← Back to Search
Toxicological Effects Of Clofibric Acid And Diclofenac On Plasma Thyroid Hormones Of An Indian Major Carp, Cirrhinus Mrigala During Short And Long-term Exposures.
M. Saravanan, J. Hur, N. Arul, M. Ramesh
Published 2014 · Chemistry, Medicine
Save to my Library
Download via 🐼 PaperPanda Download via oaDOI Download via OAB Download via LibKey Download via Google Google ScholarAnalyze on Scholarcy Visualize in Litmaps
Reduce the time it takes to create your bibliography by a factor of 10 by using the world’s favourite reference manager
Time to take this seriously.
In the present investigation, the toxicity of most commonly detected pharmaceuticals in the aquatic environment namely clofibric acid (CA) and diclofenac (DCF) was investigated in an Indian major carp Cirrhinus mrigala. Fingerlings of C. mrigala were exposed to different concentrations (1, 10 and 100μgL(-1)) of CA and DCF for a period of 96h (short term) and 35 days (long term). The toxic effects of CA and DCF on thyroid hormones (THs) such as thyroid stimulating hormone (TSH), thyroxine (T4) and triiodothyronine (T3) levels were evaluated. During the short and long-term exposure period TSH level was found to be decreased at all concentrations of CA (except at the end of 14(th) day in 1 and 10μgL(-l) and 21(st) day in 1μgL(-l)) whereas in DCF exposed fish TSH level was found to be increased when compared to control groups. T4 level was found to be decreased at 1 and 100μgL(-l) of CA exposure at the end of 96h. However, T4 level was decreased at all concentrations of CA and DCF during long-term (35 days) exposure period. Fish exposed to all concentrations of CA and DCF had lower level of T3 in both the treatments. These results suggest that both CA and DCF drugs induced significant changes (P<0.01 and P<0.05) on thyroid hormonal levels of C. mrigala. The alterations of these hormonal levels can be used as potential biomarkers in monitoring of pharmaceutical drugs in aquatic organisms.
This paper references
SEASONAL CHANGES IN THE OVULATION RESPONSE OF XENOPUS LAEVIS TO METHYL TESTOSTERONE
Howard A. Shapiro (1939)
The Thyroid Gland.
S. Ingbar (1965)
Comparative vertebrate endocrinology
P. Bentley (1976)
An approach to immunoassay.
W. Walker (1977)
Drugs and drug metabolites as environmental contaminants: chlorophenoxyisobutyrate and salicyclic acid in sewage water effluent.
C. Hignite (1977)
Photoperiodic regulation of thyroid responsiveness to TSH in Fundulus heteroclitus.
E. Grau (1985)
Standard methods for the examination of water and wastewater : supplement to the sixteenth edition
A. E. Greenberg (1988)
Fish as model systems.
D. Powers (1989)
Growth hormone stimulates hepatic thyroxine 5'-monodeiodinase activity and 3,5,3'-triiodothyronine levels in rainbow trout (Salmo gairdneri).
D. Maclatchy (1990)
Hepatic UDP-glucuronyltransferase(s) activity toward thyroid hormones in rats: induction and effects on serum thyroid hormone levels following treatment with various enzyme inducers.
K. Saito (1991)
Chronic fasting reduces the response of the thyroid to growth hormone and TSH, and alters the growth hormone-related changes in hepatic 5'-monodeiodinase activity in rainbow trout, Oncorhynchus mykiss.
J. Leatherland (1992)
Endocrine Responses as Indicators of Sublethal Toxic Stress in Fish from Polluted Environments
A. Hontela (1993)
The effect of short-term exposure to three chemicals on the blood chemistry of the pinfish (Lagodon rhomboides)
L. Folmar (1993)
Plasma vitellogenin, 17β-estradiol, T3 and T4 levels in sexually maturing rainbow trout Oncorhynchus mykiss following sublethal HCN exposure
S. Ruby (1993)
Endocrine and metabolic dysfunction in yellow perch, Perca flavescens, exposed to organic contaminants and heavy metals in the St. Lawrence River
A. Hontela (1995)
Low hepatic 7-ethoxyresorufin-O-deethylase (EROD) activity and minor alterations in retinoid and thyroid hormone levels in flounder (Platichthys flesus) exposed to the polychlorinated biphenyl (PCB) mixture, Clophen A50.
