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Iron-based Nanoparticles And Their Potential Toxicity: Focus On Oxidative Stress And Apoptosis.

J. Paunovic, D. Vučević, T. Radosavljević, S. Mandić-Rajčević, I. Pantic
Published 2019 · Chemistry, Medicine

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Recently, there have been several studies indicating that iron-based nanomaterials may exhibit certain toxic properties. Compared to conventional iron and iron oxides, iron nanoparticles (FeNPs) have some unique physical and chemical traits which impact their absorption, biodistribution and elimination. Facilitated passage through biological barriers enables FeNPs to reach various tissues and cells, and interact with a variety of different compounds. Currently, most of the recent research is focused on the potential cytotoxicity of FeNPs, and its implications on cell viability and functions. Some studies suggested that, in certain cell types, FeNPs may increase levels of oxidative stress and induce generation of reactive oxygen species. Oxidative stress may be one of the most important mechanisms by which FeNPs exhibit cytotoxic effects. Some authors have also suggested that, in certain conditions, exposure to FeNPs, in combination with other factors, may lead to changes in intracellular signaling resulting in programmed cell death. In this short review, we focus on the recent research on potential cytotoxicity of iron-based nanomaterials, and the potential implications of this new knowledge in medicine, chemistry and biology.
This paper references
10.1080/10837450.2017.1337793
Iron oxide magnetic nanoparticles as antimicrobials for therapeutics
Lucas de Alcântara Sica de Toledo (2018)
10.1080/1040841X.2016.1267708
Iron oxide nanoparticles in modern microbiology and biotechnology
Ranmadugala Dinali (2017)
10.1007/s00411-018-0754-5
Gold-coated iron oxide nanoparticles trigger apoptosis in the process of thermo-radiotherapy of U87-MG human glioma cells
Ali Neshastehriz (2018)
10.1166/JNN.2010.2488
Oxidative stress and apoptosis induced by iron oxide nanoparticles in cultured human umbilical endothelial cells.
Mo-Tao Zhu (2010)
10.1016/j.tiv.2014.07.010
Magnetic iron oxide nanoparticles induce autophagy preceding apoptosis through mitochondrial damage and ER stress in RAW264.7 cells.
Eunjung Park (2014)
10.1166/jnn.2019.16548
Superparamagnetic Iron Oxide Nanoparticles/Doxorubicin-Loaded Starch-Octanoic Micelles for Targeted Tumor Therapy.
Liyong Jie (2019)
10.1016/j.jtemb.2016.03.017
Are iron oxide nanoparticles safe? Current knowledge and future perspectives.
Vanessa Valdiglesias (2016)
10.1186/s12868-017-0369-9
Iron oxide nanoparticles may damage to the neural tissue through iron accumulation, oxidative stress, and protein aggregation
Zahra Yarjanli (2017)
10.1016/j.jfda.2014.01.007
Reactive oxygen species-related activities of nano-iron metal and nano-iron oxides.
H. Wu (2014)
10.1166/jbn.2019.2678
Superparamagnetic Iron Oxide Nanoparticles for Cancer Diagnosis and Therapy.
Liqin Xie (2019)
10.1021/es300839e
Transformations of nanomaterials in the environment.
G. Lowry (2012)
10.2147/OTT.S95644
Combination of cold atmospheric plasma and iron nanoparticles in breast cancer: gene expression and apoptosis study
A. Jalili (2016)
10.1016/j.lfs.2019.05.048
Long-term biodistribution and toxicity of curcumin capped iron oxide nanoparticles after single-dose administration in mice.
N. Elbialy (2019)
10.3390/ma12040617
Superparamagnetic Iron Oxide Nanoparticles—Current and Prospective Medical Applications
J. Dulińska-Litewka (2019)
10.1016/j.nano.2016.01.005
Iron oxide nanoparticles as magnetic relaxation switching (MRSw) sensors: Current applications in nanomedicine.
