Online citations, reference lists, and bibliographies.
← Back to Search

Pharmaceutical Formulation Of HSA Hybrid Coated Iron Oxide Nanoparticles For Magnetic Drug Targeting.

J. Zaloga, Marina Poettler, G. Leitinger, R. Friedrich, G. Almer, S. Lyer, E. Baum, R. Tietze, Ralph Heimke-Brinck, H. Mangge, F. Dörje, Geoffrey Lee, C. Alexiou
Published 2016 · Medicine, Chemistry

Cite This
Download PDF
Analyze on Scholarcy
Share
In this work we present a new formulation of superparamagnetic iron oxide nanoparticles (SPIONs) for magnetic drug targeting. The particles were reproducibly synthesized from current good manufacturing practice (cGMP) - grade substances. They were surface coated using fatty acids as anchoring molecules for human serum albumin. We comprehensively characterized the physicochemical core-shell structure of the particles using sophisticated methods. We investigated biocompatibility and cellular uptake of the particles using an established flow cytometric method in combination with microwave-plasma assisted atomic emission spectroscopy (MP-AES). The cytotoxic drug mitoxantrone was adsorbed on the protein shell and we showed that even in complex media it is slowly released with a close to zero order kinetics. We also describe an in vitro proof-of-concept assay in which we clearly showed that local enrichment of this SPION-drug conjugate with a magnet allows site-specific therapeutic effects.
This paper references
10.1038/nnano.2015.47
Mapping protein binding sites on the biomolecular corona of nanoparticles.
Philip M. Kelly (2015)
Efficient drugdelivery using magnetic nanoparticles – biodistribution and therapeutic effects in tumour bearing rabbits , Nanomed
S. Lyer R. Tietze (2013)
10.1039/c2nr31185b
Cell "vision": complementary factor of protein corona in nanotoxicology.
M. Mahmoudi (2012)
10.1016/j.colsurfb.2012.02.022
Probing nanoparticle interactions in cell culture media.
A. Sabuncu (2012)
10.1007/s10616-010-9263-3
Albumin and mammalian cell culture: implications for biotechnology applications
G. Francis (2010)
10.1016/J.IJPHARM.2007.05.066
Effect of the microencapsulation of nanoparticles on the reduction of burst release.
A. S. Hasan (2007)
Visualization of superparamagnetic nanoparticles in vascular tissue using X mu CT and histology , Histochem
S. Lyer (2011)
10.2217/nnm.14.81
Development of nanoparticles for clinical use.
T. Skotland (2014)
10.1088/0953-8984/18/38/S25
Determination of the magnetic particle distribution in tumour tissue by means of x-ray tomography
O. Brunke (2006)
10.1021/JA01548A024
The Interaction of Human Serum Albumin with Long-chain Fatty Acid Anions
D. S. Goodman (1958)
10.1529/BIOPHYSJ.104.047746
The hydrodynamic radii of macromolecules and their effect on red blood cell aggregation.
J. Armstrong (2004)
10.3109/08916934.2012.755960
Colourful death: Six-parameter classification of cell death by flow cytometry—Dead cells tell tales
L. Munoz (2013)
10.1021/LA0484725
Protein adsorption onto silica nanoparticles: conformational changes depend on the particles' curvature and the protein stability.
M. Lundqvist (2004)
Zeta Potentials and Isoelectric Points of Biomolecules: The Effects of Ion Types and Ionic Strengths
Sema Salgın (2012)
10.1155/2010/597304
Mitoxantrone Loaded Superparamagnetic Nanoparticles for Drug Targeting: A Versatile and Sensitive Method for Quantification of Drug Enrichment in Rabbit Tissues Using HPLC-UV
Rainer Dr. Tietze (2010)
Clinical experiences with magnetic drug targeting: a phase I study with 4'-epidoxorubicin in 14 patients with advanced solid tumors.
A. Lübbe (1996)
Magnetic nanoparticlebased drug delivery for cancer therapy , Biochem
R. P. Friedrich
10.1021/la301104a
Impact of the nanoparticle-protein corona on colloidal stability and protein structure.
J. Gebauer (2012)
10.1021/mp400154a
Determination of drug release kinetics from nanoparticles: overcoming pitfalls of the dynamic dialysis method.
Sweta Modi (2013)
10.1021/nn305337c
Temperature: the "ignored" factor at the NanoBio interface.
M. Mahmoudi (2013)
10.1007/s00204-012-0837-z
Interference of engineered nanoparticles with in vitro toxicity assays
A. Kroll (2012)
10.2217/nnm.15.159
Nanomedical innovation: the SEON-concept for an improved cancer therapy with magnetic nanoparticles.
