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Toxicological Effects Of Clofibric Acid And Diclofenac On Plasma Thyroid Hormones Of An Indian Major Carp, Cirrhinus Mrigala During Short And Long-term Exposures.

M. Saravanan, J. Hur, N. Arul, M. Ramesh
Published 2014 · Chemistry, Medicine

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In the present investigation, the toxicity of most commonly detected pharmaceuticals in the aquatic environment namely clofibric acid (CA) and diclofenac (DCF) was investigated in an Indian major carp Cirrhinus mrigala. Fingerlings of C. mrigala were exposed to different concentrations (1, 10 and 100μgL(-1)) of CA and DCF for a period of 96h (short term) and 35 days (long term). The toxic effects of CA and DCF on thyroid hormones (THs) such as thyroid stimulating hormone (TSH), thyroxine (T4) and triiodothyronine (T3) levels were evaluated. During the short and long-term exposure period TSH level was found to be decreased at all concentrations of CA (except at the end of 14(th) day in 1 and 10μgL(-l) and 21(st) day in 1μgL(-l)) whereas in DCF exposed fish TSH level was found to be increased when compared to control groups. T4 level was found to be decreased at 1 and 100μgL(-l) of CA exposure at the end of 96h. However, T4 level was decreased at all concentrations of CA and DCF during long-term (35 days) exposure period. Fish exposed to all concentrations of CA and DCF had lower level of T3 in both the treatments. These results suggest that both CA and DCF drugs induced significant changes (P<0.01 and P<0.05) on thyroid hormonal levels of C. mrigala. The alterations of these hormonal levels can be used as potential biomarkers in monitoring of pharmaceutical drugs in aquatic organisms.
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10.17159/sajs.2020/5730
Occurrence of pharmaceuticals in aquatic environments: A review and potential impacts in South Africa
N. Ngqwala (2020)
10.1016/j.envpol.2019.07.069
Mechanistic insight into the adsorption of diclofenac by MIL-100: Experiments and theoretical calculations.
S. Zhuang (2019)
10.1080/1354750X.2019.1642958
Protective effects of betanin against paracetamol and diclofenac induced neurotoxicity and endocrine disruption in rats
T. Motawi (2019)
10.1016/j.scitotenv.2018.11.072
Pharmaceuticals in freshwater aquatic environments: A comparison of the African and European challenge.
Samuel Fekadu (2019)
10.1039/C9TA06735C
Core–shell TiO2@C ultralong nanotubes with enhanced adsorption of antibiotics
Zhe Wang (2019)
10.1016/j.jwpe.2019.100927
Occurrence, fate and removal of pharmaceutically active compounds (PhACs) in water and wastewater treatment plants—A review
C. Couto (2019)
10.1016/J.MICROC.2019.104079
Removal of selected pharmaceuticals from aqueous matrices with activated carbon under flow conditions
Mohammed Elabadsa (2019)
10.1016/j.scitotenv.2019.04.323
Long-term exposure to the non-steroidal anti-inflammatory drug (NSAID) naproxen causes thyroid disruption in zebrafish at environmentally relevant concentrations.
Chao Xu (2019)
10.1016/j.heliyon.2019.e01434
Chronic amoxicillin exposure affects Labeo rohita: assessment of hematological, ionic compounds, biochemical, and enzymological activities
S. Umamaheswari (2019)
10.1016/j.chemosphere.2017.09.120
Emerging contaminants in Indian environmental matrices - A review.
J. M. Philip (2018)
Interaction of pharmaceutical & personal care products (PPCPs) and endocrine disrupting contaminants (EDCs) with microbial communities in South African wastewater treatment works and environmental waters
E. Archer (2018)
Environmental and human health risk assessment of pharmaceuticals in surface and drinking water treated by conventional and membrane separation processes
Amanda Vitória Santos (2018)
10.1016/j.chemosphere.2017.04.084
Eco-pharmacovigilance of non-steroidal anti-inflammatory drugs: Necessity and opportunities.
Bingshu He (2017)
10.1007/s11356-017-9653-6
Assessment of nonsteroidal anti-inflammatory drugs by ultrasonic-assisted extraction and GC-MS in Mgeni and Msunduzi river sediments, KwaZulu-Natal, South Africa
B. P. Gumbi (2017)
10.4314/WSA.V43I4.16
Pharmaceutical and personal care products (PPCPs) as endocrine disrupting contaminants (EDCs) in South African surface waters
Edward Archer (2017)
10.1016/j.chemosphere.2016.10.105
Detection and quantification of acidic drug residues in South African surface water using gas chromatography-mass spectrometry.
B. P. Gumbi (2017)
10.1016/J.PSEP.2017.08.025
Single and mixture adsorption of clofibric acid, tetracycline and paracetamol onto Activated carbon developed from cotton cloth residue
N. Boudrahem (2017)
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