Online citations, reference lists, and bibliographies.
← Back to Search

Lipid Nanoparticles (SLN, NLC) In Cosmetic And Pharmaceutical Dermal Products.

J. Pardeike, A. Hommoss, R. Mueller
Published 2009 · Chemistry, Medicine

Cite This
Download PDF
Analyze on Scholarcy
Share
Solid lipid nanoparticles (SLN) are distinguishable from nanostructured lipid carriers (NLC) by the composition of the solid particle matrix. Both are an alternative carrier system to liposomes and emulsions. This review paper focuses on lipid nanoparticles for dermal application. Production of lipid nanoparticles and final products containing lipid nanoparticles is feasible by well-established production methods. SLN and NLC exhibit many features for dermal application of cosmetics and pharmaceutics, i.e. controlled release of actives, drug targeting, occlusion and associated with it penetration enhancement and increase of skin hydration. Due to the production of lipid nanoparticles from physiological and/or biodegradable lipids, this carrier system exhibits an excellent tolerability. The lipid nanoparticles are a "nanosafe" carrier. Furthermore, an overview of the cosmetic products currently on the market is given and the improvement of the benefit/risk ratio of the topical therapy is shown.
This paper references
10.1016/S0378-5173(98)00404-9
Enzymatic degradation of SLN-effect of surfactant and surfactant mixtures.
C. Olbrich (1999)
10.1002/JPS.20335
Evaluation of indomethacin percutaneous absorption from nanostructured lipid carriers (NLC): in vitro and in vivo studies.
M. Ricci (2005)
Investigations on the occlusive properties of solid lipid nanoparticles (SLN).
S. Wissing (2001)
10.1016/J.IJPHARM.2004.02.032
Development of a controlled release formulation based on SLN and NLC for topical clotrimazole delivery.
E. Souto (2004)
Investigations on the occlusive properties of solid lipid nanoparticles ( SLN )
S. A. issing
10.1016/S0378-5173(99)00413-5
Solid lipid nanoparticles as drug carriers for topical glucocorticoids.
C. A. S. Maia (2000)
10.1002/JPS.2600690703
Clearance of 141C3-labeled microspheres from blood and distribution in specific organs following intravenous and intraarterial administration in beagle dogs.
M. Kanke (1980)
The use of SLN and NLC as topical particulate carriers for imidazole antifungal agents.
E. Souto (2006)
10.1016/S0378-5173(01)00660-3
Surfactant, but not the size of solid lipid nanoparticles (SLN) influences viability and cytokine production of macrophages.
N. Schöler (2001)
10.1002/JPS.2600670418
Physiological effects of subvisible microspheres administered intravenously to beagle dogs.
H. Schroeder (1978)
10.17169/REFUBIUM-12273
SLN and NLC for topical delivery of antifungals
E. Souto (2005)
10.1016/S0169-409X(01)00105-3
Solid lipid nanoparticles: production, characterization and applications.
W. Mehnert (2001)
10.1016/J.IJPHARM.2007.03.022
Encapsulation of ascorbyl palmitate in nanostructured lipid carriers (NLC)--effects of formulation parameters on physicochemical stability.
Veerawat Teeranachaideekul (2007)
10.1016/J.IJPHARM.2006.08.007
Isotretinoin-loaded solid lipid nanoparticles with skin targeting for topical delivery.
J. Liu (2007)
10.1080/1061186021000038364
Drug Targeting by Solid Lipid Nanoparticles for Dermal Use
C. Santos Maia (2002)
10.1016/j.ijpharm.2008.01.045
Lipid nanoparticles for prolonged topical delivery: an in vitro and in vivo investigation.
C. Puglia (2008)
10.1016/J.JCONREL.2004.04.001
Glucocorticoid entrapment into lipid carriers--characterisation by parelectric spectroscopy and influence on dermal uptake.
R. Sivaramakrishnan (2004)
The hen ’ s eggchorioallantoic membrane test ( HETCAM test ) for the assessment of the eye irritation potential of chemical substances
H. hai (2001)
10.1016/S0149-2918(01)80003-5
Comparison of the cumulative irritation potential of adapalene gel and cream with that of erythromycin/tretinoin solution and gel and erythromycin/isotretinoin gel.