H. Besselink (1996)
Effects of acute exposure to mercury chloride and methylmercury on plasma cortisol, T3, T4, glucose and liver glycogen in rainbow trout (Oncorhynchus mykiss)
H. Bleau (1996)
Cloning of Tilapia Type I and III Deiodinases a
SERGE VAN DER Geyten (1996)
A mechanistic model of effects of dioxin on thyroid hormones in the rat.
M. Kohn (1996)
Endocrine, osmoregulatory, respiratory and haematological parameters in flounder exposed to the water soluble fraction of crude oil
A. AlKindi (1996)
Mechanistic Data and Risk Assessment of Selected Toxic End Points of the Thyroid Gland
C. Capen (1997)
Occurrence of the Pharmaceutical Drug Clofibric Acid and the Herbicide Mecoprop in Various Swiss Lakes and in the North Sea
H. Buser (1998)
Biochemical and histological responses in rainbow trout (Oncorhynchus mykiss) exposed to 2,3,4,7,8‐pentachlorodibenzofuran
S. B. Brown (1998)
Occurrence of drugs in German sewage treatment plants and rivers 1 Dedicated to Professor Dr. Klaus
T. Ternes (1998)
Pharmaceuticals and personal care products in the environment: agents of subtle change?
C. Daughton (1999)
Deiodination as an Index of Chemical Disruption of Thyroid Hormone Homeostasis and Thyroidal Status in Fish
J. Eales (1999)
Drug enterocyte adducts: possible causal factor for diclofenac enteropathy in rats.
C. Atchison (2000)
Thyroid hormone and central nervous system development.
S. Chan (2000)
Endocrine disruption: thyroid dysfunction in mummichogs (Fundulus heteroclitus) from a polluted habitat.
T. Zhou (2000)
Evolution of the thyroid hormone-binding protein, transthyretin.
D. Power (2000)
Evaluation of a Tier I screening battery for detecting endocrine-active compounds (EACs) using the positive controls testosterone, coumestrol, progesterone, and RU486.
J. C. O'Connor (2000)
Thyroid hormone deiodination in tissues of American plaice, Hippoglossoides platessoides: characterization and short-term responses to polychlorinated biphenyls (PCBs) 77 and 126.
B. A. Adams (2000)
Thyroid hormones in growth and development of fish.
D. Power (2001)
Determination of drugs in surface water and wastewater samples by liquid chromatography-mass spectrometry: methods and preliminary results including toxicity studies with Vibrio fischeri.
M. Farré (2001)
Effects of short-term in vivo exposure to polybrominated diphenyl ethers on thyroid hormones and hepatic enzyme activities in weanling rats.
T. Zhou (2001)
Effects on Pharmaceuticals in the Environment : an Overview and Principle Considerations
P. Pfluger (2001)
Uterotrophic and Hershberger assays for n-butylbenzene in rats
K. Yamasaki (2001)
Pharmaceuticals in the Environment
K. Kuemmerer (2001)
Diclofenac induced in vivo nephrotoxicity may involve oxidative stress-mediated massive genomic DNA fragmentation and apoptotic cell death.
E. Hickey (2001)
Thyroid of lake sturgeon, Acipenser fulvescens. II. Deiodination properties, distribution, and effects of diet, growth, and a T3 challenge.
J. Plohman (2002)
Drugs and personal care products as ubiquitous pollutants: occurrence and distribution of clofibric acid, caffeine and DEET in the North Sea.
S. Weigel (2002)
Differential effects of melatonin on plasma levels of thyroxine and triiodothyronine levels in the air-breathing fish, Clarias gariepinus, during breeding and quiescent periods.
B. B. Gupta (2002)
Thyroid hormones are important for embryonic to larval transitory phase in zebrafish.
Y. Liu (2002)
Occurrence, fate, and removal of pharmaceutical residues in the aquatic environment: a review of recent research data.
T. Heberer (2002)
Polybrominated diphenyl ethers (PBDEs), polychlorinated biphenyls (PCBs) and chlorinated paraffins (CPs) in rats-testing interactions and mechanisms for thyroid hormone effects.
Sara Hallgren (2002)
Detection of pharmaceutical contaminations of river, pond, and tap water from Cologne (Germany) and surroundings.
