Online citations, reference lists, and bibliographies.

Down-regulation Of Hsa_circ_0092125 Is Related To The Occurrence And Development Of Oral Squamous Cell Carcinoma.

Lina Gao, Q-B Wang, Y Zhi, W-H Ren, S Li, C-Y Zhao, X-M Xing, Z-C Dou, J.C. Liu, C-M Jiang, K-Q Zhi
Published 2019 · Medicine
Cite This
Download PDF
Analyze on Scholarcy
Share
Circular RNA plays an important role in regulating tumour development and progression and can serve as a biomarker for cancer. This study was performed to investigate the clinical significance of hsa_circ_0092125 expression in oral squamous cell carcinoma (OSCC). The expression of hsa_circ_0092125 in OSCC tissues and cell lines was determined by reverse transcription-quantitative PCR analysis. The association between hsa_circ_0092125 expression and clinicopathological data was determined by χ2 test. Overall survival (OS) curves were created using Kaplan-Meier survival analysis, and the differences were examined by log-rank test. Moreover, univariate and multivariate Cox analysis were employed to evaluate the risk factors of the OSCC prognosis. The expression of hsa_circ_0092125 was significantly down-regulated in OSCC tissues and cell lines. A low expression of hsa_circ_0092125 was associated with clinicopathological factors in OSCC patients, including tumour size, TNM stage, and lymph node metastasis. Kaplan-Meier survival analysis indicated that the OS time was shorter in OSCC patients with a lower hsa_circ_0092125 expression level than in those with a higher expression level. In addition, univariate and multivariate Cox analysis identified lower hsa_circ_0092125 expression, tumour size, TNM stage, and lymph node metastasis as independent risk factors for the OSCC prognosis. Thus, down-regulated expression of hsa_circ_0092125 might serve as a biomarker of the OSCC prognosis.
This paper references
10.1038/s41467-018-05872-4
Immunomodulatory role of Keratin 76 in oral and gastric cancer
Inês Sequeira (2018)
10.1038/s41388-019-0760-3
MicroRNA-1205, encoded on chromosome 8q24, targets EGLN3 to induce cell growth and contributes to risk of castration-resistant prostate cancer
Yicun Wang (2019)
10.1038/nn.3975
Neural circular RNAs are derived from synaptic genes and regulated by development and plasticity
Xintian Arthur You (2015)
10.1080/15476286.2015.1122162
Circular RNA participates in the carcinogenesis and the malignant behavior of cancer
Zhenjun Zhao (2017)
10.1161/CIRCRESAHA.115.306319
Identification and Characterization of Hypoxia-Regulated Endothelial Circular RNA.
Jes-Niels Boeckel (2015)
10.1002/ijc.31638
miR-134 targets PDCD7 to reduce E-cadherin expression and enhance oral cancer progression.
Shih-Yuan Peng (2018)
10.1186/s13046-018-0819-y
SIRT7 suppresses the epithelial-to-mesenchymal transition in oral squamous cell carcinoma metastasis by promoting SMAD4 deacetylation
W. Li (2018)
10.1016/j.canlet.2018.07.016
LncRNA-p23154 promotes the invasion-metastasis potential of oral squamous cell carcinoma by regulating Glut1-mediated glycolysis.
Yun Wang (2018)
10.1093/bioinformatics/btw496
PcircRNA_finder: a software for circRNA prediction in plants
Li Chen (2016)
10.1016/j.ebiom.2018.09.006
Cancer-associated fibroblasts contribute to oral cancer cells proliferation and metastasis via exosome-mediated paracrine miR-34a-5p
Y. Li (2018)
10.1186/s12967-016-0977-7
