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Bone Morphogenetic Proteins: A Critical Review.

Beth Bragdon, Oleksandra Moseychuk, Sven Saldanha, Daniel King, J. Julian, Anja G Nohe
Published 2011 · Medicine, Biology

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Bone Morphogenetic Proteins (BMPs) are potent growth factors belonging to the Transforming Growth Factor Beta superfamily. To date over 20 members have been identified in humans with varying functions during processes such as embryogenesis, skeletal formation, hematopoiesis and neurogenesis. Though their functions have been identified, less is known regarding levels of regulation at the extracellular matrix, membrane surface, and receptor activation. Further, current models of activation lack the integration of these regulatory mechanisms. This review focuses on the different levels of regulation, ranging from the release of BMPs into the extracellular components to receptor activation for different BMPs. It also highlights areas in research that is lacking or contradictory.
This paper references
10.1038/ng1178
Gremlin is the BMP antagonist required for maintenance of Shh and Fgf signals during limb patterning
M. Khokha (2003)
Biochim
R. Derynck (1997)
Pharmacol
B. Razani (2002)
10.1126/SCIENCE.1058379
Ventroptin: A BMP-4 Antagonist Expressed in a Double-Gradient Pattern in the Retina
Hiraki Sakuta (2001)
10.1046/j.1471-4159.2001.00273.x
Bone morphogenetic proteins (BMP6 and BMP7) enhance the protective effect of neurotrophins on cultured septal cholinergic neurons during hypoglycemia
D. Nonner (2001)
10.1042/BC20040506
FLRG, a new ADAM12‐associated protein, modulates osteoclast differentiation
L. Bartholin (2005)
10.1359/jbmr.061002
Wnt but Not BMP Signaling Is Involved in the Inhibitory Action of Sclerostin on BMP‐Stimulated Bone Formation
R. V. Van bezooijen (2007)
10.1007/s00774-008-0859-z
Matrix vesicles are carriers of bone morphogenetic proteins (BMPs), vascular endothelial growth factor (VEGF), and noncollagenous matrix proteins
Niru N. Nahar (2008)
10.1038/35001072
The organizer factors Chordin and Noggin are required for mouse forebrain development
D. Bachiller (2000)
10.1016/J.ARCHORALBIO.2005.09.010
Embryonic salivary gland dysmorphogenesis in Twisted gastrulation deficient mice.
M. Melnick (2006)
10.1101/GAD.940001
The activity and signaling range of mature BMP-4 is regulated by sequential cleavage at two sites within the prodomain of the precursor.
Y. Cui (2001)
10.1016/S1097-2765(03)00094-7
The BMP7/ActRII extracellular domain complex provides new insights into the cooperative nature of receptor assembly.
J. Greenwald (2003)
Chem
Y. Zhang (2006)
10.1006/DBIO.1998.9191
A novel BMP expressed in developing mouse limb, spinal cord, and tail bud is a potent mesoderm inducer in Xenopus embryos.
L. Gamer (1999)
10.1242/dev.00344
Cell fate specification and competence by Coco, a maternal BMP, TGFβ and Wnt inhibitor
E. Bell (2003)
10.1006/DBIO.2001.0284
Bmp6 and Bmp7 are required for cushion formation and septation in the developing mouse heart.
R. Y. Kim (2001)
10.1086/318811
Bone dysplasia sclerosteosis results from loss of the SOST gene product, a novel cystine knot-containing protein.
M. E. Brunkow (2001)
10.1515/9783111576855-015
J
Seguin Hen (1824)
10.1074/jbc.M509332200
Epidermal Growth Factor Receptor Exposed to Oxidative Stress Undergoes Src- and Caveolin-1-dependent Perinuclear Trafficking*
E. Khan (2006)
Identification of human DAN gene, mapping to the putative neuroblastoma tumor suppressor locus.
H. Enomoto (1994)
Cytokine Growth Factor Rev
K. Miyazono (2005)
10.1046/j.1365-2443.1998.00186.x
BRAM1, a BMP receptor‐associated molecule involved in BMP signalling
K. Kurozumi (1998)
10.1016/J.BBRC.2004.01.048
Human Crossveinless-2 is a novel inhibitor of bone morphogenetic proteins.
M. E. Binnerts (2004)
10.1091/MBC.E04-08-0673
Cleavages within the prodomain direct intracellular trafficking and degradation of mature bone morphogenetic protein-4.
C. Degnin (2004)
10.1242/dev.01251
Gremlin-mediated BMP antagonism induces the epithelial-mesenchymal feedback signaling controlling metanephric kidney and limb organogenesis
Odyssé Michos (2004)
10.1038/83810
Bone morphogenetic protein-3 is a negative regulator of bone density
A. Daluiski (2001)
10.1158/0008-5472.CAN-07-0436
TrkC binds to the bone morphogenetic protein type II receptor to suppress bone morphogenetic protein signaling.
W. Jin (2007)
Biochem
C. C. Rider (2006)
Cell Tissue Res
A. E. Drummond (2005)
Cytokine Growth Factor Rev
M. Yanagita (2005)
10.1093/emboj/18.1.179
XIAP, a cellular member of the inhibitor of apoptosis protein family, links the receptors to TAB1–TAK1 in the BMP signaling pathway
K. Yamaguchi (1999)
10.1186/1471-2172-6-9
BMP-6 inhibits growth of mature human B cells; induction of Smad phosphorylation and upregulation of Id1
C. Kersten (2004)
10.1074/jbc.M800850200
BMP-2/4 and BMP-6/7 Differentially Utilize Cell Surface Receptors to Induce Osteoblastic Differentiation of Human Bone Marrow-derived Mesenchymal Stem Cells*
Karen Lavery (2008)
10.1186/1750-2187-2-4
Role of RGM coreceptors in bone morphogenetic protein signaling
Peter J Halbrooks (2007)
Failure of ventral body wall closure in mouse embryos lacking a procollagen C-proteinase encoded by Bmp1, a mammalian gene related to Drosophila tolloid.
