Online citations, reference lists, and bibliographies.
← Back to Search

Antitumor Activity Of Adriamycin-incorporated Polymeric Micelles Of Poly(gamma-benzyl L-glutamate)/poly(ethylene Oxide).

Young-Il Jeong, Hee-Sam Na, Kyoung-Oh Cho, Hyun-chul Lee, J. Nah, Chong-su Cho
Published 2009 · Chemistry, Medicine

Cite This
Download PDF
Analyze on Scholarcy
Share
The multiblock copolymer composed of poly(gamma-benzyl L-glutamate) (PBLG) and poly(ethylene oxide) (PEO) was synthesized to prepare polymeric micelles as an anticancer drug carrier. Adriamycin (ADR) used as an anticancer drug was incorporated into the polymeric micelles prepared by the multiblock copolymer. The higher the drug feeding ratio, the higher the drug loading contents and the lower the drug loading efficiency. The increased drug feeding ratio resulted in increased particle sizes. At all of the formulations, particle sizes were less than 150 nm. The particles were observed as spherical shapes. ADR release from ADR-loaded polymeric micelles in vitro was decreased with an increased drug loading contents. In in vitro antitumor activity test using CT 26 tumor cells, polymeric micelles showed almost similar cytotoxicity when compared to ADR itself while polymeric micelles themselves did not affect cytotoxicity. In in vivo antitumor activity test using mice tumor xenograft model, the polymeric micelles showed improved survivability of mice with minimized weight changes and excellent tumor growth suppression efficacy. Polymeric micelles of the multiblock copolymer suggested to be a good candidate for anticancer drug delivery carrier.
This paper references
Phys - ical entrapment of adriamycin in AB block copolymer micelles
G. S. won
10.1126/SCIENCE.8128245
Biodegradable long-circulating polymeric nanospheres.
R. Gref (1994)
10.1021/BC040297G
Copoly(styrene-maleic acid)-pirarubicin micelles: high tumor-targeting efficiency with little toxicity.
K. Greish (2005)
10.1016/S0378-5173(99)00202-1
Adriamycin release from flower-type polymeric micelle based on star-block copolymer composed of poly(gamma-benzyl L-glutamate) as the hydrophobic part and poly(ethylene oxide) as the hydrophilic part.
Y. Jeong (1999)
10.1111/j.1349-7006.1998.tb00563.x
Early Phase Tumor Accumulation of Macromolecules: A Great Difference in Clearance Rate between Tumor and Normal Tissues
Youichiro Noguchi (1998)
10.1021/LA00028A012
Micelles based on AB block copolymers of poly(ethylene oxide) and poly(.beta.-benzyl L-aspartate)
G. Kwon (1993)
10.1016/S0168-3659(99)00248-5
Tumor vascular permeability and the EPR effect in macromolecular therapeutics: a review.
H. Maeda (2000)
Toxicity and antitumor activity against solid tumors of micelle-forming polymeric anticancer drug and its extremely long circulation in blood.
M. Yokoyama (1991)
10.1023/A:1016266523505
Physical Entrapment of Adriamycin in AB Block Copolymer Micelles
G. Kwon (2004)
10.1016/S0168-3659(97)00163-6
Clonazepam release from core-shell type nanoparticles in vitro.
Y. Jeong (1998)
10.1021/MA00064A011
Self-aggregates of hydrophobized polysaccharides in water. Formation and characteristics of nanoparticles
K. Akiyoshi (1993)
10.1016/J.IJPHARM.2006.05.020
Adriamycin release from self-assembling nanospheres of poly(DL-lactide-co-glycolide)-grafted pullulan.
Y. Jeong (2006)
Preparation and characterization of the micelle - forming polymeric drug indomethacin - incorporated poly ( ethylene oxide ) - poly (  - benzyl l - aspartate ) block copolymer micelles
T. Okano (1996)
10.1021/MA960457M
Cubic Phase in a Connected Micellar Network of Poly(propylene oxide)−Poly(ethylene oxide)−Poly(propylene oxide) Triblock Copolymers in Water
K. Mortensen (1997)
10.1016/0168-3659(90)90139-K
Polymer micelles as novel drug carrier: Adriamycin-conjugated poly(ethylene glycol)-poly(aspartic acid) block copolymer
Y. Masayuki (1990)
Characterization and anticancer activity of the micelle-forming polymeric anticancer drug adriamycin-conjugated poly(ethylene glycol)-poly(aspartic acid) block copolymer.
M. Yokoyama (1990)
10.1021/MA00098A020
Phase behavior of poly(propylene oxide)-poly(ethylene oxide)-poly(propylene oxide) triblock copolymer melt and aqueous solutions
K. Mortensen (1994)
10.1021/JS950204R
Preparation and Characterization of the Micelle-Forming Polymeric Drug Indomethacin-lncorporated Polyfethylene oxide)-Poly(β-benzyl L-aspartate) Block Copolymer Micelles
Sung Bum La (1996)
10.1016/0168-3659(94)90118-X
Enhanced tumor accumulation and prolonged circulation times of micelle-forming poly(ethylene oxide-aspartate) block copolymer-Adriamycin conjugates
G. Kwon (1994)
10.1021/MA00056A035
Structural study on the micelle formation of poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) triblock copolymer in aqueous solution
K. Mortensen (1993)
10.1023/A:1018998203127
Biodistribution of Micelle-Forming Polymer–Drug Conjugates
G. Kwon (2004)



