← Back to Search
Composite Microparticle Drug Delivery Systems Based On Chitosan, Alginate And Pectin With Improved PH-sensitive Drug Release Property.
Cui-Yun Yu, Bo-Cheng Yin, Wei Zhang, S. Cheng, X. Zhang, R. Zhuo
Published 2009 · Chemistry, Medicine
Download PDFAnalyze on Scholarcy
Composite microparticle drug delivery systems based on chitosan, alginate and pectin with improved pH sensitivity were developed for oral delivery of protein drugs, using bovine serum albumin (BSA) as a model drug. The composite drug-loaded microparticles with a mean particle size less than 200mum were prepared by a convenient shredding method. Since the microparticles were formed by tripolyphosphate cross-linking, electrostatic complexation by alginate and/or pectin, as well as ionotropic gelation with calcium ions, the microparticles exhibited an improved pH-sensitive drug release property. The in vitro drug release behaviors of the microparticles were studied in simulated gastric (pH 1.2 and pH 5.0), intestinal (pH 7.4) and colonic (pH 6.0 and pH 6.8 with enzyme) media. For the composite microparticles with suitable compositions, the releases of BSA at pH 1.2 and pH 5.0 could be effectively sustained, while the releases at pH 7.4, pH 6.8 and pH 6.0 increased significantly, especially in the presence of pectinase. These results clearly suggested that the microparticles had potential for site-specific protein drug delivery through oral administration.
This paper references
Enzymatically and chemically de-esterified lime pectins: characterisation, polyelectrolyte behaviour and calcium binding properties.
M. Ralet (2001)
A novel pH-sensitive hydrogel composed of N,O-carboxymethyl chitosan and alginate cross-linked by genipin for protein drug delivery.
Sung-Ching Chen (2004)
pH-sensitive film coatings: towards a better understanding and facilitated optimization.
F. Siepmann (2008)
Pectin-based systems for colon-specific drug delivery via oral route.
L. Liu (2003)
Polyionic hydrocolloids for the intestinal delivery of protein drugs: alginate and chitosan--a review.
M. George (2006)
Study of the near‐neutral pH‐sensitivity of chitosan/gelatin hydrogels by turbidimetry and microcantilever deflection
J. Mao (2006)
Recent advances on chitosan-based micro- and nanoparticles in drug delivery.
S. Agnihotri (2004)
Studies of pectin HM/Eudragit RL/Eudragit NE film-coating formulations intended for colonic drug delivery.
R. Semdé (2000)
A novel approach to prepare tripolyphosphate/chitosan complex beads for controlled release drug delivery.
X. Shu (2000)
pH sensitive alginate-guar gum hydrogel for the controlled delivery of protein drugs.
M. George (2007)
Pectin/chitosan mixtures as coatings for colon-specific drug delivery: an in vitro evaluation
M. J. Fernández-Hervás (1998)
Nanoparticles as potential oral delivery systems of proteins and vaccines: a mechanistic approach.
A. des Rieux (2006)
Characterization of insulin-loaded alginate nanoparticles produced by ionotropic pre-gelation through DSC and FTIR studies
B. Sarmento (2006)
Development of time-, pH-, and enzyme-controlled colonic drug delivery using spray-dried chitosan acetate and hydroxypropyl methylcellulose.
J. Nunthanid (2008)
Chitosan chemistry and pharmaceutical perspectives.
M. Kumar (2004)
In vitro evaluation of pectin-HPMC compression coated 5-aminosalicylic acid tablets for colonic delivery.
M. Turkoğlu (2002)
Protonation constants of chitosan with different molecular weight and degree of deacetylation
Q. Wang (2006)
Release of albumin from chitosan-coated pectin beads in vitro.
T. Kim (2003)
Alginate microspheres of isoniazid for oral sustained drug delivery.
R. Rastogi (2007)
Biphasic drug release: the permeability of films containing pectin, chitosan and HPMC.
K. Ofori-Kwakye (2001)
In situ gelling pectin formulations for oral drug delivery at high gastric pH.