Ulrich Jux (2002)
Aquatic ecotoxicity of pharmaceuticals including the assessment of combination effects.
M. Cleuvers (2003)
Dosages de thyroxine (T4) et tri-iodothyronine (T3) : techniques et place dans le bilan thyroïdien fonctionnel
R. Sapin (2003)
Effects of ammonium perchlorate on the reproductive performance and thyroid follicle histology of zebrafish.
R. Patiño (2003)
Determination of polar pharmaceuticals in sewage water of Greece by gas chromatography-mass spectrometry.
V. Koutsouba (2003)
Diclofenac residues as the cause of vulture population decline in Pakistan
J. Oaks (2004)
Developmental changes of thyroid hormones in the fathead minnow, Pimephales promelas.
Helen M Crane (2004)
Acute and chronic effects of clofibrate and clofibric acid on the enzymes acetylcholinesterase, lactate dehydrogenase and catalase of the mosquitofish, Gambusia holbrooki.
B. Nunes (2004)
Toxic effects of the non-steroidal anti-inflammatory drug diclofenac. Part I: histopathological alterations and bioaccumulation in rainbow trout.
J. Schwaiger (2004)
The occurrence of selected human pharmaceutical compounds in UK estuaries.
K. Thomas (2004)
Endocrine and metabolic changes in Anguilla anguilla L. following exposure to beta-naphthoflavone--a microsomal enzyme inducer.
M. Teles (2005)
Circulating thyroid hormone levels and iodothyronine deiodinase activities in Nile tilapia (Oreochromis niloticus) following dietary exposure to Endosulfan and Aroclor 1254.
Ana Maria Coimbra (2005)
Determination of select antidepressants in fish from an effluent-dominated stream.
B. Brooks (2005)
AhR-agonist-induced transcriptional changes of genes involved in thyroid function in primary porcine thyrocytes.
P. Pocar (2006)
Mechanisms of action underlying the antiandrogenic effects of the fungicide prochloraz.
P. Laier (2006)
Ecotoxicology of human pharmaceuticals.
K. Fent (2006)
Pharmaceuticals in the Environment in Italy: Causes, Occurrence, Effects and Control
E. Zuccato (2006)
Consequences of treated water recycling as regards pharmaceuticals and drugs in surface and ground waters of a medium-sized Mediterranean catchment.
M. Rabiet (2006)
Implications of Research on Assays to Characterize Thyroid Toxicants
R. Zoeller (2007)
Changes in the thyroid status modify the metabolite pattern of air-breathing perch (Anabas testudineus) during monocrotophos (Nuvacran) exposure
V. S. Peter (2007)
Effects of acute and subchronic exposures to waterborne selenite on the physiological stress response and oxidative stress indicators in juvenile rainbow trout.
L. L. Miller (2007)
Influence of coconut husk r etting effluent on metabolic, interrenal and thyroid functions in the air-breathing perch, Anabas testudineus Bloch
V. S. Peter (2007)
Analysis of the effects diclofenac has on Japanese medaka (Oryzias latipes) using real-time PCR.
Han Na Hong (2007)
Thyroid disruption in walleye (Sander vitreus) exposed to environmental contaminants: cloning and use of iodothyronine deiodinases as molecular biomarkers.
Michelle Picard-Aitken (2007)
Human pharmaceuticals in the aquatic environment: a challenge to Green Chemistry.
Sushil K. Khetan (2007)
General Background on the Hypothalamic-Pituitary-Thyroid (HPT) Axis
R. Zoeller (2007)
Thyroid disrupting chemicals: mechanisms and mixtures.
K. Crofton (2008)
European eel (Anguilla anguilla L.) metallothionein, endocrine, metabolic and genotoxic responses to copper exposure.
M. Oliveira (2008)
Evolutionary conservation of human drug targets in organisms used for environmental risk assessments.
L. Gunnarsson (2008)
Effects of persistent organic pollutants on the thyroid function of the European sea bass (Dicentrarchus labrax) from the Aegean sea, is it an endocrine disruption?
J. G. Schnitzler (2008)
Changes in plasma thyroid hormones and cortisol levels in crucian carp (Carassius auratus) exposed to the extracted microcystins.