C. Queille-Roussel (2001)
10.1179/016164107X187017
Solid lipid nanoparticles: could they help to improve the efficacy of pharmacologic treatments for brain tumors?
A. Brioschi (2007)
10.1023/A:1016121319668
A Novel Phase Inversion-Based Process for the Preparation of Lipid Nanocarriers
B. Heurtault (2004)
10.1211/0022357023754
Cytotoxicity studies of Dynasan 114 solid lipid nanoparticles (SLN) on RAW 264.7 macrophages—impact of phagocytosis on viability and cytokine production
C. Olbrich (2004)
The choice of lipids and surfactants for injectable extravenous microspheres.
J. Pietkiewicz (2004)
10.1016/J.EJPB.2005.12.007
Stabilization of all-trans retinol by loading lipophilic antioxidants in solid lipid nanoparticles.
J. Jee (2006)
10.1016/J.IJPHARM.2007.05.060
Nanostructured lipid carrier (NLC) based gel of celecoxib.
M. Joshi (2008)
10.1002/CHIN.200748264
Solid Lipid Nanoparticles for Targeted Brain Drug Delivery
P. Blasi (2007)
Solid lipidnanspheres fromwarmmicroemuslion
S. H. ohla (1997)
Coenzyme Q 10 loaded NLCs : preparation , occlusion properties and penetration enhancement
R. H. Müller
10.1016/S0378-5173(02)00220-X
The influence of the crystallinity of lipid nanoparticles on their occlusive properties.
S. Wissing (2002)
10.1080/026520400417685
Effect of solid lipid nanoparticles (SLN) on cytokine production and the viability of murine peritoneal macrophages.
N. Schöler (2000)
10.1211/jpp.59.8.0002
Solid lipid nanoparticles (SLN) as carriers for the topical delivery of econazole nitrate: in‐vitro characterization, ex‐vivo and in‐vivo studies
V. Sanna (2007)
10.1016/S0378-5173(01)00882-1
Effect of lipid matrix and size of solid lipid nanoparticles (SLN) on the viability and cytokine production of macrophages.
N. Schöler (2002)
10.1016/S0378-5173(02)00081-9
Preparation of solid lipid nanoparticles with clobetasol propionate by a novel solvent diffusion method in aqueous system and physicochemical characterization.
F. Hu (2002)
10.1016/j.ijpharm.2008.01.008
Solid lipid nanoparticles for pulmonary delivery of insulin.
J. Liu (2008)
10.1016/S0927-7765(02)00053-X
Design of lipid nanoparticles for the oral delivery of hydrophilic macromolecules
M. Garcia-Fuentes (2003)
10.1016/J.EJPB.2004.02.015
Evaluation of the physical stability of SLN and NLC before and after incorporation into hydrogel formulations.
E. Souto (2004)
10.1016/J.IJBIOMAC.2005.05.003
A new healthy sunscreen system for human: solid lipid nanoparticles as carrier for 3,4,5-trimethoxybenzoylchitin and the improvement by adding Vitamin E.
Chunjin Song (2005)
In vivo skin hydration properties of a coenzyme Q 10 containing cream with nanostructured lipid carriers ( NLC )
J. ardeike (2006)
Nanostructured Lipid Drug Carriers
M. Radtke
10.1159/000056328
Effects of Skin Occlusion on Percutaneous Absorption: An Overview
H. Zhai (2001)
10.1016/j.jconrel.2005.09.052
Podophyllotoxin-loaded solid lipid nanoparticles for epidermal targeting.
Huabing Chen (2006)
10.1016/S0378-5173(00)00623-2
Preparation of semisolid drug carriers for topical application based on solid lipid nanoparticles.
A. Lippacher (2001)
Prolongedefficacyof the insect repellent lemon oil by incorporation into solid lipid nanoparticles ( SLNTM )
A. Lippacher
10.1080/02652040500162436
SLN and NLC for topical delivery of ketoconazole
E. Souto (2005)
STATEMENT ON THE VALIDITY OF IN-VITRO TESTS FOR SKIN IRRITATION
T. Hartung (2007)
10.1016/S0939-6411(03)00067-5
Solid lipid nanoparticle and microemulsion for topical delivery of triptolide.
