Online citations, reference lists, and bibliographies.
← Back to Search

Signaling Gene Cascade In Silver Nanoparticle Induced Apoptosis.

P. Gopinath, Sonit Kumar Gogoi, Pallab Sanpui, A. Paul, A. Chattopadhyay, S. Ghosh
Published 2010 · Chemistry, Medicine

Cite This
Download PDF
Analyze on Scholarcy
Share
Nanoscale materials are presently gaining much importance for biological applications especially in the field of medicine. The large numbers of nanomaterial based products that are currently being developed - with projected applications in medicine - have inspired a growing interest in exploring their impact on cellular gene expression. The present study examines the effects of silver nanoparticles (NPs) on genes expression in an endeavor to assess the fundamental mechanisms that contribute to silver NP induced programmed cell death. Here, we have used RT-PCR to study the gene expression, flow cytometry analyses to probe the extent of apoptosis (FACS) and atomic force microscopy (AFM) to follow the cell membrane topology change induced by Ag NPs. The gene expression study revealed that Ag NP induced p53-mediated apoptotic pathway through which most of the chemotherapeutic drugs trigger apoptosis (programmed cell death). The results also suggest that Ag NPs could be attributed as therapeutic agent for biomedical and pharmaceutical applications.
This paper references
10.1016/J.TIV.2005.06.034
In vitro toxicity of nanoparticles in BRL 3A rat liver cells.
S. Hussain (2005)
10.1016/S0092-8674(03)00116-8
Mitochondria Releasing Power for Life and Unleashing the Machineries of Death
D. Newmeyer (2003)
10.1016/S0378-5173(03)00128-5
Development of polymeric nanoparticulate drug delivery systems: evaluation of nanoparticles based on biotinylated poly(ethylene glycol) with sugar moiety.
I. Kim (2003)
10.1007/s11010-008-9980-5
Understanding apoptotic signaling pathways in cytosine deaminase-uracil phosphoribosyl transferase-mediated suicide gene therapy in vitro
P. Gopinath (2008)
10.1016/S0092-8674(00)80085-9
Induction of Apoptotic Program in Cell-Free Extracts: Requirement for dATP and Cytochrome c
X. Liu (1996)
10.1146/ANNUREV.IMMUNOL.16.1.395
BCL-2 family: regulators of cell death.
D. Chao (1998)
10.1136/bmj.322.7301.1536
What is apoptosis, and why is it important? Education and debate
A. Renehan (2001)
Mol
P. Gopinath (2008)
10.1126/SCIENCE.275.5303.1129
Prevention of Apoptosis by Bcl-2: Release of Cytochrome c from Mitochondria Blocked
J. Yang (1997)
Proc
I. Roy (2005)
10.1074/JBC.273.16.9357
Caspase-3 Is Required for DNA Fragmentation and Morphological Changes Associated with Apoptosis*
R. Jänicke (1998)
10.1088/0957-4484/19/7/075104
Implications of silver nanoparticle induced cell apoptosis for in vitro gene therapy.
P. Gopinath (2008)
10.1126/SCIENCE.275.5303.1132
The Release of Cytochrome c from Mitochondria: A Primary Site for Bcl-2 Regulation of Apoptosis
R. Kluck (1997)
Nat
A. K. Salem (2003)
10.1016/j.ijfoodmicro.2008.03.004
The antibacterial properties of a novel chitosan-Ag-nanoparticle composite.
Pallab Sanpui (2008)
10.1126/science.7878464
Apoptosis in the pathogenesis and treatment of disease
C. Thompson (1995)
10.1016/J.ADDR.2004.02.014
Nanoparticle and targeted systems for cancer therapy.
L. Brannon-Peppas (2004)
10.1016/S0006-3495(94)80490-4
Imaging of the membrane surface of MDCK cells by atomic force microscopy.
C. le Grimellec (1994)
10.1016/j.toxlet.2008.04.009
Cellular responses induced by silver nanoparticles: In vitro studies.
