← Back to Search
Cromolyn Sodium Encapsulated PLGA Nanoparticles: An Attempt To Improve Intestinal Permeation.
Ravi R. Patel, Sundeep Chaurasia, G. Khan, P. Chaubey, N. Kumar, B. Mishra
Published 2016 · Medicine, Chemistry
Download PDFAnalyze on Scholarcy
High hydrophilicity curtails the intestinal permeation of cromolyn sodium (CS) which in turn compels to compromise with its multiple biological activities. Hence, the present research was intended with an objective to develop CS encapsulated polylactide-co-glycolide (PLGA) nanoparticles (CS-PNs) for enhancing intestinal permeation. The CS-PNs were prepared by double emulsification solvent evaporation method (W1/O/W2). The "Quality by Design" approach using box-behnken experimental design was employed to enhance encapsulation of CS inside CS-PNs without compromising with particle size. The polymer concentration, surfactant concentration and organic/aqueous phase ratio significantly affected the physicochemical properties of CS-PNs. The optimized CS-PNs were subjected to various solid-state and surface characterization studies using FTIR, DSC, XRD, TEM and AFM, which pointed towards the encapsulation of CS inside the spherical shaped nanoparticles without any physical as well as chemical interactions. Ex-vivo intestinal permeation study demonstrated ∼4 fold improvements in CS permeation by forming CS-PNs as compared to pure CS. Further, in-vivo intestinal uptake study performed using confocal microscopy, after oral administration confirmed the permeation potential of CS-PNs. Thus, the findings of the studies suggest that CS-PNs could provide a superior therapeutic carrier system of CS, with enhanced intestinal permeation.
This paper references
Uptake of FITC-Chitosan Nanoparticles by A549 Cells
M. Huang (2004)
Toxicological study of the primaquine phosphate loaded chitosan nanoparticles in mice.
Rampal Rajera (2013)
Formulation, optimization and characterization of cationic polymeric nanoparticles of mast cell stabilizing agent using the Box–Behnken experimental design
Balaram Gajra (2016)
A new double emulsion solvent diffusion technique for encapsulating hydrophilic molecules in PLGA nanoparticles.
Einat Cohen-Sela (2009)
Haloperidol-loaded PLGA nanoparticles: systematic study of particle size and drug content.
A. Budhian (2007)
Rationally developed core–shell polymeric-lipid hybrid nanoparticles as a delivery vehicle for cromolyn sodium: implications of lipid envelop on in vitro and in vivo behaviour of nanoparticles upon oral administration
Ravi R. Patel (2015)
Optimization of Hydrogels for Transdermal Delivery of Lisinopril by Box–Behnken Statistical Design
R. Gannu (2009)
The characteristics and improved intestinal permeability of vancomycin PLGA-nanoparticles as colloidal drug delivery system.
P. Zakeri-Milani (2013)
In-vitro release of acyclovir loaded Eudragit RLPO(®) nanoparticles for sustained drug delivery.
A. Gandhi (2014)
Facilitated nanoscale delivery of insulin across intestinal membrane models.
Camile B. Woitiski (2011)
An improved everted gut sac as a simple and accurate technique to measure paracellular transport across the small intestine
L. Barthe (2010)
Formulation and evaluation of solid lipid nanoparticles of a water soluble drug: Zidovudine.
S. Singh (2010)
Oral Delivery of Sodium Cromolyn: Preliminary Studies In Vivo and In Vitro
A. Leone-Bay (2004)
Improved delivery of cromolyn from oral proliposomal beads.
D. Deshmukh (2008)
Formulation and optimization of piroxicam proniosomes by 3-factor, 3-level box-behnken design
Ajay B. Solanki (2008)
Lipopolysaccharide based oral nanocarriers for the improvement of bioavailability and anticancer efficacy of curcumin.
Sundeep Chaurasia (2015)
Alginate/Chitosan Nanoparticles are Effective for Oral Insulin Delivery
B. Sarmento (2007)
Optimization of Parameters for the Fabrication of Curcumin Loaded Polymeric Nanoparticles Using Taguchi Robust Design
Sundeep Chaurasia (2014)
Curcumin-polymeric nanoparticles against colon-26 tumor-bearing mice: cytotoxicity, pharmacokinetic and anticancer efficacy studies
Sundeep Chaurasia (2016)
Development and optimization of polymeric nanoparticles of antitubercular drugs using central composite factorial design*
Ruchi Chawla (2014)
Production of haloperidol-loaded PLGA nanoparticles for extended controlled drug release of haloperidol
A. Budhian (2005)
Oral Absorption Enhancement of Cromolyn Sodium Through Noncovalent Complexation
Xuan Ding (2004)
Investigation of Critical Variables of Core–Shell Polymer Lipid Hybrid Nanoparticles by Using Plackett-Burman Screening Design
Ravi R. Patel (2014)
Formulation and Optimization of Polymeric Nanoparticles for Intranasal Delivery of Lorazepam Using Box-Behnken Design: In Vitro and In Vivo Evaluation
D. Sharma (2014)
Mast cells of two types differing in neutral protease composition in the human aortic intima. Demonstration of tryptase- and tryptase/chymase-containing mast cells in normal intimas, fatty streaks, and the shoulder region of atheromas.