Zhinan Mei (2003)
10.1142/9781860949074_0009
Solid Lipid Nanoparticles as Drug Carriers
K. Mäder (2006)
10.1016/S0378-5173(02)00268-5
Incorporation of cyclosporin A in solid lipid nanoparticles (SLN).
E. Ugazio (2002)
10.1016/J.TOXLET.2007.05.230
In vitro skin irritation test: Increasing the sensitivity of the EpiDerm skin irritation protocol evaluated in the ECVAM skin irritation validation study
Helena Kanďárová (2007)
Development of a controlled release formulation based on SLN and NLC for topical clotrimazole delivery
E. B. Soutoa (2004)
10.1016/J.ADDR.2007.04.006
Lipid nanoparticles for improved topical application of drugs for skin diseases.
M. Schäfer-Korting (2007)
10.1016/S0378-5173(99)00430-5
Preserved solid lipid nanoparticles (SLN) at low concentrations do cause neither direct nor indirect cytotoxic effects in peritoneal macrophages.
N. Schöler (2000)
10.1016/S0168-3659(99)00223-0
Vitamin A-loaded solid lipid nanoparticles for topical use: drug release properties.
V. Jenning (2000)
10.1016/S0378-5173(99)00417-2
Influence of high pressure homogenisation equipment on nanodispersions characteristics.
S. Liedtke (2000)
10.1016/S0378-5173(02)00684-1
Cosmetic applications for solid lipid nanoparticles (SLN).
S. Wissing (2003)
Solid lipid nanoparticles — determination of in vivo toxicity . 1 st World Meeting on Pharmaceutics , Biopharmaceutics , Pharmaceutical Technology , Budapest
H. eyhers (1995)
10.1016/0300-483X(82)90079-8
Activation systems in tissue culture toxicity studies.
J. Fry (1982)
10.1016/j.ejpb.2008.05.008
Lipid nanoparticles as vehicles for topical psoralen delivery: solid lipid nanoparticles (SLN) versus nanostructured lipid carriers (NLC).
Jia-You Fang (2008)
10.1080/02652040010000361
Encapsulation of retinoids in solid lipid nanoparticles (SLN).
V. Jenning (2001)
10.1016/S0939-6411(02)00130-3
Solvent injection as a new approach for manufacturing lipid nanoparticles--evaluation of the method and process parameters.
M. Schubert (2003)
Solid lipid nanoparticles ( SLN ) as a novel carrier systemoffereingprolonged release of perfumeAllure ( Chanel )
S. A. issing
10.1016/J.JCONREL.2005.09.045
Lipid nanoparticles for skin penetration enhancement-correlation to drug localization within the particle matrix as determined by fluorescence and parelectric spectroscopy.
S. Lombardi Borgia (2005)
10.1016/S0939-6411(03)00040-7
The influence of solid lipid nanoparticles on skin hydration and viscoelasticity--in vivo study.
S. Wissing (2003)
Solid lipid nanoparticles (SLN) for topical drug delivery: incorporation of the lipophilic drugs N,N-diethyl-m-toluamide and vitamin K.
Y. Işcan (2005)
10.1016/0378-5173(86)90081-5
Evaluation of poly(lactic acid) as a biodegradable drug delivery system for parenteral administration
A. Smith (1986)
10.1166/JNN.2007.809
Solid lipid nanoparticles incorporating melatonin as new model for sustained oral and transdermal delivery systems.
L. Priano (2007)
10.1016/J.EJPB.2004.11.002
Novel nanoparticulate carrier system based on carnauba wax and decyl oleate for the dispersion of inorganic sunscreens in aqueous media.
J. R. Villalobos-Hernández (2005)
10.1016/0378-5173(92)90210-S
Alkylcyanoacrylate drug carriers: II. Cytotoxicity of cyanoacrylate nanoparticles with different alkyl chain length
C. Lherm (1992)
10.1016/S0939-6411(02)00123-6
AFM imaging of calixarene based solid lipid nanoparticles in gel matrices.