S. Arora (2008)
10.1073/PNAS.0408039101
Optical tracking of organically modified silica nanoparticles as DNA carriers: a nonviral, nanomedicine approach for gene delivery.
I. Roy (2005)
10.1016/S0006-3495(96)79483-3
Atomic force microscopy study of the secretory granule lumen.
V. Parpura (1996)
10.1016/0092-8674(95)90411-5
Bad, a heterodimeric partner for Bcl-xL and Bcl-2, displaces bax and promotes cell death
E. Yang (1995)
10.1016/j.toxlet.2008.04.015
The apoptotic effect of nanosilver is mediated by a ROS- and JNK-dependent mechanism involving the mitochondrial pathway in NIH3T3 cells.
Yi-Hong Hsin (2008)
10.1038/NMAT974
Multifunctional nanorods for gene delivery
A. Salem (2003)
10.1002/anie.200802801
An apoptosis-inducing small molecule that binds to heat shock protein 70.
Darren R. Williams (2008)
Angew
D. R. Williams (2008)
10.1016/0092-8674(93)90508-N
bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death
L. Boise (1993)
10.1007/3-540-26367-5_1
A
A. Spring (2005)
10.1021/LA060661V
Green fluorescent protein-expressing Escherichia coli as a model system for investigating the antimicrobial activities of silver nanoparticles.
Sonit Kumar Gogoi (2006)
10.1021/nn800596w
Cytotoxicity and genotoxicity of silver nanoparticles in human cells.
P. V. AshaRani (2009)
10.1007/S12033-007-9026-3
Apoptotic Induction with Bifunctional E.coli Cytosine Deaminase-Uracil Phosphoribosyltransferase Mediated Suicide Gene Therapy is Synergized by Curcumin Treatment In vitro
P. Gopinath (2008)
10.1083/JCB.139.5.1281
Movement of Bax from the Cytosol to Mitochondria during Apoptosis
K. G. Wolter (1997)
10.5040/9781474284028.0024
S
A. Kumar (1824)



This paper is referenced by
TİTANYUM DİOKSİTİN A549 HÜCRELERİ ÜZERİNDEKİ APOPTOTİK ETKİLERİ
A. Kaplan (2017)
10.1016/j.cbi.2018.07.028
Thermal Co-reduction engineered silver nanoparticles induce oxidative cell damage in human colon cancer cells through inhibition of reduced glutathione and induction of mitochondria-involved apoptosis.
N. Dasgupta (2018)
Investigating the immunotoxicology of silver nanoparticles in vitro
A. Hastings (2012)
10.3390/nano10081527
Recent Advances in Surface Nanoengineering for Biofilm Prevention and Control. Part II: Active, Combined Active and Passive, and Smart Bacteria-Responsive Antibiofilm Nanocoatings
P. Balaure (2020)
10.22159/AJPCR.2018.V11I11.29383
EFFECTS OF SILVER NANOPARTICLES ON THYROID GLAND STRUCTURE AND FUNCTION IN FEMALE RATS
A. Sulaiman (2018)
Toxicity of silver nanoparticles in mouse embryonic stem cells and chemical based reprogramming of somatic cells to sphere cells
P. Krishnamurthy (2011)
10.5012/BKCS.2011.32.5.1583
Preparation of Silver Nanoparticles in Ultrasonic Vibration-Induced Nanodroplets of Isopropyl Alcohol in Combination with Ionic Liquids
U. Shin (2011)
10.1007/978-3-030-34544-0_1
Nanoparticles and Plant Interaction with Respect to Stress Response
M. S. Iqbal (2020)
10.1007/S40995-017-0431-6
Applications of Plant Flavonoids in the Green Synthesis of Colloidal Silver Nanoparticles and Impacts on Human Health
M. Hussain (2019)
10.1016/j.colsurfb.2016.01.043
Carbon dots incorporated polymeric hydrogels as multifunctional platform for imaging and induction of apoptosis in lung cancer cells.