N. Suzuki (1996)
Hum
S. Mazerbourg (2006)
Cytokine Growth Factor Rev
M. Kawabata (1998)
10.1016/j.yexcr.2008.11.019
Protein related to DAN and cerberus (PRDC) inhibits osteoblastic differentiation and its suppression promotes osteogenesis in vitro.
H. Ideno (2009)
10.1074/jbc.M206736200
Negative Regulation of Epstein-Barr Virus Latent Membrane Protein 1-mediated Functions by the Bone Morphogenetic Protein Receptor IA-binding Protein, BRAM1*
Pei-Jung Chung (2002)
10.1016/J.GENE.2004.01.029
hCHL2, a novel chordin-related gene, displays differential expression and complex alternative splicing in human tissues and during myoblast and osteoblast maturation.
A. Oren (2004)
10.1074/jbc.M701570200
Brorin, a Novel Secreted Bone Morphogenetic Protein Antagonist, Promotes Neurogenesis in Mouse Neural Precursor Cells*
N. Koike (2007)
Res
E. Bonucci (1967)
Activin receptor-like kinases: a novel subclass of cell-surface receptors with predicted serine/threonine kinase activity.
P. ten Dijke (1993)
10.1093/HUMUPD/DML014
Genomic analyses facilitate identification of receptors and signalling pathways for growth differentiation factor 9 and related orphan bone morphogenetic protein/growth differentiation factor ligands.
S. Mazerbourg (2006)
10.1016/J.CYTOGFR.2005.02.007
BMP antagonists: their roles in development and involvement in pathophysiology.
M. Yanagita (2005)
10.1074/jbc.M109.028506
Site-specific Cleavage of BMP4 by Furin, PC6, and PC7*
Sylvia M. Nelsen (2009)
10.1016/j.cytogfr.2009.10.010
Smad signaling in skeletal development and regeneration.
Buer Song (2009)
10.1083/JCB.140.4.767
Oligomeric Structure of Type I and Type II Transforming Growth Factor β Receptors: Homodimers Form in the ER and Persist at the Plasma Membrane
L. Gilboa (1998)
10.1242/jcs.002949
BMP-9 signals via ALK1 and inhibits bFGF-induced endothelial cell proliferation and VEGF-stimulated angiogenesis
M. Scharpfenecker (2007)
10.1074/jbc.M301716200
Sclerostin Is a Novel Secreted Osteoclast-derived Bone Morphogenetic Protein Antagonist with Unique Ligand Specificity*
N. Kusu (2003)
10.1038/nm1217
Kielin/chordin-like protein, a novel enhancer of BMP signaling, attenuates renal fibrotic disease
J. Lin (2005)
10.1371/journal.pgen.0020216
Genetic Analysis of the Roles of BMP2, BMP4, and BMP7 in Limb Patterning and Skeletogenesis
A. Bandyopadhyay (2006)
Bone Joint Surg
BahamondeM.E (2001)
Rev
E. Gazzerro (2006)
10.1016/j.bpj.2009.05.061
FRET reveals novel protein-receptor interaction of bone morphogenetic proteins receptors and adaptor protein 2 at the cell surface.
Beth Bragdon (2009)
10.7150/IJBS.5.192
BMP-13 Emerges as a Potential Inhibitor of Bone Formation
B. Shen (2009)
10.1016/b978-0-12-384931-1.00016-7
P
J. Lackie (2013)
10.1038/nature01245
Structural basis of BMP signalling inhibition by the cystine knot protein Noggin
J. Groppe (2002)
10.1016/J.CEB.2007.02.015
Negative regulation of TGF-β receptor/Smad signal transduction
S. Itoh (2007)
10.1038/nature03466
Generation and annotation of the DNA sequences of human chromosomes 2 and 4
L. Hillier (2005)
10.1074/JBC.M207362200
Molecular Basis of Bone Morphogenetic Protein-15 Signaling in Granulosa Cells*
R. K. Moore (2003)
The control of cell fate along the dorsal-ventral axis of the Drosophila embryo.
R. P. Ray (1991)
Chem
E. Di Pasquale (2009)
Biol
D. G. Simmons (2002)
Cytokine Growth Factor Rev
E. Corradini (2009)
10.1016/J.DEVCEL.2005.09.008
The structure of the follistatin:activin complex reveals antagonism of both type I and type II receptor binding.
T. Thompson (2005)
10.1210/JC.2005-2650
Identification of new variants of human BMP15 gene in a large cohort of women with premature ovarian failure.
E. di Pasquale (2006)
10.1002/GENE.10167
Consequences of knocking out BMP signaling in the mouse
G. Zhao (2003)
10.1038/35015500
The evolutionarily conserved BMP-binding protein Twisted gastrulation promotes BMP signalling
M. Oelgeschläger (2000)
Characterization of the nucleational core complex responsible for mineral induction by growth plate cartilage matrix vesicles.
L. Wu (1993)
10.1016/S1359-6101(97)00036-1
Signal transduction by bone morphogenetic proteins.