M. Kaartinen (1994)
Chitosans as Absorption Enhancers for Poorly Absorbable Drugs 2: Mechanism of Absorption Enhancement
N. G. Schipper (2004)
Mechanistic Understanding of Oral Drug Absorption Enhancement of Cromolyn Sodium by an Amino Acid Derivative
Adam W. G. Alani (2007)
The effect of the oral administration of polymeric nanoparticles on the efficacy and toxicity of tamoxifen.
A. Jain (2011)
Formulation and optimization of itraconazole polymeric lipid hybrid nanoparticles (Lipomer) using box behnken design
B. Gajra (2014)
Enhanced bioavailability and intestinal uptake of Gemcitabine HCl loaded PLGA nanoparticles after oral delivery.
G. Joshi (2014)
PLGA nanoparticles containing praziquantel: effect of formulation variables on size distribution.
R. Mainardes (2005)
Development and Optimization of Atorvastatin Calcium Loaded Oral Biodegradable Polymeric Nanoparticles Using Central Composite Design
Nagendra Kumar (2014)
Optimizing drug delivery systems using systematic "design of experiments." Part I: fundamental aspects.
B. Singh (2005)
Particle engineering of materials for oral inhalation by dry powder inhalers. II-Sodium cromoglicate.
L. Nolan (2011)
Second generation lipid nanoparticles (NLC) as an oral drug carrier for delivery of lercanidipine hydrochloride.
N. Ranpise (2014)
Development of novel polymer-stabilized diosmin nanosuspensions: in vitro appraisal and ex vivo permeation.
May S. Freag (2013)
Development and optimization of curcumin-loaded mannosylated chitosan nanoparticles using response surface methodology in the treatment of visceral leishmaniasis
P. Chaubey (2014)
Development and optimization of baicalin-loaded solid lipid nanoparticles prepared by coacervation method using central composite design.
Jifu Hao (2012)
pH-sensitive chitosan/alginate core-shell nanoparticles for efficient and safe oral insulin delivery.
Piyasi Mukhopadhyay (2015)
This paper is referenced by
Comparison of bulk and microfluidics methods for the formulation of poly-lactic-co-glycolic acid (PLGA) nanoparticles modified with cell-penetrating peptides of different architectures
Sarah Streck (2019)
Development and in vitro characterization of chitosan-coated polymeric nanoparticles for oral delivery and sustained release of the immunosuppressant drug mycophenolate mofetil
M. Mohammed (2019)
Comparative Study of Ex Vivo Transmucosal Permeation of Pioglitazone Nanoparticles for the Treatment of Alzheimer’s Disease
Marcelle Silva-Abreu (2018)
3-month parenteral PLGA microsphere formulations of risperidone: Fabrication, characterization and neuropharmacological assessments.
Sundeep Chaurasia (2017)
DEVELOPMENT OF ONCE-DAILY MYCOPHENOLATE MOFETIL SUSTAINED RELEASE ORAL NANOPARTICLES
M. Mohammed (2017)
Fabrication of long-acting insulin formulation based on poly (3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) nanoparticles: preparation, optimization, characterization, and in vitro evaluation
Samane Bayrami (2019)
In vitro evaluation of folate-modified PLGA nanoparticles containing paclitaxel for ovarian cancer therapy.
Marcela Tavares Luiz (2019)
Exemestane encapsulated vitamin E-TPGS–polymeric nanoparticles: preparation, optimization, characterization, and in vitro cytotoxicity assessment
B. Mishra (2017)
Cromolyn‐crosslinked chitosan nanoparticles for the treatment of allergic rhinitis
Angela Abruzzo (2019)
Hydrophobic ion pair loaded self-emulsifying drug delivery system (SEDDS): A novel oral drug delivery approach of cromolyn sodium for management of bronchial asthma.
Marwa Hasanein Asfour (2020)
Sublingual dendritic cells targeting by aptamer: Possible approach for improvement of sublingual immunotherapy efficacy.
Sanaz Keshavarz Shahbaz (2020)
Unraveling the thermodynamics, binding mechanism and conformational changes of HSA with chromolyn sodium: Multispecroscopy, isothermal titration calorimetry and molecular docking studies.
Shama Yasmeen (2017)
PHBV/PLGA nanoparticles for enhanced delivery of 5-fluorouracil as promising treatment of colon cancer
Somayeh Handali (2019)
Tinidazole functionalized homogeneous electrospun chitosan/poly (ε-caprolactone) hybrid nanofiber membrane: Development, optimization and its clinical implications.
G. Khan (2017)
Highly water-soluble mast cell stabiliser-encapsulated solid lipid nanoparticles with enhanced oral bioavailability
Ravi R. Patel (2016)
PLGA nanoparticles for intravitreal peptide delivery: statistical optimization, characterization and toxicity evaluation
R. Bisht (2018)
Development of porous spray-dried inhalable particles using an organic solvent-free technique
L. Gallo (2019)