D. Li (2008)
The involvement of thyroid hormones and cortisol in the osmotic acclimation of Solea senegalensis.
F. Arjona (2008)
Pharmaceuticals and endocrine disrupting compounds in U.S. drinking water.
M. Benotti (2009)
Pharmaceuticals and personal care products: research needs for the next decade.
B. Brooks (2009)
Effects of exposure to acetochlor on the expression of thyroid hormone related genes in larval and adult rare minnow (Gobiocypris rarus).
W. Li (2009)
Veterinary diclofenac threatens Africa's endangered vulture species.
V. Naidoo (2009)
Thyrotropin in teleost fish.
D. Mackenzie (2009)
Thyroid hormones as a potential early biomarker of exposure to 4-nonylphenol in adult male shubunkins (Carassius auratus).
A. Zaccaroni (2009)
Human health risk assessment from the presence of human pharmaceuticals in the aquatic environment.
V. Cunningham (2009)
Disruption of the thyroid system by diethylstilbestrol and ioxynil in the sea bream (Sparus aurata).
I. Morgado (2009)
Occurrence of pharmaceuticals and personal care products in fish: results of a national pilot study in the United States.
A. Ramirez (2009)
Thyroid hormone modifies the metabolic response of air-breathing perch (Anabas testudineus Bloch) to nimbecidine exposure
M. Peter (2009)
Exposure to DE-71 alters thyroid hormone levels and gene transcription in the hypothalamic-pituitary-thyroid axis of zebrafish larvae.
Liqin Yu (2010)
Evidence for thyroid endocrine disruption in wild fish in San Francisco Bay, California, USA. Relationships to contaminant exposures.
N. Brar (2010)
Ecotoxicological aspects related to the presence of pharmaceuticals in the aquatic environment.
L. Santos (2010)
Removal of pharmaceuticals during wastewater treatment and environmental risk assessment using hazard indexes.
M. Gros (2010)
Endocrine disruptors and thyroid hormone physiology.
M. Jugan (2010)
Pharmaceuticals in the aquatic environment: A critical review of the evidence for health effects in fish
Jenna Corcoran (2010)
Changes of thyroid hormone levels and related gene expression in zebrafish on early life stage exposure to triadimefon.
Shaoying Liu (2011)
Thyroid dysfunction in sea bass (Dicentrarchus labrax): underlying mechanisms and effects of polychlorinated biphenyls on thyroid hormone physiology and metabolism.
J. G. Schnitzler (2011)
The role of thyroid hormones in stress response of fish.
M. Peter (2011)
Fish thyroidal and stress responses in contamination monitoring--an integrated biomarker approach.
M. Oliveira (2011)
GC-MS analysis and ecotoxicological risk assessment of triclosan, carbamazepine and parabens in Indian rivers.
B. Ramaswamy (2011)
Disruptive effects of persistent organohalogen contaminants on thyroid function in white whales (Delphinapterus leucas) from Svalbard.
G. D. Villanger (2011)
Behavior of pharmaceuticals and drugs of abuse in a drinking water treatment plant (DWTP) using combined conventional and ultrafiltration and reverse osmosis (UF/RO) treatments.
M. R. Boleda (2011)
Pharmaceutical residues in environmental waters and wastewater: current state of knowledge and future research
D. Fatta-Kassinos (2011)
Detection of Some Hormonal Responses of Yellowfin Sea Bream (Acanthopagrus latus) in Mahshahr Creeks (North West of Persian Gulf)
A. Movahedinia (2011)
Parental transfer of polybrominated diphenyl ethers (PBDEs) and thyroid endocrine disruption in zebrafish.
L. Yu (2011)
Regulation of iodothyronine deiodinases and sodium iodide symporter mRNA expression by perchlorate in larvae and adult Chinese rare minnow (Gobiocypris rarus).
W. Li (2011)
The pituitary-thyroid axis during the parr-smolt transformation of Coho salmon, Oncorhynchus kisutch: quantification of TSH β mRNA, TSH, and thyroid hormones.
D. A. Larsen (2011)
Ecotoxicological impacts of clofibric acid and diclofenac in common carp (Cyprinus carpio) fingerlings: hematological, biochemical, ionoregulatory and enzymological responses.
M. Saravanan (2011)
Effects of the anti-thyroidal compound potassium-perchlorate on the thyroid system of the zebrafish.