M. Kawabata (1998)
Cell Res
C. S. Hill (2009)
Biochem
Y. T. Xiao (2007)
10.1124/pr.54.3.431
Caveolae: From Cell Biology to Animal Physiology
B. Razani (2002)
10.1002/(SICI)1097-4644(19990201)72:2<177::AID-JCB2>3.0.CO;2-#
Effects of GDF7/BMP12 on proliferation and alkaline phosphatase expression in rat osteoblastic osteosarcoma ROS 17/2.8 cells
K. Furuya (1999)
10.1038/sj.onc.1207386
Bone morphogenetic protein-5, -6 and -7 inhibit growth and induce apoptosis in human myeloma cells
T. B. Rø (2004)
10.1242/jcs.01402
Dynamics and interaction of caveolin-1 isoforms with BMP-receptors
Anja G Nohe (2005)
10.1006/BBRC.1996.0889
cDNA cloning and genomic structure of human bone morphogenetic protein-3B (BMP-3b).
J. Hino (1996)
10.1007/s100380050054
Genomic organization and mapping of the human activin receptor type IIB (hActR-IIB) gene
S. Ishikawa (1998)
10.1016/J.YDBIO.2004.04.015
A new role for BMP5 during limb development acting through the synergic activation of Smad and MAPK pathways.
V. Zuzarte-Luís (2004)
10.1007/s11095-008-9551-1
BMP-7 and Proximal Tubule Epithelial Cells: Activation of Multiple Signaling Pathways Reveals a Novel Anti-fibrotic Mechanism
R. Motazed (2008)
10.1074/jbc.M605330200
Regulation of Bone Morphogenetic Protein-4 Activity by Sequence Elements within the Prodomain*
Shailaja Sopory (2006)
10.1089/104303403764539369
Induction of reparative dentin formation by ultrasound-mediated gene delivery of growth/differentiation factor 11.
M. Nakashima (2003)
Gene Ther
M. Nakashima (2003)
Curr
F. Ramirez (2009)
10.1359/jbmr.080216
Targeted Deletion of the Sclerostin Gene in Mice Results in Increased Bone Formation and Bone Strength
X. Li (2008)
10.1159/000015048
Assignment1 of the BMPR1A and BMPR1B genes to human chromosome 10q22.3 and 4q23→q24 byin situ hybridization and radiation hybrid map ping
H. Ide (1998)
10.1128/MCB.15.7.3479
Human type II receptor for bone morphogenic proteins (BMPs): extension of the two-kinase receptor model to the BMPs.
F. Liu (1995)
10.1002/(SICI)1096-8628(19990101)82:1<70::AID-AJMG14>3.0.CO;2-Y
Left-right axis malformations associated with mutations in ACVR2B, the gene for human activin receptor type IIB.
R. Kosaki (1999)
10.1016/j.tcb.2008.11.003
Shedding microvesicles: artefacts no more.
Emanuele Cocucci (2009)
Biochem
C. J. Donaldson (1992)
10.1016/j.cytogfr.2009.10.007
Recent advances in BMP receptor signaling.
C. Sieber (2009)
10.1016/J.MOLCEL.2007.05.006
XIAP induces NF-kappaB activation via the BIR1/TAB1 interaction and BIR1 dimerization.
M. Lu (2007)
10.1016/J.BBRC.2004.02.075
USAG-1: a bone morphogenetic protein antagonist abundantly expressed in the kidney.
M. Yanagita (2004)
10.1007/s10006-004-0528-x
Evaluation der osteoinduktiven Potenz von gentechnisch modifizierten BMP-2-Varianten
Dr. Dr. K. K. Würzler (2004)
10.1039/B304943D
Caveolin-1 isoform reorganization studied by image correlation spectroscopy.
Anja G Nohe (2004)
10.1172/JCI119537
Ectopic induction of tendon and ligament in rats by growth and differentiation factors 5, 6, and 7, members of the TGF-beta gene family.
N. M. Wolfman (1997)
10.1186/1478-811X-3-3
Differential effects of ERK and p38 signaling in BMP-2 stimulated hypertrophy of cultured chick sternal chondrocytes
G. Reilly (2004)
10.1016/J.CARDIORES.2007.08.003
ERK signaling is a central regulator for BMP-4 dependent capillary sprouting.
Q. Zhou (2007)
10.1016/j.jmb.2008.06.074
A new model for growth factor activation: type II receptors compete with the prodomain for BMP-7.
G. Sengle (2008)
Nat
S. C. Little (2009)
10.1038/17820
The head inducer Cerberus is a multifunctional antagonist of Nodal, BMP and Wnt signals
S. Piccolo (1999)
10.1101/GAD.9.22.2795
A requirement for bone morphogenetic protein-7 during development of the mammalian kidney and eye.
A. T. Dudley (1995)
10.1016/S0092-8674(03)00432-X
Mechanisms of TGF-β Signaling from Cell Membrane to the Nucleus
Y. Shi (2003)
10.1016/J.CELLSIG.2003.08.011
Signal transduction of bone morphogenetic protein receptors.
Anja G Nohe (2004)
10.1515/BC.2001.149
Cooperativity of Binding Epitopes and Receptor Chains in the BMP/TGFß Superfamily
P. Knaus (2001)
10.1126/science.271.5247.360
Bone Morphogenetic Protein-1: The Type I Procollagen C-Proteinase
E. Kessler (1996)
10.1084/jem.20031454
Sclerostin Is an Osteocyte-expressed Negative Regulator of Bone Formation, But Not a Classical BMP Antagonist
R. V. Van bezooijen (2004)
10.3109/10425179509030980
Cloning and sequence of bone morphogenetic protein 4 (BMP-4) from a human placental cDNA library.
