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Pharmaceutical Formulation Of HSA Hybrid Coated Iron Oxide Nanoparticles For Magnetic Drug Targeting.

J. Zaloga, Marina Poettler, G. Leitinger, R. Friedrich, G. Almer, S. Lyer, E. Baum, R. Tietze, Ralph Heimke-Brinck, H. Mangge, F. Dörje, Geoffrey Lee, C. Alexiou
Published 2016 · Medicine, Chemistry

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In this work we present a new formulation of superparamagnetic iron oxide nanoparticles (SPIONs) for magnetic drug targeting. The particles were reproducibly synthesized from current good manufacturing practice (cGMP) - grade substances. They were surface coated using fatty acids as anchoring molecules for human serum albumin. We comprehensively characterized the physicochemical core-shell structure of the particles using sophisticated methods. We investigated biocompatibility and cellular uptake of the particles using an established flow cytometric method in combination with microwave-plasma assisted atomic emission spectroscopy (MP-AES). The cytotoxic drug mitoxantrone was adsorbed on the protein shell and we showed that even in complex media it is slowly released with a close to zero order kinetics. We also describe an in vitro proof-of-concept assay in which we clearly showed that local enrichment of this SPION-drug conjugate with a magnet allows site-specific therapeutic effects.
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