
10.3389/fbioe.2020.564667
Chlorella vulgaris Extract as a Serum Replacement That Enhances Mammalian Cell Growth and Protein Expression
Jian Yao Ng (2020)
10.3390/biomimetics5040049
Biomimetic Hybrid Systems for Tissue Engineering
Omid Yousefzade (2020)
10.1016/j.jece.2020.104702
Xanthan gum-derived materials for applications in environment and eco-friendly materials: A review
M. H. A. Elella (2020)
10.1016/j.ijbiomac.2020.10.083
Preparation and characterisation of a gellan gum-based hydrogel enabling osteogenesis and inhibiting Enterococcus faecalis.
L. Xu (2020)
10.1016/j.tifs.2020.12.026
Polysaccharides obtained from natural edible sources and their role in modulating the immune system: Biologically active potential that can be exploited against COVID-19
Jhonatas Rodrigues Barbosa (2021)
10.1016/j.ijbiomac.2020.12.012
Development of composite hydrogel based on hydroxyapatite mineralization over pectin reinforced with cellulose nanocrystal.
Daniele M Catori (2020)
Semantic Scholar Logo Some data provided by SemanticScholar