S. Oida (1995)
10.1095/biolreprod.102.006858
Uterine Sensitization-Associated Gene-1: A Novel Gene Induced Within the Rat Endometrium at the Time of Uterine Receptivity/Sensitization for the Decidual Cell Reaction1
D. Simmons (2002)
Chem
S. M. Nelsen (2009)
Biochem
J. W. Wertz (2008)
10.1074/JBC.275.14.9901
IHG-2, a Mesangial Cell Gene Induced by High Glucose, Is Human gremlin
R. Mcmahon (2000)
10.1091/MBC.11.3.1023
Bone morphogenetic protein receptor complexes on the surface of live cells: a new oligomerization mode for serine/threonine kinase receptors.
L. Gilboa (2000)
10.1093/emboj/17.4.1019
Role of TAK1 and TAB1 in BMP signaling in early Xenopus development
H. Shibuya (1998)
10.1101/GAD.1021802
Activin type IIA and IIB receptors mediate Gdf11 signaling in axial vertebral patterning.
S. Oh (2002)
10.1002/biof.15
BMP modulators regulate the function of BMP during body patterning and disease progression
M. Yanagita (2009)
10.1210/MEND.15.5.0639
Evolution and classification of cystine knot-containing hormones and related extracellular signaling molecules.
U. Vitt (2001)
10.1101/GAD.9.22.2808
BMP-7 is an inducer of nephrogenesis, and is also required for eye development and skeletal patterning.
G. Luo (1995)
10.1242/dev.02368
Mutation of an upstream cleavage site in the BMP4 prodomain leads to tissue-specific loss of activity
D. Goldman (2006)
10.1530/REP.1.01072
The structural basis of TGF-beta, bone morphogenetic protein, and activin ligand binding.
S. J. Lin (2006)
10.1177/1534650105277713
Ann
Ericka Stricklin-Parker (2005)
Identification of type I receptors for osteogenic protein-1 and bone morphogenetic protein-4.
P. ten Dijke (1994)
Early embryonic lethality in Bmp5;Bmp7 double mutant mice suggests functional redundancy within the 60A subgroup.
M. Solloway (1999)
Cytokine Growth Factor Rev
T. W. Axelrad (2009)
Cytokine Growth Factor Rev
B. Song (2009)
10.1242/dev.00536
Six1 is required for the early organogenesis of mammalian kidney
Pin-Xian Xu (2003)
10.1016/j.ceb.2009.05.005
Extracellular microfibrils: contextual platforms for TGFbeta and BMP signaling.
F. Ramirez (2009)
10.1007/s11154-006-9000-6
Bone morphogenetic proteins and their antagonists
E. Gazzerro (2006)
10.1016/0925-4773(96)00543-6
Evidence that mouse Bmp8a (Op2) and Bmp8b are duplicated genes that play a role in spermatogenesis and placental development
G. Zhao (1996)
10.1128/MCB.00022-06
Different Routes of Bone Morphogenic Protein (BMP) Receptor Endocytosis Influence BMP Signaling
A. Hartung (2006)
Trends Cell Biol
E. Cocucci (2009)
Dev
J. J. Pearce (1999)
Mol
O. Avsian-Kretchmer (2004)
10.1242/dev.00901
A novel chordin-like BMP inhibitor, CHL2, expressed preferentially in chondrocytes of developing cartilage and osteoarthritic joint cartilage
N. Nakayama (2004)
10.1016/j.bpj.2010.04.070
Casein kinase 2 beta-subunit is a regulator of bone morphogenetic protein 2 signaling.
Beth Bragdon (2010)
10.1210/ME.2003-0227
Comparative genomic analysis of the eight-membered ring cystine knot-containing bone morphogenetic protein antagonists.
O. Avsian-Kretchmer (2004)
10.1074/JBC.M503328200
Crystal Structure of BMP-9 and Functional Interactions with Pro-region and Receptors*
M. A. Brown (2005)
10.1016/j.mcn.2009.02.006
In vitro guidance of retinal axons by a tectal lamina-specific glycoprotein Nel
Yulan Jiang (2009)
10.1002/(SICI)1097-4652(199702)170:2<153::AID-JCP7>3.0.CO;2-N
Activation of protein kinase A is a pivotal step involved in both BMP‐2‐ and cyclic AMP‐induced chondrogenesis
Y. Lee (1997)
10.1359/jbmr.2004.19.1.111
Adenovirus Mediated BMP‐13 Gene Transfer Induces Chondrogenic Differentiation of Murine Mesenchymal Progenitor Cells
H. Nochi (2004)
10.1016/J.BBRC.2007.05.148
Rudiment incisors survive and erupt as supernumerary teeth as a result of USAG-1 abrogation.
A. Murashima-Suginami (2007)
10.1242/jcs.03400
Endofin acts as a Smad anchor for receptor activation in BMP signaling
Weibin Shi (2007)
10.1161/CIRCRESAHA.107.165530
Bone Morphogenetic Protein-9 Is a Circulating Vascular Quiescence Factor
L. David (2008)
10.1074/jbc.M513414200
Heparan Sulfate Proteoglycans (HSPGs) Modulate BMP2 Osteogenic Bioactivity in C2C12 Cells*
Xiangyang Jiao (2007)
Metab
T. Nakase (2006)
Morphogenetic Protein (BMP)-17 and BMP-18 Compositions
B. Bragdon (2003)
10.1074/jbc.274.2.584
Endoglin Is an Accessory Protein That Interacts with the Signaling Receptor Complex of Multiple Members of the Transforming Growth Factor-β Superfamily*
N. Barbara (1999)
10.1111/j.1742-4658.2007.06187.x
Type I receptor binding of bone morphogenetic protein 6 is dependent on N‐glycosylation of the ligand
Stefan Saremba (2008)
10.1126/SCIENCE.280.5368.1455
Noggin, cartilage morphogenesis, and joint formation in the mammalian skeleton.