P. Shahgaldian (2003)
10.1016/j.jconrel.2008.02.011
Influence of oil content on physicochemical properties and skin distribution of Nile red-loaded NLC.
Veerawat Teeranachaideekul (2008)
The next generation after the liposomes : solid lipid nanoparticles ( SLN , LIPOPEARLS ) as dermal carrier in cosmetics
R. H. üller (1998)
10.1080/10837450600561182
Influence of the Formulation for Solid Lipid Nanoparticles Prepared with a Membrane Contactor
Assma Ahmed El-Harati (2006)
10.1080/03639040600814676
Formulation and Evaluation of Nanostructured Lipid Carrier (NLC)–based Gel of Valdecoxib
M. Joshi (2006)
10.1002/JPS.2600670417
Distribution of radiolabeled subvisible microspheres after intravenous administration to beagle dogs.
H. Schroeder (1978)
10.1007/s11095-006-9225-9
Cyproterone Acetate Loading to Lipid Nanoparticles for Topical Acne Treatment: Particle Characterisation and Skin Uptake
J. Štecová (2006)
10.1016/J.ADDR.2003.12.002
Solid lipid nanoparticles for parenteral drug delivery.
S. Wissing (2004)
10.1016/S0939-6411(00)00087-4
Solid lipid nanoparticles (SLN) for controlled drug delivery - a review of the state of the art.
R. Mueller (2000)
Solid lipid nanoparticles (SLN)--effects of lipid composition on in vitro degradation and in vivo toxicity.
H. Weyhers (2006)
10.1023/A:1012043315093
Cytotoxicity of Solid Lipid Nanoparticles as a Function of the Lipid Matrix and the Surfactant
R. Mueller (2004)
10.1016/J.COLSURFB.2007.03.002
Studies on oral absorption of stearic acid SLN by a novel fluorometric method.
H. Yuan (2007)
10.1016/J.JCONREL.2005.07.023
Preparation of solid lipid nanoparticles using a membrane contactor.
C. Charcosset (2005)
Lipid nanoparticles (NLC) as novel carrier for cosmetics : Special features & state of commercialisation
R. Mueller (2007)
Scaling up feasibility of the production of solid lipid nanoparticles (SLN).
S. Gohla (2001)
Solid lipid nanoparticles (SLN)--a novel carrier for UV blockers.
S. Wissing (2001)
10.1016/S0169-409X(02)00118-7
Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) in cosmetic and dermatological preparations.
R. Mueller (2002)
10.1023/B:PHAM.0000019291.36636.c1
Structural Characterization of Q10-Loaded Solid Lipid Nanoparticles by NMR Spectroscopy
Sylvia A. Wissing (2004)
10.1016/J.EJPB.2007.01.015
Cetyl palmitate-based NLC for topical delivery of Coenzyme Q(10) - development, physicochemical characterization and in vitro release studies.
Veerawat Teeranachaideekul (2007)
10.1023/A:1015874121860
Optimization of Spray-Dried and -Congealed Lipid Micropellets and Characterization of Their Surface Morphology by Scanning Electron Microscopy
T. Eldem (2004)
10.1016/J.COLSURFA.2007.07.035
Effect of beeswax modification on the lipid matrix and solid lipid nanoparticle crystallinity
A. Attama (2008)
10.1002/JPS.21088
Alternative methods for eye and skin irritation tests: an overview.
M. Vinardell (2008)
Eval - uation of indomethacin percutaneous absorption from nanostructured lipid carriers ( NLC ) : in vitro and in vivo studies
V. anna (2005)
10.1016/S0041-008X(03)00301-6
Cyclooxygenases in the skin: pharmacological and toxicological implications.
J. L. Lee (2003)
10.1016/J.IJPHARM.2006.02.045
Oral bioavailability of cyclosporine: solid lipid nanoparticles (SLN) versus drug nanocrystals.
R. Mueller (2006)
10.1016/S0168-3659(97)01653-2
Solid lipid nanoparticles (SLN) as potential carrier for human use: interaction with human granulocytes
R. Mueller (1997)
10.5580/12d7
The efficacy of topical cyproterone acetate alcohol lotion versus placebo in the treatment of the mild to moderate acne vulgaris: a double blind study.