D. Alcántara (2016)
10.1016/j.taap.2018.04.028
Feraheme® suppresses immune function of human T lymphocytes through mitochondrial damage and mitoROS production
Ankit Shah (2018)
10.1002/anie.201800883
Synthesis of Sub-2 nm Iron-Doped NiSe2 Nanowires and Their Surface-Confined Oxidation for Oxygen Evolution Catalysis.
C. Gu (2018)
10.2147/IJN.S173954
Doxorubicin and indocyanine green loaded superparamagnetic iron oxide nanoparticles with PEGylated phospholipid coating for magnetic resonance with fluorescence imaging and chemotherapy of glioma
C. Shen (2019)
10.1080/10643389.2013.790747
Biocatalytic Synthesis Pathways, Transformation, and Toxicity of Nanoparticles in the Environment
A. D. Dwivedi (2014)
10.1111/jmi.12585
Iron oxide nanoparticles decrease nuclear fractal dimension of buccal epithelial cells in a time‐dependent manner
D. Nikolovski (2017)
10.1021/acsami.9b17512
Iron-Based Core-Shell Nanowires for Combinatorial Drug Delivery, Photothermal and Magnetic Therapy.
Aldo Isaac Martínez Banderas (2019)
10.1166/jbn.2019.2689
Superparamagnetic Iron Oxide Nanoparticles as Magnetic Resonance Imaging Contrast Agents and Induced Autophagy Response in Endothelial Progenitor Cells.
Lizhi Zhang (2019)
10.1080/17435390.2017.1342011
Toxicogenomics of iron oxide nanoparticles in the nematode C. elegans
L. Gonzalez-Moragas (2017)
10.1021/acs.nanolett.7b05310
Magnetic Iron Oxide Nanowires Formed by Reactive Dewetting.
R. Bennett (2018)
10.1002/jbt.22225
Toxicity of iron oxide nanoparticles: Size and coating effects
M. Abakumov (2018)
10.1016/j.envpol.2017.09.052
Environmental transformations and ecological effects of iron-based nanoparticles.
Cheng Lei (2018)
10.2147/IJN.S127549
Iron oxide magnetic nanoparticles combined with actein suppress non-small-cell lung cancer growth in a p53-dependent manner
M. Wang (2017)
10.1016/j.chemosphere.2018.09.120
Zinc and iron oxide nanoparticles improved the plant growth and reduced the oxidative stress and cadmium concentration in wheat.
M. Rizwan (2019)
10.1016/j.jhazmat.2016.01.066
Where does the toxicity of metal oxide nanoparticles come from: The nanoparticles, the ions, or a combination of both?
D. Wang (2016)
10.1016/j.chemosphere.2019.124562
Toxicity of superparamagnetic iron oxide nanoparticles to the microalga Chlamydomonas reinhardtii.
J. Hurtado-Gallego (2019)
10.1515/reveh-2016-0063
Recent advances on iron oxide magnetic nanoparticles as sorbents of organic pollutants in water and wastewater treatment
A. M. Gutiérrez (2017)
10.3390/antibiotics7020046
Iron Oxide Nanoparticles for Biomedical Applications: A Perspective on Synthesis, Drugs, Antimicrobial Activity, and Toxicity
L. S. Arias (2018)
10.1016/j.scitotenv.2008.11.022
Aggregation and disaggregation of iron oxide nanoparticles: Influence of particle concentration, pH and natural organic matter.
M. Baalousha (2009)
10.1016/j.colsurfb.2017.07.025
Activatable interpolymer complex-superparamagnetic iron oxide nanoparticles as magnetic resonance contrast agents sensitive to oxidative stress.
Eunsoo Yoo (2017)
10.1016/j.watres.2016.05.019
An overview of preparation and applications of stabilized zero-valent iron nanoparticles for soil and groundwater remediation.
X. Zhao (2016)
10.1016/j.toxlet.2018.04.033
Characterization of superparamagnetic iron oxide nanoparticle-induced apoptosis in PC12 cells and mouse hippocampus and striatum.
Yutong Liu (2018)
10.1016/j.envpol.2016.04.034
Incorporation of zero valent iron nanoparticles in the matrix of cationic resin beads for the remediation of Cr(VI) contaminated waters.
A. Toli (2016)



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