K. Itoh (2007)
This paper is referenced by
Sodium alginate coated mesoporous silica for dual bio-responsive controlled drug delivery
N. Yuan (2018)
Chitosan-alginate matrices loaded with leaf extracts of Anredera cordifolia Steenis as a gastrointestinal extended-release formulation
Elsa Anisa Krisanti (2019)
Desenvolvimento de uma formulação tópica contendo fluconazol nanoencapsulado para o tratamento de candidíase vulvovaginal
T. A. Reis (2014)
A honeycomb composite of mollusca shell matrix and calcium alginate.
Hua-jian You (2016)
Naturally and synthetic smart composite biomaterials for tissue regeneration.
R. Pérez (2013)
pH-Sensitive Hollow Alginate-Chitosan Hydrogel Beads for Bitter Gourd Delivery
Hong-Ru Lin (2014)
Development and in vitro/in vivo evaluation of Zn-pectinate microparticles reinforced with chitosan for the colonic delivery of progesterone
Hytham H Gadalla (2016)
Polysaccharides as Composite Biomaterials
I. Wahab (2016)
Pectin and charge modified pectin hydrogel beads as a colon-targeted drug delivery carrier.
Jiyoung Jung (2013)
Novel Smart Chitosan-Grafted Alginate Microcapsules pH-Sensitive Hydrogel for Oral Protein Delivery: Release and Bio-Evaluation Studies
Mohamed Mohy Eldin (2016)
Seaweed based sustainable films and composites for food and pharmaceutical applications: A review
H. A. Khalil (2017)
The effect of centrifugation speed and Chitosan-Sodium Tripolyphosphate ratio toward the nanoencapsulation of Sambiloto (Andrographis paniculata) for the formulation of Hepatitis B drug
Devi Permata Sari (2018)
Stimuli-Responsive Polymers: Design and Applications
A. K. Bajpai (2014)
Effect of alginate composition on profile release and characteristics of chitosan-alginate microparticles loaded with mangosteen extract
Kamarza Mulia (2017)
Preparation, physical characterization, and stability of Ferrous-Chitosan microcapsules using different iron sources
Noer Abyor Handayani (2017)
α-Mangostin Hydrogel Film Based Chitosan–Alginate for Recurrent Aphthous Stomatitis
Nasrul Wathoni (2019)
pH-Responsive Polymers: Properties, Synthesis, and Applications
L. García-Fernández (2014)
Potential effects of alginate–pectin biocomposite on the release of folic acid and their physicochemical characteristics
Pegah Kiaei Pour (2020)
In vitro and in vivo evaluation of pectin-based nanoparticles for hepatocellular carcinoma drug chemotherapy.
Cui-Yun Yu (2014)
Microencapsulation and antimicrobial activity of carvacrol in a pectin-alginate matrix
Xiuxiu Sun (2019)
Hydrogels Based on Chitosan and Chitosan Derivatives for Biomedical Applications
Kessily B. Rufato (2018)
Smart instructive polymer substrates for tissue engineering
C. Custódio (2014)
Spray drying formulation of albendazole microspheres by experimental design. In vitro–in vivo studies
A. García (2015)
Functionalized Polymers for Enhance Oral Bioavailability of Sensitive Molecules
Y. A. Pérez (2016)
A STUDY ON PLANT POLYMER: PECTIN PRODUCTION AND MODIFICATION
I. Alemzadeh (2010)
Preparation of chitosan microspheres by ionotropic gelation under a high voltage electrostatic field for protein delivery.
Lihua Ma (2010)
Dextran-based hydrogel microspheres obtained in w/o emulsion: preparation, characterisation and in vivo studies
Maria Antonietta Casadei (2014)
Fine-tuning the assembly of highly stable oppositely charged cerium oxide nanoparticles in solution and at interfaces
Sribharani Sekar (2016)
Interactions between ß-lactoglobulin and nutraceutical ligands riboflavin, vitamin D₃ and lysozyme : formation, physico-chemical and biological characterization of functional delivery scaffolds
Fatoumata Diarrassouba (2013)
Glucose-responsive composite microparticles based on chitosan, concanavalin A and dextran for insulin delivery.
Ruixue Yin (2010)
Therapeutic effect of chitosan modification on salmon-calcitonin-loaded PLGA nanoparticles
Min-Jeong Lee (2011)
Preparation and characterization of chitosan microsphere loading bovine serum albumin
Qingshen Sun (2012)See more