This paper is referenced by
10.1007/s10396-013-0438-3
Effect of fractionation on treatment outcome in local dual-frequency sonication and Dox-encapsulated nanomicelles
H. Hasanzadeh (2013)
10.1039/c0cs00085j
Biohybrid block copolymers: towards functional micelles and vesicles.
Gad Fuks (2011)
10.1016/j.ijpharm.2009.08.041
Combination antitumor effects of micelle-loaded anticancer drugs in a CT-26 murine colorectal carcinoma model.
H. Na (2010)
10.1016/j.ijpharm.2012.04.048
Paclitaxel-incorporated nanoparticles of hydrophobized polysaccharide and their antitumor activity.
S. Lee (2012)
10.1007/s10396-013-0484-x
Dual-frequency ultrasound activation of nanomicellar doxorubicin in targeted tumor chemotherapy
H. Hasanzadeh (2013)
10.1016/j.nano.2010.05.005
Advances in polymeric micelles for drug delivery and tumor targeting.
U. Kedar (2010)
10.2147/IJN.S19491
Doxorubicin-incorporated polymeric micelles composed of dextran-b-poly(DL-lactide-co-glycolide) copolymer
Y. Jeong (2011)
10.1007/s11671-009-9427-2
Self-Assembled Polymeric Micellar Nanoparticles as Nanocarriers for Poorly Soluble Anticancer Drug Ethaselen
Xinru Li (2009)
10.1049/iet-nbt.2014.0076
Optimisation of processing variables effective on self-assembly of folate targeted Synpronic-based micelles for docetaxel delivery in melanoma cells.
Somayeh Taymouri (2015)
10.1002/POLB.22259
Biomedical Applications of Biodegradable Polymers.
B. Ulery (2011)
10.1039/C3NJ41155A
Preparation and biological characterization of pH-responsive PASP-g-PEG-DDA-Hyd-ADR
Hailong Huang (2013)
Effect of Local Dual Frequency Sonication on Drug Distribution from Nanomicelles
H. Hasanzadeh (2010)
10.1007/s10856-011-4262-2
Glycyrrhetinic acid-functionalized degradable micelles as liver-targeted drug carrier
W. Huang (2011)
10.1080/09205063.2013.789357
A novel chitosan-based thermosensitive hydrogel containing doxorubicin liposomes for topical cancer therapy
Wenxi Wang (2013)
10.1002/APP.39623
Poly(methyl methacrylate)/poly(ethylene glycol)/poly(ethylene glycol dimethacrylate) micelles: Preparation, characterization, and application as doxorubicin carriers
L. Yu (2014)
10.1002/mabi.201400451
Amphiphilic PEO-b-PBLG diblock and PBLG-b-PEO-b-PBLG triblock copolymer based nanoparticles: doxorubicin loading and in vitro evaluation.
Dipti Kakkar (2015)
10.1080/00914037.2018.1552860
Sorafenib loaded pluronic F127-lithocholic acid micelles for prostate cancer therapy: Formulation, optimization, and in vitro evaluation against LNCaP cells
Noha Nasehi (2020)
10.3109/02652048.2010.534823
Self-assembled polyion complex micelles for sustained release of hydrophilic drug
Jinfang Yuan (2011)
10.1016/J.CARBPOL.2011.11.087
A novel carboxymethyl chitosan-based folate/Fe3O4/CdTe nanoparticle for targeted drug delivery and cell imaging
J. Shen (2012)
10.1016/j.ultsonch.2011.03.018
Effect of local dual frequency sonication on drug distribution from polymeric nanomicelles.
H. Hasanzadeh (2011)
10.1007/s40005-016-0294-4
Dioxadet-loaded nanogels as a potential formulation for glioblastoma treatment
Roman Voeikov (2016)
10.1016/j.actbio.2010.04.021
Glycyrrhetinic acid-modified poly(ethylene glycol)-b-poly(gamma-benzyl l-glutamate) micelles for liver targeting therapy.
W. Huang (2010)
10.1007/s11095-015-1784-1
Polymeric Micelles: Recent Advancements in the Delivery of Anticancer Drugs
A. Gothwal (2015)
10.1016/j.ijpharm.2013.12.046
Investigation of thermo-sensitive amphiphilic micelles as drug carriers for chemotherapy in cholangiocarcinoma in vitro and in vivo.
X. Wang (2014)
10.1007/s12272-011-0308-8
Combination of paclitaxel- and retinoic acid-incorporated nanoparticles for the treatment of CT-26 colon carcinoma
Gun-Young Hong (2011)
10.1248/BPB.B13-00540
Selective delivery of oxaliplatin to tumor tissue by nanocarrier system enhances overall therapeutic efficacy of the encapsulated oxaliplatin.
A. S. Lila (2014)
10.1016/j.ijpharm.2014.12.040
Nanoemulsions produced by rotor-stator high speed stirring.
P. Scholz (2015)
10.1016/j.ijpharm.2020.119537
Nanoparticles based on natural, engineered or synthetic proteins and polypeptides for drug delivery applications.
Evangelos Georgilis (2020)
Semantic Scholar Logo Some data provided by SemanticScholar