F. Schmidt (2012)
Bioconcentration and metabolism of decabromodiphenyl ether (BDE-209) result in thyroid endocrine disruption in zebrafish larvae.
Qi Chen (2012)
Waterborne exposure to microcystin-LR alters thyroid hormone levels and gene transcription in the hypothalamic-pituitary-thyroid axis in zebrafish larvae.
W. Yan (2012)
Occurrence of pharmaceutical compounds in wastewater and sludge from wastewater treatment plants: removal and ecotoxicological impact of wastewater discharges and sludge disposal.
J. Martín (2012)
Reproductive biomarkers to identify endocrine disruption in Clarias gariepinus exposed to 4-nonylphenol.
A. Sayed (2012)
Effects of Ibuprofen on hematological, biochemical and enzymological parameters of blood in an Indian major carp, Cirrhinus mrigala.
M. Saravanan (2012)
Effects of butachlor on reproduction and hormone levels in adult zebrafish (Danio rerio).
Juhua Chang (2013)
Short and long-term effects of clofibric acid and diclofenac on certain biochemical and ionoregulatory responses in an Indian major carp, Cirrhinus mrigala.
M. Saravanan (2013)
Fate and removal of typical pharmaceuticals and personal care products by three different treatment processes.
Yujie He (2013)
Assessing the exposure risk and impacts of pharmaceuticals in the environment on individuals and ecosystems
K. Arnold (2013)
Thyroid endocrine disruption in zebrafish larvae following exposure to hexaconazole and tebuconazole.
L. Yu (2013)
Mechanism-based testing strategy using in vitro approaches for identification of thyroid hormone disrupting chemicals.
A. Murk (2013)
Non-steroidal anti-inflammatory drugs in Indian rivers
Govindaraj Shanmugam (2013)
Zebrafish as a model to study peripheral thyroid hormone metabolism in vertebrate development.
Marjolein Heijlen (2013)
Alteration in certain enzymological parameters of an Indian major carp, Cirrhinus mrigala exposed to short- and long-term exposure of clofibric acid and diclofenac
M. Saravanan (2013)
Exposure of zebrafish embryos/larvae to TDCPP alters concentrations of thyroid hormones and transcriptions of genes involved in the hypothalamic-pituitary-thyroid axis.
Q. Wang (2013)
Thyroid endocrine system disruption by pentachlorophenol: an in vitro and in vivo assay.
Y. Guo (2013)
Exposure to monocrotophos pesticide causes disruption of the hypothalamic-pituitary-thyroid axis in adult male goldfish (Carassius auratus).
X. Zhang (2013)
Analysis of multi-class pharmaceuticals in fish tissues by ultra-high-performance liquid chromatography tandem mass spectrometry.
B. Huerta (2013)
Storage effect on the analysis of pharmaceuticals and personal care products in wastewater.
G. Fedorova (2014)
Cytotoxicity of binary mixtures of human pharmaceuticals in a fish cell line: approaches for non-monotonic concentration-response relationships.
Peter A. Bain (2014)
Plasma metabolites, ions and thyroid hormones levels, and hepatic enzymes׳ activity in Caspian roach (Rutilus rutilus caspicus) exposed to waterborne manganese.
S. M. Hoseini (2014)
Occurrence and fate of antibiotic, analgesic/anti-inflammatory, and antifungal compounds in five wastewater treatment processes.
P. Guerra (2014)
Effects of waterborne cadmium on thyroid hormone levels and related gene expression in Chinese rare minnow larvae.
Z. Li (2014)
Global risk of pharmaceutical contamination from highly populated developing countries.
M. Rehman (2015)
This paper is referenced by
Response of Two Crop Plants, Zea mays L. and Solanum lycopersicum L., to Diclofenac and Naproxen
A. Siemieniuk (2021)
Treatment of healthcare wastewater using the peroxi-photoelectrocoagulation process: Predictive models for COD, color removal and electrical energy consumption
Samuel Fekadu (2021)
Endocrine disruption of pharmaceuticals on marine organisms: Thyroidal, gonadotrophic, and behavioral responses
Juan Carlos Balasch (2021)
Electrochemical degradation of antivirus drug lamivudine formulation: photoelectrocoagulation, peroxi-electrocoagulation, and peroxi-photoelectrocoagulation processes
Samuel Fekadu (2021)
First investigations on removal of nitrazepam from water using biochar derived from macroalgae low-cost adsorbent: kinetics, isotherms and thermodynamics studies
M. K. Nazal (2021)
Effect of ibuprofen in vivo and in vitro on the sperm quality of the striped catfish Pseudoplatystoma magdaleniatum
Sara E. Gallego-Ríos (2021)
Long-term exposure of marine mussels to paracetamol: is time a healer or a killer?