L. Brunet (1998)
10.1074/jbc.M109.036608
Bone Morphogenetic Protein 15 (BMP15) Acts as a BMP and Wnt Inhibitor during Early Embryogenesis*
E. Di Pasquale (2009)
10.1186/1471-2148-9-277
The origin of bmp16, a novel Bmp2/4 relative, retained in teleost fish genomes
N. Feiner (2009)
10.1242/jcs.031286
BMP2 induction of actin cytoskeleton reorganization and cell migration requires PI3-kinase and Cdc42 activity
C. Gamell (2008)
10.1016/j.yjmcc.2010.01.010
Bone morphogenetic protein 4 mediates myocardial ischemic injury through JNK-dependent signaling pathway.
A. Pachori (2010)
10.1128/MCB.23.8.2969-2980.2003
Mammalian Twisted Gastrulation Is Essential for Skeleto-Lymphogenesis
T. Nosaka (2003)
10.1074/jbc.M601362200
Inhibition of Bone Morphogenetic Protein 1 by Native and Altered Forms of α2-Macroglobulin*
Y. Zhang (2006)
10.1074/jbc.M700456200
von Willebrand Factor Type C Domain-containing Proteins Regulate Bone Morphogenetic Protein Signaling through Different Recognition Mechanisms*
J. Zhang (2007)
10.1016/j.cytogfr.2009.10.003
Bone morphogenetic proteins in orthopaedic surgery.
T. W. Axelrad (2009)
10.1016/J.CYTOGFR.2005.01.009
BMP receptor signaling: transcriptional targets, regulation of signals, and signaling cross-talk.
K. Miyazono (2005)
10.1111/J.1432-1033.1996.0295N.X
Human bone morphogenetic protein 2 contains a heparin-binding site which modifies its biological activity.
R. Ruppert (1996)
10.1101/GAD.12.10.1438
Noggin-mediated antagonism of BMP signaling is required for growth and patterning of the neural tube and somite.
J. McMahon (1998)
10.1093/emboj/cdg599
Osteocyte control of bone formation via sclerostin, a novel BMP antagonist
David G. Winkler (2003)
10.1074/jbc.M102750200
The Mode of Bone Morphogenetic Protein (BMP) Receptor Oligomerization Determines Different BMP-2 Signaling Pathways*
A. Nohe (2002)
10.1101/SQB.1992.057.01.046
Extracellular morphogens in Drosophila embryonic dorsal-ventral patterning.
K. Anderson (1992)
10.1016/J.BBRC.2005.10.024
Mechanism of osteogenic induction by FK506 via BMP/Smad pathways.
F. Kugimiya (2005)
10.1007/S11373-005-9066-2
Molecular cloning, expression and characterization of the zebrafish bram1 gene, a BMP receptor-associated molecule.
K. Wu (2006)
10.1074/JBC.M402376200
Protein Related to DAN and Cerberus Is a Bone Morphogenetic Protein Antagonist That Participates in Ovarian Paracrine Regulation*
S. Sudo (2004)
10.1101/GAD.306504
The activity of the Nodal antagonist Cerl-2 in the mouse node is required for correct L/R body axis.
S. Marques (2004)
10.1016/j.molcel.2007.11.039
Cooperative assembly of TGF-beta superfamily signaling complexes is mediated by two disparate mechanisms and distinct modes of receptor binding.
J. Groppe (2008)
10.1016/j.bbrc.2008.08.066
Caveolin-1 regulates BMPRII localization and signaling in vascular smooth muscle cells.
Jeffrey W. Wertz (2008)
10.1038/cr.2008.325
Nucleocytoplasmic shuttling of Smad proteins
C. Hill (2009)
10.1007/s00774-005-0622-7
BMP-2 prevents apoptosis of the N1511 chondrocytic cell line through PI3K/Akt-mediated NF-κB activation
K. Sugimori (2005)
Physiol
Y. S. Lee (1997)
Cytokine Growth Factor Rev
C. Sieber (2009)
10.1186/1741-7007-7-59
Receptor oligomerization and beyond: a case study in bone morphogenetic proteins
Kai Heinecke (2009)
10.1046/J.1523-1755.2000.00081.X
The family of bone morphogenetic proteins.
P. Ducy (2000)
10.1002/jcp.20480
Interaction and functional cooperation between the serine/threonine kinase bone morphogenetic protein type II receptor with the tyrosine kinase stem cell factor receptor
S. Hassel (2006)
10.1111/j.1365-2443.2004.00799.x
Modulation of GDF5/BRI‐b signalling through interaction with the tyrosine kinase receptor Ror2
M. Sammar (2004)
10.1242/dev.01094
BMP10 is essential for maintaining cardiac growth during murine cardiogenesis
H. Chen (2004)
10.1074/jbc.M006114200
Identification and Characterization of a Novel Follistatin-like Protein as a Binding Protein for the TGF-β Family*
K. Tsuchida (2000)
10.1073/pnas.201367598
Human disease-causing NOG missense mutations: Effects on noggin secretion, dimer formation, and bone morphogenetic protein binding
J. Marcelino (2001)
10.1016/j.febslet.2009.10.044
A novel neural‐specific BMP antagonist, Brorin‐like, of the Chordin family
Hiroyuki Miwa (2009)
10.1002/(SICI)1520-6408(1998)22:4<321::AID-DVG3>3.0.CO;2-8
Mice lacking Bmp6 function.