Profiling and bioinformatics analyses reveal differential circular RNA expression in radioresistant esophageal cancer cells
Huafang Su (2016)
10.1080/15476286.2016.1271524
Insights into circular RNA biology
Karoline K. Ebbesen (2017)
10.1038/bcj.2016.81
CircRNAs in hematopoiesis and hematological malignancies
Alberto Bonizzato (2016)
10.3389/fonc.2018.00398
Circular RNA Expression in Oral Squamous Cell Carcinoma
Yu-fan Wang (2018)
10.1007/s00018-017-2688-5
Molecular roles and function of circular RNAs in eukaryotic cells
Lesca Miriam Holdt (2017)
10.1111/jcmm.13789
Circular RNAs: Methodological challenges and perspectives in cardiovascular diseases
Matteo Carrara (2018)
10.1016/j.molcel.2015.03.027
Circular RNAs in the Mammalian Brain Are Highly Abundant, Conserved, and Dynamically Expressed.
Agnieszka Rybak-Wolf (2015)
10.1080/15476286.2016.1227905
Circular RNAs: Unexpected outputs of many protein-coding genes
Jeremy E. Wilusz (2017)
10.1016/j.molcel.2014.08.019
circRNA biogenesis competes with pre-mRNA splicing.
Reut Ashwal-Fluss (2014)
10.1111/febs.14132
hsa_circ_0013958: a circular RNA and potential novel biomarker for lung adenocarcinoma
X. Zhu (2017)
10.1016/j.canlet.2017.06.027
Circular RNA MYLK as a competing endogenous RNA promotes bladder cancer progression through modulating VEGFA/VEGFR2 signaling pathway.
Zhenyu Zhong (2017)
10.1038/onc.2017.89
circRNA_100290 plays a role in oral cancer by functioning as a sponge of the miR-29 family
Liu Fang Chen (2017)
10.1016/j.biomaterials.2018.03.015
Nucleosome-inspired nanocarrier obtains encapsulation efficiency enhancement and side effects reduction in chemotherapy by using fullerenol assembled with doxorubicin.
Jinglong Tang (2018)
10.1038/s41419-018-0893-2
Screening for long noncoding RNAs associated with oral squamous cell carcinoma reveals the potentially oncogenic actions of DLEU1
Koyo Nishiyama (2018)
10.1016/j.cell.2015.02.014
The RNA Binding Protein Quaking Regulates Formation of circRNAs
Simon J Conn (2015)
10.1002/mc.21880
MicroRNA-1322 regulates ECRG2 allele specifically and acts as a potential biomarker in patients with esophageal squamous cell carcinoma.
Tengfei Zhang (2013)
10.3390/cancers10100348
Role of COX-2/PGE2 Mediated Inflammation in Oral Squamous Cell Carcinoma
Walaa Hamed Shaker Nasry (2018)
10.1159/000491624
Salivary Circular RNAs Hsa_Circ_0001874 and Hsa_Circ_0001971 as Novel Biomarkers for the Diagnosis of Oral Squamous Cell Carcinoma
Siyu Zhao (2018)
10.1007/s10517-016-3357-7
Plasma Levels of hsa-miR-619-5p and hsa-miR-1184 Differ in Prostatic Benign Hyperplasia and Cancer
Evgeny Knyazev (2016)
10.1080/15476286.2016.1227904
The emerging role and clinical implication of human exonic circular RNA
Dongbin Lyu (2017)
10.1080/15476286.2016.1220473
The emerging landscape of circular RNA in life processes
Shibin Qu (2017)
10.1101/gr.202895.115
Diverse alternative back-splicing and alternative splicing landscape of circular RNAs.
Xiao-Ou Zhang (2016)
10.1080/15476286.2016.1269999
Increased complexity of circRNA expression during species evolution
R. Dong (2017)
10.1002/jcp.27162
Circular RNA circ-VANGL1 as a competing endogenous RNA contributes to bladder cancer progression by regulating miR-605-3p/VANGL1 pathway.
Zhihua Zeng (2019)
10.1186/s12943-017-0663-2
CircRNA: functions and properties of a novel potential biomarker for cancer
Shujuan Meng (2017)



This paper is referenced by
Semantic Scholar Logo Some data provided by SemanticScholar