Wulan Koagouw (2021)
Effects of pesticide NeemAzal-T/S on thyroid, stress hormone and some cytokines levels in freshwater common carp, Cyprinus carpio L
Nuh Korkmaz (2021)
ABATEMENT OF ANTICANCER DRUGS VIA ELECTROCHEMICAL OXIDATION PROCESS: A REVIEW
Charulata Sivodia (2020)
Occurrence of pharmaceuticals in aquatic environments: A review and potential impacts in South Africa
P. Bessong (2020)
Mitigation of clofibric acid pollution by adsorption: A review of recent developments
Joshua O. Ighalo (2020)
Clofibric acid removal by ion exchange using a magnetic ion exchange resin: equilibrium, kinetics, reusability and characterisation
Rabia Altunterim (2020)
Reynoutria japonica, an invasive herb as a source of activated carbon for the removal of xenobiotics from water.
Ivan Koutník (2020)
Occurrence and risk assessment of pharmaceutically active compounds in water supply systems in Brazil.
A. M. Santos (2020)
Magnetic gelatin-activated biochar synthesis from agricultural biomass for the removal of sodium diclofenac from aqueous solution: adsorption performance and external influence
Nguyen Thi Minh Tam (2020)
Occurrence of pharmaceuticals in aquatic environments: A review and potential impacts in South Africa
N. Ngqwala (2020)
Mechanistic insight into the adsorption of diclofenac by MIL-100: Experiments and theoretical calculations.
S. Zhuang (2019)
Protective effects of betanin against paracetamol and diclofenac induced neurotoxicity and endocrine disruption in rats
T. Motawi (2019)
Pharmaceuticals in freshwater aquatic environments: A comparison of the African and European challenge.
Samuel Fekadu (2019)
Core–shell TiO2@C ultralong nanotubes with enhanced adsorption of antibiotics
Zhe Wang (2019)
Occurrence, fate and removal of pharmaceutically active compounds (PhACs) in water and wastewater treatment plants—A review
C. Couto (2019)
Removal of selected pharmaceuticals from aqueous matrices with activated carbon under flow conditions
Mohammed Elabadsa (2019)
Long-term exposure to the non-steroidal anti-inflammatory drug (NSAID) naproxen causes thyroid disruption in zebrafish at environmentally relevant concentrations.
Chao Xu (2019)
Chronic amoxicillin exposure affects Labeo rohita: assessment of hematological, ionic compounds, biochemical, and enzymological activities
S. Umamaheswari (2019)
Emerging contaminants in Indian environmental matrices - A review.
J. M. Philip (2018)
Interaction of pharmaceutical & personal care products (PPCPs) and endocrine disrupting contaminants (EDCs) with microbial communities in South African wastewater treatment works and environmental waters
E. Archer (2018)
Environmental and human health risk assessment of pharmaceuticals in surface and drinking water treated by conventional and membrane separation processes
Amanda Vitória Santos (2018)
Eco-pharmacovigilance of non-steroidal anti-inflammatory drugs: Necessity and opportunities.
Bingshu He (2017)
Assessment of nonsteroidal anti-inflammatory drugs by ultrasonic-assisted extraction and GC-MS in Mgeni and Msunduzi river sediments, KwaZulu-Natal, South Africa
B. P. Gumbi (2017)
Pharmaceutical and personal care products (PPCPs) as endocrine disrupting contaminants (EDCs) in South African surface waters
Edward Archer (2017)
Detection and quantification of acidic drug residues in South African surface water using gas chromatography-mass spectrometry.
B. P. Gumbi (2017)
Single and mixture adsorption of clofibric acid, tetracycline and paracetamol onto Activated carbon developed from cotton cloth residue
N. Boudrahem (2017)See more