S. Lyer (2015)
10.1016/J.BIOMATERIALS.2004.10.012
Synthesis and surface engineering of iron oxide nanoparticles for biomedical applications.
A. Gupta (2005)
10.1177/106002808602000201
Mitoxantrone
T. Poirier (1986)
10.1016/j.nano.2013.05.001
Efficient drug-delivery using magnetic nanoparticles--biodistribution and therapeutic effects in tumour bearing rabbits.
R. Tietze (2013)
10.1016/0022-1759(91)90198-O
A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry.
I. Nicoletti (1991)
10.1016/J.JMMM.2006.10.1205
In vitro investigation of the behaviour of magnetic particles by a circulating artery model
C. Seliger (2007)
10.2147/IJN.S63433
Development and characterization of magnetic iron oxide nanoparticles with a cisplatin-bearing polymer coating for targeted drug delivery
H. Unterweger (2014)
Removal of fatty acids from serum albumin by charcoal treatment.
R. F. Chen (1967)
10.1146/annurev-bioeng-071811-150124
The effect of nanoparticle size, shape, and surface chemistry on biological systems.
Alexandre Albanese (2012)
10.2165/00003495-199141030-00007
Mitoxantrone. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in the chemotherapy of cancer.
D. Faulds (1991)
The effect of nanoparticle size
A. Albanese (2012)
10.1021/la302660p
Designed polyelectrolyte shell on magnetite nanocore for dilution-resistant biocompatible magnetic fluids.
Ildikó Y. Tóth (2012)
10.1007/s00418-011-0780-8
Visualization of superparamagnetic nanoparticles in vascular tissue using XμCT and histology
Rainer Dr. Tietze (2011)
10.1208/s12248-012-9339-4
Challenges in Development of Nanoparticle-Based Therapeutics
N. Desai (2012)
10.1158/1078-0432.CCR-04-2223
Cell Death Independent of Caspases: A Review
L. Bröker (2005)
10.2147/IJN.S68539
Development of a lauric acid/albumin hybrid iron oxide nanoparticle system with improved biocompatibility
J. Zaloga (2014)
10.1038/sj.bjp.0707251
Physiological and pathological changes in the redox state of human serum albumin critically influence its binding properties
K. Oettl (2007)
10.1021/am301301f
Ultrasound-triggered BSA/SPION hybrid nanoclusters for liver-specific magnetic resonance imaging.
Bingbo Zhang (2012)
Designed polyelectrolyte shell on magnetite nanocore for dilutionresistant biocompatible magnetic fluids , Langmuir : ACS J
S. Bahadir (2012)
10.1016/j.bbrc.2015.08.030
Magnetic iron oxide nanoparticles: Recent trends in design and synthesis of magnetoresponsive nanosystems.
E. Tombácz (2015)
10.3390/ijms160819291
Tangential Flow Ultrafiltration Allows Purification and Concentration of Lauric Acid-/Albumin-Coated Particles for Improved Magnetic Treatment
J. Zaloga (2015)
10.1016/j.bbrc.2015.08.022
Magnetic nanoparticle-based drug delivery for cancer therapy.
R. Tietze (2015)
10.1111/jcmm.12130
Cancer research by means of tissue engineering – is there a rationale?
R. Horch (2013)
10.1038/nmat2442
Understanding biophysicochemical interactions at the nano-bio interface.
A. Nel (2009)
10.3390/ijms16059368
Different Storage Conditions Influence Biocompatibility and Physicochemical Properties of Iron Oxide Nanoparticles
Jan Zaloga (2015)



This paper is referenced by
10.3390/antibiotics7020046
Iron Oxide Nanoparticles for Biomedical Applications: A Perspective on Synthesis, Drugs, Antimicrobial Activity, and Toxicity
L. S. Arias (2018)
10.7150/ntno.19379
Multifunctional PEGylated Albumin/IR780/Iron Oxide Nanocomplexes for Cancer Photothermal Therapy and MR Imaging
Ssu-Yu Suei Lin (2018)
10.21767/2254-6081.100061
Anti-Cancer Effect of UV Irradiation at Presence of Cadmium Oxide (CdO) Nanoparticles on DNA of Cancer Cells: A Photodynamic Therapy Study
A. Heidari (2016)
10.1088/1361-6528/aacf4a
Influence of medium viscosity and intracellular environment on the magnetization of superparamagnetic nanoparticles in silk fibroin solutions and 3T3 mouse fibroblast cell cultures.