M. Solloway (1998)
10.1042/BST0340458
Heparin/heparan sulphate binding in the TGF-β cytokine superfamily
C. Rider (2006)
10.1002/scin.5591770124
Genes to cells
Nihon Bunshi Seibutsu Gakkai (1996)
Eur
R. Ruppert (1996)
10.1152/AJPCELL.00234.2001
C2C12 myoblast/osteoblast transdifferentiation steps enhanced by epigenetic inhibition of BMP2 endocytosis.
C. Rauch (2002)
10.1196/annals.1346.005
BMP and BMP Inhibitors in Bone
V. Rosen (2006)
10.3109/08977199609003229
Heterodimeric bone morphogenetic proteins show enhanced activity in vitro and in vivo.
D. Israel (1996)
10.1093/bioinformatics/bti042
Genome-wide midrange transcription profiles reveal expression level relationships in human tissue specification
I. Yanai (2005)
Characterization of bone morphogenetic protein-6 signaling pathways in osteoblast differentiation.
T. Ebisawa (1999)
10.1128/MCB.21.2.636-643.2001
Mutation and Analysis of Dan, the Founding Member of the Dan Family of Transforming Growth Factor β Antagonists
M. S. Dionne (2001)
Bone Joint Surg
NickelJ (2001)
Mol
M. S. Dionne (2001)
Mech
F. C. Wardle (1999)
10.3181/0510-MR-345
Bone Morphogenetic Proteins and Their Receptors in the Eye
R. Wordinger (2007)
10.1016/j.jprot.2008.11.011
Proteomic analysis of extracellular matrix and vesicles.
Z. Xiao (2009)
10.1074/JBC.275.12.8785
Biosynthesis, Post-translation Modification, and Functional Characterization of Drm/Gremlin*
L. Z. Topol' (2000)
10.1101/GAD.9.17.2105
Bone morphogenetic protein-4 is required for mesoderm formation and patterning in the mouse.
G. Winnier (1995)
10.1038/374360A0
Multiple defects and perinatal death in mice deficient in follistatin
M. Matzuk (1995)
10.1006/DBIO.2001.0200
A novel chordin-like protein inhibitor for bone morphogenetic proteins expressed preferentially in mesenchymal cell lineages.
N. Nakayama (2001)
10.1016/J.CRVI.2003.09.012
GeneNote: whole genome expression profiles in normal human tissues.
O. Shmueli (2003)
10.1016/0092-8674(92)90316-5
Expression cloning of noggin, a new dorsalizing factor localized to the Spemann organizer in Xenopus embryos
W. C. Smith (1992)
10.1126/SCIENCE.1116848
Regulation of Mammalian Tooth Cusp Patterning by Ectodin
Y. Kassai (2005)
10.1016/J.BBRC.2006.05.045
Purification and identification of a BMP-like factor from bovine serum.
K. Kodaira (2006)
10.1074/JBC.M400521200
Noggin and Sclerostin Bone Morphogenetic Protein Antagonists Form a Mutually Inhibitory Complex*
David G. Winkler (2004)
10.1038/44157
Signal relay by BMP antagonism controls the SHH/FGF4 feedback loop in vertebrate limb buds
A. Zúñiga (1999)
10.1182/BLOOD-2006-07-034124
Identification of BMP9 and BMP10 as functional activators of the orphan activin receptor-like kinase 1 (ALK1) in endothelial cells.
L. David (2007)
10.1016/0168-9525(92)90096-m
Localized enhancement and repression of the activity of the TGF-beta family member, decapentaplegic, is necessary for dorsal-ventral pattern formation in the Drosophila embryo.
E. Ferguson (1992)
10.3109/08977199509028956
Growth/differentiation factor-10: a new member of the transforming growth factor-beta superfamily related to bone morphogenetic protein-3.
N. Cunningham (1995)
10.1126/science.150.3698.893
Bone: Formation by Autoinduction
M. Urist (1965)
10.1016/j.devcel.2008.06.013
Crossveinless-2 Is a BMP feedback inhibitor that binds Chordin/BMP to regulate Xenopus embryonic patterning.
Andrea L. Ambrosio (2008)
10.1210/ENDO.141.12.7851
Bone Morphogenetic Proteins Induce Gremlin, a Protein That Limits Their Activity in Osteoblasts1
R. Pereira (2000)
10.1359/jbmr.2002.17.2.293
A Role for the BMP Antagonist Chordin in Endochondral Ossification
D. Zhang (2002)
10.1006/DBIO.2001.0388
Intracellular BMP signaling regulation in vertebrates: pathway or network?
A. von Bubnoff (2001)
10.1101/GAD.10.13.1657
The gene encoding bone morphogenetic protein 8B is required for the initiation and maintenance of spermatogenesis in the mouse.
G. Q. Zhao (1996)
10.1074/jbc.M308665200
Protein Kinase C-independent Activation of Protein Kinase D Is Involved in BMP-2-induced Activation of Stress Mitogen-activated Protein Kinases JNK and p38 and Osteoblastic Cell Differentiation*
J. Lemonnier (2004)
10.1007/s00441-005-1153-1
TGFβ signalling in the development of ovarian function
A. Drummond (2005)
10.1111/j.1469-7580.2005.00447.x
The role of growth/differentiation factor 5 (GDF5) in the induction and survival of midbrain dopaminergic neurones: relevance to Parkinson's disease treatment
A. Sullivan (2005)
10.1006/DBIO.1999.9240
A mouse cerberus/Dan-related gene family.
J. Pearce (1999)
10.1007/s00774-006-0718-8
Potential roles of bone morphogenetic proteins (BMPs) in skeletal repair and regeneration
T. Nakase (2006)
10.1016/S0888-7543(05)80181-8
A bone morphogenetic protein subfamily: chromosomal localization of human genes for BMP5, BMP6, and BMP7.