F. Iraji (2006)
10.1016/J.IJPHARM.2006.12.045
Cytotoxicity of submicron emulsions and solid lipid nanoparticles for dermal application.
W. Weyenberg (2007)
10.1080/03639040701833708
Investigation of Nanostructured Lipid Carriers for Transdermal Delivery of Flurbiprofen
F. Han (2008)
Oral insulin delivery by means of solid lipid nanoparticles
B. Sarmento (2007)
Prolonged release of parfumes by nano lipid carriers ( NLC ) technology
R. H. üller
Optimization of spraydried andcongealed lipidmicropellets and characterization of their surfacemorphology by scanning electron microscopy
A. A. l-Harati (1991)
10.1007/BF02980228
Lung-targeting delivery of dexamethasone acetate loaded solid lipid nanoparticles
Qing-yu Xiang (2007)
10.1016/S0939-6411(99)00075-2
Vitamin A loaded solid lipid nanoparticles for topical use: occlusive properties and drug targeting to the upper skin.
V. Jenning (2000)
10.1080/10717540600739914
Nanostructured Lipid Carriers-Containing Anticancer Compounds: Preparation, Characterization, and Cytotoxicity Studies
M. Bondì (2007)
10.1016/J.EJPB.2006.10.019
Nanoparticles--an efficient carrier for drug delivery into the hair follicles.
J. Lademann (2007)
10.1016/J.IJPHARM.2007.05.061
Solid lipid nanoparticles (SLN) of tretinoin: potential in topical delivery.
Kumar A. Shah (2007)
10.1016/0378-5173(96)04539-5
Cytotoxicity of magnetite-loaded polylactide, polylactide/glycolide particles and solid lipid nanoparticles
R. Mueller (1996)
Lipid-based colloidal carriers for peptide and protein delivery – liposomes versus lipid nanoparticles
S. Martins (2007)
Nanostructured lipid carrier : A delivery system with protective functions
R. Petersen (2006)
10.1208/pt070364
Evaluation of alternative strategies to optimize ketorolac transdermal delivery
C. Puglia (2008)
10.1016/S0168-3659(02)00056-1
Solid lipid nanoparticles as carrier for sunscreens: in vitro release and in vivo skin penetration.
S. Wissing (2002)
10.1201/9781420039207.CH11
Solid Lipid Nanoparticles for Topical Delivery
Zhinan Mei (2005)
An evaluation of the OECD proposal for the harmonised classification of eye irritants and corrosives
M. Prinsen (1999)
10.1016/S0378-5173(03)00135-2
Preparation of solid lipid nanoparticles by a solvent emulsification-diffusion technique.
M. Trotta (2003)



This paper is referenced by
10.1007/s40089-015-0161-8
Development of nanostructured lipid carrier for dacarbazine delivery
Musallam Almousallam (2015)
10.17169/REFUBIUM-15652
Nanostructured Lipid Carriers (NLC) in dermal and personal care formulations
A. Hommoss (2009)
A comparative histological study on the skin occlusion performance of a cream made of solid lipid nanoparticles and Vaseline
H. Hamishehkar (2015)
NANOTECHNOLOGY-BASED COSMECEUTICALS: A REVIEW Review Article
Sanjukta Duarah (2016)
debenone-loaded solid lipid nanoparticles for drug delivery to the skin : In vitro valuation
ucia Montenegroa (2012)
Bioactive Umbelliferone and its derivatives : An update
Trideva Sastri (2019)
Lipid Nanoparticles : Future of Oral Drug Delivery and their Current Trends and Regulatory Issues
Kriti Soni (2016)
10.1211/jpp.61.08.0004
Evaluation of percutaneous absorption of the repellent diethyltoluamide and the sunscreen ethylhexyl p‐methoxycinnamate‐loaded solid lipid nanoparticles: an in‐vitro study
C. Puglia (2009)
10.1016/j.ejps.2020.105296
Development, Skin Targeting And Antifungal Efficacy Of Topical Lipid Nanoparticles Containing Itraconazole.