Ana Lorena Urbano-Bojorge (2018)
10.2147/IJN.S132369
Selection of potential iron oxide nanoparticles for breast cancer treatment based on in vitro cytotoxicity and cellular uptake
Johanna M Poller (2017)
10.3390/nano10081577
Superparamagnetic Iron Oxide Nanoparticles Carrying Chemotherapeutics Improve Drug Efficacy in Monolayer and Spheroid Cell Culture by Enabling Active Accumulation
K. Nguyen (2020)
10.1016/j.jconrel.2018.07.007
Targeting of drug‐loaded nanoparticles to tumor sites increases cell death and release of danger signals
Magdalena Alev (2018)
10.3389/fonc.2019.00059
Functionalized Superparamagnetic Iron Oxide Nanoparticles (SPIONs) as Platform for the Targeted Multimodal Tumor Therapy
Christina Janko (2019)
10.3389/fimmu.2018.02266
Inert Coats of Magnetic Nanoparticles Prevent Formation of Occlusive Intravascular Co-aggregates With Neutrophil Extracellular Traps
Rostyslav Bilyy (2018)
10.1093/cvr/cvy219
From design to the clinic: practical guidelines for translating cardiovascular nanomedicine
I. Cicha (2018)
10.3390/molecules22071030
Albumin and Hyaluronic Acid-Coated Superparamagnetic Iron Oxide Nanoparticles Loaded with Paclitaxel for Biomedical Applications
E. Vismara (2017)
Excessive Human Serum Albumin Might Weaken Anticancer Effect of Cisplatin and Etoposide
Z. Yang (2016)
10.1016/B978-0-444-63505-1.00016-6
Biosynthesis of Nanoparticles by Aspergillus and Its Medical Applications
A. G. Rodrigues (2016)
10.1002/9783527800681.CH2
Nanoscale Drugs: A Key to Revolutionary Progress in Pharmacy and Healthcare
Simon Sebastian Raesch (2016)
10.1186/s11671-016-1521-7
Tissue Plasminogen Activator Binding to Superparamagnetic Iron Oxide Nanoparticle—Covalent Versus Adsorptive Approach
R. Friedrich (2016)
10.3390/molecules25194425
Synthesis and Characterization of Citrate-Stabilized Gold-Coated Superparamagnetic Iron Oxide Nanoparticles for Biomedical Applications.
René Stein (2020)
10.1016/J.JMMM.2016.09.034
Strategies to optimize the biocompatibility of iron oxide nanoparticles – “SPIONs safe by design”
Christina Janko (2017)
10.1016/j.drudis.2019.09.020
Iron oxide nanoparticles for therapeutic applications.
E. Alphandéry (2019)
10.2147/IJN.S187886
Cellular effects of paclitaxel-loaded iron oxide nanoparticles on breast cancer using different 2D and 3D cell culture models
S. Lugert (2019)
10.1016/j.colsurfb.2017.09.057
Studies on the adsorption and desorption of mitoxantrone to lauric acid/albumin coated iron oxide nanoparticles.
J. Zaloga (2018)
10.3390/PHARMACEUTICS11010003
Graphene Oxide Functional Nanohybrids with Magnetic Nanoparticles for Improved Vectorization of Doxorubicin to Neuroblastoma Cells
Luigi Lerra (2018)
10.1080/17425247.2019.1554647
Magnetic iron oxide nanoparticles for drug delivery: applications and characteristics
T. Vangijzegem (2019)
10.1002/chem.201701491
Synthesis of Magnetic-Nanoparticle/Ansamitocin Conjugates-Inductive Heating Leads to Decreased Cell Proliferation In Vitro and Attenuation Of Tumour Growth In Vivo.
K. Seidel (2017)
10.1016/j.ejpb.2019.07.024
Synthesis and characterization of acetyl curcumin-loaded core/shell liposome nanoparticles via an electrospray process for drug delivery, and theranostic applications.
Ankireddy Seshadri Reddy (2019)
10.1016/j.bbrc.2018.07.105
Nano-chemotherapeutic efficacy of (-) -epigallocatechin 3-gallate mediating apoptosis in A549 cells: Involvement of reactive oxygen species mediated Nrf2/Keap1signaling.
B. Velavan (2018)
10.3389/fphar.2016.00434
Weakening Impact of Excessive Human Serum Albumin (eHSA) on Cisplatin and Etoposide Anticancer Effect in C57BL/6 Mice with Tumor and in Human NSCLC A549 Cells
Zhen Yang (2016)
10.1002/CITE.201600077
Innovative toxikologische Untersuchungsmethoden für Eisenoxidnanopartikel in der Nanomedizin
C. Janko (2017)
Semantic Scholar Logo Some data provided by SemanticScholar