G. Hahn (1992)
10.1172/JCI3459
Bone morphogenetic proteins induce the expression of noggin, which limits their activity in cultured rat osteoblasts.
E. Gazzerro (1998)
10.1074/jbc.M704883200
Bone Morphogenetic Proteins Signal through the Transforming Growth Factor-β Type III Receptor*
Kellye C Kirkbride (2008)
10.1515/9783111697888-007
E
Adam S. Opalski (1824)
Dev
R. Y. Kim (2001)
Chem
R. K. Moore (2003)
BMC Cell Biol
B. Herrera (2009)
Genes Dev
A. T. Dudley (1995)
Invest
E. Gazzerro (1998)
10.1186/1471-2121-10-20
A rapid and sensitive bioassay for the simultaneous measurement of multiple bone morphogenetic proteins. Identification and quantification of BMP4, BMP6 and BMP9 in bovine and human serum
B. Herrera (2008)
10.1006/DBIO.2002.0779
Extracellular regulation of BMP signaling in vertebrates: a cocktail of modulators.
W. Balemans (2002)
10.1016/0092-8674(94)90068-X
Xenopus chordin: A novel dorsalizing factor activated by organizer-specific homeobox genes
Y. Sasai (1994)
10.1016/0006-291X(92)91194-U
Molecular cloning and binding properties of the human type II activin receptor.
C. Donaldson (1992)
10.1242/dev.00674
Wise, a context-dependent activator and inhibitor of Wnt signalling
N. Itasaki (2003)
10.1359/jbmr.2003.18.11.2060
Activation of p38 Mitogen‐Activated Protein Kinase and c‐Jun‐NH2‐Terminal Kinase by BMP‐2 and Their Implication in the Stimulation of Osteoblastic Cell Differentiation
J. Guicheux (2003)
10.1038/ng0696-189
Mutations in the activin receptor–like kinase 1 gene in hereditary haemorrhagic telangiectasia type 2
D. W. Johnson (1996)
10.1016/j.mod.2008.06.011
Twisted gastrulation mutation suppresses skeletal defect phenotypes in Crossveinless 2 mutant mice
M. Ikeya (2008)
Mice deficient for BMP2 are nonviable and have defects in amnion/chorion and cardiac development.
H. Zhang (1996)
10.1016/j.ydbio.2009.11.013
Cv2, functioning as a pro-BMP factor via twisted gastrulation, is required for early development of nephron precursors.
M. Ikeya (2010)
10.1016/S0925-4773(99)00114-8
Bone morphogenetic protein 1 regulates dorsal-ventral patterning in early Xenopus embryos by degrading chordin, a BMP4 antagonist
F. Wardle (1999)
10.1128/MCB.14.9.5961
Characterization and cloning of a receptor for BMP-2 and BMP-4 from NIH 3T3 cells.
Beth B. Koenig (1994)
Mech
G. Q. Zhao (1996)
Chem
N. P. Barbara (1999)
10.1016/j.cytogfr.2009.10.008
The RGM/DRAGON family of BMP co-receptors.
Elena Corradini (2009)
10.1101/GAD.13.4.424
Bmp4 is required for the generation of primordial germ cells in the mouse embryo.
Kirstie A. Lawson (1999)
10.1038/46794
Silencing of TGF-β signalling by the pseudoreceptor BAMBI
D. Onichtchouk (1999)
10.1074/jbc.M109.002881
Bone Morphogenetic Protein (BMP) and Activin Type II Receptors Balance BMP9 Signals Mediated by Activin Receptor-like Kinase-1 in Human Pulmonary Artery Endothelial Cells*
P. Upton (2009)
10.1038/emboj.2009.162
TAK1 is an essential regulator of BMP signalling in cartilage
Jae-Hyuck Shim (2009)
10.1016/S0092-8674(00)80045-8
Antagonistic Signaling by Caronte, a Novel Cerberus-Related Gene, Establishes Left–Right Asymmetric Gene Expression
Y. Yokouchi (1999)
10.1242/jcs.00519
Effect of the distribution and clustering of the type I A BMP receptor (ALK3) with the type II BMP receptor on the activation of signalling pathways
Anja G Nohe (2003)
10.1006/DBIO.1994.1300
BMP5 and the molecular, skeletal, and soft-tissue alterations in short ear mice.
J. King (1994)
10.1073/PNAS.92.17.7632
Cloning and characterization of a human type II receptor for bone morphogenetic proteins.
Bradley Rosenzweig (1995)
10.1016/J.YDBIO.2005.06.012
BMP-3 is a novel inhibitor of both activin and BMP-4 signaling in Xenopus embryos.
L. Gamer (2005)
10.1074/JBC.M504629200
Identification of Receptors and Signaling Pathways for Orphan Bone Morphogenetic Protein/Growth Differentiation Factor Ligands Based on Genomic Analyses*
S. Mazerbourg (2005)
10.1016/S0022-5320(67)80034-0
Fine structure of early cartilage calcification.
E. Bonucci (1967)
10.1074/jbc.M707820200
Targeting of Bone Morphogenetic Protein Growth Factor Complexes to Fibrillin*
G. Sengle (2008)
10.1038/SJ.KI.5002626
Expression of BMP-7 and USAG-1 (a BMP antagonist) in kidney development and injury.
M. Tanaka (2008)
Kidney Int
P. Ducy (2000)
Dev
W. Balemans (2002)
Biol
P. Knaus (2001)
Mol
U. A. Vitt (2001)
10.1038/ncb1870
Bone morphogenetic protein heterodimers assemble heteromeric type I receptor complexes to pattern the dorsoventral axis.