Abhay Sachdev (2016)
10.1002/jat.3199
Cytotoxicity and apoptosis induced by silver nanoparticles in human liver HepG2 cells in different dispersion media
Y. Xue (2016)
10.1007/s12011-015-0562-6
In Vitro Selective Anti-Proliferative Effect of Zinc Oxide Nanoparticles Against Co-Cultured C2C12 Myoblastoma Cancer and 3T3-L1 Normal Cells
M. Chandrasekaran (2015)
10.1016/j.colsurfb.2011.06.022
Comparative evaluation of antibacterial activity of silver nanoparticles synthesized using Rhizophora apiculata and glucose.
J. Antony (2011)
Self-contained 3D Differentiation of Reprogrammed Amniotic Fluid Derived Stem Cells for Congenital Heart Repair
Christopher Tsao (2017)
10.1007/s00436-015-4838-8
Hydrothermal synthesis of titanium dioxide nanoparticles: mosquitocidal potential and anticancer activity on human breast cancer cells (MCF-7)
K. Murugan (2015)
NIOSH Current Intelligence Bulletin: Health Effects of Occupational Exposure to Silver Nanomaterials
H. Leddy (2016)
10.2131/jts.44.155
Mechanisms of silver nanoparticles-induced cytotoxicity and apoptosis in rat tracheal epithelial cells.
J. Tang (2019)
Silver nanoparticles -- allies or adversaries?
T. Bartłomiejczyk (2013)
10.1016/j.ijpharm.2019.118591
PEGylated AgNP covered with cationic carbosilane dendrons to enhance antibacterial and inhibition of biofilm properties.
Andrea Barrios-Gumiel (2019)
10.1002/jat.3097
Comparative cytotoxicity of dolomite nanoparticles in human larynx HEp2 and liver HepG2 cells
Maqusood Ahamed (2015)
10.1016/B978-0-444-53864-2.00005-0
Toxicity of Silver Nanomaterials in Higher Eukaryotes
Marcin Kruszewski (2011)
Silver : water disinfection and toxicity
L. Fewtrell (2014)
In Vitro Evaluation of Cytotoxic and Anti-HCV-4 Properties of Sofosbuvir Encapsulated Chitosan Nanoparticles
Samah A Loutfy (2020)
10.1016/j.tiv.2018.03.015
Proteomics study of silver nanoparticles on Caco-2 cells
S. Gioria (2018)
10.1016/j.colsurfb.2014.10.012
Statistical analysis of gold nanoparticle-induced oxidative stress and apoptosis in myoblast (C2C12) cells.
R. Wahab (2014)
10.1371/journal.pone.0102564
Hormesis Effects of Silver Nanoparticles at Non-Cytotoxic Doses to Human Hepatoma Cells
Zhi-Hao Jiao (2014)
10.1088/2053-1591/abb155
One-step growth method of silver nanowires in aqueous environment
X. Liu (2020)
10.1177/0960327118769718
Comparative cytotoxicity and apoptotic pathways induced by nanosilver in human liver HepG2 and L02 cells
Y. Xue (2018)
10.1016/j.chemosphere.2015.03.079
Comparative cytotoxic response of nickel ferrite nanoparticles in human liver HepG2 and breast MFC-7 cancer cells.
M. Ahamed (2015)
10.5114/FN.2015.56543
Toxic effects of silver nanoparticles in mammals--does a risk of neurotoxicity exist?
Joanna Skalska (2015)
10.3892/ijmm.2019.4265
Mechanism of cell death induced by silica nanoparticles in hepatocyte cells is by apoptosis
Ye Yang (2019)
10.3390/ijms151223936
Inhalation of Silver Nanomaterials—Seeing the Risks
Ioannis G Theodorou (2014)
See more
Semantic Scholar Logo Some data provided by SemanticScholar