J. S. Passos (2020)
10.3390/nano9091204
Improved Dermal Delivery of Cyclosporine A Loaded in Solid Lipid Nanoparticles
Abderrazzaq Essaghraoui (2019)
10.1016/j.nano.2019.102026
Development of Halobetasol-loaded nanostructured lipid carrier for dermal administration: Optimization, physicochemical and biopharmaceutical behavior, and therapeutic efficacy.
Paulina Carvajal-Vidal (2019)
10.1016/j.ejpb.2016.07.018
Itraconazole-loaded nanostructured lipid carriers (NLC) for pulmonary treatment of aspergillosis in falcons.
J. Pardeike (2016)
10.1021/la3017968
Template-free uniform-sized hollow hydrogel capsules with controlled shell permeation and optical responsiveness.
Junoh Kim (2012)
10.15171/APB.2016.06
The Effect of Particle Size on the Deposition of Solid Lipid Nanoparticles in Different Skin Layers: A Histological Study.
Z. MardhiahAdib (2016)
Preparo e caracterização de carreadores lipídicos nanoestruturados para bupivacaína em excesso enantiomérico (S75:R25) : Development and characterization of nanostructured lipid carriers for enantiomeric excess (S75:R25) of bupivacaine
Rodrigues da Silva (2017)
10.1063/1.4895804
Single or functionalized fullerenes interacting with heme group
W. C. Costa (2014)
10.1517/17425247.2015.1021681
Advances in lipid-based drug delivery: enhancing efficiency for hydrophobic drugs
G. Wang (2015)
10.1080/10584587.2011.576951
Study on Stability of Coenzyme Q10-Loaded Nanostructured Lipid Carriers
Q. Xia (2011)
10.5650/jos.ess17051
Preparation of Salicylic Acid Loaded Nanostructured Lipid Carriers Using Box-Behnken Design: Optimization, Characterization and Physicochemical Stability.
Ketrawee Pantub (2017)
10.1016/j.ijpharm.2017.07.049
Breaching barriers in glioblastoma. Part II: Targeted drug delivery and lipid nanoparticles.
A. Miranda (2017)
10.3390/nano7060122
A Review of the Structure, Preparation, and Application of NLCs, PNPs, and PLNs
Qianwen Li (2017)
10.1016/J.INDCROP.2014.08.042
Incorporation of Achyrocline satureioides (Lam.) DC extracts into topical nanoemulsions obtained by means of spontaneous emulsification procedure
J. Bidone (2014)
10.1016/j.toxlet.2016.01.018
Toxicity and inflammatory response in Swiss albino mice after intraperitoneal and oral administration of polyurethane nanoparticles.
A. H. Silva (2016)
10.4028/www.scientific.net/MSF.694.170
Preparation and Characterization of Coenzyme Q10-Loaded Nanostructured Lipid Carriers
Q. Xia (2011)
Estudos de fotoestabilidade de fármacos e ativos cosméticos nano e microencapsulados
L. N. Pereira (2010)
10.1159/000324053
Drug Release and Skin Penetration from Solid Lipid Nanoparticles and a Base Cream: A Systematic Approach from a Comparison of Three Glucocorticoids
P. Schlupp (2011)
10.1201/B15642-8
Nanotechnology Applications in Urology
Himanshu Aggarwal (2013)
10.1007/s40005-013-0051-x
Nanosuspensions: a new approach for organ and cellular targeting in infectious diseases
Shegokar Ranjita (2013)
10.1016/j.ejps.2016.08.030
Nanostructured lipid carriers as robust systems for topical lidocaine-prilocaine release in dentistry.
Lígia N M Ribeiro (2016)
10.1016/J.EURPOLYMJ.2016.05.022
Simple design of chemically crosslinked plant oil nanoparticles by triazolinedione-ene chemistry
Subrata Chattopadhyay (2016)
10.1002/9783527610419.NTLS0257
Solid Lipid Nanoparticles to Improve Brain Drug Delivery
P. Blasi (2012)
10.7282/T3Z89BSD
FABRICATION AND CHARACTERIZATION OF LOW CRYSTALLINE CURCUMIN LOADED LIPID NANOPARTICLES
Yuechao Du (2011)
See more
Semantic Scholar Logo Some data provided by SemanticScholar