Shawn C Little (2009)
10.1016/J.BBRC.2007.08.045
Bone morphogenetic protein.
Y. Xiao (2007)



This paper is referenced by
10.0001/809
The role of topical application of bone morphogenetic protein 7 (BMP7) on bone healing on rabbits (Immunohistochemical study on TGF-β 3 & IGF-1R)
Rabab I Ghareeb (2015)
10.1016/j.aaf.2019.12.008
Identification of three members of the Bmp family from yellow catfish Pelteobagrus fulvidraco and their transcriptional responses to a high fat diet
Zhi-Peng Tai (2020)
10.1002/adhm.201801000
Materials Science and Design Principles of Growth Factor Delivery Systems in Tissue Engineering and Regenerative Medicine.
Ramesh Subbiah (2019)
10.1038/onc.2011.175
Evidence for the transmission of neoplastic properties from transformed to normal human stem cells
T. Werbowetski-Ogilvie (2011)
10.1016/j.expneurol.2011.11.002
Phenotypic analysis of astrocytes derived from glial restricted precursors and their impact on axon regeneration
C. Haas (2012)
10.2174/1574888X09666141002122232
Ligament and tendon repair through regeneration using mesenchymal stem cells.
B. Ramdass (2015)
10.1002/pro.2485
The DAN family: Modulators of TGF‐β signaling and beyond
Kristof Nolan (2014)
10.1371/journal.pone.0177375
Calcification in dermal fibroblasts from a patient with GGCX syndrome accompanied by upregulation of osteogenic molecules
Yumi Okubo (2017)
10.16966/2576-5833.109
Factors that Affect the Osteoclastogenesis of RAW264.7 Cells
J. Nguyen (2017)
10.1038/ncomms13247
Notch regulates BMP responsiveness and lateral branching in vessel networks via SMAD6
K. Mouillesseaux (2016)
The role of bone morphogenetic protein 2 in SMA-directed angiogenesis during distraction osteogenesis
T. Cheng (2015)
10.1016/j.cellsig.2012.12.003
Bone morphogenetic protein-9 activates Smad and ERK pathways and supports human osteoclast function and survival in vitro.
D. Fong (2013)
10.1016/j.gene.2015.10.005
Transcriptional regulation of gilthead seabream bone morphogenetic protein (BMP) 2 gene by bone- and cartilage-related transcription factors.
Cátia L Marques (2016)
10.1016/j.theriogenology.2015.11.011
BMP-1 participates in the selection and dominance of buffalo follicles by regulating the proliferation and apoptosis of granulosa cells.
X. Lei (2016)
10.1101/cshperspect.a018887
Control of Adult Neurogenesis by Short-Range Morphogenic-Signaling Molecules.
Y. Choe (2015)
10.20821/JBS.46.0_70
BMP signaling-related proteins are differentially expressed in the adult cerebellum
Gandhervin Kesavamoorthy (2016)
10.1186/s13287-017-0537-y
CK2.1, a bone morphogenetic protein receptor type Ia mimetic peptide, repairs cartilage in mice with destabilized medial meniscus
Hemanth Akkiraju (2017)
10.18632/aging.103161
The role of SIRT1 in BMP2-induced chondrogenic differentiation and cartilage maintenance under oxidative stress
Y. Lu (2020)
BMP9 et BMP10 dans le remodelage vasculaire périnatal
Sandrine Levet (2013)
10.1186/s12935-019-0906-y
Resveratrol is a promising agent for colorectal cancer prevention and treatment: focus on molecular mechanisms
Mohadese Honari (2019)
10.1002/ajh.23110
Targeting the hepcidin–ferroportin axis to develop new treatment strategies for anemia of chronic disease and anemia of inflammation
C. C. Sun (2012)
10.1111/his.13006
Gremlin1 expression associates with serrated pathway and favourable prognosis in colorectal cancer
Ari Pelli (2016)
Characterisation of the role of canonical BMP-Smad 1/5/8 signalling in the development of ventral midbrain dopaminergic neurons
S. Hegarty (2013)
[Bone morphogenetic proteins (BMP): clinical application for reconstruction of bone defects].
G. Sierra-García (2016)
10.4018/978-1-4666-3604-0.CH064
BMP Signaling in Regenerative Medicine
Julia Zimmer (2013)
10.1016/j.ibror.2017.06.002
BMP7 expression in the adult rat brain
Y. Kusakawa (2017)
10.3390/ijms19010039
BMP Signalling at the Crossroad of Liver Fibrosis and Regeneration
B. Herrera (2017)
10.1016/j.prosdent.2018.09.008
Preclinical application of recombinant human bone morphogenetic protein 2 on bone substitutes for vertical bone augmentation: A systematic review and meta-analysis.
Fei Teng (2019)
10.7916/D8Q246NR
Serum regulation of Inhibitor of DNA Binding/Differentiation 1 expression by a BMP pathway and BMP Responsive Element
Thera C Lewis (2013)
10.2337/db13-0808
Growth Differentiation Factor-5 Promotes Brown Adipogenesis in Systemic Energy Expenditure
E. Hinoi (2013)
EFFECT OF BMP TREATMENT ON PERIOSTIN GENE EXPRESSION IN PRE-OSTEOBLASTIC MC 3 T 3E 1 MOUSE CELLS By
Vincent Lee Khang (2019)
10.1590/1807-3107bor-2020.vol34.0006
Smad1/5 signal transduction regulates the ameloblastic differentiation of induced pluripotent stem cells.
Zhi Liu (2020)
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